JPS6447393A - Novel physiologically active polypeptide - Google Patents

Novel physiologically active polypeptide

Info

Publication number
JPS6447393A
JPS6447393A JP62203431A JP20343187A JPS6447393A JP S6447393 A JPS6447393 A JP S6447393A JP 62203431 A JP62203431 A JP 62203431A JP 20343187 A JP20343187 A JP 20343187A JP S6447393 A JPS6447393 A JP S6447393A
Authority
JP
Japan
Prior art keywords
polypeptide
physiologically active
active polypeptide
antitumor
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62203431A
Other languages
Japanese (ja)
Inventor
Satoshi Nakamura
Tsukio Sakugi
Kazuo Kitai
Yataro Ichikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP62203431A priority Critical patent/JPS6447393A/en
Publication of JPS6447393A publication Critical patent/JPS6447393A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]

Abstract

PURPOSE:To produce a physiologically active antitumor polypeptide, by forming a DNA region coding a physiologically active polypeptide expressed by a specific amino acid sequence or a polypeptide having Met bonded to the amino terminal of the above polypeptide. CONSTITUTION:A recombinant microbial cell containing a DNA region coding a physiologically active polypeptide expressed by an amino acid sequence of formula I or a polypeptide having Met bonded to the amino terminal of the above polypeptide is cultured to produce and accumulate a physiologically active polypeptide in the cultured product. The objective physiologically active polypeptide is separated from the cultured product. The polypeptide is an antitumor polypeptide different from conventional human TNF protein and provides a pharmaceutical composition having excellent antitumor activity.
JP62203431A 1987-08-18 1987-08-18 Novel physiologically active polypeptide Pending JPS6447393A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62203431A JPS6447393A (en) 1987-08-18 1987-08-18 Novel physiologically active polypeptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62203431A JPS6447393A (en) 1987-08-18 1987-08-18 Novel physiologically active polypeptide

Publications (1)

Publication Number Publication Date
JPS6447393A true JPS6447393A (en) 1989-02-21

Family

ID=16473973

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62203431A Pending JPS6447393A (en) 1987-08-18 1987-08-18 Novel physiologically active polypeptide

Country Status (1)

Country Link
JP (1) JPS6447393A (en)

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