FR2260334A1 - Indanes e.g. (5-(1,3-dimethyl)indanyl) acetic acid, alcohols and amine - used as antiinflammatory and analgesic agents - Google Patents

Indanes e.g. (5-(1,3-dimethyl)indanyl) acetic acid, alcohols and amine - used as antiinflammatory and analgesic agents

Info

Publication number
FR2260334A1
FR2260334A1 FR7501002A FR7501002A FR2260334A1 FR 2260334 A1 FR2260334 A1 FR 2260334A1 FR 7501002 A FR7501002 A FR 7501002A FR 7501002 A FR7501002 A FR 7501002A FR 2260334 A1 FR2260334 A1 FR 2260334A1
Authority
FR
France
Prior art keywords
antiinflammatory
indanes
indanyl
alcohols
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7501002A
Other languages
English (en)
French (fr)
Other versions
FR2260334B1 (de
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hexachimie SA
Original Assignee
Hexachimie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB5726/74A external-priority patent/GB1492175A/en
Application filed by Hexachimie SA filed Critical Hexachimie SA
Publication of FR2260334A1 publication Critical patent/FR2260334A1/fr
Application granted granted Critical
Publication of FR2260334B1 publication Critical patent/FR2260334B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/194—Radicals derived from thio- or thiono carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/32—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by introduction of halogenated alkyl groups into ring compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/34—Monohydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7501002A 1974-02-07 1975-01-14 Indanes e.g. (5-(1,3-dimethyl)indanyl) acetic acid, alcohols and amine - used as antiinflammatory and analgesic agents Granted FR2260334A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB5726/74A GB1492175A (en) 1974-02-07 1974-02-07 Indane derivatives
GB3722074 1974-08-23
GB5429274 1974-12-16

Publications (2)

Publication Number Publication Date
FR2260334A1 true FR2260334A1 (en) 1975-09-05
FR2260334B1 FR2260334B1 (de) 1978-08-18

Family

ID=27254687

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7501002A Granted FR2260334A1 (en) 1974-02-07 1975-01-14 Indanes e.g. (5-(1,3-dimethyl)indanyl) acetic acid, alcohols and amine - used as antiinflammatory and analgesic agents

Country Status (12)

Country Link
JP (2) JPS51125367A (de)
AR (4) AR206619A1 (de)
CA (1) CA1063618A (de)
CH (2) CH603533A5 (de)
DD (3) DD117209A5 (de)
DE (1) DE2504689A1 (de)
DK (2) DK42475A (de)
ES (1) ES434478A1 (de)
FR (1) FR2260334A1 (de)
NL (2) NL7501518A (de)
NO (3) NO750175L (de)
SE (3) SE418395B (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2289176A1 (fr) * 1974-10-29 1976-05-28 Sandoz Sa Nouveaux derives d'acides alcanoiques, leur preparation et leur application comme medicaments
FR2390428A1 (fr) * 1977-05-04 1978-12-08 Hoffmann La Roche Nouveaux composes polyeniques, leur preparation et leur application en tant que medicaments
EP0008256A2 (de) * 1978-07-24 1980-02-20 HEXACHIMIE Société anonyme dite: Indan-essigsäureester, ihre Bereitung und diese enthaltende Arzneimittel

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA882957B (en) * 1987-04-27 1989-12-27 Syntex Pharma Int Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal anti-inflammatory drugs

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2289176A1 (fr) * 1974-10-29 1976-05-28 Sandoz Sa Nouveaux derives d'acides alcanoiques, leur preparation et leur application comme medicaments
FR2390428A1 (fr) * 1977-05-04 1978-12-08 Hoffmann La Roche Nouveaux composes polyeniques, leur preparation et leur application en tant que medicaments
EP0008256A2 (de) * 1978-07-24 1980-02-20 HEXACHIMIE Société anonyme dite: Indan-essigsäureester, ihre Bereitung und diese enthaltende Arzneimittel
EP0008256A3 (de) * 1978-07-24 1980-12-10 HEXACHIMIE Société anonyme dite: Indan-essigsäureester, ihre Bereitung und diese enthaltende Arzneimittel
EP0034838A2 (de) * 1978-07-24 1981-09-02 HEXACHIMIE Société anonyme dite: Halogen-äthylester der Indanessigsäure und ihre Herstellung
EP0034838A3 (de) * 1978-07-24 1981-10-07 HEXACHIMIE Société anonyme dite: Halogen-äthylester der Indanessigsäure und ihre Herstellung

Also Published As

Publication number Publication date
NO800268L (no) 1975-08-08
SE7501339L (de) 1975-08-08
SE7713839L (sv) 1977-12-06
NO750176L (de) 1975-09-01
AR206619A1 (es) 1976-08-06
JPS5711295B2 (de) 1982-03-03
SE7501338L (de) 1975-08-08
CH605567A5 (de) 1978-09-29
AU7793675A (en) 1976-08-05
NO146136B (no) 1982-04-26
CH603533A5 (de) 1978-08-31
CA1063618A (en) 1979-10-02
AR206620A1 (es) 1976-08-06
NO146136C (no) 1982-08-04
DK42475A (de) 1975-10-06
NL7501519A (nl) 1975-08-11
DD118271A5 (de) 1976-02-20
SE418395B (sv) 1981-05-25
DK42575A (de) 1975-10-06
DD117209A5 (de) 1976-01-05
JPS51125368A (en) 1976-11-01
AR211541A1 (es) 1978-01-30
NO750175L (de) 1975-09-01
JPS51125367A (en) 1976-11-01
FR2260334B1 (de) 1978-08-18
DD123319A5 (de) 1976-12-12
SE418177B (sv) 1981-05-11
ES434478A1 (es) 1977-03-16
DE2504689A1 (de) 1975-08-14
JPS5711296B2 (de) 1982-03-03
NL7501518A (nl) 1975-08-11
AR206862A1 (es) 1976-08-23

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