FR2290891A1 - Support destine a liberer lentement un corps actif, en particulier un medicament, et sa fabrication - Google Patents
Support destine a liberer lentement un corps actif, en particulier un medicament, et sa fabricationInfo
- Publication number
- FR2290891A1 FR2290891A1 FR7534821A FR7534821A FR2290891A1 FR 2290891 A1 FR2290891 A1 FR 2290891A1 FR 7534821 A FR7534821 A FR 7534821A FR 7534821 A FR7534821 A FR 7534821A FR 2290891 A1 FR2290891 A1 FR 2290891A1
- Authority
- FR
- France
- Prior art keywords
- manufacture
- medicinal product
- active body
- slowly release
- support intended
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Nanotechnology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US523720A US3926188A (en) | 1974-11-14 | 1974-11-14 | Laminated drug dispenser |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2290891A1 true FR2290891A1 (fr) | 1976-06-11 |
| FR2290891B1 FR2290891B1 (Sortimente) | 1978-11-10 |
Family
ID=24086191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7534821A Granted FR2290891A1 (fr) | 1974-11-14 | 1975-11-14 | Support destine a liberer lentement un corps actif, en particulier un medicament, et sa fabrication |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3926188A (Sortimente) |
| JP (1) | JPS6059203B2 (Sortimente) |
| CA (1) | CA1056685A (Sortimente) |
| CH (1) | CH634226A5 (Sortimente) |
| DE (1) | DE2549856C2 (Sortimente) |
| FR (1) | FR2290891A1 (Sortimente) |
| GB (1) | GB1477813A (Sortimente) |
| IT (1) | IT1050619B (Sortimente) |
| MX (2) | MX158867A (Sortimente) |
| SE (1) | SE439432B (Sortimente) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4182330A (en) * | 1977-07-25 | 1980-01-08 | Alza Corporation | Means for administering amphipathic medicament |
| US4304232A (en) * | 1979-03-14 | 1981-12-08 | Alza Corporation | Unit system having multiplicity of means for dispensing useful agent |
| GR69960B (Sortimente) * | 1979-09-12 | 1982-07-22 | Barbara Ellen Simpson | |
| US4314557A (en) * | 1980-05-19 | 1982-02-09 | Alza Corporation | Dissolution controlled active agent dispenser |
| JPS5770816A (en) * | 1980-10-17 | 1982-05-01 | Ono Pharmaceut Co Ltd | Multilayered film preparation of prostagladin of prolonged action |
| DE3115763A1 (de) * | 1981-04-18 | 1982-11-04 | Edgar Dr.med. 6238 Hofheim Lenhard | Medizinische depotsonde zur lokalen protrahierten wirkstoffreisetzung |
| US4370313A (en) * | 1981-10-26 | 1983-01-25 | Eaton Laboratories, Inc. | Nitrofurantoin dosage form |
| JPS58134019A (ja) * | 1982-02-05 | 1983-08-10 | Ono Pharmaceut Co Ltd | プロスタグランジン含有持続放出型三層状フイルム製剤及びその製造方法 |
| US4571039A (en) * | 1983-04-15 | 1986-02-18 | Stanley Poler | Eye-medicating contact-lens construction |
| US4639244A (en) * | 1983-05-03 | 1987-01-27 | Nabil I. Rizk | Implantable electrophoretic pump for ionic drugs and associated methods |
| US4564364A (en) * | 1983-05-26 | 1986-01-14 | Alza Corporation | Active agent dispenser |
| US4601893A (en) * | 1984-02-08 | 1986-07-22 | Pfizer Inc. | Laminate device for controlled and prolonged release of substances to an ambient environment and method of use |
| US4863445A (en) * | 1984-07-30 | 1989-09-05 | Baxter Travenol Laboratories, Inc. | Assembly for inhibiting microbial growth in collected fluid |
| US4693895A (en) * | 1984-10-26 | 1987-09-15 | Alza Corporation | Colon delivery system |
| US4627851A (en) * | 1984-10-26 | 1986-12-09 | Alza Corporation | Colonic-therapeutic delivery system |
| CH667001A5 (de) * | 1985-09-03 | 1988-09-15 | Hugo Degen | Untermatratze. |
| US4880633A (en) * | 1986-03-12 | 1989-11-14 | Merck & Co., Inc. | Transdermal drug delivery system |
| US4938759A (en) * | 1986-09-02 | 1990-07-03 | Alza Corporation | Transdermal delivery device having a rate controlling adhesive |
| US4908027A (en) * | 1986-09-12 | 1990-03-13 | Alza Corporation | Subsaturated transdermal therapeutic system having improved release characteristics |
| US5344656A (en) * | 1986-09-12 | 1994-09-06 | Alza Corporation | Subsaturated transdermal therapeutic system having improved release characteristics |
| US4841968A (en) * | 1986-09-26 | 1989-06-27 | Southern Research Institute | Antithrombotic/thrombolytic suture and methods of making and using the same |
| US4830860A (en) * | 1986-10-30 | 1989-05-16 | Pfizer Inc. | Stressed polymeric device for controlled release of a substance to an ambient environment |
| JPS63143581A (ja) * | 1986-12-05 | 1988-06-15 | Nissha Printing Co Ltd | ホログラム成型品 |
| US4892778A (en) * | 1987-05-27 | 1990-01-09 | Alza Corporation | Juxtaposed laminated arrangement |
| EP0303306B1 (en) * | 1987-08-08 | 1993-03-10 | Akzo N.V. | Contraceptive implant |
| DK530787D0 (da) * | 1987-10-09 | 1987-10-09 | Bukh Meditec | Indretning til indfoering i en legemshulhed |
| US5071645A (en) * | 1987-10-19 | 1991-12-10 | Ppg Industries, Inc. | Process of producing an active agent delivery device |
| US5035886A (en) * | 1987-10-19 | 1991-07-30 | Ppg Industries, Inc. | Active agent delivery device |
| US4959208A (en) * | 1987-10-19 | 1990-09-25 | Ppg Industries, Inc. | Active agent delivery device |
| US4781924A (en) | 1987-11-09 | 1988-11-01 | Alza Corporation | Transdermal drug delivery device |
| US4906475A (en) * | 1988-02-16 | 1990-03-06 | Paco Pharmaceutical Services | Estradiol transdermal delivery system |
| US5004610A (en) * | 1988-06-14 | 1991-04-02 | Alza Corporation | Subsaturated nicotine transdermal therapeutic system |
| GB8815968D0 (en) * | 1988-07-05 | 1988-08-10 | Pfizer Ltd | Veterinary devices |
| US5053227A (en) * | 1989-03-22 | 1991-10-01 | Cygnus Therapeutic Systems | Skin permeation enhancer compositions, and methods and transdermal systems associated therewith |
| US5059426A (en) * | 1989-03-22 | 1991-10-22 | Cygnus Therapeutic Systems | Skin permeation enhancer compositions, and methods and transdermal systems associated therewith |
| US4973468A (en) * | 1989-03-22 | 1990-11-27 | Cygnus Research Corporation | Skin permeation enhancer compositions |
| US5124157A (en) | 1989-08-18 | 1992-06-23 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
| US5217718A (en) * | 1989-08-18 | 1993-06-08 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
| US5508038A (en) * | 1990-04-16 | 1996-04-16 | Alza Corporation | Polyisobutylene adhesives for transdermal devices |
| WO1992002211A1 (en) * | 1990-08-09 | 1992-02-20 | Endocon, Inc. | Multiple drug delivery system |
| JPH0444601U (Sortimente) * | 1990-08-22 | 1992-04-15 | ||
| JPH0444666U (Sortimente) * | 1990-08-22 | 1992-04-15 | ||
| US5538735A (en) * | 1993-02-19 | 1996-07-23 | Ahn; Sam S. | Method of making a drug delivery system using hollow fibers |
| JP3720386B2 (ja) * | 1993-12-27 | 2005-11-24 | 住友製薬株式会社 | 薬物放出制御製剤 |
| US5466233A (en) * | 1994-04-25 | 1995-11-14 | Escalon Ophthalmics, Inc. | Tack for intraocular drug delivery and method for inserting and removing same |
| US5660848A (en) * | 1994-11-02 | 1997-08-26 | The Population Council, Center For Biomedical Research | Subdermally implantable device |
| CN1245960C (zh) * | 2000-05-26 | 2006-03-22 | 高田宽治 | 具有3层结构的非口服用制剂 |
| US20020148138A1 (en) * | 2001-04-06 | 2002-10-17 | Egan Brian A. | Smart tread boot covers |
| EP2316394B1 (en) | 2001-06-12 | 2016-11-23 | The Johns Hopkins University | Reservoir device for intraocular drug delivery |
| US7306580B2 (en) * | 2003-04-16 | 2007-12-11 | Cook Incorporated | Medical device with therapeutic agents |
| ES2442675T3 (es) * | 2003-07-10 | 2014-02-12 | Warner Chilcott (Ireland) Limited | Dispositivos intravaginales de suministro de fármacos |
| CN102144961A (zh) * | 2003-09-18 | 2011-08-10 | 参天制药株式会社 | 经巩膜递送 |
| US20050244465A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Drug delivery systems and methods for treatment of an eye |
| DE102004050457A1 (de) * | 2004-10-12 | 2006-04-13 | Capsulution Nanoscience Ag | Segmentierte Vorrichtung für die verzögerte Freisetzung von Molekülen in tangentialer Richtung durch dünne Filme und Anwendungen derselben |
| US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
| CN104147005B (zh) | 2005-02-09 | 2018-07-03 | 参天制药株式会社 | 用于治疗疾病或病症的液体制剂 |
| JP5528708B2 (ja) | 2006-02-09 | 2014-06-25 | 参天製薬株式会社 | 安定な製剤ならびにそれらを調製および使用する方法 |
| JP5506378B2 (ja) | 2006-03-23 | 2014-05-28 | 参天製薬株式会社 | 血管透過性に関連する疾患または病気のための製剤および方法 |
| US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
| EP2391419B1 (en) | 2009-01-29 | 2019-06-12 | ForSight Vision4, Inc. | Posterior segment drug delivery |
| CA2764063C (en) | 2009-06-03 | 2019-05-14 | Forsight Labs, Llc | Anterior segment drug delivery |
| US20110066141A1 (en) * | 2009-09-11 | 2011-03-17 | Cook Incorporated | Implantable medical device having an anti-gastric distress agent |
| US20110098797A1 (en) * | 2009-10-23 | 2011-04-28 | Cleek Robert L | Drug eluting composite |
| US9320890B2 (en) * | 2009-11-09 | 2016-04-26 | W. L. Gore & Associates, Inc. | Drug eluting composite |
| US9504771B2 (en) | 2009-11-09 | 2016-11-29 | W. L. Gore & Associates, Inc. | Drug eluting composite |
| US10166142B2 (en) | 2010-01-29 | 2019-01-01 | Forsight Vision4, Inc. | Small molecule delivery with implantable therapeutic device |
| KR101914119B1 (ko) | 2010-03-16 | 2018-11-02 | 타이탄 파머슈티컬즈 인코퍼레이티드 | 약물 전달용 이종 이식가능 장치 |
| EP2600876B1 (en) | 2010-08-05 | 2015-04-29 | Forsight Vision4, Inc. | Combined drug delivery methods and apparatus |
| CN103209664A (zh) | 2010-08-05 | 2013-07-17 | 弗赛特影像4股份有限公司 | 可植入的治疗装置 |
| LT2600930T (lt) | 2010-08-05 | 2021-04-12 | Forsight Vision4, Inc. | Injekcinis aparatas, skirtas vaisto tiekimui |
| US20140031769A1 (en) | 2010-11-19 | 2014-01-30 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
| EP4249059B1 (en) | 2011-06-28 | 2025-07-30 | ForSight Vision4, Inc. | An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye |
| ES2912370T3 (es) | 2011-09-14 | 2022-05-25 | Forsight Vision5 Inc | Aparato para inserción ocular |
| ES2864203T3 (es) | 2011-09-16 | 2021-10-13 | Forsight Vision4 Inc | Aparato de intercambio de fluido |
| WO2013056213A1 (en) * | 2011-10-14 | 2013-04-18 | Purdue Research Foundation | Ingestible multi-sheet unit having predetermined functions and combinations |
| CN104884006B (zh) | 2012-10-26 | 2017-12-15 | 弗赛特影像5股份有限公司 | 用于持续释放药物到眼睛的眼科系统 |
| AU2014236455B2 (en) | 2013-03-14 | 2018-07-12 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
| CN105246438B (zh) | 2013-03-28 | 2018-01-26 | 弗赛特影像4股份有限公司 | 用于输送治疗物质的眼科植入物 |
| CA2957548A1 (en) | 2014-08-08 | 2016-02-11 | Forsight Vision4, Inc. | Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof |
| US10226419B2 (en) * | 2014-09-08 | 2019-03-12 | ProMed Pharma, LLC | Methods for manufacturing implants |
| US10500091B2 (en) | 2014-11-10 | 2019-12-10 | Forsight Vision4, Inc. | Expandable drug delivery devices and methods of use |
| WO2016168141A1 (en) | 2015-04-13 | 2016-10-20 | Forsight Vision5, Inc. | Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent |
| CA3005238A1 (en) | 2015-11-20 | 2017-05-26 | Forsight Vision4, Inc. | Porous structures for extended release drug delivery devices |
| EP3439591B1 (en) | 2016-04-05 | 2020-09-23 | ForSight Vision4, Inc. | Implantable ocular drug delivery devices |
| CA3082891A1 (en) | 2017-11-21 | 2019-05-31 | Forsight Vision4, Inc. | Fluid exchange apparatus for expandable port delivery system and methods of use |
| USD1033637S1 (en) | 2022-01-24 | 2024-07-02 | Forsight Vision4, Inc. | Fluid exchange device |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3630200A (en) * | 1969-06-09 | 1971-12-28 | Alza Corp | Ocular insert |
| US3832252A (en) * | 1970-09-29 | 1974-08-27 | T Higuchi | Method of making a drug-delivery device |
| US3854480A (en) * | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB906422A (en) * | 1958-05-02 | 1962-09-19 | Wellcome Found | Improvements in and relating to prolonged acting pharmaceutical preparations |
| US2928770A (en) * | 1958-11-28 | 1960-03-15 | Frank M Bardani | Sustained action pill |
| US3416530A (en) * | 1966-03-02 | 1968-12-17 | Richard A. Ness | Eyeball medication dispensing tablet |
| US3618604A (en) * | 1969-06-09 | 1971-11-09 | Alza Corp | Ocular insert |
| US3625214A (en) * | 1970-05-18 | 1971-12-07 | Alza Corp | Drug-delivery device |
| US3797485A (en) * | 1971-03-26 | 1974-03-19 | Alza Corp | Novel drug delivery device for administering drug into blood circulation in blood vessel |
| US3851648A (en) * | 1973-10-11 | 1974-12-03 | Mead Johnson & Co | Zero-order release device |
-
1974
- 1974-11-14 US US523720A patent/US3926188A/en not_active Expired - Lifetime
-
1975
- 1975-10-15 GB GB4228975A patent/GB1477813A/en not_active Expired
- 1975-11-06 IT IT69740/75A patent/IT1050619B/it active
- 1975-11-06 DE DE2549856A patent/DE2549856C2/de not_active Expired
- 1975-11-12 JP JP50136148A patent/JPS6059203B2/ja not_active Expired
- 1975-11-12 CA CA239,459A patent/CA1056685A/en not_active Expired
- 1975-11-13 CH CH1472575A patent/CH634226A5/de not_active IP Right Cessation
- 1975-11-13 SE SE7512744A patent/SE439432B/xx not_active IP Right Cessation
- 1975-11-14 MX MX6132A patent/MX158867A/es unknown
- 1975-11-14 FR FR7534821A patent/FR2290891A1/fr active Granted
- 1975-11-14 MX MX161923A patent/MX158868A/es unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3854480A (en) * | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| US3630200A (en) * | 1969-06-09 | 1971-12-28 | Alza Corp | Ocular insert |
| US3832252A (en) * | 1970-09-29 | 1974-08-27 | T Higuchi | Method of making a drug-delivery device |
Also Published As
| Publication number | Publication date |
|---|---|
| US3926188A (en) | 1975-12-16 |
| FR2290891B1 (Sortimente) | 1978-11-10 |
| GB1477813A (en) | 1977-06-29 |
| CH634226A5 (de) | 1983-01-31 |
| MX158868A (es) | 1989-03-27 |
| MX158867A (es) | 1989-03-27 |
| IT1050619B (it) | 1981-03-20 |
| JPS6059203B2 (ja) | 1985-12-24 |
| SE439432B (sv) | 1985-06-17 |
| SE7512744L (sv) | 1977-05-15 |
| DE2549856A1 (de) | 1976-05-20 |
| DE2549856C2 (de) | 1985-01-03 |
| CA1056685A (en) | 1979-06-19 |
| JPS5170807A (Sortimente) | 1976-06-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR2290891A1 (fr) | Support destine a liberer lentement un corps actif, en particulier un medicament, et sa fabrication | |
| SE413285B (sv) | Saett att framstaella en laekemedelsbaerare i folieform med inkorporerad verksam substans | |
| AT347588B (de) | Arzneimittelwirkstofftraeger | |
| IT7849462A0 (it) | Corpo di capsula in particolare per una capsula per la somministrazione di sostanze medicamentose come pure procedimento e dispositivo per lasua produzione | |
| NL930058I1 (nl) | Werkwijze voor de bereiding van een 15-deoxy-16-geoxygeneerde prostaanzuurderivaten bevattend geneesmiddel met anti-maagsapafscheidende werking en voor een prostaanzuurderivaat geschikt voor gebruik bij deze werkwijze | |
| AR206618A1 (es) | Agente enzimaticamente degradable biodesgastable util como vehiculo para suministrar una droga levemente soluble en agua | |
| IL46499A0 (en) | Analgesic formulations having enhanced therapeutic activity and comprising a naphthyl propionic acid derivative | |
| BE860307A (fr) | Compositions biologiquement actives utilisables comme medicament | |
| DK137681C (da) | Insecticidt og acaricidt virksomme o-ethyl-s-n-propyl-o-vinyl-thionothiolphosphorsyreestere | |
| BE796196A (fr) | Corps catalytiquement actif | |
| NL166010C (nl) | Werkwijze voor de bereiding van een geneesmiddel met anti-arteriosclerotische werkzaamheid, gevormd genees- middel en werkwijze voor de bereiding van anti- -arteriosclerotisch werkzame abietamidederivaten. | |
| BE835915A (fr) | Nouveau medicament du type numapeptide | |
| FR2313059A1 (fr) | Nouvelles solutions pharmaceutiques stables et leur preparation | |
| ZA75790B (en) | New 2-amino-6-dialkylaminodihydropyridines their production and their medicinal use | |
| FR2281766A1 (fr) | Oestratetraenes et medicament contenant ces substances | |
| BE838507A (fr) | Comprimes pharmaceutiques | |
| JPS5377073A (en) | Piperadine derivative compound and its production and medical drugs containing said compound | |
| FR2314719A1 (fr) | Nouveau medicament notamment diuretique | |
| BE849383A (fr) | Compositions pharmaceutiques a proprietes anticonvulsives contenant des phenylsilanes | |
| BE839309A (fr) | Nouvel antibiotique, sa preparation et medicament le contenant | |
| DK137129C (da) | Insecticidt og acaricidt virksomme o-phenylthionothiolphosphorsyreestere | |
| BE843255A (fr) | Nouvelles amidines terpenoaromatiques utilisables comme medicament | |
| DK133988C (da) | Insecticidt og acaricidt virksomme 0-ethyl-0-n-propyl-0-vinyl-thionophosphorsyreestere | |
| BE845708A (fr) | Nouveau metabolite, sa preparation et son application comme medicament | |
| RO72360A2 (ro) | Medicament activ in cardiopatii |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |