ES440890A1 - Process for manufacture of cycloalkyl derivatives of 11aryloxyy33aminoo22propanols - Google Patents

Process for manufacture of cycloalkyl derivatives of 11aryloxyy33aminoo22propanols

Info

Publication number
ES440890A1
ES440890A1 ES440890A ES440890A ES440890A1 ES 440890 A1 ES440890 A1 ES 440890A1 ES 440890 A ES440890 A ES 440890A ES 440890 A ES440890 A ES 440890A ES 440890 A1 ES440890 A1 ES 440890A1
Authority
ES
Spain
Prior art keywords
formula
group
see formula
cycloalkyl
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES440890A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES440890A1 publication Critical patent/ES440890A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure to prepare cycloalkyl derivatives of 1-aryloxy-3-amino-2-propanoles, of formula: **(See formula)** where R is cycloalkyl of 3 to 11 carbon atoms, cyclohexylmethyl, exo-2-norbornyl, 1-adamantyl, or 1-indanyl; A is alkylene of 1 to 3 carbon atoms or vinylene; Y is carbamoyl, cyclohexylcarbamoyl, N, N-dimethylcarbamoyl, cyclohexylmethylcarbamoyl, hydroxylamino, cyano, carboxy, alkoxycarbonyl, morpholino, or a molecular portion of the formula: **(See formula)** characterized in that a compound of the formula is reacted: **(See formula)** wherein A and Y are as defined hereinabove with the proviso that the amino group is protected by a hydrogenolizable radical and that the carboxyl group is present as a lower carboalkoxy group and X is a molecular portion of the formula: **(See formula)** where Z is halogen, alkylsulfonate or arylsulfonate; with an amine of formula R-NH2 where R is as defined above; and, if necessary, hydrogenolize the protected amino group or hydrolyze the lower carboalkoxy group. (Machine-translation by Google Translate, not legally binding)
ES440890A 1974-09-12 1975-09-12 Process for manufacture of cycloalkyl derivatives of 11aryloxyy33aminoo22propanols Expired ES440890A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50540874A 1974-09-12 1974-09-12

Publications (1)

Publication Number Publication Date
ES440890A1 true ES440890A1 (en) 1977-04-01

Family

ID=24010183

Family Applications (1)

Application Number Title Priority Date Filing Date
ES440890A Expired ES440890A1 (en) 1974-09-12 1975-09-12 Process for manufacture of cycloalkyl derivatives of 11aryloxyy33aminoo22propanols

Country Status (9)

Country Link
JP (1) JPS51125038A (en)
BE (1) BE833291A (en)
DD (1) DD122519A5 (en)
DE (1) DE2540552A1 (en)
DK (1) DK405775A (en)
ES (1) ES440890A1 (en)
FR (1) FR2284321A1 (en)
NL (1) NL7510781A (en)
SE (1) SE7510153L (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2522325B1 (en) * 1982-02-26 1985-08-09 Delalande Sa NOVEL ARYLIC DERIVATIVES OF PIPERAZINE, HOMOPIPERAZINE AND N, N'-DIALKYL DIAMINO-1,2 ETHANE, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
US4665094A (en) * 1985-08-29 1987-05-12 Merck & Co., Inc. Oculoselective beta-blockers for treatment of elevated intraocular pressure
US4945182A (en) * 1985-12-24 1990-07-31 Merck & Co., Inc. Oculoselective beta-blockers
JP3441665B2 (en) 1999-02-04 2003-09-02 株式会社資生堂 (2-Substituted oxyphenyl) alkaneamide derivatives, hair tonics, skin external preparations
PL209602B1 (en) 2005-10-20 2011-09-30 Inst Chemii Bioorg Pan Synthesis of amide of the 3- (4-hydroxyphenyl)propane acid
ES2602789T3 (en) 2007-02-09 2017-02-22 Ocera Therapeutics, Inc. Connector intermediates for the synthesis of macrocyclic modulators of the ghrelin receptor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1937477C3 (en) * 1969-07-23 1980-04-10 C.H. Boehringer Sohn, 6507 Ingelheim I-phenoxy-2-hydroxy-3- (l -methylcycloalkylamino) propane, process for their preparation and medicaments containing them
GB1391444A (en) * 1971-07-13 1975-04-23 Ici Ltd Chemical process for the manufacture of alkanolamine derivatives

Also Published As

Publication number Publication date
NL7510781A (en) 1976-03-16
BE833291A (en) 1976-03-11
SE7510153L (en) 1976-05-07
FR2284321B1 (en) 1978-07-28
DE2540552A1 (en) 1976-03-25
DD122519A5 (en) 1976-10-12
DK405775A (en) 1976-03-13
JPS51125038A (en) 1976-11-01
FR2284321A1 (en) 1976-04-09

Similar Documents

Publication Publication Date Title
ES440890A1 (en) Process for manufacture of cycloalkyl derivatives of 11aryloxyy33aminoo22propanols
ES306983A1 (en) Procedure to stabilize an organic substance against deterioration. (Machine-translation by Google Translate, not legally binding)
ES329130A1 (en) Procedure for the preparation of new derivatives of the isoindoline sulfonilurea. (Machine-translation by Google Translate, not legally binding)
FR2222097A1 (en)
ES399786A1 (en) Process for the manufacture of tetrasubstituted ureas
ES438799A1 (en) Vincaminic acid amides
GB1246044A (en) Arylamine sensitizing compounds for electrophotography
ES404678A1 (en) 6-aminoalkylamino-hexahydrophenanthridines useful as antiarrhythmic agents
ES300569A1 (en) Procedure for obtaining amidas from antranilic acid (Machine-translation by Google Translate, not legally binding)
ES427900A1 (en) Substituted beta-lactams and their preparation
ES446444A1 (en) Process for the preparation of carbonyl alpha-perfluoro derivatives
ES454266A1 (en) Shinkina penishirinruino seizoho
ES430341A1 (en) Preparation of sulphonyl-benzamide derivatives
ES386847A1 (en) Amino-oxy carboxylic acid amides
ES301365A1 (en) A method for the preparation of a diuretic compound (Machine-translation by Google Translate, not legally binding)
ES407133A1 (en) Dibenzoxirenazepine derivatives
ES287547A1 (en) Procedure for the production of N- (2,3-dimethylene) antranilic acid and its salts (Machine-translation by Google Translate, not legally binding)
ES413391A1 (en) Preparation of n-tertiary aminoalkyl-2-alkoxy benzamides and benzoic anhydride derivatives produced during it
ES394803A1 (en) Leucauramine derivatives
ES302128A1 (en) Procedure for the preparation of new N-substituted N-arilesulfonilureas. (Machine-translation by Google Translate, not legally binding)
ES430905A1 (en) Tetrazole coumarin derivatives
ES329306A1 (en) A method to produce a compound useful as an anti-inflammatory and uricosuric agent. (Machine-translation by Google Translate, not legally binding)
ES277406A1 (en) A procedure for preparing tetracycline derivatives (Machine-translation by Google Translate, not legally binding)
ES292441A2 (en) A procedure for the manufacture of peptides (Machine-translation by Google Translate, not legally binding)
ES287550A1 (en) Procedure for the production of N- (2,3-dimethylene) -antranilic acid and its salts (Machine-translation by Google Translate, not legally binding)