FR2370057A1 - PROCESS FOR THE PRODUCTION OF 9- (B-D-ARABINOFURANOSYL) -ADENINE, 5'-PHOSPHATE - Google Patents

PROCESS FOR THE PRODUCTION OF 9- (B-D-ARABINOFURANOSYL) -ADENINE, 5'-PHOSPHATE

Info

Publication number
FR2370057A1
FR2370057A1 FR7732871A FR7732871A FR2370057A1 FR 2370057 A1 FR2370057 A1 FR 2370057A1 FR 7732871 A FR7732871 A FR 7732871A FR 7732871 A FR7732871 A FR 7732871A FR 2370057 A1 FR2370057 A1 FR 2370057A1
Authority
FR
France
Prior art keywords
aqueous
phosphate
adenine
arabinofuranosyl
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7732871A
Other languages
French (fr)
Other versions
FR2370057B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/831,703 external-priority patent/US4123609A/en
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of FR2370057A1 publication Critical patent/FR2370057A1/en
Application granted granted Critical
Publication of FR2370057B1 publication Critical patent/FR2370057B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé pour la préparation de 9-( beta -D-arabinofuranosyl)adénine, 5' -phosphate Elle comporte un procédé de production d'un ester, le 9-( beta -D-arabidofuranosyl)adénine, 5'-phosphate, les étapes impliquant de transformer la 9-( beta -D-arabinofuranosyl)adenine en un produit intermédiaire 5'-mono-phosphorylé en présence d'un solvant au trialcoyl-phosphate, de soumettre le mélange réactionnel à une hydrolyse aqueuse, d'ajuster le pH du mélange d'hydrolyse aqueuse en l'élevant suffisamment pour provoquer la séparation entre phases liquides aqueuse et non-aqueuse, de retirer le solvant trialcoyl-phosphate du mélange aqueux, de maintenir le mélange aqueux résiduel à un pH auquel l'ester produit est insoluble pour provoquer la précipitation dudit ester produit à partir du mélange aqueux et d'isoler ledit ester produit. Le produit obtenu est un médicament connu.The invention relates to a process for the preparation of 9- (beta -D-arabinofuranosyl) adenine, 5 '-phosphate. It comprises a process for the production of an ester, 9- (beta -D-arabidofuranosyl) adenine, 5' -phosphate, the steps involving converting 9- (beta -D-arabinofuranosyl) adenine into a 5'-mono-phosphorylated intermediate in the presence of a trialkyl-phosphate solvent, subjecting the reaction mixture to aqueous hydrolysis, adjusting the pH of the aqueous hydrolysis mixture raising it sufficiently to cause separation between aqueous and non-aqueous liquid phases, removing the trialkyl-phosphate solvent from the aqueous mixture, maintaining the residual aqueous mixture at a pH at which the ester produced is insoluble to cause precipitation of said ester produced from the aqueous mixture and to isolate said ester produced. The product obtained is a known drug.

FR7732871A 1976-11-03 1977-11-02 PROCESS FOR THE PRODUCTION OF 9- (B-D-ARABINOFURANOSYL) -ADENINE, 5'-PHOSPHATE Granted FR2370057A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73842576A 1976-11-03 1976-11-03
US05/831,703 US4123609A (en) 1976-11-03 1977-09-12 Process for the production of 9-(β-D-arabinofuranosyl)adenine, 5'-phosphate

Publications (2)

Publication Number Publication Date
FR2370057A1 true FR2370057A1 (en) 1978-06-02
FR2370057B1 FR2370057B1 (en) 1980-06-13

Family

ID=27113366

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7732871A Granted FR2370057A1 (en) 1976-11-03 1977-11-02 PROCESS FOR THE PRODUCTION OF 9- (B-D-ARABINOFURANOSYL) -ADENINE, 5'-PHOSPHATE

Country Status (12)

Country Link
JP (1) JPS5356691A (en)
AT (1) AT358187B (en)
CA (2) CA1077030A (en)
CH (1) CH626377A5 (en)
DE (1) DE2749056A1 (en)
DK (1) DK151263C (en)
ES (1) ES463768A1 (en)
FR (1) FR2370057A1 (en)
GB (1) GB1559456A (en)
HK (1) HK3884A (en)
NL (1) NL191060C (en)
SE (1) SE442404B (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1383572A (en) * 1964-02-28 1964-12-24 Necchi Spa Improvements in automatic shut-off devices for sewing machines
US3413282A (en) * 1965-03-17 1968-11-26 Ajinomoto Kk Method of preparing 5'-nucleotides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE756704A (en) * 1969-09-26 1971-03-01 Parke Davis & Co PROCESS FOR THE PRODUCTION OF 5'-PHOSPHATE OF 9- (BETA-D- ARABINOFURANOSYL) ADENINE AND ITS SALTS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1383572A (en) * 1964-02-28 1964-12-24 Necchi Spa Improvements in automatic shut-off devices for sewing machines
US3413282A (en) * 1965-03-17 1968-11-26 Ajinomoto Kk Method of preparing 5'-nucleotides

Also Published As

Publication number Publication date
DE2749056A1 (en) 1978-05-18
CA1088927A (en) 1980-11-04
DE2749056C2 (en) 1987-07-16
GB1559456A (en) 1980-01-16
NL191060C (en) 1995-01-02
CH626377A5 (en) 1981-11-13
AT358187B (en) 1980-08-25
ATA779577A (en) 1980-01-15
NL7712102A (en) 1978-05-08
DK151263C (en) 1988-05-16
HK3884A (en) 1984-01-20
FR2370057B1 (en) 1980-06-13
NL191060B (en) 1994-08-01
ES463768A1 (en) 1978-06-01
SE7712368L (en) 1978-05-04
DK151263B (en) 1987-11-16
JPS5356691A (en) 1978-05-23
SE442404B (en) 1985-12-23
DK487177A (en) 1978-05-04
CA1077030A (en) 1980-05-06

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Legal Events

Date Code Title Description
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0432, 920617

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0432, 771102

CP Supplementary protection certificate (spc) filed