FR2284321A1 - 1-phenoxy-3-aminopropan-2-ols - with cardiac anti-arrhythmic activity and low beta-blocking activity - Google Patents

1-phenoxy-3-aminopropan-2-ols - with cardiac anti-arrhythmic activity and low beta-blocking activity

Info

Publication number
FR2284321A1
FR2284321A1 FR7528137A FR7528137A FR2284321A1 FR 2284321 A1 FR2284321 A1 FR 2284321A1 FR 7528137 A FR7528137 A FR 7528137A FR 7528137 A FR7528137 A FR 7528137A FR 2284321 A1 FR2284321 A1 FR 2284321A1
Authority
FR
France
Prior art keywords
activity
aminopropan
ols
phenoxy
arrhythmic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7528137A
Other languages
French (fr)
Other versions
FR2284321B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FR2284321A1 publication Critical patent/FR2284321A1/en
Application granted granted Critical
Publication of FR2284321B1 publication Critical patent/FR2284321B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1-Phenoxy-3-aminopropan-2-ols of formula (I) and (II), their hydrates and acid-addition salts: (where in (I) R is 3-11C cycloalkyl, 1-indanyl, 1-adamantyl or exo-2-norbornyl; A is vinylene or 1-3C alkylene; Y is NH2, CN, alkoxycarbonyl, OH, carbamoyl, N-Cyclohexyl-methylcarbamoyl, N,N-dimethylcarbamoyl, morpholinyl, a group of formula R is cyclohexylmethyl and Y is carbamoyl; or R is -CHMe2 and Y is cyclohexylcarbamoyl or cyclohexylmethylcarbamoyl) are used in the treatment of cardiac arrhythmias they have little beta-blocking action.
FR7528137A 1974-09-12 1975-09-12 1-phenoxy-3-aminopropan-2-ols - with cardiac anti-arrhythmic activity and low beta-blocking activity Granted FR2284321A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50540874A 1974-09-12 1974-09-12

Publications (2)

Publication Number Publication Date
FR2284321A1 true FR2284321A1 (en) 1976-04-09
FR2284321B1 FR2284321B1 (en) 1978-07-28

Family

ID=24010183

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7528137A Granted FR2284321A1 (en) 1974-09-12 1975-09-12 1-phenoxy-3-aminopropan-2-ols - with cardiac anti-arrhythmic activity and low beta-blocking activity

Country Status (9)

Country Link
JP (1) JPS51125038A (en)
BE (1) BE833291A (en)
DD (1) DD122519A5 (en)
DE (1) DE2540552A1 (en)
DK (1) DK405775A (en)
ES (1) ES440890A1 (en)
FR (1) FR2284321A1 (en)
NL (1) NL7510781A (en)
SE (1) SE7510153L (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2522325A1 (en) * 1982-02-26 1983-09-02 Delalande Sa NOVEL ARYLIC DERIVATIVES OF PIPERAZINE, HOMOPIPERAZINE AND N, N'-DIALKYL DIAMINO-1,2 ETHANE, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC USE
WO2008130464A1 (en) * 2007-02-09 2008-10-30 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4665094A (en) * 1985-08-29 1987-05-12 Merck & Co., Inc. Oculoselective beta-blockers for treatment of elevated intraocular pressure
US4945182A (en) * 1985-12-24 1990-07-31 Merck & Co., Inc. Oculoselective beta-blockers
JP3441665B2 (en) * 1999-02-04 2003-09-02 株式会社資生堂 (2-Substituted oxyphenyl) alkaneamide derivatives, hair tonics, skin external preparations
PL209602B1 (en) 2005-10-20 2011-09-30 Inst Chemii Bioorg Pan Synthesis of amide of the 3- (4-hydroxyphenyl)propane acid

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1937477A1 (en) * 1969-07-23 1971-02-04 Boehringer Sohn Ingelheim New 1-phenoxy-2-hydroxy-3-cycloalkylaminopropanes and processes for their preparation
GB1391444A (en) * 1971-07-13 1975-04-23 Ici Ltd Chemical process for the manufacture of alkanolamine derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1937477A1 (en) * 1969-07-23 1971-02-04 Boehringer Sohn Ingelheim New 1-phenoxy-2-hydroxy-3-cycloalkylaminopropanes and processes for their preparation
GB1391444A (en) * 1971-07-13 1975-04-23 Ici Ltd Chemical process for the manufacture of alkanolamine derivatives

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2522325A1 (en) * 1982-02-26 1983-09-02 Delalande Sa NOVEL ARYLIC DERIVATIVES OF PIPERAZINE, HOMOPIPERAZINE AND N, N'-DIALKYL DIAMINO-1,2 ETHANE, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC USE
WO2008130464A1 (en) * 2007-02-09 2008-10-30 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same
US9371297B2 (en) 2007-02-09 2016-06-21 Ocera Therapeutics, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same
US9949949B2 (en) 2007-02-09 2018-04-24 Ocera Therapeutics, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same
US10258602B2 (en) 2007-02-09 2019-04-16 Ocera Therapeutics, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same

Also Published As

Publication number Publication date
DK405775A (en) 1976-03-13
FR2284321B1 (en) 1978-07-28
SE7510153L (en) 1976-05-07
ES440890A1 (en) 1977-04-01
JPS51125038A (en) 1976-11-01
NL7510781A (en) 1976-03-16
DE2540552A1 (en) 1976-03-25
BE833291A (en) 1976-03-11
DD122519A5 (en) 1976-10-12

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Legal Events

Date Code Title Description
ST Notification of lapse