FR2140054A1 - Amine n-oxide derivs of phenylureas - with antiarrhythmic activity - Google Patents

Amine n-oxide derivs of phenylureas - with antiarrhythmic activity

Info

Publication number
FR2140054A1
FR2140054A1 FR7219166A FR7219166A FR2140054A1 FR 2140054 A1 FR2140054 A1 FR 2140054A1 FR 7219166 A FR7219166 A FR 7219166A FR 7219166 A FR7219166 A FR 7219166A FR 2140054 A1 FR2140054 A1 FR 2140054A1
Authority
FR
France
Prior art keywords
phenylureas
amine
lower alkyl
derivs
antiarrhythmic activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7219166A
Other languages
French (fr)
Other versions
FR2140054B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2140054A1 publication Critical patent/FR2140054A1/en
Application granted granted Critical
Publication of FR2140054B1 publication Critical patent/FR2140054B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C07C317/42—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Phenylurea derivs. of formula (I), their salts with acids, and their quaternary ammonium salts: (where X is H, halogen, CF3, NO2, NH2, dialkylamino, acyloxy, OH, or lower alkyl, alkoxy, alkylmercapto or alkanoyl; R is H, lower alkyl, lower alkenyl, cycloalkyl, X-substd. phenyl or X-substd. phenylakyl; R' and R2 are H, lower alkyl, cycloalkyl, monocyclic aryl or lower alkylaryl, or NR'R2 is 13C satd. 5- to 7-membered monocyclic heterocyclyl; n is 1, 2,3 or 4; A is lower alkylene; is a 13C basic N-contg.residue; and Y is O, S, SO, SO2 or methylene). Antiarrhythmics which can be used in the same way as procainamide.
FR7219166A 1971-05-28 1972-05-29 Amine n-oxide derivs of phenylureas - with antiarrhythmic activity Granted FR2140054A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14814571A 1971-05-28 1971-05-28

Publications (2)

Publication Number Publication Date
FR2140054A1 true FR2140054A1 (en) 1973-01-12
FR2140054B1 FR2140054B1 (en) 1975-08-08

Family

ID=22524491

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7219166A Granted FR2140054A1 (en) 1971-05-28 1972-05-29 Amine n-oxide derivs of phenylureas - with antiarrhythmic activity

Country Status (4)

Country Link
CH (1) CH546232A (en)
DE (1) DE2226009A1 (en)
FR (1) FR2140054A1 (en)
HU (1) HU164978B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7526798A (en) * 1997-04-18 1998-11-27 Smithkline Beecham Plc Acetamide and urea derivatives, process for their preparation and their use in the treatment of cns disorders

Also Published As

Publication number Publication date
CH546232A (en) 1974-02-28
FR2140054B1 (en) 1975-08-08
HU164978B (en) 1974-05-28
DE2226009A1 (en) 1973-01-25

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Legal Events

Date Code Title Description
ST Notification of lapse