GB1477813A - Sustained release dispensers - Google Patents

Sustained release dispensers

Info

Publication number
GB1477813A
GB1477813A GB4228975A GB4228975A GB1477813A GB 1477813 A GB1477813 A GB 1477813A GB 4228975 A GB4228975 A GB 4228975A GB 4228975 A GB4228975 A GB 4228975A GB 1477813 A GB1477813 A GB 1477813A
Authority
GB
United Kingdom
Prior art keywords
active agent
agent
dispenser
lamina
correlation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4228975A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of GB1477813A publication Critical patent/GB1477813A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Nanotechnology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1477813 Active agent dispenser ALZA CORP 15 Oct 1975 [14 Nov 1974] 42289/75 Heading A5B An active agent dispenser dispenses an active agent of low water solubility (as defined) by diffusion from a polymer matrix characterised in that the dispenser is a laminate of: (a) a core lamina of crystalline particles of the active agent dispersed in a polymer matrix having a permeability, P, to the agent, the core lamina having a thickness, 2t, and being partly covered by: (b) at least one outer lamina of an active agent release rate controlling polymer having a permeability, P', to the agent and a thickness, t', such that the core lamina has an exposed surface area, A, from which the agent is dispensed and the outer lamina has an exposed surface area, A', from which the active agent may be dispensed, and the correlation is at least 2 and the correlation is at least 3 times the correlation where k is a constant dependent on the geometrical shape of the laminate. The active agent is preferably a drug, e.g. chloroamphicerol, physostignine or hydrocortisone, and the dispenser sized and shaped for insertion in the eye. Cylindrical and sandwich type dispensers are exemplified.
GB4228975A 1974-11-14 1975-10-15 Sustained release dispensers Expired GB1477813A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US523720A US3926188A (en) 1974-11-14 1974-11-14 Laminated drug dispenser

Publications (1)

Publication Number Publication Date
GB1477813A true GB1477813A (en) 1977-06-29

Family

ID=24086191

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4228975A Expired GB1477813A (en) 1974-11-14 1975-10-15 Sustained release dispensers

Country Status (10)

Country Link
US (1) US3926188A (en)
JP (1) JPS6059203B2 (en)
CA (1) CA1056685A (en)
CH (1) CH634226A5 (en)
DE (1) DE2549856C2 (en)
FR (1) FR2290891A1 (en)
GB (1) GB1477813A (en)
IT (1) IT1050619B (en)
MX (2) MX158867A (en)
SE (1) SE439432B (en)

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AR221964A1 (en) * 1979-09-12 1981-03-31 Lilly Co Eli DEVICE FOR RUMINANTS
US4314557A (en) * 1980-05-19 1982-02-09 Alza Corporation Dissolution controlled active agent dispenser
JPS5770816A (en) * 1980-10-17 1982-05-01 Ono Pharmaceut Co Ltd Multilayered film preparation of prostagladin of prolonged action
DE3115763A1 (en) * 1981-04-18 1982-11-04 Edgar Dr.med. 6238 Hofheim Lenhard Medical depot probe for the local protracted release of active substance
US4370313A (en) * 1981-10-26 1983-01-25 Eaton Laboratories, Inc. Nitrofurantoin dosage form
JPS58134019A (en) * 1982-02-05 1983-08-10 Ono Pharmaceut Co Ltd Slow-releasing triple-layered film pharmaceutical containing prostaglandin and its preparation
US4571039A (en) * 1983-04-15 1986-02-18 Stanley Poler Eye-medicating contact-lens construction
US4639244A (en) * 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
US4564364A (en) * 1983-05-26 1986-01-14 Alza Corporation Active agent dispenser
US4601893A (en) * 1984-02-08 1986-07-22 Pfizer Inc. Laminate device for controlled and prolonged release of substances to an ambient environment and method of use
US4863445A (en) * 1984-07-30 1989-09-05 Baxter Travenol Laboratories, Inc. Assembly for inhibiting microbial growth in collected fluid
US4693895A (en) * 1984-10-26 1987-09-15 Alza Corporation Colon delivery system
US4627851A (en) * 1984-10-26 1986-12-09 Alza Corporation Colonic-therapeutic delivery system
CH667001A5 (en) * 1985-09-03 1988-09-15 Hugo Degen UNDER MATTRESS.
US4880633A (en) * 1986-03-12 1989-11-14 Merck & Co., Inc. Transdermal drug delivery system
US4938759A (en) * 1986-09-02 1990-07-03 Alza Corporation Transdermal delivery device having a rate controlling adhesive
US5344656A (en) * 1986-09-12 1994-09-06 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4908027A (en) * 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4841968A (en) * 1986-09-26 1989-06-27 Southern Research Institute Antithrombotic/thrombolytic suture and methods of making and using the same
US4830860A (en) * 1986-10-30 1989-05-16 Pfizer Inc. Stressed polymeric device for controlled release of a substance to an ambient environment
JPS63143581A (en) * 1986-12-05 1988-06-15 Nissha Printing Co Ltd Hologram molded article
US4892778A (en) * 1987-05-27 1990-01-09 Alza Corporation Juxtaposed laminated arrangement
ATE86484T1 (en) * 1987-08-08 1993-03-15 Akzo Nv CONTRACEPTIVE IMPLANT.
DK530787D0 (en) * 1987-10-09 1987-10-09 Bukh Meditec DEVICE FOR INTRODUCTION IN A BODY
US5035886A (en) * 1987-10-19 1991-07-30 Ppg Industries, Inc. Active agent delivery device
US5071645A (en) * 1987-10-19 1991-12-10 Ppg Industries, Inc. Process of producing an active agent delivery device
US4959208A (en) * 1987-10-19 1990-09-25 Ppg Industries, Inc. Active agent delivery device
US4781924A (en) 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device
US4906475A (en) * 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
US5004610A (en) * 1988-06-14 1991-04-02 Alza Corporation Subsaturated nicotine transdermal therapeutic system
GB8815968D0 (en) * 1988-07-05 1988-08-10 Pfizer Ltd Veterinary devices
US5059426A (en) * 1989-03-22 1991-10-22 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US4973468A (en) * 1989-03-22 1990-11-27 Cygnus Research Corporation Skin permeation enhancer compositions
US5053227A (en) * 1989-03-22 1991-10-01 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US5124157A (en) 1989-08-18 1992-06-23 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
US5217718A (en) * 1989-08-18 1993-06-08 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
US5508038A (en) * 1990-04-16 1996-04-16 Alza Corporation Polyisobutylene adhesives for transdermal devices
JPH11508224A (en) * 1990-08-09 1999-07-21 エンドコン・インコーポレーテッド Multiple drug delivery system
JPH0444601U (en) * 1990-08-22 1992-04-15
JPH0444666U (en) * 1990-08-22 1992-04-15
US5538735A (en) * 1993-02-19 1996-07-23 Ahn; Sam S. Method of making a drug delivery system using hollow fibers
JP3720386B2 (en) * 1993-12-27 2005-11-24 住友製薬株式会社 Drug release controlled formulation
US5466233A (en) * 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
US5660848A (en) * 1994-11-02 1997-08-26 The Population Council, Center For Biomedical Research Subdermally implantable device
AU2001260612B9 (en) * 2000-05-26 2005-06-09 Kanji Takada Nonoral preparation having three-layer structure
US20020148138A1 (en) * 2001-04-06 2002-10-17 Egan Brian A. Smart tread boot covers
US7883717B2 (en) 2001-06-12 2011-02-08 Johns Hopkins University Reservoir device for intraocular drug delivery
US7306580B2 (en) * 2003-04-16 2007-12-11 Cook Incorporated Medical device with therapeutic agents
ES2442675T3 (en) * 2003-07-10 2014-02-12 Warner Chilcott (Ireland) Limited Intravaginal drug delivery devices
CN1882338A (en) * 2003-09-18 2006-12-20 马库赛特公司 Transscleral delivery
US20050244465A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Drug delivery systems and methods for treatment of an eye
DE102004050457A1 (en) * 2004-10-12 2006-04-13 Capsulution Nanoscience Ag Segmented device for the sustained release of molecules in the tangential direction through thin films and applications thereof
US8663639B2 (en) 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
WO2006086750A1 (en) 2005-02-09 2006-08-17 Macusight, Inc. Liquid formulations for treatment of diseases or conditions
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BRPI0709016A2 (en) 2006-03-23 2011-06-21 Macusight Inc formulations and methods for diseases or conditions related to vascular permeability
US8399006B2 (en) 2009-01-29 2013-03-19 Forsight Vision4, Inc. Posterior segment drug delivery
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
CN104887388B (en) 2009-06-03 2018-01-09 弗赛特影像5股份有限公司 Anterior segment drug conveys
US20110066141A1 (en) * 2009-09-11 2011-03-17 Cook Incorporated Implantable medical device having an anti-gastric distress agent
US20110098797A1 (en) * 2009-10-23 2011-04-28 Cleek Robert L Drug eluting composite
US9320890B2 (en) * 2009-11-09 2016-04-26 W. L. Gore & Associates, Inc. Drug eluting composite
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US10226419B2 (en) * 2014-09-08 2019-03-12 ProMed Pharma, LLC Methods for manufacturing implants
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US3851648A (en) * 1973-10-11 1974-12-03 Mead Johnson & Co Zero-order release device

Also Published As

Publication number Publication date
IT1050619B (en) 1981-03-20
FR2290891A1 (en) 1976-06-11
JPS6059203B2 (en) 1985-12-24
SE7512744L (en) 1977-05-15
MX158868A (en) 1989-03-27
SE439432B (en) 1985-06-17
CH634226A5 (en) 1983-01-31
DE2549856A1 (en) 1976-05-20
JPS5170807A (en) 1976-06-18
MX158867A (en) 1989-03-27
US3926188A (en) 1975-12-16
DE2549856C2 (en) 1985-01-03
FR2290891B1 (en) 1978-11-10
CA1056685A (en) 1979-06-19

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19931015