JPS6423899A - Novel physiologically active polypeptide - Google Patents

Novel physiologically active polypeptide

Info

Publication number
JPS6423899A
JPS6423899A JP62180029A JP18002987A JPS6423899A JP S6423899 A JPS6423899 A JP S6423899A JP 62180029 A JP62180029 A JP 62180029A JP 18002987 A JP18002987 A JP 18002987A JP S6423899 A JPS6423899 A JP S6423899A
Authority
JP
Japan
Prior art keywords
amino acid
polypeptide
acid sequence
physiologically active
active polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62180029A
Other languages
Japanese (ja)
Inventor
Tsukio Sakugi
Satoshi Nakamura
Kazuo Kitai
Yataro Ichikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP62180029A priority Critical patent/JPS6423899A/en
Publication of JPS6423899A publication Critical patent/JPS6423899A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Abstract

PURPOSE:To obtain a polypeptide having a special amino acid sequence, improved specific activity, reaction spectrum extended into a wide region and antitumor activity with reduced side effects. CONSTITUTION:A polypeptide containing a sequence containing substitution of at least the 35th Ala into other amino acids in an amino acid sequence in which one or more amino acid residues are substituted, deficient or inserted in an amino acid sequence of the 1st Val to the 157th Leu expressed by the formula. A polypeptide having at least the 35th Ala substituted with His, Met or Gln is preferred.
JP62180029A 1987-07-21 1987-07-21 Novel physiologically active polypeptide Pending JPS6423899A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62180029A JPS6423899A (en) 1987-07-21 1987-07-21 Novel physiologically active polypeptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62180029A JPS6423899A (en) 1987-07-21 1987-07-21 Novel physiologically active polypeptide

Publications (1)

Publication Number Publication Date
JPS6423899A true JPS6423899A (en) 1989-01-26

Family

ID=16076225

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62180029A Pending JPS6423899A (en) 1987-07-21 1987-07-21 Novel physiologically active polypeptide

Country Status (1)

Country Link
JP (1) JPS6423899A (en)

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