FR2374906A2 - Nouveaux derives du dithiole-1,2, leur preparation et les compositions qui les contiennent - Google Patents

Nouveaux derives du dithiole-1,2, leur preparation et les compositions qui les contiennent

Info

Publication number
FR2374906A2
FR2374906A2 FR7638901A FR7638901A FR2374906A2 FR 2374906 A2 FR2374906 A2 FR 2374906A2 FR 7638901 A FR7638901 A FR 7638901A FR 7638901 A FR7638901 A FR 7638901A FR 2374906 A2 FR2374906 A2 FR 2374906A2
Authority
FR
France
Prior art keywords
alkyl
dithiole
derivs
thione
pyrazinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7638901A
Other languages
English (en)
Other versions
FR2374906B2 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7638901A priority Critical patent/FR2374906A2/fr
Priority to NLAANVRAGE7701107,A priority patent/NL171985C/xx
Priority to IL7751403A priority patent/IL51403A/xx
Priority to HU77RO00000914A priority patent/HU172528B/hu
Priority to ZM14/77A priority patent/ZM1477A1/xx
Priority to US05/766,966 priority patent/US4110450A/en
Priority to PT66175A priority patent/PT66175B/fr
Priority to SE7701460A priority patent/SE427274B/xx
Priority to JP52013472A priority patent/JPS5822119B2/ja
Priority to DK55477A priority patent/DK55477A/da
Priority to LU76728A priority patent/LU76728A1/xx
Priority to CH158277A priority patent/CH618699A5/fr
Priority to IE270/77A priority patent/IE44561B1/en
Priority to PH7719438A priority patent/PH12367A/en
Priority to GB5365/77A priority patent/GB1518071A/en
Priority to EG78/77A priority patent/EG13739A/xx
Priority to AU22138/77A priority patent/AU509092B2/en
Priority to SU772449656A priority patent/SU683622A3/ru
Priority to AR266495A priority patent/AR224095A1/es
Priority to CA271,425A priority patent/CA1073906A/fr
Priority to DE2705641A priority patent/DE2705641C3/de
Priority to OA56067A priority patent/OA05565A/fr
Priority to AT90277A priority patent/AT348535B/de
Priority to ES455790A priority patent/ES455790A1/es
Priority to ES455789A priority patent/ES455789A1/es
Priority to ES458688A priority patent/ES458688A1/es
Priority to ES458690A priority patent/ES458690A1/es
Priority to ES458689A priority patent/ES458689A1/es
Priority to US05/855,196 priority patent/US4144339A/en
Priority to US05/855,385 priority patent/US4138487A/en
Priority to AT153578A priority patent/AT349485B/de
Publication of FR2374906A2 publication Critical patent/FR2374906A2/fr
Priority to CH1030879A priority patent/CH619463A5/fr
Priority to CH1030979A priority patent/CH619464A5/fr
Application granted granted Critical
Publication of FR2374906B2 publication Critical patent/FR2374906B2/fr
Priority to HK174/81A priority patent/HK17481A/xx
Priority to KE3126A priority patent/KE3126A/xx
Priority to MY1/82A priority patent/MY8200001A/xx
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/16—Halogen atoms; Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nouveaux dérivés du dithiole-1,2 de gormule générale I dans laquelle : 1 degrés Het représente un radical hétérocyclique aromatique à 6 chaînons contenant 2 atomes d'azote substitué par pyrrolidino, pipéridino, morpholino, N-alcoylpipérazinyl- I ou mercapto et R représente alcoyle (1 à 4 atomes de carbone), alcoyloxy-carbonyle (1 à 4 atomes de carbone), carboxy, carbamoyle ou N-alcoylcarbamoyle (1 à 4 atomes de carbone), 2 degrés Het représente un radical hétérocyclique aromatique à 6 chaînons contenant 2 atomes d'azote, éventuellement substitué par halogène, alcoyle, alcoyloxy, mercapto, alcoylthio, dialcoylamino, pyrrolidino, pipéridino, morpholino ou N-alcoylpipérazinyl-1 et R représente alcoyle (1 à 4 atomes de carbone) substitué par alcoyloxycarbonyle 1 à 4 atomes de carbone) ou -CH(R 5 )OH dans lequel R5 représente hydrogène ou alcoyle (1 à 3 atomes de carbone), leur préparation et les compositions qui les contiennent. Ces nouveaux composés sont particulièrement utiles comme antibilharziens.
FR7638901A 1976-02-10 1976-12-23 Nouveaux derives du dithiole-1,2, leur preparation et les compositions qui les contiennent Granted FR2374906A2 (fr)

Priority Applications (36)

Application Number Priority Date Filing Date Title
FR7638901A FR2374906A2 (fr) 1976-12-23 1976-12-23 Nouveaux derives du dithiole-1,2, leur preparation et les compositions qui les contiennent
NLAANVRAGE7701107,A NL171985C (nl) 1976-02-10 1977-02-02 Werkwijze voor het bereiden van preparaten met werking tegen schistosomiasis, de aldus verkregen gevormde preparaten en werkwijze voor het bereiden van 1,2-dithioolverbindingen.
HU77RO00000914A HU172528B (hu) 1976-02-10 1977-02-08 Sposob poluchenija novykh proizvodnykh s 1,2-ditiol-3-tion gruppoj
IL7751403A IL51403A (en) 1976-02-10 1977-02-08 5-diazinyl-1,2-dithiole-3-thione derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
CA271,425A CA1073906A (fr) 1976-02-10 1977-02-09 Derives du dithiole-1,2, leur preparation et les compositions qui les contiennent
PT66175A PT66175B (fr) 1976-02-10 1977-02-09 Nouveaux derives du dithiole-1,2, leur preparation et les compositions qui les contiennent
SE7701460A SE427274B (sv) 1976-02-10 1977-02-09 Forfarande for framstellning av derivat av 1,2-ditiol-3-tion med verkan mot blodparasiter
JP52013472A JPS5822119B2 (ja) 1976-02-10 1977-02-09 ジチオ−ル誘導体
DK55477A DK55477A (da) 1976-02-10 1977-02-09 Fremgangsmade til fremstilling af derivater af 1,2-dithiol
LU76728A LU76728A1 (fr) 1976-02-10 1977-02-09
CH158277A CH618699A5 (fr) 1976-02-10 1977-02-09
IE270/77A IE44561B1 (en) 1976-02-10 1977-02-09 1,2-dithiole derivatives
PH7719438A PH12367A (en) 1976-02-10 1977-02-09 1,2-dithiole derivatives
GB5365/77A GB1518071A (en) 1976-02-10 1977-02-09 1,2-dithiole derivatives
EG78/77A EG13739A (en) 1976-02-10 1977-02-09 Nouveaux derives du dithiole 1,2 leur preparation et les compositions qui les contiennent
AU22138/77A AU509092B2 (en) 1976-02-10 1977-02-09 1, 2-dithiole derivatives
SU772449656A SU683622A3 (ru) 1976-02-10 1977-02-09 Способ получени производных 1,2-дитиоланов
AR266495A AR224095A1 (es) 1976-02-10 1977-02-09 Procedimiento de preparacion de nuevos derivados de ditiol-1,2 tiona-3
ZM14/77A ZM1477A1 (en) 1976-02-10 1977-02-09 1,2-dithiole derivatives
US05/766,966 US4110450A (en) 1976-02-10 1977-02-09 1,2-dithiole derivatives
DE2705641A DE2705641C3 (de) 1976-02-10 1977-02-10 U-Dithiol-3-thione, Verfahren zu deren Herstellung und diese enthaltende Zusammensetzungen
OA56067A OA05565A (fr) 1976-02-10 1977-02-10 Nouveaux dérivés du dithiole-1,2 et leur procédé de préparation.
AT90277A AT348535B (de) 1976-02-10 1977-02-10 Verfahren zur herstellung von neuen 1,2- dithiolderivaten
ES455790A ES455790A1 (es) 1976-02-10 1977-02-10 Procedimiento de preparacion de nuevos derivados del di- tiol-1,2.
ES455789A ES455789A1 (es) 1976-02-10 1977-02-10 Procedimiento de preparacion de nuevos derivados del di- tiol-1,2.
ES458690A ES458690A1 (es) 1976-12-23 1977-05-11 Procedimiento de preparacion de nuevos derivados del ditiol-1,2.
ES458689A ES458689A1 (es) 1976-02-10 1977-05-11 Procedimiento de preparacion de nuevos derivados del ditiol-1,2.
ES458688A ES458688A1 (es) 1976-02-10 1977-05-11 Procedimiento de preparacion de nuevos derivados del ditiol-1,2.
US05/855,196 US4144339A (en) 1976-02-10 1977-11-28 1,2-Dithiole pyrimidines
US05/855,385 US4138487A (en) 1976-02-10 1977-11-28 1,2-Dithiole derivatives
AT153578A AT349485B (de) 1976-12-23 1978-03-03 Verfahren zur herstellung von neuen 1,2- dithiolderivaten
CH1030879A CH619463A5 (fr) 1976-02-10 1979-11-19
CH1030979A CH619464A5 (en) 1976-12-23 1979-11-19 Process for the preparation of new 1,2-dithiole derivatives
HK174/81A HK17481A (en) 1976-02-10 1981-04-30 1,2-dithiole derivatives
KE3126A KE3126A (en) 1976-02-10 1981-05-06 1,2-dithiole derivatives
MY1/82A MY8200001A (en) 1976-02-10 1982-12-30 1,2 - dithiole derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7638901A FR2374906A2 (fr) 1976-12-23 1976-12-23 Nouveaux derives du dithiole-1,2, leur preparation et les compositions qui les contiennent

Publications (2)

Publication Number Publication Date
FR2374906A2 true FR2374906A2 (fr) 1978-07-21
FR2374906B2 FR2374906B2 (fr) 1980-09-19

Family

ID=9181472

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7638901A Granted FR2374906A2 (fr) 1976-02-10 1976-12-23 Nouveaux derives du dithiole-1,2, leur preparation et les compositions qui les contiennent

Country Status (3)

Country Link
CH (1) CH619464A5 (fr)
ES (1) ES458690A1 (fr)
FR (1) FR2374906A2 (fr)

Also Published As

Publication number Publication date
FR2374906B2 (fr) 1980-09-19
CH619464A5 (en) 1980-09-30
ES458690A1 (es) 1978-02-16

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