JPS5551045A - Preparation of endorphin - Google Patents

Preparation of endorphin

Info

Publication number
JPS5551045A
JPS5551045A JP12392578A JP12392578A JPS5551045A JP S5551045 A JPS5551045 A JP S5551045A JP 12392578 A JP12392578 A JP 12392578A JP 12392578 A JP12392578 A JP 12392578A JP S5551045 A JPS5551045 A JP S5551045A
Authority
JP
Japan
Prior art keywords
compound
amino acid
reacting
protected
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12392578A
Other languages
Japanese (ja)
Other versions
JPS6155520B2 (en
Inventor
Masahiko Fujino
Tadashi Nishimura
Susumu Shinagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP12392578A priority Critical patent/JPS5551045A/en
Publication of JPS5551045A publication Critical patent/JPS5551045A/en
Publication of JPS6155520B2 publication Critical patent/JPS6155520B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PURPOSE: To prepare the title compound having definite optical purity, and useful as an analogesic agent, a growth hormone secretive agent, etc. for clinical use, by the fragment condensation of peptides (some of which are novel) containing threonine or isoleucine as a carboxy-terminated amino acid.
CONSTITUTION: A (protected) endorphin having an N-terminated amino acid sequence of formula III, is prepared by (1) reacting a novel compound II with a peptide residue having protected N-terminals, optionally reacted with a compound I (R1W4, R6W7 are protecting group), and (2) eliminating the protecting groups, if necessary. As an alternative process, a polypeptide having an N-terminted amino acid sequence of formula V is prepared by reacting the above peptide residue with a compound IV. Both of the reactions are preferably carried out in the presence of dicyclohexyl carbodiimide and N-hydroxy-5-norbornene-2,3-dicarboxylic imide, at -30W50°C.
COPYRIGHT: (C)1980,JPO&Japio
JP12392578A 1978-10-06 1978-10-06 Preparation of endorphin Granted JPS5551045A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12392578A JPS5551045A (en) 1978-10-06 1978-10-06 Preparation of endorphin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12392578A JPS5551045A (en) 1978-10-06 1978-10-06 Preparation of endorphin

Publications (2)

Publication Number Publication Date
JPS5551045A true JPS5551045A (en) 1980-04-14
JPS6155520B2 JPS6155520B2 (en) 1986-11-28

Family

ID=14872729

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12392578A Granted JPS5551045A (en) 1978-10-06 1978-10-06 Preparation of endorphin

Country Status (1)

Country Link
JP (1) JPS5551045A (en)

Also Published As

Publication number Publication date
JPS6155520B2 (en) 1986-11-28

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