FR2347396A1 - Polymeres d'orthoesters, leur preparation et leur utilisation - Google Patents

Polymeres d'orthoesters, leur preparation et leur utilisation

Info

Publication number
FR2347396A1
FR2347396A1 FR7710402A FR7710402A FR2347396A1 FR 2347396 A1 FR2347396 A1 FR 2347396A1 FR 7710402 A FR7710402 A FR 7710402A FR 7710402 A FR7710402 A FR 7710402A FR 2347396 A1 FR2347396 A1 FR 2347396A1
Authority
FR
France
Prior art keywords
preparation
orthoester
polymers
orthoester polymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7710402A
Other languages
English (en)
French (fr)
Other versions
FR2347396B1 (enExample
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of FR2347396A1 publication Critical patent/FR2347396A1/fr
Application granted granted Critical
Publication of FR2347396B1 publication Critical patent/FR2347396B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G4/00—Condensation polymers of aldehydes or ketones with polyalcohols; Addition polymers of heterocyclic oxygen compounds containing in the ring at least once the grouping —O—C—O—
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polyethers (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
FR7710402A 1976-04-08 1977-04-06 Polymeres d'orthoesters, leur preparation et leur utilisation Granted FR2347396A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/675,185 US4066747A (en) 1976-04-08 1976-04-08 Polymeric orthoesters housing beneficial drug for controlled release therefrom

Publications (2)

Publication Number Publication Date
FR2347396A1 true FR2347396A1 (fr) 1977-11-04
FR2347396B1 FR2347396B1 (enExample) 1980-12-12

Family

ID=24709398

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7710402A Granted FR2347396A1 (fr) 1976-04-08 1977-04-06 Polymeres d'orthoesters, leur preparation et leur utilisation

Country Status (10)

Country Link
US (4) US4066747A (enExample)
JP (1) JPS52123500A (enExample)
AU (1) AU507701B2 (enExample)
CA (1) CA1112798A (enExample)
CH (1) CH633567A5 (enExample)
DE (1) DE2715502A1 (enExample)
FR (1) FR2347396A1 (enExample)
GB (1) GB1518638A (enExample)
IT (1) IT1082732B (enExample)
SE (1) SE421321B (enExample)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4387215A (en) * 1973-03-30 1983-06-07 Bailey William J Polycyclic ring-opened polymers
US4328204A (en) * 1977-03-02 1982-05-04 Ethicon, Inc. Absorbable polymer-drug compounds and method for making same
US4211674A (en) * 1978-04-10 1980-07-08 Polak's Frutal Works B.V. Cyclic acetals and ketals and their use in perfume compositions
US4282201A (en) * 1979-02-02 1981-08-04 Alza Corporation Pharmaceutical comprising drug and polymer
DE2928636A1 (de) * 1979-07-16 1981-02-12 Hoechst Ag Strahlungsempfindliches gemisch und verfahren zur herstellung von reliefbildern
US4425473A (en) 1980-02-04 1984-01-10 Toagosei Chemical Industry Co., Ltd. Polymerizable bicyclic orthoester compounds
US4304767A (en) * 1980-05-15 1981-12-08 Sri International Polymers of di- (and higher functionality) ketene acetals and polyols
US4346709A (en) * 1980-11-10 1982-08-31 Alza Corporation Drug delivery devices comprising erodible polymer and erosion rate modifier
US4322323A (en) * 1980-12-01 1982-03-30 Alza Corporation Erodible device comprising surfactant for modifying the rate of erosion of the device
US4489056A (en) * 1982-06-30 1984-12-18 Merck & Co., Inc. Acid anhydrides as rate controlling agent for the erosion of polymers which latter polymers have beneficial substances dispersed throughout their matrix or where the polymer matrix surrounds the beneficial substance
US4530840A (en) * 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
JPS6067531A (ja) * 1983-09-22 1985-04-17 Toshiba Corp 樹脂組成物
US4841968A (en) * 1986-09-26 1989-06-27 Southern Research Institute Antithrombotic/thrombolytic suture and methods of making and using the same
US4969872A (en) * 1989-03-08 1990-11-13 Alza Corporation Intravenous system for delivering a beneficial agent with delivery rate control via permeable surface area variance
JPH05502465A (ja) * 1989-08-28 1993-04-28 ファーマスーティカル　デリバリー　システムズ 治療薬剤の制御放出のために有用な生体内で分解し得るポリマー
US5030457A (en) * 1989-08-28 1991-07-09 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
US5620700A (en) * 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
US5461140A (en) * 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
US6440457B1 (en) * 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
US5912268A (en) * 1995-05-22 1999-06-15 Alza Corporation Dosage form and method for treating incontinence
US6262115B1 (en) * 1995-05-22 2001-07-17 Alza Coporation Method for the management of incontinence
EP0747375A1 (en) * 1995-06-05 1996-12-11 General Electric Company Method for making orthoester monomers
US6919373B1 (en) * 1996-11-12 2005-07-19 Alza Corporation Methods and devices for providing prolonged drug therapy
US20040062799A1 (en) * 1997-09-29 2004-04-01 Ayer Atul D. Therapeutic composition and delivery system for administering drug
US6486248B2 (en) 2001-01-08 2002-11-26 Milliken & Company Liquid colorant and method
DK1404324T4 (da) * 2001-06-11 2011-07-11 Xenoport Inc Prolægemidler af GABA analoger, sammensætninger og anvendelser deraf
AU2002345638A1 (en) * 2001-06-11 2002-12-23 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) * 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US20050208132A1 (en) * 2002-07-29 2005-09-22 Gayatri Sathyan Methods and dosage forms for reducing side effects of benzisozazole derivatives
US20050232995A1 (en) * 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
US7101912B2 (en) 2002-12-06 2006-09-05 Xenoport, Inc. Carbidopa prodrugs and derivatives, and compositions and uses thereof
WO2004053192A1 (en) * 2002-12-11 2004-06-24 Xenoport, Inc. Orally administered dosage forms of fused gaba analog prodrugs having reduced toxicity
CA2520468A1 (en) * 2003-03-31 2004-10-21 Xenoport, Inc. Treating or preventing hot flashes using prodrugs of gaba analogs
EP2354120A1 (en) 2003-08-20 2011-08-10 XenoPort, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
WO2005019163A2 (en) * 2003-08-20 2005-03-03 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
CA2537837A1 (en) * 2003-09-11 2005-03-24 Xenoport, Inc. Treating and/or preventing urinary incontinence using prodrugs of gaba analogs
US8114909B2 (en) * 2003-09-17 2012-02-14 Xenoport, Inc. Treating or preventing restless legs syndrome using prodrugs of GABA analogs
US7329413B1 (en) * 2003-11-06 2008-02-12 Advanced Cardiovascular Systems, Inc. Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof
PT1751087E (pt) * 2004-06-04 2012-09-10 Xenoport Inc Derivados de levodopa e as suas composições e utilizações
WO2005121070A1 (en) * 2004-06-04 2005-12-22 Xenoport, Inc. Levodopa prodrugs, and compositions and uses thereof
US20060128676A1 (en) * 2004-07-13 2006-06-15 Pharmacofore, Inc. Compositions of nicotinic agonists and therapeutic agents and methods for treating or preventing diseases or pain
US7494985B2 (en) * 2004-11-03 2009-02-24 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use
WO2006050471A2 (en) * 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
US8795725B2 (en) * 2004-11-04 2014-08-05 Xenoport, Inc. GABA analog prodrug sustained release oral dosage forms
WO2006091790A1 (en) * 2005-02-23 2006-08-31 Xenoport, Inc. Platinum-containing compounds exhibiting cytostatic activity, synthesis and methods of use
EP2338881A1 (en) 2005-02-23 2011-06-29 Prexa Pharmaceuticals, Inc. Dopamine transporter inhibitors for use in treatment of movement disorders and other CNS indications
US7351740B2 (en) 2005-06-20 2008-04-01 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
WO2007027476A2 (en) * 2005-08-26 2007-03-08 Xenoport, Inc. Treating premature ejaculation using gabapentin and pregabalin prodrugs
CN101365439B (zh) * 2005-12-05 2012-12-26 克塞诺波特公司 左旋多巴前体药物甲磺酸盐、其组合物及其用途
JP5371746B2 (ja) 2006-05-26 2013-12-18 ファーマコフォア， インコーポレイテッド フェノール性オピオイドの制御放出
WO2008005371A2 (en) * 2006-06-29 2008-01-10 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
WO2008027557A2 (en) * 2006-08-31 2008-03-06 Spherics, Inc. Topiramate compositions and methods of enhancing its bioavailability
US7585996B2 (en) * 2006-09-15 2009-09-08 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
US7740699B2 (en) * 2006-10-05 2010-06-22 E.I. Du Pont De Nemours And Company Orthoformate-protected polyols
EP1973528B1 (en) 2006-11-17 2012-11-07 Supernus Pharmaceuticals, Inc. Sustained-release formulations of topiramate
EP2101752A1 (en) * 2006-12-08 2009-09-23 Xenoport, Inc. Use of prodrugs of gaba analogs for treating diseases
US7709527B2 (en) * 2006-12-21 2010-05-04 Xenoport, Inc. Levodopa dimethyl-substituted diester prodrugs compositions, and methods of use
TW200843731A (en) * 2006-12-21 2008-11-16 Xenoport Inc Catechol protected levodopa diester prodrugs, compositions, and methods of use
US8956642B2 (en) * 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US8475823B2 (en) * 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
JP2012505885A (ja) * 2008-10-20 2012-03-08 ゼノポート，インコーポレーテッド レボドパエステルプロドラッグを合成する方法
US8399513B2 (en) * 2008-10-20 2013-03-19 Xenoport, Inc. Levodopa prodrug mesylate hydrate
WO2011028234A1 (en) * 2009-09-04 2011-03-10 Xenoport, Inc. Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid
WO2011056240A2 (en) 2009-11-09 2011-05-12 Xenoport, Inc. Pharmaceutical compositions and oral dosage forms of a levodopa prodrug and methods of use
WO2011091164A1 (en) * 2010-01-22 2011-07-28 Xenoport, Inc. Oral dosage forms having a high loading of a tranexamic acid prodrug
WO2012050907A2 (en) 2010-09-28 2012-04-19 The Regents Of The University Of California Gaba agonists in the treatment of disorders associated with metabolic syndrome and gaba combinations in treatment or prophylaxis of type i diabetes
US10335406B2 (en) 2015-10-01 2019-07-02 Elysium Therapeutics, Inc. Opioid compositions resistant to overdose and abuse
GB2556817B (en) 2015-10-01 2019-11-06 Elysium Therapeutics Inc Polysubunit opioid prodrugs resistant to overdose and abuse
EP3595663A4 (en) 2017-03-17 2021-01-13 Elysium Therapeutics, Inc. MULTI-UNIT OPIOID MEDICINES RESISTANT TO OVERDOSE AND ABUSE

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2636884A (en) * 1953-04-28 J-moxoeane
US3328427A (en) * 1963-10-31 1967-06-27 Celanese Corp Mono, ortho and oxetane esters of trimethylol compounds
DE1592655C2 (de) * 1966-07-13 1972-03-30 Gewerkschaft Victor, Chemische Werke, 4620 Castrop Rauxel Düngemittelgranulat mit kontollierter Nährstoffabgabe
US4015970A (en) * 1968-09-06 1977-04-05 Airwick Industries, Inc. Granular products for soil treatment
US3887699A (en) * 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3696123A (en) * 1970-03-19 1972-10-03 Siegfried H Schroeter Dihydrocarbonoxyoxethanes
US3673216A (en) * 1970-05-01 1972-06-27 Gen Electric Alkoxyoxetanes
US3914402A (en) * 1973-06-14 1975-10-21 Alza Corp Ophthalmic dosage form, for releasing medication over time
US3911098A (en) * 1974-02-11 1975-10-07 American Cyanamid Co Medicament carrier

Also Published As

Publication number Publication date
GB1518638A (en) 1978-07-19
SE421321B (sv) 1981-12-14
JPS52123500A (en) 1977-10-17
IT1082732B (it) 1985-05-21
US4155740A (en) 1979-05-22
CH633567A5 (de) 1982-12-15
FR2347396B1 (enExample) 1980-12-12
SE7703816L (sv) 1977-10-09
US4066747A (en) 1978-01-03
DE2715502C2 (enExample) 1988-01-28
DE2715502A1 (de) 1977-10-20
AU507701B2 (en) 1980-02-21
CA1112798A (en) 1981-11-17
US4119579A (en) 1978-10-10
JPS619968B2 (enExample) 1986-03-27
AU2393377A (en) 1978-10-12
US4136252A (en) 1979-01-23

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Legal Events

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