GB2014581A - Polypeptides and Methods for the Preparation Thereof - Google Patents
Polypeptides and Methods for the Preparation ThereofInfo
- Publication number
- GB2014581A GB2014581A GB7847642A GB7847642A GB2014581A GB 2014581 A GB2014581 A GB 2014581A GB 7847642 A GB7847642 A GB 7847642A GB 7847642 A GB7847642 A GB 7847642A GB 2014581 A GB2014581 A GB 2014581A
- Authority
- GB
- United Kingdom
- Prior art keywords
- polypeptides
- seryl
- methods
- alamyl
- asparagyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C07K7/062—Serum thymic factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Biologically active polypeptides containing the following polypeptide segment: -ALA-LYS-SER-GLN- are disclosed. Biological activity is generally retained upon substitution of an amino acid radical selected from L- asparagyl, L-glutamyl, L-threonyl, glycyl, L-valyl, L-leucyl, L-alamyl, L- seryl, sarcosyl, 2-methylalonyl, D- asparagyl, D-glutamyl, D-threonyl, D- valyl, D-leucyl, D-alamyl and D-seryl for either or both of L-alanyl in the first position and L-seryl in the third position, which polypeptides are capable of induction of the differentiation of T-lymphocytes, as measured by the acquisition of the thymic differentiation antigen Th-1, as well as B-lymphocytes as measured by the acquisition of the differentiation antigen Bu-1. The polypeptides are thus useful in thymic function and immunity areas such as in treatment for congential absence of thymus. Also provided are methods of manufacture of the polypeptides, therapeutic compositions, and methods of use of the polypeptides.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85849677A | 1977-12-08 | 1977-12-08 | |
US94053178A | 1978-09-08 | 1978-09-08 | |
US05/960,550 US4232008A (en) | 1978-11-17 | 1978-11-17 | Tetrapeptides and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2014581A true GB2014581A (en) | 1979-08-30 |
GB2014581B GB2014581B (en) | 1982-05-19 |
Family
ID=27420392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7847642A Expired GB2014581B (en) | 1977-12-08 | 1978-12-07 | Tetrapeptides and methods for the preparation thereof |
Country Status (19)
Country | Link |
---|---|
JP (1) | JPS5498719A (en) |
CA (1) | CA1120031A (en) |
CH (1) | CH642058A5 (en) |
DE (1) | DE2853002A1 (en) |
DK (1) | DK149595C (en) |
ES (1) | ES475857A1 (en) |
FI (1) | FI67368C (en) |
FR (1) | FR2411174A1 (en) |
GB (1) | GB2014581B (en) |
GR (1) | GR65013B (en) |
IE (1) | IE47611B1 (en) |
IL (1) | IL56150A (en) |
IT (1) | IT1110889B (en) |
NL (1) | NL7812004A (en) |
NO (1) | NO149631C (en) |
NZ (1) | NZ189101A (en) |
PT (1) | PT68883A (en) |
SE (1) | SE444687B (en) |
YU (1) | YU41322B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0016611A2 (en) * | 1979-03-14 | 1980-10-01 | Ortho Pharmaceutical Corporation | Tripeptides, process for their preparation, therapeutic compositions containing them and methods for their use |
EP0018793A2 (en) * | 1979-04-26 | 1980-11-12 | Ortho Pharmaceutical Corporation | Peptides and process for their preparation |
WO2004004753A1 (en) * | 2002-07-09 | 2004-01-15 | Terentiev Alexandr Alexandrovi | Peptide having an immunoregulatory property and the composition of said peptide |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4215111A (en) * | 1979-03-14 | 1980-07-29 | Ortho Pharmaceutical Corporation | Peptides having ubiquitin-like activity |
US4426324A (en) * | 1979-09-28 | 1984-01-17 | Hoffmann-La Roche Inc. | Immunopotentiating peptides |
JPS5711950A (en) | 1980-06-25 | 1982-01-21 | Kureha Chem Ind Co Ltd | Peptide and its synthesis |
FR2546164B1 (en) * | 1983-05-16 | 1987-07-17 | Centre Nat Rech Scient | NOVEL PEPTIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS ELASTASE INHIBITORS |
FR2741076B1 (en) | 1995-11-15 | 1998-01-30 | Rech De Pathologie Appliquee S | PEPTIDE CONJUGATES DERIVED FROM THERMAL HORMONES, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2544348C3 (en) * | 1975-10-03 | 1979-12-13 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | L-leucine-13-motiline, process for its preparation and agent containing the same |
GB1572889A (en) * | 1977-05-25 | 1980-08-06 | Inst Nat Sante Rech Med | Polypeptides |
FR2423481A2 (en) * | 1978-04-21 | 1979-11-16 | Anvar | Polypeptide analogues of serum thymus factor - with thymus hormonal or antagonistic activity |
FR2391994A1 (en) * | 1977-05-25 | 1978-12-22 | Anvar | Polypeptide analogues of serum thymus factor - with thymus hormonal or antagonistic activity |
-
1978
- 1978-12-06 NZ NZ189101A patent/NZ189101A/en unknown
- 1978-12-07 IT IT52239/78A patent/IT1110889B/en active
- 1978-12-07 ES ES475857A patent/ES475857A1/en not_active Expired
- 1978-12-07 FI FI783769A patent/FI67368C/en not_active IP Right Cessation
- 1978-12-07 IE IE2423/78A patent/IE47611B1/en unknown
- 1978-12-07 DK DK554078A patent/DK149595C/en not_active IP Right Cessation
- 1978-12-07 NO NO784128A patent/NO149631C/en unknown
- 1978-12-07 DE DE19782853002 patent/DE2853002A1/en not_active Withdrawn
- 1978-12-07 IL IL56150A patent/IL56150A/en unknown
- 1978-12-07 GR GR57816A patent/GR65013B/en unknown
- 1978-12-07 SE SE7812614A patent/SE444687B/en not_active IP Right Cessation
- 1978-12-07 FR FR7834508A patent/FR2411174A1/en active Granted
- 1978-12-07 PT PT68883A patent/PT68883A/en unknown
- 1978-12-07 CA CA000317547A patent/CA1120031A/en not_active Expired
- 1978-12-07 GB GB7847642A patent/GB2014581B/en not_active Expired
- 1978-12-08 CH CH1256678A patent/CH642058A5/en not_active IP Right Cessation
- 1978-12-08 YU YU2880/78A patent/YU41322B/en unknown
- 1978-12-08 JP JP15116378A patent/JPS5498719A/en active Granted
- 1978-12-08 NL NL7812004A patent/NL7812004A/en not_active Application Discontinuation
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0016611A2 (en) * | 1979-03-14 | 1980-10-01 | Ortho Pharmaceutical Corporation | Tripeptides, process for their preparation, therapeutic compositions containing them and methods for their use |
EP0016611A3 (en) * | 1979-03-14 | 1981-01-07 | Ortho Pharmaceutical Corporation | Tripeptides, process for their preparation, therapeutic compositions containing them and methods for their use |
EP0018793A2 (en) * | 1979-04-26 | 1980-11-12 | Ortho Pharmaceutical Corporation | Peptides and process for their preparation |
EP0018793A3 (en) * | 1979-04-26 | 1981-01-07 | Ortho Pharmaceutical Corporation | Peptides and process for their preparation |
WO2004004753A1 (en) * | 2002-07-09 | 2004-01-15 | Terentiev Alexandr Alexandrovi | Peptide having an immunoregulatory property and the composition of said peptide |
Also Published As
Publication number | Publication date |
---|---|
IT1110889B (en) | 1986-01-06 |
SE7812614L (en) | 1979-06-09 |
FR2411174A1 (en) | 1979-07-06 |
NL7812004A (en) | 1979-06-12 |
GR65013B (en) | 1980-06-12 |
DK149595B (en) | 1986-08-04 |
IE47611B1 (en) | 1984-05-02 |
JPS5498719A (en) | 1979-08-03 |
YU41322B (en) | 1987-02-28 |
DK149595C (en) | 1987-03-23 |
CH642058A5 (en) | 1984-03-30 |
NO149631B (en) | 1984-02-13 |
DE2853002A1 (en) | 1979-06-13 |
NO784128L (en) | 1979-06-11 |
FI67368C (en) | 1985-03-11 |
GB2014581B (en) | 1982-05-19 |
FI783769A (en) | 1979-06-09 |
NO149631C (en) | 1984-05-23 |
IT7852239A0 (en) | 1978-12-07 |
IE782423L (en) | 1979-06-08 |
IL56150A0 (en) | 1979-03-12 |
FR2411174B1 (en) | 1984-05-25 |
JPS6327360B2 (en) | 1988-06-02 |
DK554078A (en) | 1979-06-09 |
IL56150A (en) | 1982-02-28 |
FI67368B (en) | 1984-11-30 |
YU288078A (en) | 1983-02-28 |
SE444687B (en) | 1986-04-28 |
CA1120031A (en) | 1982-03-16 |
PT68883A (en) | 1979-01-01 |
NZ189101A (en) | 1984-07-06 |
ES475857A1 (en) | 1980-01-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |