FR2216268A1 - Catalytic hydrogenation of 6-methylenetetracyclines - using rhodium-tert phosphine complex catalyst giving a stereospecific prod. in high yield - Google Patents

Catalytic hydrogenation of 6-methylenetetracyclines - using rhodium-tert phosphine complex catalyst giving a stereospecific prod. in high yield

Info

Publication number
FR2216268A1
FR2216268A1 FR7403435A FR7403435A FR2216268A1 FR 2216268 A1 FR2216268 A1 FR 2216268A1 FR 7403435 A FR7403435 A FR 7403435A FR 7403435 A FR7403435 A FR 7403435A FR 2216268 A1 FR2216268 A1 FR 2216268A1
Authority
FR
France
Prior art keywords
methylenetetracyclines
rhodium
stereospecific
prod
high yield
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7403435A
Other languages
English (en)
French (fr)
Other versions
FR2216268B1 (fi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27406609&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2216268(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR2216268A1 publication Critical patent/FR2216268A1/fr
Application granted granted Critical
Publication of FR2216268B1 publication Critical patent/FR2216268B1/fr
Granted legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/645—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/822—Rhodium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
FR7403435A 1973-02-01 1974-02-01 Catalytic hydrogenation of 6-methylenetetracyclines - using rhodium-tert phosphine complex catalyst giving a stereospecific prod. in high yield Granted FR2216268A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32851473A 1973-02-01 1973-02-01
US36806073A 1973-06-08 1973-06-08
US42827873A 1973-12-26 1973-12-26

Publications (2)

Publication Number Publication Date
FR2216268A1 true FR2216268A1 (en) 1974-08-30
FR2216268B1 FR2216268B1 (fi) 1978-01-06

Family

ID=27406609

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7403435A Granted FR2216268A1 (en) 1973-02-01 1974-02-01 Catalytic hydrogenation of 6-methylenetetracyclines - using rhodium-tert phosphine complex catalyst giving a stereospecific prod. in high yield

Country Status (18)

Country Link
JP (1) JPS5912111B2 (fi)
AR (1) AR210453A1 (fi)
CA (1) CA1027117A (fi)
CH (1) CH589605A5 (fi)
DD (1) DD110855A5 (fi)
DE (1) DE2403714C2 (fi)
ES (1) ES422758A1 (fi)
FI (1) FI58492C (fi)
FR (1) FR2216268A1 (fi)
IE (1) IE38797B1 (fi)
IL (1) IL44084A (fi)
IN (1) IN138662B (fi)
LU (1) LU69288A1 (fi)
NL (1) NL166921B (fi)
NO (2) NO151585C (fi)
PH (1) PH14446A (fi)
SE (1) SE435619C (fi)
YU (1) YU39915B (fi)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0086046A1 (en) * 1982-01-19 1983-08-17 Plurichemie Anstalt A process for the preparation of alpha-6-DEOXYTETRACYCLINES
US4597904A (en) * 1983-08-17 1986-07-01 Hovione Inter Ltd. Process for the preparation of α-6-deoxy-tetracyclines
USRE32535E (en) * 1982-01-19 1987-10-27 Plurichemie Anstalt Process for the preparation of α-6-deoxytetracyclines
US4973719A (en) * 1988-10-28 1990-11-27 Ranbaxy Laboratories Limited Process for the production of alpha-6-deoxytetracyclines
US4987242A (en) * 1988-10-28 1991-01-22 Jagmohan Khanna Hydrogenation catalyst useful in the production of alpha-6-deoxytetracyclines
US4997959A (en) * 1989-04-03 1991-03-05 Ranbaxy Laboratories Limited Process for the production of alpha-6-deoxytetracyclines
US5049683A (en) * 1989-01-04 1991-09-17 Houba, Inc. Process for the production of alpha-6-deoxytetracyclines

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR208347A1 (es) * 1974-12-19 1976-12-20 Pfizer Mejora en la produccion de alfa-6-deoxitetraciclinas
YU41093B (en) * 1978-04-12 1986-12-31 Pliva Pharm & Chem Works Process for preparing 6-deoxy-5hydroxy-tetracycline
PT76061A (en) * 1982-12-30 1983-01-01 Stable homogeneous hydrogenation rhodium catalyst - useful in high yield prodn. of doxycycline by stereospecific hydrogenation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639439A (en) * 1964-12-10 1972-02-01 Shell Oil Co Rhodium (i) halide complexes
US3489786A (en) * 1964-12-10 1970-01-13 Shell Oil Co Hydrogenation process
GB1121643A (en) * 1966-02-07 1968-07-31 Ici Ltd Hydrogenation process
CH579531A5 (fi) * 1972-02-24 1976-09-15 Ankerfarm Spa
AR208347A1 (es) * 1974-12-19 1976-12-20 Pfizer Mejora en la produccion de alfa-6-deoxitetraciclinas

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0086046A1 (en) * 1982-01-19 1983-08-17 Plurichemie Anstalt A process for the preparation of alpha-6-DEOXYTETRACYCLINES
FR2530490A1 (fr) * 1982-01-19 1984-01-27 Plurichemie Anstalt Procede de preparation de nouveaux catalyseurs contenant du rhodium et leur application
US4500458A (en) * 1982-01-19 1985-02-19 Plurichemie Anstalt Process for the preparation of α-6-deoxytetracyclines
USRE32535E (en) * 1982-01-19 1987-10-27 Plurichemie Anstalt Process for the preparation of α-6-deoxytetracyclines
US4597904A (en) * 1983-08-17 1986-07-01 Hovione Inter Ltd. Process for the preparation of α-6-deoxy-tetracyclines
US4973719A (en) * 1988-10-28 1990-11-27 Ranbaxy Laboratories Limited Process for the production of alpha-6-deoxytetracyclines
US4987242A (en) * 1988-10-28 1991-01-22 Jagmohan Khanna Hydrogenation catalyst useful in the production of alpha-6-deoxytetracyclines
US5049683A (en) * 1989-01-04 1991-09-17 Houba, Inc. Process for the production of alpha-6-deoxytetracyclines
US4997959A (en) * 1989-04-03 1991-03-05 Ranbaxy Laboratories Limited Process for the production of alpha-6-deoxytetracyclines

Also Published As

Publication number Publication date
IN138662B (fi) 1976-03-06
ES422758A1 (es) 1976-08-01
NO151585C (no) 1985-05-08
NO740320L (no) 1974-08-02
NO151585B (no) 1985-01-21
CH589605A5 (fi) 1977-07-15
YU39915B (en) 1985-06-30
CA1027117A (en) 1978-02-28
FI58492C (fi) 1986-09-05
DE2403714C2 (de) 1987-04-09
NO153806B (no) 1986-02-17
IE38797B1 (en) 1978-06-07
SE435619C (sv) 1985-11-18
IL44084A (en) 1977-10-31
DD110855A5 (fi) 1975-01-12
NL7401340A (fi) 1974-08-05
AU6490674A (en) 1975-07-31
PH14446A (en) 1981-07-22
FR2216268B1 (fi) 1978-01-06
NL166921B (nl) 1981-05-15
DE2403714A1 (de) 1974-08-22
NO153806C (no) 1986-05-28
IE38797L (en) 1974-08-01
LU69288A1 (fi) 1974-09-25
IL44084A0 (en) 1974-05-16
SE435619B (sv) 1984-10-08
FI58492B (fi) 1980-10-31
JPS5912111B2 (ja) 1984-03-21
SE7400879L (fi) 1974-09-12
YU25374A (en) 1982-02-28
NO843825L (no) 1974-08-02
JPS49102662A (fi) 1974-09-27
AR210453A1 (es) 1977-08-15

Similar Documents

Publication Publication Date Title
GEP19970948B (en) Method for Production of Imidazolidine
GB1377233A (en) Substituted para-fluorophenols and their use as cyan couplers
GB1472050A (en) Non-ionic x-ray contrast agents
ATE58534T1 (de) 2-pyrimidinyl-l-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
FR2216268A1 (en) Catalytic hydrogenation of 6-methylenetetracyclines - using rhodium-tert phosphine complex catalyst giving a stereospecific prod. in high yield
DE3680800D1 (de) Verfahren zur herstellung von (6r)-tetrahydro-l-biopterin.
ES423736A1 (es) Procedimiento para la preparacion de aldehido 3-metil-mer- capto-propionico.
GB1454801A (en) 1,3-oxazino 5,6-c- rifamycins and method for preparing same
ES436314A1 (es) Procedimiento para la preparacion de nuevos 1-ariloxi-2-hi- droxi-3-alquinilaminopropanos.
ES423824A1 (es) Procedimiento para la obtencion de compuestos azoicos que contienen como minimo un grupo ciano en la posicion orto conrelacion al puente azoico.
GB925429A (en) Indole derivatives
ES425221A1 (es) Procedimiento mejorado para producir 6-desoxitetraciclinas.
BE810415A (en) Catalytic hydrogenation of 6-methylenetetracyclines - using rhodium-tert phosphine complex catalyst giving a stereospecific prod. in high yield
ES426340A1 (es) Procedimiento para la obtencion de lactonas.
ES453544A1 (es) Un procedimiento para la preparacion de derivados de etila- mina.
PH10050A (en) Method of producing l-glutamic acid by fermentation
GB1243214A (en) Nucleoside 6'-phosphonic acids and the corresponding phosphonates
AT342583B (de) Verfahren zur herstellung von neuen carbazol-derivaten
ES371134A1 (es) Un procedimiento para producir derivados de benzodiazepin-2-ona.
BG35036A3 (en) Method for preparing aromatic amines
GB1306725A (en) Hydrogenated benz-epsilon-indenes and phenanthrenes and a process for the preparation thereof
ES431912A1 (es) Un procedimiento mejorado para la preparacion de un agente antibacteriano.
GB1290361A (fi)
GB1440372A (en) Process for the preparation of tetracyclines
DK347684A (da) Fremgangsmaade til epoxidisomerisering

Legal Events

Date Code Title Description
CL Concession to grant licences
CD Change of name or company name
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0359, 920601

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0359, 740201

CL Concession to grant licences
CL Concession to grant licences