FR2248050A1 - 4,5-dihydro-4h-s-triazolo (4,3-a) (1,4) benzodiazepine - cns depressants, anti-convulsants, anti-aggressives and somatic reflex in - Google Patents
4,5-dihydro-4h-s-triazolo (4,3-a) (1,4) benzodiazepine - cns depressants, anti-convulsants, anti-aggressives and somatic reflex inInfo
- Publication number
- FR2248050A1 FR2248050A1 FR7307084A FR7307084A FR2248050A1 FR 2248050 A1 FR2248050 A1 FR 2248050A1 FR 7307084 A FR7307084 A FR 7307084A FR 7307084 A FR7307084 A FR 7307084A FR 2248050 A1 FR2248050 A1 FR 2248050A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- aggressives
- convulsants
- benzodiazepine
- triazolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical compound N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 title 1
- 230000002539 anti-aggressive effect Effects 0.000 title 1
- 230000001773 anti-convulsant effect Effects 0.000 title 1
- 229940125681 anticonvulsant agent Drugs 0.000 title 1
- 239000001961 anticonvulsive agent Substances 0.000 title 1
- 239000003874 central nervous system depressant Substances 0.000 title 1
- 230000011514 reflex Effects 0.000 title 1
- 230000000392 somatic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- YZPAKBGVJIVPEU-UHFFFAOYSA-N 1,2-benzodiazepin-6-one Chemical compound N1=NC=CC=C2C(=O)C=CC=C21 YZPAKBGVJIVPEU-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- -1 polymethyleneimino Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/34—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a carbon skeleton further substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK560071AA DK138854B (da) | 1970-11-23 | 1971-11-15 | Analogifremgangsmåde til fremstilling af s-triazolo(4,3-a)(1,4)benzodiazepinderivater eller 5-oxider eller salte deraf. |
| CH291772A CH567509A5 (en) | 1972-02-29 | 1972-02-29 | Diazepin derivs - prepd from triazolobenzodiazepinones and phenylmagnesiumhalide are central depressants, tranquillisers and |
| CH681972A CH569737A5 (en) | 1972-05-08 | 1972-05-08 | 4,5-dihydro-4h-s-triazolo (4,3-a) (1,4) benzodiazepine - cns depressants, anti-convulsants, anti-aggressives and somatic reflex in |
| CH681872 | 1972-05-08 | ||
| DK248872AA DK140988B (da) | 1971-11-15 | 1972-05-18 | Analogifremgangsmåde til fremstilling af et s-triazolo (4,3-a)(1,4) benzodiazepinderivater. |
| DK248772A DK140987B (da) | 1971-11-15 | 1972-05-18 | Analogifremgangsmåde til fremstilling af s-triazolo (4,3-a)(1,4) benzodiazepinderivater eller additionssalte deraf med uorganiske eller organiske syrer. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2248050A1 true FR2248050A1 (en) | 1975-05-16 |
| FR2248050B1 FR2248050B1 (enrdf_load_stackoverflow) | 1977-01-21 |
Family
ID=27543704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7307084A Granted FR2248050A1 (en) | 1971-11-15 | 1973-02-28 | 4,5-dihydro-4h-s-triazolo (4,3-a) (1,4) benzodiazepine - cns depressants, anti-convulsants, anti-aggressives and somatic reflex in |
Country Status (5)
| Country | Link |
|---|---|
| AR (1) | AR200859A1 (enrdf_load_stackoverflow) |
| CA (1) | CA1008856A (enrdf_load_stackoverflow) |
| DD (1) | DD104529A5 (enrdf_load_stackoverflow) |
| FR (1) | FR2248050A1 (enrdf_load_stackoverflow) |
| NL (1) | NL7302504A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0059386B1 (de) * | 1981-02-27 | 1985-09-18 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Imidazodiazepine, Zwischenprodukte und Verfahren zu ihrer Herstellung, sowie diese enthaltende Arzneimittel |
| FR2584401A1 (fr) * | 1985-07-04 | 1987-01-09 | Ile De France | Nouveau benzamide, son procede de preparation et son application dans le domaine therapeutique |
-
1973
- 1973-02-19 CA CA164,025A patent/CA1008856A/en not_active Expired
- 1973-02-22 NL NL7302504A patent/NL7302504A/xx not_active Application Discontinuation
- 1973-02-26 DD DD16909773A patent/DD104529A5/xx unknown
- 1973-02-28 FR FR7307084A patent/FR2248050A1/fr active Granted
- 1973-02-28 AR AR24686173A patent/AR200859A1/es active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0059386B1 (de) * | 1981-02-27 | 1985-09-18 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Imidazodiazepine, Zwischenprodukte und Verfahren zu ihrer Herstellung, sowie diese enthaltende Arzneimittel |
| FR2584401A1 (fr) * | 1985-07-04 | 1987-01-09 | Ile De France | Nouveau benzamide, son procede de preparation et son application dans le domaine therapeutique |
| EP0210893A1 (fr) * | 1985-07-04 | 1987-02-04 | Laboratoires DELAGRANGE, Société Anonyme | Benzamides, leur procédé de préparation et leur application dans le domaine thérapeutique |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1008856A (en) | 1977-04-19 |
| AR200859A1 (es) | 1974-12-27 |
| DD104529A5 (enrdf_load_stackoverflow) | 1974-03-12 |
| FR2248050B1 (enrdf_load_stackoverflow) | 1977-01-21 |
| NL7302504A (enrdf_load_stackoverflow) | 1973-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |