SE8203674L - Sett att framstella en toxoid - Google Patents

Sett att framstella en toxoid

Info

Publication number
SE8203674L
SE8203674L SE8203674A SE8203674A SE8203674L SE 8203674 L SE8203674 L SE 8203674L SE 8203674 A SE8203674 A SE 8203674A SE 8203674 A SE8203674 A SE 8203674A SE 8203674 L SE8203674 L SE 8203674L
Authority
SE
Sweden
Prior art keywords
acid
toxoid
pseudomonas aeruginosa
elastase
activity
Prior art date
Application number
SE8203674A
Other languages
English (en)
Other versions
SE442086B (sv
Inventor
Y Homma
K Morihara
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1083676A external-priority patent/JPS5296727A/ja
Priority claimed from JP1083776A external-priority patent/JPS5296728A/ja
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of SE8203674L publication Critical patent/SE8203674L/sv
Publication of SE442086B publication Critical patent/SE442086B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6448—Elastases, e.g. pancreatic elastase (3.4.21.36); leukocyte elastase (3.4.31.37)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (4)

Patentkrav SAtt att framstAlla en toxoid, avledd frail elastas frAn Pseudomonas aeruginosa,kAnnetecknat datav, Ott elastas, bildad fran Pseudomonas aeruginosa, i en lamplig buffertlAsning behandlas med
1. -6-procentig formalin eller 0,25-5 M oximetansulfinsyra till att ge en toxoid mcd f6ljande fysikalisk-kemiska egenskaper: (I: molvikt: 47 000 (gelfiltrering)
2. ultraviolett absorptionsspektrum: maximum nn (g278 21,2, % 0,1 M KCl), minimum 252 mm1
3. isoelektrisk punkt: pH 6,5 (elektrofores med acetatfilM)
4. ingaende aminosyror: (aminosyra i 2/100 g protein) asparginsyra (14,2), tyrosin (9,9), fenylalanin (7,0), glotaminsyra (6,5), arginin (6,5), alanin (5,3), glycin (,6), serin (5,6), treonin (5,0), valin (4,9), leucin (4,3), lysin (3,9), meticnin (2,9), prolinisoleucin (2,7), histidin (2,6), trYptofan (g,S), cystin/2 (1,2), ammoniak (0,9) (totalt 94,7 g) (S) utseende: fArglost pulver 6. antigenaktivitet Orly 7. elastasaktivitet:ativ.
SE8203674A 1976-02-05 1982-06-14 Sett att framstella en toxoid, avledd fran elastas fran pseudomonas aeruginosa SE442086B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1083676A JPS5296727A (en) 1976-02-05 1976-02-05 Toxoid of pseudomonas aeruginosa protease
JP1083776A JPS5296728A (en) 1976-02-05 1976-02-05 Toxoid of pseudomonas aeruginosa elastase

Publications (2)

Publication Number Publication Date
SE8203674L true SE8203674L (sv) 1982-06-14
SE442086B SE442086B (sv) 1985-12-02

Family

ID=26346182

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7701037A SE442269B (sv) 1976-02-05 1977-02-01 Sett att framstella en toxoid, avledd fran proteas fran pseudomona aeruginosa
SE8203674A SE442086B (sv) 1976-02-05 1982-06-14 Sett att framstella en toxoid, avledd fran elastas fran pseudomonas aeruginosa

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7701037A SE442269B (sv) 1976-02-05 1977-02-01 Sett att framstella en toxoid, avledd fran proteas fran pseudomona aeruginosa

Country Status (6)

Country Link
US (1) US4160023A (sv)
CA (1) CA1085293A (sv)
CH (1) CH628679A5 (sv)
DE (1) DE2704767A1 (sv)
FR (1) FR2362154A1 (sv)
SE (2) SE442269B (sv)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1256370A (en) * 1984-02-24 1989-06-27 Yuzuru Homma Toxoids of elastase of pseudomonas aeruginosa origin
US5233024A (en) * 1991-04-09 1993-08-03 The Brigham & Women's Hospital Anti-idiotypic monoclonal antibodies for mucoid pseudomonas aeruginosa, their preparation and use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2528972A (en) * 1947-05-15 1950-11-07 Western Reserve University Prophylactic toxoid compound and method of making same
US3135662A (en) * 1961-01-05 1964-06-02 Burroughs Wellcome Co Diphtheria toxoid preparation and its production
US3658986A (en) * 1969-07-02 1972-04-25 Victor N Tompkins Immunization methods against toxic effects of bacterial infection
US3674863A (en) * 1969-12-08 1972-07-04 Parke Davis & Co Polyvalent immunizing agents and methods for their production
US3987164A (en) * 1970-10-20 1976-10-19 Yuzuru Homma Method for prevention of pseudomonas aeruginosa infections
US3928565A (en) * 1971-10-19 1975-12-23 Yuzuru Homma Pharmaceutical preparation of pseudomonas aeruginosa bacterial component possessing anti-tumor and anti-infection properties
FR2111719B1 (sv) * 1970-10-20 1975-02-07 Yuzuru Homma
FR2180594A1 (en) * 1972-04-21 1973-11-30 Research Corp Reducing elastase - elaborating bacterial infection - using bacterial elastase as antigen
FR2227861B1 (sv) * 1973-05-04 1976-07-02 Anvar
DE2340911A1 (de) * 1973-08-13 1975-05-07 Behringwerke Ag Tetanus-antigen und verfahren zu seiner herstellung
JPS51133489A (en) * 1975-05-14 1976-11-19 Tokyo Daigaku Process for producing microbial components of pseudomonas aeruginosa h aving antimicrobial and antitumor activities
JPS5296729A (en) * 1976-02-05 1977-08-13 Shionogi & Co Ltd Mixed vaccin for cyanomycosis

Also Published As

Publication number Publication date
CH628679A5 (de) 1982-03-15
SE442269B (sv) 1985-12-16
FR2362154A1 (fr) 1978-03-17
DE2704767C2 (sv) 1987-07-23
DE2704767A1 (de) 1977-08-18
FR2362154B1 (sv) 1983-04-29
SE7701037L (sv) 1977-08-06
CA1085293A (en) 1980-09-09
SE442086B (sv) 1985-12-02
US4160023A (en) 1979-07-03

Similar Documents

Publication Publication Date Title
Lord et al. Laser-excited Raman spectroscopy of biomolecules: II. Native ribonuclease and α-chymotrypsin
Ohta et al. Thermostable protease from thermophilic bacteria: I. thermostability, physicochemical properties, and amino acid composition
McLaren Photochemistry of enzymes, proteins, and viruses
Phillips The N-terminal groups of calf-thymus histones
Geisler et al. Purification of smooth‐muscle desmin and a protein‐chemical comparison of desmins from chicken gizzard and hog stomach
Fujimaki et al. Diffusable bitter peptides in peptic hydrolyzate of soybean protein
Maeda et al. Some chemical properties of the venom of the rattlesnake, Crotalus viridis helleri
Smith et al. Purification and properties of a c-type cytochrome from Micrococcus denitrificans
KR840006198A (ko) 항원성 합성 펩타이드의 제조방법
DE69723812D1 (de) Aminosäurezusammensetzungen
Fry et al. Isolation and partial characterization of a chromophore-peptide fragment from pepsin digests of phytochrome
Garfinkel et al. Raman spectra of amino acids and related compounds. x. the raman spectra of certain peptides and of lysozyme1-3
Burton et al. Thymic hormone-like restoration by human prealbumin of azathioprine sensitivity of spleen cells from thymectomized mice.
Ruey et al. Amino acid composition and specificity of a keratinase of Trichophyton mentagrophytes
SE8203674L (sv) Sett att framstella en toxoid
SE8203912D0 (sv) Forfarande for totalt eller partiellt avlegsnande av asparaginsyra och glutaminsyra fran proteinhydrolysat och blandningar av aminosyror samt aminosyrakompositioner erhallna genom forfarandet med hogt neringsverde
Dinamarca et al. DDT-dehydrochlorinase II: Subunits, sulfhydryl groups, and chemical composition
Vivanco-Martinez et al. Chemical modification of carboxyl groups in human Fcγ fragment: structural role and effect on the complement fixation
Marik et al. Studies on phytohemagglutinins XVI. Subunit structure of the pea isophytohemagglutinins
NO942930D0 (no) Forbindelser og produkter basert på Amadori-reaksjoner samt fremgangsmåte til fremstilling av bruk av samme
Hayakawa et al. Copolymerization of the Leuchs anhydrides of the eighteen amino acids common to protein
Otey et al. Studies on polycysteine peptides and proteins. II. Apparent dissociation constants, and ultraviolet and infrared absorption spectra of isomeric cystinylcystine peptides
HIRADO et al. Purification and characterization of a bovine colostrum low molecular weight cysteine proteinase inhibitor
Abe et al. Electrophoretical analysis of zein and isolation of its components
Jönsson Purification and some properties of a protease from Alternaria tenuissima

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8203674-0

Effective date: 19910117

Format of ref document f/p: F