FR2319342A1 - Nouvelles cyclobut-1-ene-3,4-diones substituees, leur procede de preparation et leur application - Google Patents

Nouvelles cyclobut-1-ene-3,4-diones substituees, leur procede de preparation et leur application

Info

Publication number
FR2319342A1
FR2319342A1 FR7622243A FR7622243A FR2319342A1 FR 2319342 A1 FR2319342 A1 FR 2319342A1 FR 7622243 A FR7622243 A FR 7622243A FR 7622243 A FR7622243 A FR 7622243A FR 2319342 A1 FR2319342 A1 FR 2319342A1
Authority
FR
France
Prior art keywords
cyclobut
diones
ene
substitutes
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7622243A
Other languages
English (en)
Other versions
FR2319342B1 (fr
Inventor
Charon R Ganellin
Rodney C Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
GlaxoSmithKline LLC
Original Assignee
Smith Kline and French Laboratories Ltd
GlaxoSmithKline LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd, GlaxoSmithKline LLC filed Critical Smith Kline and French Laboratories Ltd
Publication of FR2319342A1 publication Critical patent/FR2319342A1/fr
Application granted granted Critical
Publication of FR2319342B1 publication Critical patent/FR2319342B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR7622243A 1975-07-31 1976-07-21 Nouvelles cyclobut-1-ene-3,4-diones substituees, leur procede de preparation et leur application Granted FR2319342A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB31971/75A GB1563090A (en) 1975-07-31 1975-07-31 Cyclobutene-diones

Publications (2)

Publication Number Publication Date
FR2319342A1 true FR2319342A1 (fr) 1977-02-25
FR2319342B1 FR2319342B1 (fr) 1978-11-17

Family

ID=10331111

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7622243A Granted FR2319342A1 (fr) 1975-07-31 1976-07-21 Nouvelles cyclobut-1-ene-3,4-diones substituees, leur procede de preparation et leur application

Country Status (9)

Country Link
US (1) US4062863A (fr)
JP (1) JPS5219664A (fr)
AU (1) AU503067B2 (fr)
BE (1) BE843839A (fr)
DE (1) DE2634429A1 (fr)
FR (1) FR2319342A1 (fr)
GB (1) GB1563090A (fr)
IE (1) IE44124B1 (fr)
ZA (1) ZA763652B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005985A1 (fr) * 1978-05-30 1979-12-12 Smith Kline & French Laboratories Limited Composés de 3-nitro-pyrrole, procédés pour leur préparation et compositions pharmaceutiques les contenant
FR2505835A1 (fr) * 1981-05-18 1982-11-19 Bristol Myers Co Nouvelles 1,2-diaminocyclobutene-3,4-diones, leur procede de preparation et composition pharmaceutique les contenant
GR880100311A (en) * 1987-05-14 1989-02-23 Bristol Myers Co Chemical intermediates preparation method
EP0496561A2 (fr) * 1991-01-22 1992-07-29 American Home Products Corporation Dérivés d'acide[[(2-amino-3,4-dioxo-1-cyclobuten-1-yl)amino]alkyl]

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ186965A (en) 1977-04-20 1980-02-21 Ici Ltd Guanidino derivatives and pharmaceutical compositions
US4165378A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
IL57416A (en) * 1978-05-30 1983-03-31 Smith Kline French Lab Nitro compounds,processes for preparing them and compositions containing them
DE3069889D1 (en) * 1979-01-18 1985-02-14 Ici Plc Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
US4394508A (en) * 1980-06-07 1983-07-19 Bristol-Myers Company Chemical compounds
US4510309A (en) * 1981-03-03 1985-04-09 Bristol-Myers Company Histamine H2 -antagonists
US4395553A (en) * 1981-05-18 1983-07-26 Bristol-Myers Company Chemical compounds
US4522943A (en) * 1981-05-18 1985-06-11 Bristol-Myers Company Chemical compounds
US4788184A (en) * 1981-05-18 1988-11-29 Bristol-Myers Company Substituted 3-cyclobutene-1,2-diones as anti-ulcer agents
US4526973A (en) * 1981-05-18 1985-07-02 Bristol-Myers Company Chemical compounds
US4539316A (en) * 1981-05-18 1985-09-03 Bristol-Myers Company Pyridine derivatives of 1,2-diaminocyclobutene-3,4-diones
US4546188A (en) * 1981-05-18 1985-10-08 Bristol-Myers Company Substituted 1,2-diaminocyclobutene-3,4-diones
US4525477A (en) * 1981-12-02 1985-06-25 Smith Kline & French Laboratories Limited 2-Thiazolyl, isothiazolyl, oxazolyl and isoxazolyl alkylamino-3-nitro-heterocyclic compounds
JPS58190097A (ja) * 1982-04-30 1983-11-05 日本メクトロン株式会社 回路基板の製造法
FI832520L (fi) * 1982-07-12 1984-01-13 Bristol Myers Co Farmaceutiska foerfaranden och sammansaettningar
AU1956283A (en) * 1982-10-02 1984-04-05 Smith Kline & French Laboratories Limited 1-(3-(4-(substited aminomethyl)pyrid-2-yl-oxy)-prop-1-yl- amino) - 2-aminocyclobut-i-ene-3,4-diones
JO1279B1 (en) * 1982-12-23 1985-04-20 جون ايف روبرت Pyridine derivatives
DE3408327A1 (de) * 1984-03-07 1985-09-12 Ludwig Heumann & Co GmbH, 8500 Nürnberg Diaminderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS60255756A (ja) * 1984-06-01 1985-12-17 Ikeda Mohandou:Kk アミノアルキルフエノキシ誘導体
CN111349014A (zh) * 2020-03-30 2020-06-30 绵阳达高特新材料有限公司 一种方酸甲胺甲酯的制备方法
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005985A1 (fr) * 1978-05-30 1979-12-12 Smith Kline & French Laboratories Limited Composés de 3-nitro-pyrrole, procédés pour leur préparation et compositions pharmaceutiques les contenant
FR2505835A1 (fr) * 1981-05-18 1982-11-19 Bristol Myers Co Nouvelles 1,2-diaminocyclobutene-3,4-diones, leur procede de preparation et composition pharmaceutique les contenant
FR2513250A1 (fr) * 1981-05-18 1983-03-25 Bristol Myers Co Nouvelles cyclobutene-3,4-diones substituees
GR880100311A (en) * 1987-05-14 1989-02-23 Bristol Myers Co Chemical intermediates preparation method
FR2621915A1 (fr) * 1987-05-14 1989-04-21 Bristol Myers Co Produits chimiques intermediaires utilisables pour la preparation de certains agents anti-histaminiques h2 et leur procede de preparation
FR2628738A1 (fr) * 1987-05-14 1989-09-22 Bristol Myers Co Produits chimiques intermediaires utilisables pour la preparation de certains agents anti-histaminiques h2
BE1002037A3 (fr) * 1987-05-14 1990-05-29 Bristol Myers Squibbcy Intermediaires chimiques et procede.
AT395973B (de) * 1987-05-14 1993-04-26 Bristol Myers Co 1-amino-2-(phenoxypropylamino)-1-cyclobuten-3,4 dionderivate und ihre verwendung
EP0496561A2 (fr) * 1991-01-22 1992-07-29 American Home Products Corporation Dérivés d'acide[[(2-amino-3,4-dioxo-1-cyclobuten-1-yl)amino]alkyl]
EP0496561A3 (en) * 1991-01-22 1992-12-23 American Home Prod (((2-amino-3,4-dioxo-1-cyclo-buten-1-yl)amino)alkyl)-acid derivatives

Also Published As

Publication number Publication date
US4062863A (en) 1977-12-13
IE44124B1 (en) 1981-08-26
IE44124L (en) 1977-01-31
AU503067B2 (en) 1979-08-23
BE843839A (fr) 1977-01-06
DE2634429A1 (de) 1977-02-10
GB1563090A (en) 1980-03-19
JPS5219664A (en) 1977-02-15
FR2319342B1 (fr) 1978-11-17
AU1645176A (en) 1978-02-02
ZA763652B (en) 1977-05-25

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Legal Events

Date Code Title Description
ST Notification of lapse