FR2404435A1 - Compositions pharmaceutiques absorbables a base de copolyoxalates isomorphes - Google Patents

Compositions pharmaceutiques absorbables a base de copolyoxalates isomorphes

Info

Publication number
FR2404435A1
FR2404435A1 FR7827664A FR7827664A FR2404435A1 FR 2404435 A1 FR2404435 A1 FR 2404435A1 FR 7827664 A FR7827664 A FR 7827664A FR 7827664 A FR7827664 A FR 7827664A FR 2404435 A1 FR2404435 A1 FR 2404435A1
Authority
FR
France
Prior art keywords
isomorphic
pharmaceutical compositions
compositions based
absorbable polymer
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7827664A
Other languages
English (en)
Other versions
FR2404435B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethicon Inc
Original Assignee
Ethicon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethicon Inc filed Critical Ethicon Inc
Publication of FR2404435A1 publication Critical patent/FR2404435A1/fr
Application granted granted Critical
Publication of FR2404435B1 publication Critical patent/FR2404435B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/16—Dicarboxylic acids and dihydroxy compounds
    • C08G63/18—Dicarboxylic acids and dihydroxy compounds the acids or hydroxy compounds containing carbocyclic rings

Abstract

L'invention concerne une composition de dépôt pharmaceutique. pour une administration parentérale de quantités efficaces d'un médicament lentement libéré sur une période étendue de temps et qui comprend une combinaison de 1 à 99 % en poids d'une composition d'un médicament dans une quantité de dépôt effective supérieure à la seule dose unitaire, et un polymère solide et absorbable non réactif vis-à-vis des tissus corporels et qui subit une biodégradation en présence des fluides corporels en produits qui sont métabolisés ou évacués dans le corps sans aucune réaction néfaste du corps. Selon l'invention, on emploie, pour le polymère absorbable, des polymères de polyoxalates isomorphes comprenant des unité d'oxalates et linéaires ayant pour formule générale :
FR7827664A 1977-09-28 1978-09-27 Compositions pharmaceutiques absorbables a base de copolyoxalates isomorphes Granted FR2404435A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/837,060 US4130639A (en) 1977-09-28 1977-09-28 Absorbable pharmaceutical compositions based on isomorphic copolyoxalates

Publications (2)

Publication Number Publication Date
FR2404435A1 true FR2404435A1 (fr) 1979-04-27
FR2404435B1 FR2404435B1 (fr) 1983-07-29

Family

ID=25273405

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7827664A Granted FR2404435A1 (fr) 1977-09-28 1978-09-27 Compositions pharmaceutiques absorbables a base de copolyoxalates isomorphes

Country Status (8)

Country Link
US (1) US4130639A (fr)
JP (1) JPS5452722A (fr)
AU (1) AU518228B2 (fr)
CA (1) CA1100041A (fr)
DE (1) DE2842088A1 (fr)
FR (1) FR2404435A1 (fr)
GB (1) GB1592830A (fr)
ZA (1) ZA785492B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2404436A1 (fr) * 1977-09-28 1979-04-27 Ethicon Inc Compositions pharmaceutiques absorbables a base de poly (alcoylene oxalates)

Families Citing this family (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0076636B1 (fr) * 1981-09-30 1988-02-24 National Research Development Corporation Compositions à libération prolongée
US5277900A (en) * 1982-08-07 1994-01-11 Henkel Kommanditgesellschaft Auf Aktien Method for blood coagulation on hard tissues
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
US4568536A (en) * 1985-02-08 1986-02-04 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4650665A (en) * 1985-02-08 1987-03-17 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
AU606383B2 (en) * 1987-03-06 1991-02-07 Research Triangle Institute Polymer blends for selective biodegradability
CH672887A5 (fr) * 1987-10-14 1990-01-15 Debiopharm Sa
US6353030B1 (en) 1990-08-01 2002-03-05 Novartis Ag Relating to organic compounds
US5371171A (en) * 1993-03-05 1994-12-06 Baylor University Poly(methylene oxalate) and precursors thereto
US5451643A (en) * 1993-03-05 1995-09-19 Baylor University Poly(alkylene dicarboxylates) and synthesis thereof
US5561212A (en) * 1993-03-05 1996-10-01 Baylor University Poly(methylene oxalate), a new composition of matter
DE69918159T2 (de) 1998-11-20 2005-03-17 The University Of Connecticut, Farmington Verfahren und vorrichtung zur steuerung der gewebeimplantat-interaktionen
US20030099682A1 (en) * 1998-11-20 2003-05-29 Francis Moussy Apparatus and method for control of tissue/implant interactions
US20020095157A1 (en) 1999-07-23 2002-07-18 Bowman Steven M. Graft fixation device combination
US6179840B1 (en) 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
CA2365376C (fr) 2000-12-21 2006-03-28 Ethicon, Inc. Utilisation d'implants en mousse renforces ayant une meilleure integrite pour la reparation et la regeneration de tissus mous
US6599323B2 (en) 2000-12-21 2003-07-29 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
US6743232B2 (en) 2001-02-26 2004-06-01 David W. Overaker Tissue scaffold anchor for cartilage repair
US6575986B2 (en) 2001-02-26 2003-06-10 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US6656488B2 (en) * 2001-04-11 2003-12-02 Ethicon Endo-Surgery, Inc. Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering
MXPA03009727A (es) 2001-04-26 2004-01-29 Control Delivery Sys Inc SISTEMA DE SUMINISTRO DE FaRMACOS DE LIBERACIoN PROLONGADA QUE CONTIENE COFARMACOS.
DE60229375D1 (de) 2001-05-11 2008-11-27 Ortho Mcneil Janssen Pharm Immunmodulations-vorrichtung zur verwendung in tieren
US20030003127A1 (en) * 2001-06-27 2003-01-02 Ethicon, Inc. Porous ceramic/porous polymer layered scaffolds for the repair and regeneration of tissue
US6626950B2 (en) 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
WO2003007790A2 (fr) 2001-07-16 2003-01-30 Depuy Products, Inc. Echafaudages de matrice extracellulaire poreux hybrides biologique/synthetique
US8025896B2 (en) 2001-07-16 2011-09-27 Depuy Products, Inc. Porous extracellular matrix scaffold and method
EP1416879A4 (fr) 2001-07-16 2007-04-25 Depuy Products Inc Dispositif et procede chirurgicaux unitaires
WO2003007839A2 (fr) 2001-07-16 2003-01-30 Depuy Products, Inc. Dispositifs a base de matieres biologiquement derivees d'origine naturelle
WO2003007784A2 (fr) 2001-07-16 2003-01-30 Depuy Products, Inc. Dispositif et procede de regeneration du menisque
WO2003007879A2 (fr) * 2001-07-16 2003-01-30 Depuy Products, Inc. Structure de support et methode de reparation et de regeneration de cartilage
US7819918B2 (en) 2001-07-16 2010-10-26 Depuy Products, Inc. Implantable tissue repair device
US6916321B2 (en) * 2001-09-28 2005-07-12 Ethicon, Inc. Self-tapping resorbable two-piece bone screw
US6808518B2 (en) * 2001-09-28 2004-10-26 Ethicon, Inc. Methods and devices for treating diseased blood vessels
US6773436B2 (en) * 2001-09-28 2004-08-10 Depuy Mitek, Inc. Absorbable bone anchor
CA2465860A1 (fr) 2001-11-02 2004-04-22 Insert Therapeutics, Inc. Procedes et compositions permettant l'utilisation therapeutique de l'interference arn
US6921402B2 (en) * 2001-12-27 2005-07-26 Ethicon, Inc. Polymer-based orthopedic screw and driver system with increased insertion torque tolerance and associated method for making and using same
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US7824701B2 (en) 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US7491234B2 (en) 2002-12-03 2009-02-17 Boston Scientific Scimed, Inc. Medical devices for delivery of therapeutic agents
US8197837B2 (en) 2003-03-07 2012-06-12 Depuy Mitek, Inc. Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US10583220B2 (en) * 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
US7897384B2 (en) * 2003-09-08 2011-03-01 Ethicon, Inc. Chondrocyte therapeutic delivery system
US8257963B2 (en) * 2007-06-01 2012-09-04 Depuy Mitek, Inc. Chondrocyte container and method of use
US7927599B2 (en) 2003-09-08 2011-04-19 Ethicon, Inc. Chondrocyte therapeutic delivery system
WO2005030091A2 (fr) * 2003-09-25 2005-04-07 Scios Inc. Stents et protheses intra-luminales contenant des inhibiteurs de kinase map
US7316822B2 (en) * 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7901461B2 (en) * 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
US20050149030A1 (en) * 2003-12-19 2005-07-07 Depuy Spine, Inc. Facet joint fixation system
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US8221780B2 (en) 2004-04-20 2012-07-17 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8137686B2 (en) 2004-04-20 2012-03-20 Depuy Mitek, Inc. Nonwoven tissue scaffold
US7569233B2 (en) 2004-05-04 2009-08-04 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
WO2005120462A2 (fr) * 2004-06-07 2005-12-22 Callisyn Pharmaceuticals, Inc. Hydrogel polymere reticule biodegradable et biocompatible prepare a partir de melanges de macromeres de pva et/ou de peg
US8821559B2 (en) * 2004-08-27 2014-09-02 Codman & Shurtleff, Inc. Light-based implants for treating Alzheimer's disease
US7354627B2 (en) 2004-12-22 2008-04-08 Depuy Products, Inc. Method for organizing the assembly of collagen fibers and compositions formed therefrom
US20060142773A1 (en) 2004-12-29 2006-06-29 Depuy Mitek, Inc. Abrasive cutting system and method
US7858077B2 (en) * 2005-01-28 2010-12-28 Bezwada Biomedical Llc Functionalized phenolic esters and amides and polymers therefrom
US7691364B2 (en) * 2005-01-28 2010-04-06 Bezwada Biomedical, Llc Functionalized drugs and polymers derived therefrom
US20090130163A1 (en) * 2005-02-18 2009-05-21 Abraxis Bio Scoence, Inc. Drugs With Improved Hydrophobicity For Incorporation in Medical Devices
US7288108B2 (en) * 2005-03-14 2007-10-30 Codman & Shurtleff, Inc. Red light implant for treating Parkinson's disease
USRE47266E1 (en) 2005-03-14 2019-03-05 DePuy Synthes Products, Inc. Light-based implants for treating Alzheimer's disease
US8092528B2 (en) 2005-05-27 2012-01-10 Depuy Spine, Inc. Intervertebral ligament having a helical bone fastener
US20060286289A1 (en) * 2005-06-15 2006-12-21 Rita Prajapati Method of intraoperative coating therapeutic agents onto sutures
US20060287676A1 (en) * 2005-06-15 2006-12-21 Rita Prajapati Method of intra-operative coating therapeutic agents onto sutures, composite sutures and methods of use
US20060287675A1 (en) * 2005-06-15 2006-12-21 Prajapati Rita T Method of intra-operative coating therapeutic agents onto sutures composite sutures and methods of use
US7351253B2 (en) * 2005-06-16 2008-04-01 Codman & Shurtleff, Inc. Intranasal red light probe for treating Alzheimer's disease
US7595062B2 (en) 2005-07-28 2009-09-29 Depuy Products, Inc. Joint resurfacing orthopaedic implant and associated method
US8318973B2 (en) * 2005-10-21 2012-11-27 Bezwada Biomedical, Llc Functionalized sinapic acid and methyl sinapate
US8167920B2 (en) * 2005-10-31 2012-05-01 Codman & Shurtleff, Inc. Intranasal delivery of compounds that reduce intrancranial pressure
US20070112360A1 (en) * 2005-11-15 2007-05-17 Patrick De Deyne Bioprosthetic device
US8007526B2 (en) 2005-12-01 2011-08-30 Bezwada Biomedical, Llc Difunctionalized aromatic compounds and polymers therefrom
US7935843B2 (en) * 2005-12-09 2011-05-03 Bezwada Biomedical, Llc Functionalized diphenolics and absorbable polymers therefrom
US8709094B2 (en) * 2006-06-26 2014-04-29 DePuy Synthes Products, LLC Anti-adhesion sheet
US20080014152A1 (en) * 2006-07-13 2008-01-17 Di Mauro Thomas M Intranasal delivery of clenbuterol across the cribriform plate and into the brain
US20100114129A1 (en) * 2006-07-20 2010-05-06 Wheatley Margaret A Tissue joining devices capable of delivery of bioactive agents and methods of use thereof
US20080081323A1 (en) * 2006-09-29 2008-04-03 Daniel Keeley Regenerative Medicine Devices and Melt-Blown Methods of Manufacture
US8114159B2 (en) * 2006-11-20 2012-02-14 Depuy Spine, Inc. Anterior spinal vessel protector
US8105382B2 (en) 2006-12-07 2012-01-31 Interventional Spine, Inc. Intervertebral implant
US7871440B2 (en) 2006-12-11 2011-01-18 Depuy Products, Inc. Unitary surgical device and method
US9039768B2 (en) 2006-12-22 2015-05-26 Medos International Sarl Composite vertebral spacers and instrument
JP2010524959A (ja) 2007-04-17 2010-07-22 コドマン・アンド・シャートレフ・インコーポレイテッド アルツハイマー病を処置するためのヘリウムガスボーラス中のクルクミンの鼻腔投与
US8383865B2 (en) 2007-04-17 2013-02-26 Codman & Shurtleff, Inc. Curcumin derivatives
AU2008245900B2 (en) * 2007-04-24 2013-07-25 Advanced Technologies And Regenerative Medicine, Llc Engineered renal tissue
CN101072380B (zh) * 2007-06-08 2010-12-08 华为技术有限公司 内容下发方法及系统、网络设备、移动数据业务管理平台
US8900307B2 (en) 2007-06-26 2014-12-02 DePuy Synthes Products, LLC Highly lordosed fusion cage
US20090299034A1 (en) * 2007-08-01 2009-12-03 Mabel Alamino Cejas Collagen-related peptides
ATE530576T1 (de) 2007-08-01 2011-11-15 Ethicon Inc Collagen-assoziierte peptide und ihre verwendung
US8217134B2 (en) * 2007-08-30 2012-07-10 Bezwada Biomedical, Llc Controlled release of biologically active compounds
US8026285B2 (en) 2007-09-04 2011-09-27 Bezwada Biomedical, Llc Control release of biologically active compounds from multi-armed oligomers
US8048980B2 (en) * 2007-09-17 2011-11-01 Bezwada Biomedical, Llc Hydrolysable linkers and cross-linkers for absorbable polymers
US9247973B2 (en) * 2007-09-28 2016-02-02 DePuy Synthes Products, Inc. Anti-microbial implant
CA2710142A1 (fr) 2008-01-17 2009-07-23 Beat Lechmann Implant intervertebral extensible et son procede de fabrication associe
US7745670B2 (en) * 2008-06-27 2010-06-29 Codman & Shurtleff, Inc. Curcumin-Resveratrol hybrid molecule
US9320914B2 (en) 2008-03-03 2016-04-26 DePuy Synthes Products, Inc. Endoscopic delivery of red/NIR light to the subventricular zone
US20090248092A1 (en) 2008-03-26 2009-10-01 Jonathan Bellas Posterior Intervertebral Disc Inserter and Expansion Techniques
CA2720580A1 (fr) 2008-04-05 2009-10-08 Synthes Usa, Llc Implant intervertebral extensible
US7985776B2 (en) * 2008-06-27 2011-07-26 Codman & Shurtleff, Inc. Iontophoretic delivery of curcumin and curcumin analogs for the treatment of Alzheimer's Disease
US20100021527A1 (en) 2008-07-25 2010-01-28 Chunlin Yang Collagen-related peptides and uses thereof and hemostatic foam substrates
EP2367510B1 (fr) 2008-10-10 2018-01-10 Kirk Promotion LTD. Procédé de stabilisation de dispositifs hydrauliques implantés
US7723515B1 (en) 2009-01-26 2010-05-25 Codman & Shurtleff, Inc. Methylene blue—curcumin analog for the treatment of alzheimer's disease
US20100198316A1 (en) * 2009-02-04 2010-08-05 Richard Toselli Intracranial Red Light Treatment Device For Chronic Pain
US9526620B2 (en) 2009-03-30 2016-12-27 DePuy Synthes Products, Inc. Zero profile spinal fusion cage
US9592043B2 (en) * 2009-03-31 2017-03-14 Covidien Lp Multizone implants
EP3069691A1 (fr) 2009-07-10 2016-09-21 Kirk Promotion LTD. Dispositif d'articulation de hanche
US8403988B2 (en) 2009-09-11 2013-03-26 Depuy Spine, Inc. Minimally invasive intervertebral staple distraction devices
US9615933B2 (en) * 2009-09-15 2017-04-11 DePuy Synthes Products, Inc. Expandable ring intervertebral fusion device
US9028553B2 (en) 2009-11-05 2015-05-12 DePuy Synthes Products, Inc. Self-pivoting spinal implant and associated instrumentation
WO2011061295A1 (fr) 2009-11-19 2011-05-26 Blue Medical Devices Bv Cathéter à ballonnet médical extensible à libération de composition et profil étroit
US9393129B2 (en) 2009-12-10 2016-07-19 DePuy Synthes Products, Inc. Bellows-like expandable interbody fusion cage
US8845733B2 (en) 2010-06-24 2014-09-30 DePuy Synthes Products, LLC Lateral spondylolisthesis reduction cage
US8979860B2 (en) 2010-06-24 2015-03-17 DePuy Synthes Products. LLC Enhanced cage insertion device
US20120053627A1 (en) 2010-08-30 2012-03-01 DePuy Mikek, Inc. Suture anchor and threader
US8460340B2 (en) 2010-08-30 2013-06-11 Depuy Mitek, Llc Knotless suture anchor
US8679159B2 (en) 2010-08-30 2014-03-25 Depuy Mitek, Llc Anchor driver with suture clutch
US8469998B2 (en) 2010-08-30 2013-06-25 Depuy Mitek, Llc Knotless suture anchor
US8435264B2 (en) 2010-08-30 2013-05-07 Depuy Mitek, Llc Knotless suture anchor and driver
US20120078373A1 (en) 2010-09-23 2012-03-29 Thomas Gamache Stand alone intervertebral fusion device
US11529241B2 (en) 2010-09-23 2022-12-20 DePuy Synthes Products, Inc. Fusion cage with in-line single piece fixation
US20120078372A1 (en) 2010-09-23 2012-03-29 Thomas Gamache Novel implant inserter having a laterally-extending dovetail engagement feature
US9402732B2 (en) 2010-10-11 2016-08-02 DePuy Synthes Products, Inc. Expandable interspinous process spacer implant
US8821543B2 (en) 2010-12-23 2014-09-02 Depuy Mitek, Llc Adjustable anchor systems and methods
US8814905B2 (en) 2010-11-23 2014-08-26 Depuy Mitek, Llc Surgical filament snare assemblies
US9345468B2 (en) 2010-11-23 2016-05-24 Medos International Sárl Surgical filament snare assemblies
WO2012088496A2 (fr) 2010-12-23 2012-06-28 Depuy Mitek, Inc. Systèmes et procédés d'ancrage ajustable
EP3485851B1 (fr) 2011-03-22 2021-08-25 DePuy Synthes Products, LLC Essai universel pour des cages latérales
US9248028B2 (en) 2011-09-16 2016-02-02 DePuy Synthes Products, Inc. Removable, bone-securing cover plate for intervertebral fusion cage
US8535350B2 (en) 2011-09-28 2013-09-17 Depuy Mitek, Llc Knotless suture anchor
US20130085528A1 (en) 2011-09-30 2013-04-04 Depuy Mitek, Inc. Knotless suture anchor
US20140377320A1 (en) 2011-12-22 2014-12-25 Chuv, Centre Hospitalier Universitaire Vaudois Selective Plasma Activation for Medical Implants and Wound Healing Devices
US9226764B2 (en) 2012-03-06 2016-01-05 DePuy Synthes Products, Inc. Conformable soft tissue removal instruments
US9271836B2 (en) 2012-03-06 2016-03-01 DePuy Synthes Products, Inc. Nubbed plate
US8790370B2 (en) 2012-03-30 2014-07-29 Depuy Mitek, Llc Surgical filament assemblies
US9060764B2 (en) 2012-05-07 2015-06-23 Medos International Sàrl Systems, devices, and methods for securing tissue
US8894684B2 (en) 2012-05-07 2014-11-25 Medos International Sàrl Systems, devices, and methods for securing tissue using a suture having one or more protrusions
US9345567B2 (en) 2012-05-07 2016-05-24 Medos International Sàrl Systems, devices, and methods for securing tissue using snare assemblies and soft anchors
US9060763B2 (en) 2012-05-07 2015-06-23 Medos International Sàrl Systems, devices, and methods for securing tissue
US9763655B2 (en) 2012-09-20 2017-09-19 Medos International Sarl Systems, devices, and methods for securing tissue using hard anchors
US10182921B2 (en) 2012-11-09 2019-01-22 DePuy Synthes Products, Inc. Interbody device with opening to allow packing graft and other biologics
US10022245B2 (en) 2012-12-17 2018-07-17 DePuy Synthes Products, Inc. Polyaxial articulating instrument
US9271716B2 (en) 2012-12-27 2016-03-01 Medos International Sàrl Surgical constructs and methods for securing tissue
US9522070B2 (en) 2013-03-07 2016-12-20 Interventional Spine, Inc. Intervertebral implant
US9717583B2 (en) 2014-03-13 2017-08-01 Cell and Molecular Tissue Engineering, LLC Sensors, cannulas, collars and coated surgical mesh, and corresponding systems and methods
US9352071B2 (en) 2013-03-14 2016-05-31 Ethicon, Inc. Method of forming an implantable device
US10123862B2 (en) 2013-03-14 2018-11-13 Ethicon, Inc. Randomly uniform three dimensional tissue scaffold of absorbable and non-absorbable materials
US9737293B2 (en) 2013-03-15 2017-08-22 Medos International Sàrl Surgical constructs with collapsing suture loop and methods for securing tissue
US10463471B2 (en) 2013-07-18 2019-11-05 Medos International Sarl Methods and devices for positioning and securing ligament grafts
US11426290B2 (en) 2015-03-06 2022-08-30 DePuy Synthes Products, Inc. Expandable intervertebral implant, system, kit and method
JP7023877B2 (ja) 2016-06-28 2022-02-22 イーアイティー・エマージング・インプラント・テクノロジーズ・ゲーエムベーハー 拡張可能かつ角度調節可能な関節運動式の椎間ケージ
CN109688981A (zh) 2016-06-28 2019-04-26 Eit 新兴移植技术股份有限公司 可扩张的、角度可调整的椎间笼
US10398563B2 (en) 2017-05-08 2019-09-03 Medos International Sarl Expandable cage
US10940016B2 (en) 2017-07-05 2021-03-09 Medos International Sarl Expandable intervertebral fusion cage
US10966843B2 (en) 2017-07-18 2021-04-06 DePuy Synthes Products, Inc. Implant inserters and related methods
US11045331B2 (en) 2017-08-14 2021-06-29 DePuy Synthes Products, Inc. Intervertebral implant inserters and related methods
US11446156B2 (en) 2018-10-25 2022-09-20 Medos International Sarl Expandable intervertebral implant, inserter instrument, and related methods
JP2023510662A (ja) 2019-06-04 2023-03-15 サーティー レスピラトリー リミテッド 窒素酸化物を生成するための方法および組成物、ならびに気道を介して窒素酸化物を送達するためのそれらの使用
EP3980373A1 (fr) 2019-06-04 2022-04-13 Thirty Holdings Limited Méthodes et compositions pour générer de l'oxyde nitrique et utilisations associées
US11426286B2 (en) 2020-03-06 2022-08-30 Eit Emerging Implant Technologies Gmbh Expandable intervertebral implant
EP4138794A1 (fr) 2020-04-23 2023-03-01 Thirty Respiratory Limited Procédés et compositions pour le traitement et la lutte contre la tuberculose
JP2023526584A (ja) 2020-04-23 2023-06-22 サーティー レスピラトリー リミテッド Ｓａｒｓ－ｃｏｖ及びｓａｒｓ－ｃｏｖ－２の治療に使用するための一酸化窒素または一酸化窒素放出組成物
US11850160B2 (en) 2021-03-26 2023-12-26 Medos International Sarl Expandable lordotic intervertebral fusion cage
US11752009B2 (en) 2021-04-06 2023-09-12 Medos International Sarl Expandable intervertebral fusion cage

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2278348A2 (fr) * 1974-06-28 1976-02-13 Rhone Poulenc Ind Articles chirurgicaux bioresorbables
US4141087A (en) * 1977-01-19 1979-02-27 Ethicon, Inc. Isomorphic copolyoxalates and sutures thereof
FR2404436A1 (fr) * 1977-09-28 1979-04-27 Ethicon Inc Compositions pharmaceutiques absorbables a base de poly (alcoylene oxalates)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3997512A (en) * 1973-11-21 1976-12-14 American Cyanamid Company High molecular weight polyester resin, the method of making the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2278348A2 (fr) * 1974-06-28 1976-02-13 Rhone Poulenc Ind Articles chirurgicaux bioresorbables
US4141087A (en) * 1977-01-19 1979-02-27 Ethicon, Inc. Isomorphic copolyoxalates and sutures thereof
FR2404436A1 (fr) * 1977-09-28 1979-04-27 Ethicon Inc Compositions pharmaceutiques absorbables a base de poly (alcoylene oxalates)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2404436A1 (fr) * 1977-09-28 1979-04-27 Ethicon Inc Compositions pharmaceutiques absorbables a base de poly (alcoylene oxalates)

Also Published As

Publication number Publication date
FR2404435B1 (fr) 1983-07-29
US4130639A (en) 1978-12-19
AU518228B2 (en) 1981-09-17
ZA785492B (en) 1980-05-28
JPS5452722A (en) 1979-04-25
CA1100041A (fr) 1981-04-28
GB1592830A (en) 1981-07-08
DE2842088A1 (de) 1979-04-12
AU3683578A (en) 1979-12-06

Similar Documents

Publication Publication Date Title
FR2404435A1 (fr) Compositions pharmaceutiques absorbables a base de copolyoxalates isomorphes
FR2404436A1 (fr) Compositions pharmaceutiques absorbables a base de poly (alcoylene oxalates)
CA2102454A1 (fr) Derives de l'erythromycine, leur procede de preparation, leur application comme medicaments
BR0011234A (pt) Composições de glicomanana e métodos para reduzir a viscosidade de composições de glicomanana
BR9910371A (pt) Composto, composição farmacêutica, agente para controlar os receptores relacionados com a retinóide, processos de prevenção e terapia da diabetes mellitus, de prevenção e terapia da hiperlipemia, para acentuar uma sensibilidade à insulina, para melhorar uma resistência à insulina, de prevenção e terapia da tolerância à glicose prejudicada, de prevenção e terapia de uma doença inflamatória, de prevenção de uma esclerose arterial, e, uso do composto
BE1002710A5 (fr) Preparation au diclofenac sodique a effet prolonge.
RU95110109A (ru) Комплекс, содержащий аналог человеческого инсулина, и фармацевтическая композиция на его основе
KR950000728A (ko) 포스포네이트 뉴클레오티드 에스테르 유도체
EA199900239A1 (ru) Замещенные n-[аминоиминометил или аминометил) фенил] пропиламиды
KR920702383A (ko) 치료제의 방출을 조절하는데 유용한 생부식성 중합체
DE69316217T2 (de) Anwendung von nor- und homo-gallensäurederivaten als absorptienförderer für arzneimittel
ATE38834T1 (de) 5-substituierte 1,2,4-oxadiazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
FR2390962A1 (fr) Composition de depot pharmaceutique comprenant un polymere de p-dioxanone absorbable
KR890008123A (ko) 디-3급-부틸페놀 화합물의 사이클릭 유도체
FR2370069A1 (fr) Produits de reaction d'hydrazides et d'esters insatures, et leurs applications
KR890001553A (ko) 약학적 조성물
KR900003105A (ko) N-2,3-부타디엔일 트리- 및 테트라아미노알칸 유도체
IE62751B1 (en) 3-substituted-2-oxindole-1-carboxamides for suppressing t-cell function
KR970703301A (ko) 신규 디아미노메틸리덴 유도체(novel diamincmethylidene derivative)
NO961295D0 (no) Additivblanding for kald anvendelse av mellomfraksjoner
ATE163850T1 (de) Pharmazeutische zusammensetzungen von 5ht1 agonistischen alkyl sulphonamidenfür rektale verabreichungen
KR890008079A (ko) 치환된 디카복실산- 비스(3, 5- 디카바모일- 2, 4, 6- 트리요오도아닐리드), 이의 제조방법 및 이를 함유하는 x- 선 조영제
Pisani Influence of co-medication on the metabolism of valproate
KR960703593A (ko) (R)-암로디핀에 의한 평활근 세포 이동의 억제 (Inhibition of Smooth Muscle Cell Migration by (R)-Amlodipine)
ES480041A1 (es) Procedimiento para preparar acido ciclohexilcarboxilico y sus derivados.

Legal Events

Date Code Title Description
ST Notification of lapse