FR2391994A1 - Polypeptide analogues of serum thymus factor - with thymus hormonal or antagonistic activity - Google Patents

Polypeptide analogues of serum thymus factor - with thymus hormonal or antagonistic activity

Info

Publication number
FR2391994A1
FR2391994A1 FR7715963A FR7715963A FR2391994A1 FR 2391994 A1 FR2391994 A1 FR 2391994A1 FR 7715963 A FR7715963 A FR 7715963A FR 7715963 A FR7715963 A FR 7715963A FR 2391994 A1 FR2391994 A1 FR 2391994A1
Authority
FR
France
Prior art keywords
ser
thymus
lys
hormonal
antagonistic activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7715963A
Other languages
French (fr)
Other versions
FR2391994B1 (en
Inventor
Jean-Francois Bach
Mireille Dardenne
Jean-Marie Pleau
Jean Hamburger
Evanghelos Bricas
Jean Martinez
Didier Blanot
Genevieve Auger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR7715963A priority Critical patent/FR2391994A1/en
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Priority to US05/909,163 priority patent/US4301065A/en
Priority to CH567478A priority patent/CH637111A5/en
Priority to GB21934/78A priority patent/GB1572889A/en
Priority to CA304,016A priority patent/CA1126261A/en
Priority to IT49520/78A priority patent/IT1156766B/en
Priority to NL7805717A priority patent/NL7805717A/en
Priority to JP6280578A priority patent/JPS5416425A/en
Priority to DE19782822951 priority patent/DE2822951A1/en
Publication of FR2391994A1 publication Critical patent/FR2391994A1/en
Application granted granted Critical
Publication of FR2391994B1 publication Critical patent/FR2391994B1/fr
Priority to US06/648,834 priority patent/US4680276A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C07K7/062—Serum thymic factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Full Patentees: ANVAR and I.N.S.E.R.M. Polypeptides of formula (I) are new X-Gln-Gly-Gly-Y (I) (where Y is -Ser-Asn and X is Ser-, Lys-Ser-, Ala-lys-Ser or Glx-la-Lys-Ser-, or Y can be -Ser when X is Glx-Ala-Lys-Ser-, Glx is PyroGlu or Gln). Also new are derivs. of (I) contg. 1 or 2 modified amino acids, and analogues of (I) in which one amino acid has been added or removeD. Unmodified PyroGlu-Ala-Lys-Ser-Gln-Gly-Ser-Asn (Ia) is excluded as a novel cpd., although its prepn. is included (see below).
FR7715963A 1977-05-25 1977-05-25 Polypeptide analogues of serum thymus factor - with thymus hormonal or antagonistic activity Granted FR2391994A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR7715963A FR2391994A1 (en) 1977-05-25 1977-05-25 Polypeptide analogues of serum thymus factor - with thymus hormonal or antagonistic activity
CH567478A CH637111A5 (en) 1977-05-25 1978-05-24 POLYPEPTIDE COMPOUNDS WITH THERMAL OR ANTAGONIST ACTIVITY AND METHODS OF SYNTHESIS THEREOF.
GB21934/78A GB1572889A (en) 1977-05-25 1978-05-24 Polypeptides
CA304,016A CA1126261A (en) 1977-05-25 1978-05-24 Polypeptides and processes for the synthesis thereof
US05/909,163 US4301065A (en) 1977-05-25 1978-05-24 Novel polypeptides having thymic activity or an antagonistic activity and processes for their synthesis
IT49520/78A IT1156766B (en) 1977-05-25 1978-05-24 POLYPEPTIDES EQUIPPED WITH THYME OR ANTAGONIST ACTIVITY AND PROCEDURE FOR THEIR SYNTHESIS
NL7805717A NL7805717A (en) 1977-05-25 1978-05-25 POLYPEPTIDES WITH MEDICINE ACTIVITY.
JP6280578A JPS5416425A (en) 1977-05-25 1978-05-25 Novel polypeptides having thymus activity and antagonism activity and process for synthesizing same
DE19782822951 DE2822951A1 (en) 1977-05-25 1978-05-26 NEW POLYPEPTIDES WITH THYMAL ACTIVITY OR ANTAGONISTIC ACTIVITY AND METHODS FOR THEIR PRODUCTION
US06/648,834 US4680276A (en) 1977-05-25 1984-09-10 Metal polypeptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7715963A FR2391994A1 (en) 1977-05-25 1977-05-25 Polypeptide analogues of serum thymus factor - with thymus hormonal or antagonistic activity

Publications (2)

Publication Number Publication Date
FR2391994A1 true FR2391994A1 (en) 1978-12-22
FR2391994B1 FR2391994B1 (en) 1982-11-05

Family

ID=9191260

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7715963A Granted FR2391994A1 (en) 1977-05-25 1977-05-25 Polypeptide analogues of serum thymus factor - with thymus hormonal or antagonistic activity

Country Status (1)

Country Link
FR (1) FR2391994A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2386515A1 (en) * 1977-03-14 1978-11-03 Merck & Co Inc PROCESS FOR THE PREPARATION OF PYROGLUTAMYL-ALA-LYS-SER-GLN-GLY-SER-ASN
FR2411174A1 (en) * 1977-12-08 1979-07-06 Ortho Pharma Corp NEW TETRAPEPTIDES, THEIR METHODS OF PREPARATION AND USE
FR2432503A1 (en) * 1978-05-12 1980-02-29 Takeda Chemical Industries Ltd NOVEL NONAPEPTIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
EP0016612A2 (en) * 1979-03-14 1980-10-01 Ortho Pharmaceutical Corporation Peptides having ubiquitin-like activity, process for their preparation, therapeutic compositions containing them and their use
EP0016611A2 (en) * 1979-03-14 1980-10-01 Ortho Pharmaceutical Corporation Tripeptides, process for their preparation, therapeutic compositions containing them and methods for their use
EP0018793A2 (en) * 1979-04-26 1980-11-12 Ortho Pharmaceutical Corporation Peptides and process for their preparation
EP0043247A1 (en) * 1980-06-25 1982-01-06 Kureha Kagaku Kogyo Kabushiki Kaisha Peptides for use in determining serum thymic factor

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2386515A1 (en) * 1977-03-14 1978-11-03 Merck & Co Inc PROCESS FOR THE PREPARATION OF PYROGLUTAMYL-ALA-LYS-SER-GLN-GLY-SER-ASN
FR2411174A1 (en) * 1977-12-08 1979-07-06 Ortho Pharma Corp NEW TETRAPEPTIDES, THEIR METHODS OF PREPARATION AND USE
FR2432503A1 (en) * 1978-05-12 1980-02-29 Takeda Chemical Industries Ltd NOVEL NONAPEPTIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
EP0016612A2 (en) * 1979-03-14 1980-10-01 Ortho Pharmaceutical Corporation Peptides having ubiquitin-like activity, process for their preparation, therapeutic compositions containing them and their use
EP0016611A2 (en) * 1979-03-14 1980-10-01 Ortho Pharmaceutical Corporation Tripeptides, process for their preparation, therapeutic compositions containing them and methods for their use
EP0016612A3 (en) * 1979-03-14 1981-01-07 Ortho Pharmaceutical Corporation Peptides having ubiquitin-like activity, process for their preparation ,therapeutic compositions containing them and methods for their use
EP0016611A3 (en) * 1979-03-14 1981-01-07 Ortho Pharmaceutical Corporation Tripeptides, process for their preparation, therapeutic compositions containing them and methods for their use
EP0018793A2 (en) * 1979-04-26 1980-11-12 Ortho Pharmaceutical Corporation Peptides and process for their preparation
EP0018793A3 (en) * 1979-04-26 1981-01-07 Ortho Pharmaceutical Corporation Peptides and process for their preparation
EP0043247A1 (en) * 1980-06-25 1982-01-06 Kureha Kagaku Kogyo Kabushiki Kaisha Peptides for use in determining serum thymic factor

Also Published As

Publication number Publication date
FR2391994B1 (en) 1982-11-05

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