FR2423481A2 - Polypeptide analogues of serum thymus factor - with thymus hormonal or antagonistic activity - Google Patents

Polypeptide analogues of serum thymus factor - with thymus hormonal or antagonistic activity

Info

Publication number
FR2423481A2
FR2423481A2 FR7811870A FR7811870A FR2423481A2 FR 2423481 A2 FR2423481 A2 FR 2423481A2 FR 7811870 A FR7811870 A FR 7811870A FR 7811870 A FR7811870 A FR 7811870A FR 2423481 A2 FR2423481 A2 FR 2423481A2
Authority
FR
France
Prior art keywords
ser
thymus
lys
hormonal
antagonistic activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7811870A
Other languages
French (fr)
Other versions
FR2423481B2 (en
Inventor
Jean-Francois Bach
Mireille Dardenne
Jean-Marie Pleau
Jean Hamburger
Evanghelos Bricas
Jean Martinez
Didier Blanot
Genevieve Auger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR7811870A priority Critical patent/FR2423481A2/en
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Priority to CA304,016A priority patent/CA1126261A/en
Priority to CH567478A priority patent/CH637111A5/en
Priority to US05/909,163 priority patent/US4301065A/en
Priority to IT49520/78A priority patent/IT1156766B/en
Priority to GB21934/78A priority patent/GB1572889A/en
Priority to NL7805717A priority patent/NL7805717A/en
Priority to JP6280578A priority patent/JPS5416425A/en
Priority to DE19782822951 priority patent/DE2822951A1/en
Publication of FR2423481A2 publication Critical patent/FR2423481A2/en
Application granted granted Critical
Publication of FR2423481B2 publication Critical patent/FR2423481B2/fr
Priority to US06/648,834 priority patent/US4680276A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C07K7/062—Serum thymic factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Full Patentees: ANVAR and I.N.S.E.R.M. Polypeptides of formula (I) are new X-Gln-Gly-Gly-Y (I) (where Y is -Ser-Asn and X is Ser-, Lys-Ser-, Ala-lys-Ser or Glx-la-Lys-Ser-, or Y can be -Ser when X is Glx-Ala-Lys-Ser-, Glx is PyroGlu or Gln). Also new are derivs. of (I) contg. 1 or 2 modified amino acids, and analogues of (I) in which one amino acid has been added or removeD. Unmodified PyroGlu-Ala-Lys-Ser-Gln-Gly-Ser-Asn (Ia) is excluded as a novel cpd., although its prepn. is included (see below).
FR7811870A 1977-05-25 1978-04-21 Polypeptide analogues of serum thymus factor - with thymus hormonal or antagonistic activity Granted FR2423481A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR7811870A FR2423481A2 (en) 1978-04-21 1978-04-21 Polypeptide analogues of serum thymus factor - with thymus hormonal or antagonistic activity
CH567478A CH637111A5 (en) 1977-05-25 1978-05-24 POLYPEPTIDE COMPOUNDS WITH THERMAL OR ANTAGONIST ACTIVITY AND METHODS OF SYNTHESIS THEREOF.
US05/909,163 US4301065A (en) 1977-05-25 1978-05-24 Novel polypeptides having thymic activity or an antagonistic activity and processes for their synthesis
IT49520/78A IT1156766B (en) 1977-05-25 1978-05-24 POLYPEPTIDES EQUIPPED WITH THYME OR ANTAGONIST ACTIVITY AND PROCEDURE FOR THEIR SYNTHESIS
CA304,016A CA1126261A (en) 1977-05-25 1978-05-24 Polypeptides and processes for the synthesis thereof
GB21934/78A GB1572889A (en) 1977-05-25 1978-05-24 Polypeptides
NL7805717A NL7805717A (en) 1977-05-25 1978-05-25 POLYPEPTIDES WITH MEDICINE ACTIVITY.
JP6280578A JPS5416425A (en) 1977-05-25 1978-05-25 Novel polypeptides having thymus activity and antagonism activity and process for synthesizing same
DE19782822951 DE2822951A1 (en) 1977-05-25 1978-05-26 NEW POLYPEPTIDES WITH THYMAL ACTIVITY OR ANTAGONISTIC ACTIVITY AND METHODS FOR THEIR PRODUCTION
US06/648,834 US4680276A (en) 1977-05-25 1984-09-10 Metal polypeptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7811870A FR2423481A2 (en) 1978-04-21 1978-04-21 Polypeptide analogues of serum thymus factor - with thymus hormonal or antagonistic activity

Publications (2)

Publication Number Publication Date
FR2423481A2 true FR2423481A2 (en) 1979-11-16
FR2423481B2 FR2423481B2 (en) 1983-10-21

Family

ID=9207451

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7811870A Granted FR2423481A2 (en) 1977-05-25 1978-04-21 Polypeptide analogues of serum thymus factor - with thymus hormonal or antagonistic activity

Country Status (1)

Country Link
FR (1) FR2423481A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2411174A1 (en) * 1977-12-08 1979-07-06 Ortho Pharma Corp NEW TETRAPEPTIDES, THEIR METHODS OF PREPARATION AND USE
FR2432503A1 (en) * 1978-05-12 1980-02-29 Takeda Chemical Industries Ltd NOVEL NONAPEPTIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2411174A1 (en) * 1977-12-08 1979-07-06 Ortho Pharma Corp NEW TETRAPEPTIDES, THEIR METHODS OF PREPARATION AND USE
FR2432503A1 (en) * 1978-05-12 1980-02-29 Takeda Chemical Industries Ltd NOVEL NONAPEPTIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS

Also Published As

Publication number Publication date
FR2423481B2 (en) 1983-10-21

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