FR2370057A1 - Procede de production de 9-(b-d-arabinofuranosyl)-adenine, 5'-phosphate - Google Patents
Procede de production de 9-(b-d-arabinofuranosyl)-adenine, 5'-phosphateInfo
- Publication number
- FR2370057A1 FR2370057A1 FR7732871A FR7732871A FR2370057A1 FR 2370057 A1 FR2370057 A1 FR 2370057A1 FR 7732871 A FR7732871 A FR 7732871A FR 7732871 A FR7732871 A FR 7732871A FR 2370057 A1 FR2370057 A1 FR 2370057A1
- Authority
- FR
- France
- Prior art keywords
- aqueous
- phosphate
- adenine
- arabinofuranosyl
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910019142 PO4 Inorganic materials 0.000 title abstract 5
- 239000010452 phosphate Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- OIRDTQYFTABQOQ-PKJMTWSGSA-N (2R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@H](O)C1O OIRDTQYFTABQOQ-PKJMTWSGSA-N 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- OIRDTQYFTABQOQ-UHTZMRCNSA-N Vidarabine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O OIRDTQYFTABQOQ-UHTZMRCNSA-N 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- 229930024421 Adenine Natural products 0.000 abstract 1
- 229960000643 adenine Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000007791 liquid phase Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73842576A | 1976-11-03 | 1976-11-03 | |
| US05/831,703 US4123609A (en) | 1976-11-03 | 1977-09-12 | Process for the production of 9-(β-D-arabinofuranosyl)adenine, 5'-phosphate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2370057A1 true FR2370057A1 (fr) | 1978-06-02 |
| FR2370057B1 FR2370057B1 (cs) | 1980-06-13 |
Family
ID=27113366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7732871A Granted FR2370057A1 (fr) | 1976-11-03 | 1977-11-02 | Procede de production de 9-(b-d-arabinofuranosyl)-adenine, 5'-phosphate |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5356691A (cs) |
| AT (1) | AT358187B (cs) |
| CA (2) | CA1077030A (cs) |
| CH (1) | CH626377A5 (cs) |
| DE (1) | DE2749056A1 (cs) |
| DK (1) | DK151263C (cs) |
| ES (1) | ES463768A1 (cs) |
| FR (1) | FR2370057A1 (cs) |
| GB (1) | GB1559456A (cs) |
| HK (1) | HK3884A (cs) |
| NL (1) | NL191060C (cs) |
| SE (1) | SE442404B (cs) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1383572A (fr) * | 1964-02-28 | 1964-12-24 | Necchi Spa | Perfectionnements apportés aux dispositifs automatiques d'arrêt pour machine à coudre |
| US3413282A (en) * | 1965-03-17 | 1968-11-26 | Ajinomoto Kk | Method of preparing 5'-nucleotides |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE756704A (fr) * | 1969-09-26 | 1971-03-01 | Parke Davis & Co | Procede de production du 5'-phosphate de 9-(beta-d- arabinofuranosyl) adenine et de ses sels |
-
1977
- 1977-11-02 CA CA290,047A patent/CA1077030A/en not_active Expired
- 1977-11-02 SE SE7712368A patent/SE442404B/xx not_active IP Right Cessation
- 1977-11-02 JP JP13216277A patent/JPS5356691A/ja active Pending
- 1977-11-02 FR FR7732871A patent/FR2370057A1/fr active Granted
- 1977-11-02 CH CH1335777A patent/CH626377A5/fr not_active IP Right Cessation
- 1977-11-02 DE DE19772749056 patent/DE2749056A1/de active Granted
- 1977-11-02 GB GB4564777A patent/GB1559456A/en not_active Expired
- 1977-11-02 ES ES463768A patent/ES463768A1/es not_active Expired
- 1977-11-02 NL NL7712102A patent/NL191060C/xx not_active IP Right Cessation
- 1977-11-02 AT AT779577A patent/AT358187B/de not_active IP Right Cessation
- 1977-11-02 DK DK487177A patent/DK151263C/da not_active IP Right Cessation
-
1979
- 1979-12-18 CA CA342,182A patent/CA1088927A/en not_active Expired
-
1984
- 1984-01-12 HK HK3884A patent/HK3884A/en not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1383572A (fr) * | 1964-02-28 | 1964-12-24 | Necchi Spa | Perfectionnements apportés aux dispositifs automatiques d'arrêt pour machine à coudre |
| US3413282A (en) * | 1965-03-17 | 1968-11-26 | Ajinomoto Kk | Method of preparing 5'-nucleotides |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1088927A (en) | 1980-11-04 |
| CA1077030A (en) | 1980-05-06 |
| DK151263B (da) | 1987-11-16 |
| JPS5356691A (en) | 1978-05-23 |
| NL7712102A (nl) | 1978-05-08 |
| DE2749056A1 (de) | 1978-05-18 |
| AT358187B (de) | 1980-08-25 |
| ATA779577A (de) | 1980-01-15 |
| SE442404B (sv) | 1985-12-23 |
| HK3884A (en) | 1984-01-20 |
| ES463768A1 (es) | 1978-06-01 |
| DE2749056C2 (cs) | 1987-07-16 |
| NL191060B (nl) | 1994-08-01 |
| SE7712368L (sv) | 1978-05-04 |
| CH626377A5 (en) | 1981-11-13 |
| FR2370057B1 (cs) | 1980-06-13 |
| DK487177A (da) | 1978-05-04 |
| DK151263C (da) | 1988-05-16 |
| GB1559456A (en) | 1980-01-16 |
| NL191060C (nl) | 1995-01-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE88442T1 (de) | Verfahren zur trennung von zucker und konzentrierter schwefelsaeure. | |
| EP0323152A3 (en) | Method of synthesizing oligonucleotides | |
| ZA87885B (en) | Removal of lipid soluble chemicals from biological materials by extraction with naturally occurring oils or synthetic substitutes thereof | |
| FR2333546A1 (fr) | Procede de separation par membrane de produits organiques neutres a partir d'une solution aqueuse et nouveaux produits ainsi obtenus | |
| FI922105A0 (fi) | Foerfarande foer isolering av faktor viii. | |
| GB1458800A (en) | Simultaneous refining and dewaxing of crude vegetable oil | |
| FR2370057A1 (fr) | Procede de production de 9-(b-d-arabinofuranosyl)-adenine, 5'-phosphate | |
| FR2354764A1 (fr) | Nouveaux ethers cycliques derives de l'acide prostanoique et leur procede de preparation | |
| FR2422670A1 (fr) | Procede pour l'obtention d'orthosilicates de tetraalkyle | |
| SU527416A1 (ru) | Способ получени нафтеновых кислот | |
| SU1018967A1 (ru) | Способ получени эфирного масла | |
| KR880005114A (ko) | 광학적활성 2-메틸-1-(4-트리플루오로메틸페닐)-3-피롤리디노-1-프로파논 및 그 제조방법 | |
| SU411866A1 (cs) | ||
| BG34339A3 (bg) | Метод за отделяне на киселини от течни въглеводородни фракции | |
| SU584012A1 (ru) | Способ получени пектата глицерина | |
| SU908356A1 (ru) | Способ получени арахидоновой кислоты | |
| RU95105814A (ru) | Способ получения нитрометана | |
| SU574463A1 (ru) | Способ получени фитостерина | |
| SU944577A1 (ru) | Способ получени склареола | |
| SU463450A1 (ru) | Способ получени предшедственников простагландинов | |
| KR930003497B1 (ko) | 슈크로오스 지방산 폴리에스테르의 정제방법 | |
| SU403664A1 (ru) | Способ получения бензгидрилового эфира | |
| SU487893A1 (ru) | Способ получени 0,0,0,0-тетраалкил- -изопропилен-бис-дитиофосфатов | |
| SU411074A1 (cs) | ||
| SU662573A1 (ru) | Способ получени белого нефт ного масла |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CC | Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990) |
Free format text: 92C0432, 920617 |
|
| CB | Supplementary protection certificate (spc) granted (law of 25 june 1990) |
Free format text: 92C0432, 771102 |
|
| CP | Supplementary protection certificate (spc) filed |