ATE15039T1 - Verfahren zur herstellung von 3-(1-hydroxyaethyl)- azetidinonen. - Google Patents
Verfahren zur herstellung von 3-(1-hydroxyaethyl)- azetidinonen.Info
- Publication number
- ATE15039T1 ATE15039T1 AT80102202T AT80102202T ATE15039T1 AT E15039 T1 ATE15039 T1 AT E15039T1 AT 80102202 T AT80102202 T AT 80102202T AT 80102202 T AT80102202 T AT 80102202T AT E15039 T1 ATE15039 T1 AT E15039T1
- Authority
- AT
- Austria
- Prior art keywords
- azetidinones
- preparation
- hydroxyaethyl
- thienamycin
- analogues
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- UMHGAVAUBIVOAL-UHFFFAOYSA-N 3-(1-hydroxyethyl)azetidin-2-one Chemical class CC(O)C1CNC1=O UMHGAVAUBIVOAL-UHFFFAOYSA-N 0.000 abstract 1
- WKDDRNSBRWANNC-ATRFCDNQSA-N Thienamycin Chemical compound C1C(SCCN)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 WKDDRNSBRWANNC-ATRFCDNQSA-N 0.000 abstract 1
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3405379A | 1979-04-27 | 1979-04-27 | |
| EP80102202A EP0018594B1 (de) | 1979-04-27 | 1980-04-24 | Verfahren zur Herstellung von 3-(1-Hydroxyäthyl)-azetidinonen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE15039T1 true ATE15039T1 (de) | 1985-09-15 |
Family
ID=21874008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT80102202T ATE15039T1 (de) | 1979-04-27 | 1980-04-24 | Verfahren zur herstellung von 3-(1-hydroxyaethyl)- azetidinonen. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0018594B1 (de) |
| JP (1) | JPS56108785A (de) |
| AT (1) | ATE15039T1 (de) |
| DE (1) | DE3071008D1 (de) |
| DK (1) | DK178180A (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4446146A (en) * | 1978-07-26 | 1984-05-01 | Beecham Group Limited | β-Lactam containing compounds, their preparation and use |
| PT71552B (en) * | 1979-07-23 | 1981-12-14 | Merck & Co Inc | Process for preparation of thienamycin and intermediates |
| JPS57167964A (en) * | 1981-04-09 | 1982-10-16 | Toyama Chem Co Ltd | Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative |
| EP0067517B1 (de) * | 1981-05-14 | 1986-02-26 | Beecham Group Plc | Verfahren zur Herstellung von einem Enantiomer eines Beta-Lactam Derivates |
| JPS58103358A (ja) * | 1981-10-23 | 1983-06-20 | メルク・エンド・カムパニ−・インコ−ポレ−テツド | 抗生物質中間体の製造方法 |
| HU184494B (en) * | 1981-12-30 | 1984-08-28 | Richter Gedeon Vegyeszet | Process for producing new azetidinone-caraoxylic acids |
| HU185081B (en) * | 1981-12-30 | 1984-11-28 | Richter Gedeon Vegyeszet | Process for preparing azetidinone-acetic acid derivatives |
| DE3581481D1 (de) * | 1984-10-31 | 1991-02-28 | Sumitomo Pharma | Beta-lactame und ihre herstellung. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7712093A (nl) * | 1976-11-19 | 1978-05-23 | Merck & Co Inc | Werkwijze voor het bereiden van isomere thienamycinen. |
| GB1593524A (en) * | 1976-11-19 | 1981-07-15 | Merck & Co Inc | 1-carba-2-penem-3-carboxylic acids |
| US4174316A (en) * | 1978-08-14 | 1979-11-13 | Merck & Co., Inc. | 4-Iodomethylazetidin-2-one |
| EP0082133A3 (en) * | 1979-04-19 | 1983-07-20 | Merck & Co. Inc. | A process for preparing intermediates useful for preparing 2-substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids |
| PT71552B (en) * | 1979-07-23 | 1981-12-14 | Merck & Co Inc | Process for preparation of thienamycin and intermediates |
| US4262010A (en) * | 1979-12-03 | 1981-04-14 | Merck & Co., Inc. | 6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acids |
| GR72296B (de) * | 1979-12-03 | 1983-10-18 | Merck & Co Inc | |
| IE52147B1 (en) * | 1980-03-27 | 1987-07-08 | Merck & Co Inc | 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation |
| EP0037082B1 (de) * | 1980-03-27 | 1985-03-20 | Merck & Co. Inc. | Verfahren zur Herstellung von 1-Carbapenem-Derivaten und von Zwischenprodukten via silyl-substituierter Dithioacetale |
-
1980
- 1980-04-24 EP EP80102202A patent/EP0018594B1/de not_active Expired
- 1980-04-24 AT AT80102202T patent/ATE15039T1/de not_active IP Right Cessation
- 1980-04-24 DE DE8080102202T patent/DE3071008D1/de not_active Expired
- 1980-04-25 DK DK178180A patent/DK178180A/da not_active Application Discontinuation
- 1980-04-28 JP JP5554680A patent/JPS56108785A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS56108785A (en) | 1981-08-28 |
| EP0018594A3 (en) | 1981-01-07 |
| DE3071008D1 (en) | 1985-09-26 |
| DK178180A (da) | 1980-10-28 |
| EP0018594B1 (de) | 1985-08-21 |
| EP0018594A2 (de) | 1980-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |