FR2265409A1 - 4-Oxo-4-phenyl-2-methyl(ene)-butyric acid derivs. - analgesics, antiinflammatories and hypocholesterolemiants - Google Patents
4-Oxo-4-phenyl-2-methyl(ene)-butyric acid derivs. - analgesics, antiinflammatories and hypocholesterolemiantsInfo
- Publication number
- FR2265409A1 FR2265409A1 FR7410196A FR7410196A FR2265409A1 FR 2265409 A1 FR2265409 A1 FR 2265409A1 FR 7410196 A FR7410196 A FR 7410196A FR 7410196 A FR7410196 A FR 7410196A FR 2265409 A1 FR2265409 A1 FR 2265409A1
- Authority
- FR
- France
- Prior art keywords
- phenyl
- hypocholesterolemiants
- antiinflammatories
- analgesics
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940035676 analgesics Drugs 0.000 title abstract 2
- 239000000730 antalgic agent Substances 0.000 title abstract 2
- 239000002260 anti-inflammatory agent Substances 0.000 title abstract 2
- 229940121363 anti-inflammatory agent Drugs 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- -1 3-trifluoromethylanilino Chemical group 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000008035 Back Pain Diseases 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- 208000008930 Low Back Pain Diseases 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 206010036030 Polyarthritis Diseases 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 208000030428 polyarticular arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/86—Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7410196A FR2265409A1 (en) | 1974-03-25 | 1974-03-25 | 4-Oxo-4-phenyl-2-methyl(ene)-butyric acid derivs. - analgesics, antiinflammatories and hypocholesterolemiants |
| BE154103A BE826401A (fr) | 1974-03-25 | 1975-03-06 | Ceto-acides aromatiques a action antalgique antiinflammatoire |
| US05/560,344 US4008323A (en) | 1974-03-25 | 1975-03-21 | Method of reducing cholesterol using certain aromatic keto acids |
| GB11888/75A GB1498903A (en) | 1974-03-25 | 1975-03-21 | Aromatic keto-acids and their derivatives |
| ES435949A ES435949A1 (es) | 1974-03-25 | 1975-03-24 | Procedimiento de prepracion de acidos 4-aril-4-oxo-2-meti- len-butricos. |
| ES435950A ES435950A1 (es) | 1974-03-25 | 1975-03-24 | Procedimiento de preparacion de acidos 4-aril-4-oxo-2-me- til-2-butenoicos y sus derivados amidicos. |
| DE19752513157 DE2513157A1 (de) | 1974-03-25 | 1975-03-25 | Aromatische ketosaeuren und deren derivate |
| CH383775A CH596130A5 (https=) | 1974-03-25 | 1975-03-25 | |
| CH383875A CH595322A5 (https=) | 1974-03-25 | 1975-03-25 | |
| JP3599375A JPS5610900B2 (https=) | 1974-03-25 | 1975-03-25 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7410196A FR2265409A1 (en) | 1974-03-25 | 1974-03-25 | 4-Oxo-4-phenyl-2-methyl(ene)-butyric acid derivs. - analgesics, antiinflammatories and hypocholesterolemiants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2265409A1 true FR2265409A1 (en) | 1975-10-24 |
| FR2265409B1 FR2265409B1 (https=) | 1977-11-04 |
Family
ID=9136780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7410196A Granted FR2265409A1 (en) | 1974-03-25 | 1974-03-25 | 4-Oxo-4-phenyl-2-methyl(ene)-butyric acid derivs. - analgesics, antiinflammatories and hypocholesterolemiants |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS5610900B2 (https=) |
| BE (1) | BE826401A (https=) |
| FR (1) | FR2265409A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2503140A1 (fr) * | 1981-03-31 | 1982-10-08 | Fabre Sa Pierre | Acides biphenyl-4 oxo-4 methylene-3 butyriques, leur procede de preparation et leur utilisation comme medicaments |
| FR2515038A1 (fr) * | 1981-10-22 | 1983-04-29 | Roussel Uclaf | A titre de medicaments, certains derives de l'acide 4-phenyl 4-oxo 2-butenoique et compositions les renfermant |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999019291A1 (en) * | 1997-10-14 | 1999-04-22 | Asahi Kasei Kogyo Kabushiki Kaisha | Biphenyl-5-alkanoic acid derivatives and use thereof |
-
1974
- 1974-03-25 FR FR7410196A patent/FR2265409A1/fr active Granted
-
1975
- 1975-03-06 BE BE154103A patent/BE826401A/xx not_active IP Right Cessation
- 1975-03-25 JP JP3599375A patent/JPS5610900B2/ja not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2503140A1 (fr) * | 1981-03-31 | 1982-10-08 | Fabre Sa Pierre | Acides biphenyl-4 oxo-4 methylene-3 butyriques, leur procede de preparation et leur utilisation comme medicaments |
| FR2515038A1 (fr) * | 1981-10-22 | 1983-04-29 | Roussel Uclaf | A titre de medicaments, certains derives de l'acide 4-phenyl 4-oxo 2-butenoique et compositions les renfermant |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS50135050A (https=) | 1975-10-25 |
| BE826401A (fr) | 1975-06-30 |
| JPS5610900B2 (https=) | 1981-03-11 |
| FR2265409B1 (https=) | 1977-11-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NL7605845A (en) | 2-Hydroxyethylidene cyanoacetic acid anilides - are non ulcerogenic antiphlogistics and analgesics (NL071276) | |
| FR2265409A1 (en) | 4-Oxo-4-phenyl-2-methyl(ene)-butyric acid derivs. - analgesics, antiinflammatories and hypocholesterolemiants | |
| FR2002353A1 (en) | 1 2-benzisothiazolone salts | |
| ATE84717T1 (de) | Verwendung von 6-methylen-6-desoxy-nus850906 | |
| GB1471910A (en) | Lysine salt | |
| FR2112480A1 (en) | 1-oxo-2-(p-(carboxymethyl)-phenyl) isoindoline derivs - analgesics and anti-inflammatories | |
| JPS526919A (en) | Brushless motor | |
| JPS5236460A (en) | Mos type transistor circuit | |
| SE7707511L (sv) | Organisk syraforening och sett for tillverkning och anvendning av densamma for farmaceutiska endamal | |
| JPS5296076A (en) | Rotational stop detector | |
| JPS5234311A (en) | Emergency operation method of inverter for motor drive | |
| GB1382996A (en) | Substituted biphenyls | |
| FR2125152A1 (en) | Alkoxy carbonylmethyl derivs of condensed cyclic sulphides - - with antirheumatic and allied activity | |
| JPS5252557A (en) | Inverter circuit | |
| JPS527658A (en) | Biasing system for field effect power transistors | |
| FR2238485A1 (en) | Anti-inflammatory and analgesic glyceryl esters - of substd 4-phenyl-butyric and 4-phenyl-4-oxobutyric acids | |
| FR2154308A1 (en) | N-(isopropylpyrrolidin-3-yl 3-methyl-2-phenyl pentanoates - with analgesic,spasmolytic anti ulcer,antitussive,bronchodilator,an | |
| ES398222A1 (es) | Un procedimiento para la preparacion de derivados de benzo-diazepina. | |
| SE381649B (sv) | Forfarande for tillvaratagande av en sasom avfall erhallen, i huvudsak jern sasom fororening innehallande, 15-30 %-ig svavelsyralosning vid framstellning av godselmedel | |
| GB1208814A (en) | Trans-dihydroxy-bis-hydroxycarbonylethylene salts | |
| JPS5270403A (en) | Hydraulic rotary machine | |
| FR2077856A1 (en) | 4-phenylcarbonylmethyl pyrimidines - with analgesic antiinflammatory,hypotensive and spasmolytic activity | |
| JPS5339423A (en) | Operating inverter motor | |
| JPS51133711A (en) | Method of winding coils in three-phase induction motor | |
| FR2269334A1 (en) | Anti-allergic 2-cyanoindanes and 3-cyanocoumarins - for prophylaxis and treatment of asthma, hay-fever and rhinitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |