FR2383960A1 - Intermediaire dans la synthese de l'acide 1-carba-2-penem-3-carboxylique - Google Patents

Intermediaire dans la synthese de l'acide 1-carba-2-penem-3-carboxylique

Info

Publication number
FR2383960A1
FR2383960A1 FR7821951A FR7821951A FR2383960A1 FR 2383960 A1 FR2383960 A1 FR 2383960A1 FR 7821951 A FR7821951 A FR 7821951A FR 7821951 A FR7821951 A FR 7821951A FR 2383960 A1 FR2383960 A1 FR 2383960A1
Authority
FR
France
Prior art keywords
penem
carba
synthesis
carboxylic acid
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7821951A
Other languages
English (en)
Other versions
FR2383960B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2383960A1 publication Critical patent/FR2383960A1/fr
Application granted granted Critical
Publication of FR2383960B1 publication Critical patent/FR2383960B1/fr
Priority claimed from AU79443/91A external-priority patent/AU645095B2/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Separation Of Gases By Adsorption (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

L'invention concerne des intermédiaires de synthèse. Il s'agit de composés de structure :
FR7821951A 1976-11-19 1978-07-25 Intermediaire dans la synthese de l'acide 1-carba-2-penem-3-carboxylique Granted FR2383960A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74336376A 1976-11-19 1976-11-19
US74337076A 1976-11-19 1976-11-19
US84317177A 1977-10-19 1977-10-19
AU79443/91A AU645095B2 (en) 1976-11-19 1991-07-01 Improved process for recovering organic vapors from air

Publications (2)

Publication Number Publication Date
FR2383960A1 true FR2383960A1 (fr) 1978-10-13
FR2383960B1 FR2383960B1 (fr) 1982-02-26

Family

ID=27423898

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7734768A Expired FR2371449B1 (fr) 1976-11-19 1977-11-18 Acide 1-carba-2-penem-3-carboxylique
FR7821951A Granted FR2383960A1 (fr) 1976-11-19 1978-07-25 Intermediaire dans la synthese de l'acide 1-carba-2-penem-3-carboxylique
FR7821950A Granted FR2383959A1 (fr) 1976-11-19 1978-07-25 Intermediaire de synthese de l'acide 1-carba-2-penem-3-carboxylique

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7734768A Expired FR2371449B1 (fr) 1976-11-19 1977-11-18 Acide 1-carba-2-penem-3-carboxylique

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7821950A Granted FR2383959A1 (fr) 1976-11-19 1978-07-25 Intermediaire de synthese de l'acide 1-carba-2-penem-3-carboxylique

Country Status (9)

Country Link
EP (1) EP0521203A1 (fr)
JP (1) JPS6033836B2 (fr)
CH (1) CH640856A5 (fr)
DE (1) DE2751624A1 (fr)
FR (3) FR2371449B1 (fr)
GB (1) GB1593524A (fr)
LU (1) LU78538A1 (fr)
NL (1) NL7712750A (fr)
SE (1) SE436130B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0102239A1 (fr) * 1982-08-24 1984-03-07 Sankyo Company Limited Dérivés d'azétidinone, un procédé pour leur préparation et leur application comme intermédiaires dans la préparation d'antibiotiques du type carbapénème
EP0499196A1 (fr) * 1991-02-13 1992-08-19 Fujisawa Pharmaceutical Co., Ltd. Intermédiaires et procédés pour la préparation de dérivés carbapénèmes

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2811514A1 (de) * 1977-03-19 1978-09-21 Beecham Group Ltd Ester der 7-oxo-1-azabicyclo eckige klammer auf 3.2.0 eckige klammer zu hept- 2-en-2-carbonsaeure und deren derivate, verfahren zur herstellung dieser verbindungen und diese verbindungen enthaltende pharmazeutische zubereitungen
DE2862198D1 (en) * 1977-08-06 1983-04-14 Beecham Group Plc Synthetic beta-lactam compounds, a process for their preparation and compositions containing them
AU4061378A (en) * 1977-10-19 1980-04-17 Merck & Co., Inc. 1-azabicyclo (3.2.0) hept-2-enes
AU531084B2 (en) * 1977-10-19 1983-08-11 Merck & Co., Inc. Azetidine derivatives
EP0030392B1 (fr) * 1978-01-19 1984-05-16 Beecham Group Plc Intermédiaires pour utilisation dans la préparation de carbapénèmes
US4272439A (en) * 1978-06-02 1981-06-09 Schering Corporation 6-(Substituted-hydroxymethylene penams)
NZ190994A (en) 1978-07-24 1981-10-19 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates
US4446146A (en) * 1978-07-26 1984-05-01 Beecham Group Limited β-Lactam containing compounds, their preparation and use
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
ATE15039T1 (de) * 1979-04-27 1985-09-15 Merck & Co Inc Verfahren zur herstellung von 3-(1-hydroxyaethyl)- azetidinonen.
JPS56142260A (en) * 1980-04-09 1981-11-06 Toyama Chem Co Ltd 2-azetidinone and its preparation
CA1179675A (fr) * 1981-01-30 1984-12-18 Erwin Gotschi Derives du 7-oxo-1-azabicyclo ¬3,2,0| heptene-2-
EP0059554A3 (fr) * 1981-02-27 1982-10-20 Beecham Group Plc Antibiotiques bêta-lactame, un procédé pour leur préparation et leur application en compositions pharmaceutiques
US4992542A (en) * 1984-01-24 1991-02-12 Merck & Co., Inc. 2-substituted-6-carbadethiapen-2-em-3-carboxylic acids
JPS60208981A (ja) * 1984-03-15 1985-10-21 Sanraku Inc 新規カルバペナム及びカルバペネム誘導体
EP0277743A1 (fr) * 1987-02-02 1988-08-10 Merck & Co. Inc. 2-(Hétéroaryliumalkyl)phényl-carbapénèmes, comme agents antibactériens
JPS63290879A (ja) * 1988-04-05 1988-11-28 Sankyo Co Ltd ２−メチルカルバペネム誘導体
EP0466254A1 (fr) * 1990-07-11 1992-01-15 Merck & Co. Inc. 2-Naphtyle-carbapénèmes
EP0466253A1 (fr) * 1990-07-11 1992-01-15 Merck & Co. Inc. 2-Naphtyle-carbapénèmes
US5409920A (en) * 1990-10-05 1995-04-25 Merck & Co., Inc. 2-(3-pyridyl)-carbapenem antibacterial agents
HUT75519A (en) * 1993-10-29 1997-05-28 Smithkline Beecham Plc 2-(pyrazol-3-yl)carbapenem derivatives, pharmaceutical compositions containing the same and process for their production
US20020147333A1 (en) 1993-10-29 2002-10-10 Smithkline Beecham P.L.C. 2-(pyrazol-3-yl)carbapenem derivatives
US5606051A (en) * 1993-10-29 1997-02-25 Smithkline Beecham P.L.C. 2-(pyrazol-3-yl)carbapenem derivatives
WO1996011932A1 (fr) * 1994-10-14 1996-04-25 Smithkline Beecham Plc Derives de 2-(imidazol-4-yl)carbapeneme, leurs intermediaires ainsi que leur utilisation en tant qu'antibacteriens
IL118092A0 (en) * 1995-05-03 1996-09-12 Smithkline Beecham Plc Antibacterial compounds their preparation and pharmaceutical compositions containing them
EP0823911A1 (fr) * 1995-05-03 1998-02-18 Smithkline Beecham Plc Esters de carbapenemes
US5814127A (en) * 1996-12-23 1998-09-29 American Air Liquide Inc. Process for recovering CF4 and C2 F6 from a gas
US7468364B2 (en) 2003-04-08 2008-12-23 Dainippon Sumitomo Pharma Co., Ltd. Carbapenem compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics
DE2456307A1 (de) * 1974-11-28 1976-08-12 Bayer Ag Beta-lactam-antibiotica, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
AU512383B2 (en) * 1975-11-21 1980-10-09 Merck & Co., Inc. Thinenamycin derivatives
DE2811514A1 (de) * 1977-03-19 1978-09-21 Beecham Group Ltd Ester der 7-oxo-1-azabicyclo eckige klammer auf 3.2.0 eckige klammer zu hept- 2-en-2-carbonsaeure und deren derivate, verfahren zur herstellung dieser verbindungen und diese verbindungen enthaltende pharmazeutische zubereitungen
US4553983A (en) * 1984-07-31 1985-11-19 Membrane Technology And Research, Inc. Process for recovering organic vapors from air
US4701187A (en) * 1986-11-03 1987-10-20 Air Products And Chemicals, Inc. Process for separating components of a gas stream
ATE86137T1 (de) * 1988-03-25 1993-03-15 Otto Oeko Tech Vorrichtung zur gewinnung von kohlenwasserstoffen aus hochkonzentrierten gasstroemen.
US4906256A (en) * 1989-03-23 1990-03-06 Membrane Technology & Research, Inc. Membrane process for treatment of fluorinated hydrocarbon-laden gas streams

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0102239A1 (fr) * 1982-08-24 1984-03-07 Sankyo Company Limited Dérivés d'azétidinone, un procédé pour leur préparation et leur application comme intermédiaires dans la préparation d'antibiotiques du type carbapénème
US5856556A (en) * 1982-08-24 1999-01-05 Sankyo Company, Limited Azetidinone derivatives, a process for their preparation and their use as intermediates in the preparation of carbapenem antibiotics
EP0499196A1 (fr) * 1991-02-13 1992-08-19 Fujisawa Pharmaceutical Co., Ltd. Intermédiaires et procédés pour la préparation de dérivés carbapénèmes
US5306816A (en) * 1991-02-13 1994-04-26 Fujisawa Pharmaceutical Co., Ltd. Processes for preparing carbapenem derivatives

Also Published As

Publication number Publication date
EP0521203A1 (fr) 1993-01-07
FR2371449B1 (fr) 1985-06-21
SE7713008L (sv) 1978-05-20
FR2383959B1 (fr) 1982-04-02
FR2383959A1 (fr) 1978-10-13
GB1593524A (en) 1981-07-15
NL7712750A (nl) 1978-05-23
DE2751624A1 (de) 1978-06-01
DE2751624C2 (fr) 1988-09-08
FR2371449A1 (fr) 1978-06-16
LU78538A1 (fr) 1978-07-14
FR2383960B1 (fr) 1982-02-26
CH640856A5 (en) 1984-01-31
JPS6033836B2 (ja) 1985-08-05
SE436130B (sv) 1984-11-12
JPS5387390A (en) 1978-08-01

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Legal Events

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ST Notification of lapse