FR2362154A1 - Toxoides derives de protease de pseudomonas aeruginosa et leur procede de production - Google Patents

Toxoides derives de protease de pseudomonas aeruginosa et leur procede de production

Info

Publication number
FR2362154A1
FR2362154A1 FR7703275A FR7703275A FR2362154A1 FR 2362154 A1 FR2362154 A1 FR 2362154A1 FR 7703275 A FR7703275 A FR 7703275A FR 7703275 A FR7703275 A FR 7703275A FR 2362154 A1 FR2362154 A1 FR 2362154A1
Authority
FR
France
Prior art keywords
pseudomonas aeruginosa
protease
toxoids
production process
derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7703275A
Other languages
English (en)
Other versions
FR2362154B1 (fr
Inventor
Yuzuru Homma
Kazuyuki Morihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1083776A external-priority patent/JPS5296728A/ja
Priority claimed from JP1083676A external-priority patent/JPS5296727A/ja
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of FR2362154A1 publication Critical patent/FR2362154A1/fr
Application granted granted Critical
Publication of FR2362154B1 publication Critical patent/FR2362154B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6448—Elastases, e.g. pancreatic elastase (3.4.21.36); leukocyte elastase (3.4.31.37)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Toxoïdes dérivés de protéase de Pseudomonas aeruginosa. Pour préparer le toxoïde dérivé de Pseudomonas aeruginosa, on traite la protéase produite à partir de Pseudomonas dans une solution tampon convenable avec de la formaline ou de l'acide oxyméthanesulfinique en présence de lysine. L'invention est utile pour fournir des toxoïdes utilisés pour prévenir ou traiter des infections provoquées par le Pseudomonas aeruginosa.
FR7703275A 1976-02-05 1977-02-04 Toxoides derives de protease de pseudomonas aeruginosa et leur procede de production Granted FR2362154A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1083776A JPS5296728A (en) 1976-02-05 1976-02-05 Toxoid of pseudomonas aeruginosa elastase
JP1083676A JPS5296727A (en) 1976-02-05 1976-02-05 Toxoid of pseudomonas aeruginosa protease

Publications (2)

Publication Number Publication Date
FR2362154A1 true FR2362154A1 (fr) 1978-03-17
FR2362154B1 FR2362154B1 (fr) 1983-04-29

Family

ID=26346182

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7703275A Granted FR2362154A1 (fr) 1976-02-05 1977-02-04 Toxoides derives de protease de pseudomonas aeruginosa et leur procede de production

Country Status (6)

Country Link
US (1) US4160023A (fr)
CA (1) CA1085293A (fr)
CH (1) CH628679A5 (fr)
DE (1) DE2704767A1 (fr)
FR (1) FR2362154A1 (fr)
SE (2) SE442269B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1256370A (fr) * 1984-02-24 1989-06-27 Yuzuru Homma Anatoxine d'elastase produite par pseudomonas aeruginosa
US5233024A (en) * 1991-04-09 1993-08-03 The Brigham & Women's Hospital Anti-idiotypic monoclonal antibodies for mucoid pseudomonas aeruginosa, their preparation and use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2111719A1 (fr) * 1970-10-20 1972-06-09 Eisai Co Ltd
FR2180594A1 (en) * 1972-04-21 1973-11-30 Research Corp Reducing elastase - elaborating bacterial infection - using bacterial elastase as antigen
FR2340099A1 (fr) * 1976-02-05 1977-09-02 Shionogi & Co Vaccin mixte a trois composants contre les infections par le pseudomonas aeruginosa

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2528972A (en) * 1947-05-15 1950-11-07 Western Reserve University Prophylactic toxoid compound and method of making same
US3135662A (en) * 1961-01-05 1964-06-02 Burroughs Wellcome Co Diphtheria toxoid preparation and its production
US3658986A (en) * 1969-07-02 1972-04-25 Victor N Tompkins Immunization methods against toxic effects of bacterial infection
US3674863A (en) * 1969-12-08 1972-07-04 Parke Davis & Co Polyvalent immunizing agents and methods for their production
US3987164A (en) * 1970-10-20 1976-10-19 Yuzuru Homma Method for prevention of pseudomonas aeruginosa infections
US3928565A (en) * 1971-10-19 1975-12-23 Yuzuru Homma Pharmaceutical preparation of pseudomonas aeruginosa bacterial component possessing anti-tumor and anti-infection properties
FR2227861B1 (fr) * 1973-05-04 1976-07-02 Anvar
DE2340911A1 (de) * 1973-08-13 1975-05-07 Behringwerke Ag Tetanus-antigen und verfahren zu seiner herstellung
JPS51133489A (en) * 1975-05-14 1976-11-19 Tokyo Daigaku Process for producing microbial components of pseudomonas aeruginosa h aving antimicrobial and antitumor activities

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2111719A1 (fr) * 1970-10-20 1972-06-09 Eisai Co Ltd
FR2180594A1 (en) * 1972-04-21 1973-11-30 Research Corp Reducing elastase - elaborating bacterial infection - using bacterial elastase as antigen
FR2340099A1 (fr) * 1976-02-05 1977-09-02 Shionogi & Co Vaccin mixte a trois composants contre les infections par le pseudomonas aeruginosa

Also Published As

Publication number Publication date
FR2362154B1 (fr) 1983-04-29
DE2704767C2 (fr) 1987-07-23
CH628679A5 (de) 1982-03-15
DE2704767A1 (de) 1977-08-18
SE7701037L (sv) 1977-08-06
US4160023A (en) 1979-07-03
SE8203674L (sv) 1982-06-14
CA1085293A (fr) 1980-09-09
SE442086B (sv) 1985-12-02
SE442269B (sv) 1985-12-16

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