FR2383917A2 - Nouveaux analogues dipeptidiques, leur procede de preparation et leur application a la production d'analogues polypeptidiques - Google Patents

Nouveaux analogues dipeptidiques, leur procede de preparation et leur application a la production d'analogues polypeptidiques

Info

Publication number
FR2383917A2
FR2383917A2 FR7807343A FR7807343A FR2383917A2 FR 2383917 A2 FR2383917 A2 FR 2383917A2 FR 7807343 A FR7807343 A FR 7807343A FR 7807343 A FR7807343 A FR 7807343A FR 2383917 A2 FR2383917 A2 FR 2383917A2
Authority
FR
France
Prior art keywords
analogues
application
dipeptidic
polypeptidic
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7807343A
Other languages
English (en)
Other versions
FR2383917B2 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Res Development
National Research Development Corp UK
Original Assignee
National Res Development
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Res Development, National Research Development Corp UK filed Critical National Res Development
Publication of FR2383917A2 publication Critical patent/FR2383917A2/fr
Application granted granted Critical
Publication of FR2383917B2 publication Critical patent/FR2383917B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

L'invention concerne la synthèse d'analogues peptidiques, et des intermédiaires à cet effet. L'invention décrit des analogues d'un dipeptide dont l'atome de N du groupe amide de liaison est remplacé par le groupe trivalent -CH- et où, éventuellement, la fonction carbonyle du groupe de liaison est remplacée par le groupe divalent -CH2 - de la valine. Application à la synthèse de peptides à modification isostérique.
FR7807343A 1977-03-15 1978-03-14 Nouveaux analogues dipeptidiques, leur procede de preparation et leur application a la production d'analogues polypeptidiques Granted FR2383917A2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB13192/76A GB1585061A (en) 1977-03-15 1977-03-15 Synthesis of peptides

Publications (2)

Publication Number Publication Date
FR2383917A2 true FR2383917A2 (fr) 1978-10-13
FR2383917B2 FR2383917B2 (fr) 1984-06-01

Family

ID=10018529

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7709842A Granted FR2346316A1 (fr) 1977-03-15 1977-03-31 Nouveaux analogues dipeptidiques et leur procede de preparation
FR7807343A Granted FR2383917A2 (fr) 1977-03-15 1978-03-14 Nouveaux analogues dipeptidiques, leur procede de preparation et leur application a la production d'analogues polypeptidiques

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7709842A Granted FR2346316A1 (fr) 1977-03-15 1977-03-31 Nouveaux analogues dipeptidiques et leur procede de preparation

Country Status (6)

Country Link
US (1) US4242256A (fr)
JP (2) JPS52142001A (fr)
CH (2) CH627734A5 (fr)
DE (2) DE2714141A1 (fr)
FR (2) FR2346316A1 (fr)
GB (1) GB1585061A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1585061A (en) * 1977-03-15 1981-02-25 Nat Res Dev Synthesis of peptides
NO812612L (no) * 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
CA1223602A (fr) * 1983-05-25 1987-06-30 Naohito Ohashi Preparation de 3-(3,4-dihydroxyphenyl)-serine
US4596819A (en) * 1984-01-23 1986-06-24 Warner-Lambert Company Modified tripeptides
DE3405098A1 (de) * 1984-02-14 1985-08-29 Drägerwerk AG, 2400 Lübeck Kohlenoxid-atemschutzgeraet
US4880781A (en) * 1984-08-06 1989-11-14 The Upjohn Company Renin inhibitory peptides containing an N-alkyl-histidine moiety
US4705778A (en) * 1985-10-22 1987-11-10 Sri International Orally active LHRH analogs
US5830863A (en) * 1988-06-20 1998-11-03 Merrell Pharmaceuticals Inc. Neurokinin A antagonists
US6218364B1 (en) 1988-06-20 2001-04-17 Scott L. Harbeson Fluorinated neurokinin A antagonists
US5359138A (en) * 1989-04-15 1994-10-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Poststatin and related compounds or salts thereof
FR2647453A1 (fr) 1989-05-24 1990-11-30 Rhone Poulenc Chimie Nouveau tripeptide, son procede de preparation et son utilisation
JP3398747B2 (ja) * 1992-06-04 2003-04-21 メレルダウファーマスーティカルズ インコーポレイテッド 抗血小板剤としての立体配位が制限されたペプチド類似体
US5523463A (en) * 1994-09-23 1996-06-04 Hoffmann-La Roche Inc. Method of producing halogenated and alpha-aminoalchohols
US7163918B2 (en) * 2000-08-22 2007-01-16 New River Pharmaceuticals Inc. Iodothyronine compositions
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
US20060014697A1 (en) 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US20040087797A1 (en) * 2002-10-31 2004-05-06 Pfizer Inc Dihydro-furan-2-one derivatives, their intermediates and methods of manufacture
WO2009010968A2 (fr) 2007-07-15 2009-01-22 Yitzchak Hillman Traitement de maladie par des peptides antimicrobien ou leurs inhibiteurs

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2346316A1 (fr) * 1977-03-15 1977-10-28 Nat Res Dev Nouveaux analogues dipeptidiques et leur procede de preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH369764A (de) * 1957-08-28 1963-06-15 Geigy Ag J R Verfahren zur Herstellung von neuen a-Aryl-w-amino-alkansäuren und deren Derivaten
US3732295A (en) * 1969-11-25 1973-05-08 Dompe Farmaceutici Spa Trimethoxybenzoyl-aminoalkanoic acids
GB1371490A (en) * 1971-09-29 1974-10-23 Stanley Drug Products Inc Method and compositions for inducing resistance to bacterial infections
CA1009252A (en) * 1972-10-03 1977-04-26 Santen Pharmaceutical Co. N-(mercaptoacyl) aminoacids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2346316A1 (fr) * 1977-03-15 1977-10-28 Nat Res Dev Nouveaux analogues dipeptidiques et leur procede de preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
EP0038758A1 (fr) * 1980-04-17 1981-10-28 Societe Civile Bioprojet Dérivés d'acides aminés et leur application thérapeutique

Also Published As

Publication number Publication date
FR2346316B1 (fr) 1984-02-24
US4242256A (en) 1980-12-30
CH627734A5 (fr) 1982-01-29
CH636344A5 (fr) 1983-05-31
JPS53135904A (en) 1978-11-28
GB1585061A (en) 1981-02-25
DE2811267A1 (de) 1978-09-21
FR2346316A1 (fr) 1977-10-28
FR2383917B2 (fr) 1984-06-01
JPS52142001A (en) 1977-11-26
DE2714141A1 (de) 1977-10-27

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