FR2265409A1 - 4-Oxo-4-phenyl-2-methyl(ene)-butyric acid derivs. - analgesics, antiinflammatories and hypocholesterolemiants - Google Patents

4-Oxo-4-phenyl-2-methyl(ene)-butyric acid derivs. - analgesics, antiinflammatories and hypocholesterolemiants

Info

Publication number
FR2265409A1
FR2265409A1 FR7410196A FR7410196A FR2265409A1 FR 2265409 A1 FR2265409 A1 FR 2265409A1 FR 7410196 A FR7410196 A FR 7410196A FR 7410196 A FR7410196 A FR 7410196A FR 2265409 A1 FR2265409 A1 FR 2265409A1
Authority
FR
France
Prior art keywords
phenyl
hypocholesterolemiants
antiinflammatories
analgesics
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7410196A
Other languages
French (fr)
Other versions
FR2265409B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Priority to FR7410196A priority Critical patent/FR2265409A1/en
Priority to BE154103A priority patent/BE826401A/en
Priority to GB11888/75A priority patent/GB1498903A/en
Priority to US05/560,344 priority patent/US4008323A/en
Priority to ES435950A priority patent/ES435950A1/en
Priority to ES435949A priority patent/ES435949A1/en
Priority to CH383875A priority patent/CH595322A5/xx
Priority to JP3599375A priority patent/JPS5610900B2/ja
Priority to DE19752513157 priority patent/DE2513157A1/en
Priority to CH383775A priority patent/CH596130A5/xx
Publication of FR2265409A1 publication Critical patent/FR2265409A1/en
Application granted granted Critical
Publication of FR2265409B1 publication Critical patent/FR2265409B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/86—Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpds of formula (I) and their salts esp. with arginine, lysine and piperazine: (where R1=H, halo, phenyl, halo phenyl or phenoxy R2=H or alkoxy, or R1 and R2 together form a ring e.g. phenyl or cyclohexyl condensed with the phenyl ring R3=H, when R3=methyl then A and B together form a second bond when R3=methylene then A is H and B form the second bond to R3 R4=hydroxy, alkoxy, morpholino or 3-trifluoromethylanilino) are analgesics, antiinflammatories and hypocholesterolemiants used to treat inflammatory states such as rheumatoid poly-arthritis, lumbago etc and atherosclerosis. (I) are administered orally (in unit doses of 50-1000mg) parenterally, reactally or topically.
FR7410196A 1974-03-25 1974-03-25 4-Oxo-4-phenyl-2-methyl(ene)-butyric acid derivs. - analgesics, antiinflammatories and hypocholesterolemiants Granted FR2265409A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR7410196A FR2265409A1 (en) 1974-03-25 1974-03-25 4-Oxo-4-phenyl-2-methyl(ene)-butyric acid derivs. - analgesics, antiinflammatories and hypocholesterolemiants
BE154103A BE826401A (en) 1974-03-25 1975-03-06 AROMATIC KETO-ACIDS WITH ANTI-INFLAMMATORY ANTALGIC ACTION
US05/560,344 US4008323A (en) 1974-03-25 1975-03-21 Method of reducing cholesterol using certain aromatic keto acids
GB11888/75A GB1498903A (en) 1974-03-25 1975-03-21 Aromatic keto-acids and their derivatives
ES435950A ES435950A1 (en) 1974-03-25 1975-03-24 Method of reducing cholesterol using certain aromatic keto acids
ES435949A ES435949A1 (en) 1974-03-25 1975-03-24 Method of reducing cholesterol using certain aromatic keto acids
CH383875A CH595322A5 (en) 1974-03-25 1975-03-25
JP3599375A JPS5610900B2 (en) 1974-03-25 1975-03-25
DE19752513157 DE2513157A1 (en) 1974-03-25 1975-03-25 AROMATIC KETO ACIDS AND THEIR DERIVATIVES
CH383775A CH596130A5 (en) 1974-03-25 1975-03-25

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7410196A FR2265409A1 (en) 1974-03-25 1974-03-25 4-Oxo-4-phenyl-2-methyl(ene)-butyric acid derivs. - analgesics, antiinflammatories and hypocholesterolemiants

Publications (2)

Publication Number Publication Date
FR2265409A1 true FR2265409A1 (en) 1975-10-24
FR2265409B1 FR2265409B1 (en) 1977-11-04

Family

ID=9136780

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7410196A Granted FR2265409A1 (en) 1974-03-25 1974-03-25 4-Oxo-4-phenyl-2-methyl(ene)-butyric acid derivs. - analgesics, antiinflammatories and hypocholesterolemiants

Country Status (3)

Country Link
JP (1) JPS5610900B2 (en)
BE (1) BE826401A (en)
FR (1) FR2265409A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503140A1 (en) * 1981-03-31 1982-10-08 Fabre Sa Pierre 4:Bi:phenyl 4:oxo 3:methylene butyric acid derivs. - for prevention and treatment of atherosclerosis
FR2515038A1 (en) * 1981-10-22 1983-04-29 Roussel Uclaf AS MEDICINES, CERTAIN DERIVATIVES OF 4-PHENYL 4-OXO 2-BUTENOIC ACID AND COMPOSITIONS COMPRISING THE SAME

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2304713C (en) 1997-10-14 2003-06-10 Asahi Kasei Kogyo Kabushiki Kaisha Biphenyl-5-alkanoic acid derivatives and use thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503140A1 (en) * 1981-03-31 1982-10-08 Fabre Sa Pierre 4:Bi:phenyl 4:oxo 3:methylene butyric acid derivs. - for prevention and treatment of atherosclerosis
FR2515038A1 (en) * 1981-10-22 1983-04-29 Roussel Uclaf AS MEDICINES, CERTAIN DERIVATIVES OF 4-PHENYL 4-OXO 2-BUTENOIC ACID AND COMPOSITIONS COMPRISING THE SAME

Also Published As

Publication number Publication date
FR2265409B1 (en) 1977-11-04
JPS5610900B2 (en) 1981-03-11
BE826401A (en) 1975-06-30
JPS50135050A (en) 1975-10-25

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Legal Events

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ST Notification of lapse