FR2392023A1 - NEW TRANS-5-ARYL-2,3,4,4A, 5,9, B-HEXAHYDRO-1H-PYRIDO (4,3-B) INDOLES, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM - Google Patents

NEW TRANS-5-ARYL-2,3,4,4A, 5,9, B-HEXAHYDRO-1H-PYRIDO (4,3-B) INDOLES, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM

Info

Publication number
FR2392023A1
FR2392023A1 FR7815029A FR7815029A FR2392023A1 FR 2392023 A1 FR2392023 A1 FR 2392023A1 FR 7815029 A FR7815029 A FR 7815029A FR 7815029 A FR7815029 A FR 7815029A FR 2392023 A1 FR2392023 A1 FR 2392023A1
Authority
FR
France
Prior art keywords
indoles
pyrido
hexahydro
aryl
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7815029A
Other languages
French (fr)
Other versions
FR2392023B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR2392023A1 publication Critical patent/FR2392023A1/en
Application granted granted Critical
Publication of FR2392023B1 publication Critical patent/FR2392023B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés nouveaux qui sont des trans-5-aryl-2,3,4,4a-5,9b-hexahydro-1H-pyrido Ø4,3-bõ-indoles et leurs sels acceptables du point de vue pharmaceutique. Elle concerne également un procédé à plusieurs variantes pour la préparation de ces nouveaux composés. Les composés de l'invention sont doués de propriétés tranquillisantes. Ils peuvent être formulés à ce titre en compositions pharmaceutiques destinées notamment au traitement de manifestations schizophréniques chez l'homme.The present invention relates to novel compounds which are trans-5-aryl-2,3,4,4a-5,9b-hexahydro-1H-pyrido Ø4,3-bõ-indoles and their pharmaceutically acceptable salts. It also relates to a process with several variants for the preparation of these new compounds. The compounds of the invention are endowed with tranquilizing properties. They can be formulated as such in pharmaceutical compositions intended in particular for the treatment of schizophrenic manifestations in humans.

FR7815029A 1977-05-23 1978-05-22 NEW TRANS-5-ARYL-2,3,4,4A, 5,9, B-HEXAHYDRO-1H-PYRIDO (4,3-B) INDOLES, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM Granted FR2392023A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79939277A 1977-05-23 1977-05-23

Publications (2)

Publication Number Publication Date
FR2392023A1 true FR2392023A1 (en) 1978-12-22
FR2392023B1 FR2392023B1 (en) 1980-11-07

Family

ID=25175793

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7815029A Granted FR2392023A1 (en) 1977-05-23 1978-05-22 NEW TRANS-5-ARYL-2,3,4,4A, 5,9, B-HEXAHYDRO-1H-PYRIDO (4,3-B) INDOLES, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM

Country Status (31)

Country Link
JP (1) JPS53144600A (en)
AR (2) AR217688A1 (en)
AT (1) AT368995B (en)
AU (1) AU499618B1 (en)
BE (1) BE867249A (en)
CA (1) CA1094071A (en)
CH (1) CH634321A5 (en)
CS (1) CS207612B2 (en)
DD (4) DD145537A5 (en)
DE (1) DE2822465C2 (en)
DK (1) DK226678A (en)
EG (1) EG13590A (en)
FI (1) FI63402C (en)
FR (1) FR2392023A1 (en)
GB (1) GB1586655A (en)
GR (1) GR69985B (en)
HU (3) HU187782B (en)
IE (1) IE46975B1 (en)
IL (1) IL54755A (en)
IT (1) IT1096307B (en)
LU (1) LU79684A1 (en)
NL (1) NL7804210A (en)
NO (2) NO150204C (en)
NZ (1) NZ187333A (en)
PH (1) PH13756A (en)
PL (5) PL116944B1 (en)
PT (1) PT68058B (en)
SE (2) SE441448B (en)
SU (4) SU873883A3 (en)
YU (4) YU91478A (en)
ZA (1) ZA782918B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2447379A1 (en) * 1979-01-23 1980-08-22 Pfizer TRANS-5-ARYL-2,3,4,4A-5-9B-HEXAHYDRO-1H-PYRIDO (4,3-B) -INDOLES SUBSTITUTED IN POSITION 2 DEXTROGYRES, PROCESSES AND INTERMEDIATE COMPOUNDS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451655A (en) * 1982-05-17 1984-05-29 Pfizer Inc. Process for preparing carboline derivatives and compounds used in their preparation
RU2106864C1 (en) * 1995-10-23 1998-03-20 Николай Серафимович Зефиров New approach to treatment of alzheimer's disease
US6974825B1 (en) 1996-12-20 2005-12-13 Astrazeneca Canada Inc. Compounds with analgesic effect
SE9604786D0 (en) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
SE9904675D0 (en) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0101771D0 (en) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101773D0 (en) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101770D0 (en) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101769D0 (en) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2253520A1 (en) * 1973-12-06 1975-07-04 Lab Inc
FR2264535A1 (en) * 1974-03-20 1975-10-17 Dainippon Pharmaceutical Co

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001263A (en) * 1974-04-01 1977-01-04 Pfizer Inc. 5-Aryl-1,2,3,4-tetrahydro-γ-carbolines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2253520A1 (en) * 1973-12-06 1975-07-04 Lab Inc
FR2264535A1 (en) * 1974-03-20 1975-10-17 Dainippon Pharmaceutical Co

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2447379A1 (en) * 1979-01-23 1980-08-22 Pfizer TRANS-5-ARYL-2,3,4,4A-5-9B-HEXAHYDRO-1H-PYRIDO (4,3-B) -INDOLES SUBSTITUTED IN POSITION 2 DEXTROGYRES, PROCESSES AND INTERMEDIATE COMPOUNDS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING

Also Published As

Publication number Publication date
PL116944B1 (en) 1981-07-31
CA1094071A (en) 1981-01-20
PL206903A1 (en) 1979-10-22
SE7803625L (en) 1978-11-24
ZA782918B (en) 1979-06-27
DE2822465A1 (en) 1978-11-30
BE867249A (en) 1978-11-20
PL117107B1 (en) 1981-07-31
PT68058A (en) 1978-06-01
AU499618B1 (en) 1979-04-26
JPS5711912B2 (en) 1982-03-08
NL7804210A (en) 1978-11-27
NO150204B (en) 1984-05-28
GR69985B (en) 1982-07-22
AT368995B (en) 1982-11-25
HU187782B (en) 1986-02-28
AR217688A1 (en) 1980-04-15
IL54755A (en) 1981-02-27
FI63402B (en) 1983-02-28
DE2822465C2 (en) 1986-08-28
SE8305917L (en) 1983-10-27
IE781013L (en) 1978-11-23
DD146186A5 (en) 1981-01-28
NO150204C (en) 1984-09-05
SE441448B (en) 1985-10-07
FR2392023B1 (en) 1980-11-07
GB1586655A (en) 1981-03-25
DD145537A5 (en) 1980-12-17
YU221682A (en) 1983-01-21
YU221782A (en) 1983-01-21
LU79684A1 (en) 1979-12-06
EG13590A (en) 1982-03-31
FI781612A (en) 1978-11-24
DD138321A5 (en) 1979-10-24
SE448459B (en) 1987-02-23
PL114547B1 (en) 1981-02-28
NZ187333A (en) 1984-05-31
PL114541B1 (en) 1981-02-28
SU843749A3 (en) 1981-06-30
JPS53144600A (en) 1978-12-15
CH634321A5 (en) 1983-01-31
IL54755A0 (en) 1978-07-31
AR221721A1 (en) 1981-03-13
IE46975B1 (en) 1983-11-16
ATA369678A (en) 1982-04-15
NO151862B (en) 1985-03-11
SU873883A3 (en) 1981-10-15
YU40796B (en) 1986-06-30
PH13756A (en) 1980-09-17
HU185009B (en) 1984-11-28
SU818484A3 (en) 1981-03-30
IT7823673A0 (en) 1978-05-22
YU221882A (en) 1983-01-21
HU188802B (en) 1986-05-28
DD145536A5 (en) 1980-12-17
PT68058B (en) 1979-10-24
FI63402C (en) 1983-06-10
SU841589A3 (en) 1981-06-23
NO781770L (en) 1978-11-24
SE8305917D0 (en) 1983-10-27
IT1096307B (en) 1985-08-26
NO831790L (en) 1978-11-24
YU91478A (en) 1983-01-21
CS207612B2 (en) 1981-08-31
DK226678A (en) 1978-11-24
NO151862C (en) 1985-06-19

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