SE7712368L - PROCEDURE FOR THE PREPARATION OF 9- (B-D-ARABINOFURANOSYL) ADENIN-5'-PHOSPHATE - Google Patents

PROCEDURE FOR THE PREPARATION OF 9- (B-D-ARABINOFURANOSYL) ADENIN-5'-PHOSPHATE

Info

Publication number
SE7712368L
SE7712368L SE7712368A SE7712368A SE7712368L SE 7712368 L SE7712368 L SE 7712368L SE 7712368 A SE7712368 A SE 7712368A SE 7712368 A SE7712368 A SE 7712368A SE 7712368 L SE7712368 L SE 7712368L
Authority
SE
Sweden
Prior art keywords
arabinofuranosyl
phosphate
mixture
adenin
procedure
Prior art date
Application number
SE7712368A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE442404B (en
Inventor
W E Behnke
W R Marsh
T H Haskell
Original Assignee
Parke Davis & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/831,703 external-priority patent/US4123609A/en
Application filed by Parke Davis & Co filed Critical Parke Davis & Co
Publication of SE7712368L publication Critical patent/SE7712368L/en
Publication of SE442404B publication Critical patent/SE442404B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The 9-( beta -D-arabinofuranosyl)adenine 5'-phosphate is prepared from a mixture obtained by reaction of 9-( beta -D-arabinofuranosyl)adenine with a phosphorylating agent, in a trialkyl phosphate as solvent. The mixture is then subjected to an aqueous hydrolysis, the pH of the hydrolysis mixture is adjusted to a value sufficiently high to bring about separation into aqueous and nonaqueous liquid phases; the trialkyl phosphate, which is the solvent, is removed and then the product is precipitated so as to separate it from the residual aqueous mixture and it is isolated.
SE7712368A 1976-11-03 1977-11-02 PROCEDURE FOR PREPARING 9- (BETA-D-ARABINOFURANOSYL) ADENIN-5'-PHOSPHATE SE442404B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73842576A 1976-11-03 1976-11-03
US05/831,703 US4123609A (en) 1976-11-03 1977-09-12 Process for the production of 9-(β-D-arabinofuranosyl)adenine, 5'-phosphate

Publications (2)

Publication Number Publication Date
SE7712368L true SE7712368L (en) 1978-05-04
SE442404B SE442404B (en) 1985-12-23

Family

ID=27113366

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7712368A SE442404B (en) 1976-11-03 1977-11-02 PROCEDURE FOR PREPARING 9- (BETA-D-ARABINOFURANOSYL) ADENIN-5'-PHOSPHATE

Country Status (12)

Country Link
JP (1) JPS5356691A (en)
AT (1) AT358187B (en)
CA (2) CA1077030A (en)
CH (1) CH626377A5 (en)
DE (1) DE2749056A1 (en)
DK (1) DK151263C (en)
ES (1) ES463768A1 (en)
FR (1) FR2370057A1 (en)
GB (1) GB1559456A (en)
HK (1) HK3884A (en)
NL (1) NL191060C (en)
SE (1) SE442404B (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1383572A (en) * 1964-02-28 1964-12-24 Necchi Spa Improvements in automatic shut-off devices for sewing machines
DE1645896C3 (en) * 1965-03-17 1975-01-02 Ajinomoto Co., Inc., Tokio Process for the preparation of 5'-ribonucleotides and S'-deoxyribonucleotides
BE756704A (en) * 1969-09-26 1971-03-01 Parke Davis & Co PROCESS FOR THE PRODUCTION OF 5'-PHOSPHATE OF 9- (BETA-D- ARABINOFURANOSYL) ADENINE AND ITS SALTS

Also Published As

Publication number Publication date
ES463768A1 (en) 1978-06-01
AT358187B (en) 1980-08-25
HK3884A (en) 1984-01-20
NL191060B (en) 1994-08-01
DK151263B (en) 1987-11-16
DE2749056C2 (en) 1987-07-16
CA1088927A (en) 1980-11-04
GB1559456A (en) 1980-01-16
DK487177A (en) 1978-05-04
JPS5356691A (en) 1978-05-23
ATA779577A (en) 1980-01-15
DK151263C (en) 1988-05-16
NL7712102A (en) 1978-05-08
FR2370057B1 (en) 1980-06-13
SE442404B (en) 1985-12-23
DE2749056A1 (en) 1978-05-18
FR2370057A1 (en) 1978-06-02
NL191060C (en) 1995-01-02
CH626377A5 (en) 1981-11-13
CA1077030A (en) 1980-05-06

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