FR2411174A1 - Nouveaux tetrapeptides, leurs methodes de preparation et d'utilisation - Google Patents

Nouveaux tetrapeptides, leurs methodes de preparation et d'utilisation

Info

Publication number
FR2411174A1
FR2411174A1 FR7834508A FR7834508A FR2411174A1 FR 2411174 A1 FR2411174 A1 FR 2411174A1 FR 7834508 A FR7834508 A FR 7834508A FR 7834508 A FR7834508 A FR 7834508A FR 2411174 A1 FR2411174 A1 FR 2411174A1
Authority
FR
France
Prior art keywords
gly
seryle
alanyle
valyle
threonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7834508A
Other languages
English (en)
Other versions
FR2411174B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/960,550 external-priority patent/US4232008A/en
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of FR2411174A1 publication Critical patent/FR2411174A1/fr
Application granted granted Critical
Publication of FR2411174B1 publication Critical patent/FR2411174B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C07K7/062—Serum thymic factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'INVENTION CONCERNE UN POLYPEPTIDE AYANT LA CAPACITE D'INDUIRE LA DIFFERENCIATION EN LYMPHOCYTES TTH-1 ET LYMPHOCYTE BBU-1. SELON L'INVENTION, LE POLYPEPTIDE A LA SEQUENCE SUIVANTE: R-X-LYS-Y-GLN-R, OU X ET Y SONT CHACUN DES RESIDUS AMINOACIDES NATURELS ET NON NATURELS CHOISIS DANS LE GROUPE CONSISTANT EN L-ASPARAGYLE, L-GLUTAMYLE, L-THREONYLE, GLYCYLE, L-VALYLE, L-LEUCYLE, L-ALANYLE, L-SERYLE, SARCOSYLE, 2-METHYLALANYLE, D-ASPARAGYLE, D-GLUTAMYLE, D-THREONYLE, D-VALYLE, D-LEUCYLE, D-ALANYLE ET D-SERYLE ET R ET R SONT CHACUN CHOISIS DANS LES GROUPES CONSISTANT EN:RHYDROGENEALCOYLE C-CARYLE C-CALKARYLE C-CARALKYLE C-CALCANOYLE C-CALKENYLE C-CALKYNYLE C-CGLNSARROHNHNHRN(R)ORGLYGLY-GLYGLY-GLY-SERGLY-GLY-SER-ASNOU R EST UN ALCOYLE C-C, UN ALKENYLE C-C, UN ALKYNYLE C-C, UN ARYLE C-C, UN ARALKYLE C-C, ET UN ALKARYLE C-C, A CONDITION QUE, QUAND R EST GLN, R SOIT AUTRE QUE GLY-GLY-SER-ASN. L'INVENTION S'APPLIQUE NOTAMMENT AU TRAITEMENT DE CONDITIONS RESULTANT DE DEFICIENCES RELATIVES OU ABSOLUES EN CELLULES T OU EN CELLULES B.
FR7834508A 1977-12-08 1978-12-07 Nouveaux tetrapeptides, leurs methodes de preparation et d'utilisation Granted FR2411174A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85849677A 1977-12-08 1977-12-08
US94053178A 1978-09-08 1978-09-08
US05/960,550 US4232008A (en) 1978-11-17 1978-11-17 Tetrapeptides and methods

Publications (2)

Publication Number Publication Date
FR2411174A1 true FR2411174A1 (fr) 1979-07-06
FR2411174B1 FR2411174B1 (fr) 1984-05-25

Family

ID=27420392

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7834508A Granted FR2411174A1 (fr) 1977-12-08 1978-12-07 Nouveaux tetrapeptides, leurs methodes de preparation et d'utilisation

Country Status (19)

Country Link
JP (1) JPS5498719A (fr)
CA (1) CA1120031A (fr)
CH (1) CH642058A5 (fr)
DE (1) DE2853002A1 (fr)
DK (1) DK149595C (fr)
ES (1) ES475857A1 (fr)
FI (1) FI67368C (fr)
FR (1) FR2411174A1 (fr)
GB (1) GB2014581B (fr)
GR (1) GR65013B (fr)
IE (1) IE47611B1 (fr)
IL (1) IL56150A (fr)
IT (1) IT1110889B (fr)
NL (1) NL7812004A (fr)
NO (1) NO149631C (fr)
NZ (1) NZ189101A (fr)
PT (1) PT68883A (fr)
SE (1) SE444687B (fr)
YU (1) YU41322B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126009A1 (fr) * 1983-05-16 1984-11-21 Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Nouveaux dérivés de peptides, leur préparation et leur application comme inhibiteurs de l'élastase
FR2741076A1 (fr) * 1995-11-15 1997-05-16 Rech De Pathologie Appliquee S Conjugues peptidiques derives des hormones thymiques, leur utilisation a titre de medicament et compositions les contenant

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215112A (en) * 1979-03-14 1980-07-29 Ortho Pharmaceutical Corporation Tripeptides and methods
US4215111A (en) * 1979-03-14 1980-07-29 Ortho Pharmaceutical Corporation Peptides having ubiquitin-like activity
CA1156220A (fr) * 1979-04-26 1983-11-01 George Heavner Methode et composition pour la preparation de h-sar-lys-sar-gln-nh.sub.2
US4426324A (en) * 1979-09-28 1984-01-17 Hoffmann-La Roche Inc. Immunopotentiating peptides
JPS5711950A (en) 1980-06-25 1982-01-21 Kureha Chem Ind Co Ltd Peptide and its synthesis
RU2210382C1 (ru) * 2002-07-09 2003-08-20 Терентьев Александр Александрович Пептид, обладающий иммунорегуляторным свойством, и его композиция

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2544348A1 (de) * 1975-10-03 1977-04-07 Max Planck Gesellschaft L-leucin-13-motilin, verfahren zu dessen herstellung und dasselbe enthaltendes mittel
NL7805717A (nl) * 1977-05-25 1978-11-28 Anvar Polypeptiden met geneeskundige activiteit.
FR2391994A1 (fr) * 1977-05-25 1978-12-22 Anvar Nouveaux polypeptides a activite thymique ou a activite antagoniste et leurs procedes de synthese
FR2423481A2 (fr) * 1978-04-21 1979-11-16 Anvar Nouveaux polypeptides a activite thymique ou a activite antagoniste et leurs procedes de synthese

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2544348A1 (de) * 1975-10-03 1977-04-07 Max Planck Gesellschaft L-leucin-13-motilin, verfahren zu dessen herstellung und dasselbe enthaltendes mittel
NL7805717A (nl) * 1977-05-25 1978-11-28 Anvar Polypeptiden met geneeskundige activiteit.
FR2391994A1 (fr) * 1977-05-25 1978-12-22 Anvar Nouveaux polypeptides a activite thymique ou a activite antagoniste et leurs procedes de synthese
FR2423481A2 (fr) * 1978-04-21 1979-11-16 Anvar Nouveaux polypeptides a activite thymique ou a activite antagoniste et leurs procedes de synthese

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126009A1 (fr) * 1983-05-16 1984-11-21 Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Nouveaux dérivés de peptides, leur préparation et leur application comme inhibiteurs de l'élastase
FR2546164A1 (fr) * 1983-05-16 1984-11-23 Centre Nat Rech Scient Nouveaux derives de peptides, leur preparation et leur application comme inhibiteurs de l'elastase
FR2741076A1 (fr) * 1995-11-15 1997-05-16 Rech De Pathologie Appliquee S Conjugues peptidiques derives des hormones thymiques, leur utilisation a titre de medicament et compositions les contenant
WO1997018239A1 (fr) * 1995-11-15 1997-05-22 Institut Europeen De Biologie Cellulaire Conjugues peptidiques derives des hormones thymiques, leur utilisation a titre de medicament et compositions les contenant
US6211155B1 (en) 1995-11-15 2001-04-03 Institut European De Biologie Cellulaire Peptide conjugates derived from thymic hormones, their use as a medicament and compositions containing them

Also Published As

Publication number Publication date
YU41322B (en) 1987-02-28
IL56150A0 (en) 1979-03-12
PT68883A (en) 1979-01-01
CH642058A5 (de) 1984-03-30
GR65013B (en) 1980-06-12
NO149631C (no) 1984-05-23
GB2014581A (en) 1979-08-30
SE444687B (sv) 1986-04-28
ES475857A1 (es) 1980-01-16
IT1110889B (it) 1986-01-06
DK554078A (da) 1979-06-09
NO784128L (no) 1979-06-11
CA1120031A (fr) 1982-03-16
YU288078A (en) 1983-02-28
DK149595C (da) 1987-03-23
DK149595B (da) 1986-08-04
FR2411174B1 (fr) 1984-05-25
JPS6327360B2 (fr) 1988-06-02
NZ189101A (en) 1984-07-06
SE7812614L (sv) 1979-06-09
IT7852239A0 (it) 1978-12-07
NL7812004A (nl) 1979-06-12
JPS5498719A (en) 1979-08-03
NO149631B (no) 1984-02-13
IL56150A (en) 1982-02-28
FI67368B (fi) 1984-11-30
FI67368C (fi) 1985-03-11
IE782423L (en) 1979-06-08
GB2014581B (en) 1982-05-19
FI783769A (fi) 1979-06-09
DE2853002A1 (de) 1979-06-13
IE47611B1 (en) 1984-05-02

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