IE38797L - 6 - deoxytetracyclines - Google Patents

6 - deoxytetracyclines

Info

Publication number
IE38797L
IE38797L IE740159A IE15974A IE38797L IE 38797 L IE38797 L IE 38797L IE 740159 A IE740159 A IE 740159A IE 15974 A IE15974 A IE 15974A IE 38797 L IE38797 L IE 38797L
Authority
IE
Ireland
Prior art keywords
catalyst
tetracycline
alkyl
methylenetetracyclines
anhydrotetracyclines
Prior art date
Application number
IE740159A
Other versions
IE38797B1 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27406609&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE38797(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of IE38797L publication Critical patent/IE38797L/en
Publication of IE38797B1 publication Critical patent/IE38797B1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/645—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/822—Rhodium

Abstract

6-Methylenetetracyclines are hydrogenated by treating a tetracycline with an exocyclic methylene group with H2 in the presence of a catalyst consisting of a complex of rhodium with a tertiary phosphine of formula PR1R2R3, (where R1 and R2 are phenyl opt. substd. by e.g. alkyl, alkoxy, halogen or dialkylamino gps; and R3 and R gamma are alkyl or benzyl gp), in a solvent which dissolves both the tetracycline and the catalyst. The process produces little or no undesired anhydrotetracyclines, the reduction is practically quantitative and the catalyst is stereoselective to the production of the 6 alpha-epimer. [FR2216268A1]
IE159/74A 1973-02-01 1974-01-28 Process for the preparation of tetracyclines IE38797B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32851473A 1973-02-01 1973-02-01
US36806073A 1973-06-08 1973-06-08
US42827873A 1973-12-26 1973-12-26

Publications (2)

Publication Number Publication Date
IE38797L true IE38797L (en) 1974-08-01
IE38797B1 IE38797B1 (en) 1978-06-07

Family

ID=27406609

Family Applications (1)

Application Number Title Priority Date Filing Date
IE159/74A IE38797B1 (en) 1973-02-01 1974-01-28 Process for the preparation of tetracyclines

Country Status (18)

Country Link
JP (1) JPS5912111B2 (en)
AR (1) AR210453A1 (en)
CA (1) CA1027117A (en)
CH (1) CH589605A5 (en)
DD (1) DD110855A5 (en)
DE (1) DE2403714A1 (en)
ES (1) ES422758A1 (en)
FI (1) FI58492C (en)
FR (1) FR2216268A1 (en)
IE (1) IE38797B1 (en)
IL (1) IL44084A (en)
IN (1) IN138662B (en)
LU (1) LU69288A1 (en)
NL (1) NL166921B (en)
NO (2) NO151585C (en)
PH (1) PH14446A (en)
SE (1) SE435619C (en)
YU (1) YU39915B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR208347A1 (en) * 1974-12-19 1976-12-20 Pfizer IMPROVEMENT IN THE PRODUCTION OF ALPHA-6-DEOXYTETRACYCLINES
YU41093B (en) * 1978-04-12 1986-12-31 Pliva Pharm & Chem Works Process for preparing 6-deoxy-5hydroxy-tetracycline
US4550096A (en) * 1982-01-19 1985-10-29 Plurichemie Anstalt Homogeneous catalytic system comprising rhodium, hydrazine and phosphine and a process for the preparation of same
PT76061A (en) * 1982-12-30 1983-01-01 Stable homogeneous hydrogenation rhodium catalyst - useful in high yield prodn. of doxycycline by stereospecific hydrogenation
USRE32535E (en) * 1982-01-19 1987-10-27 Plurichemie Anstalt Process for the preparation of α-6-deoxytetracyclines
DK386784A (en) * 1983-08-17 1985-02-18 Hovione Int Ltd PROCEDURE FOR PREPARING ALFA-6-DESOXY-TETRACYCLINES
US4987242A (en) * 1988-10-28 1991-01-22 Jagmohan Khanna Hydrogenation catalyst useful in the production of alpha-6-deoxytetracyclines
US4973719A (en) * 1988-10-28 1990-11-27 Ranbaxy Laboratories Limited Process for the production of alpha-6-deoxytetracyclines
US5049683A (en) * 1989-01-04 1991-09-17 Houba, Inc. Process for the production of alpha-6-deoxytetracyclines
ATE68476T1 (en) * 1989-04-03 1991-11-15 Ranbaxy Lab Ltd PROCESS FOR THE PRODUCTION OF ALPHA-6DEOXYTETRACYCLINES.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3489786A (en) * 1964-12-10 1970-01-13 Shell Oil Co Hydrogenation process
US3639439A (en) * 1964-12-10 1972-02-01 Shell Oil Co Rhodium (i) halide complexes
GB1121643A (en) * 1966-02-07 1968-07-31 Ici Ltd Hydrogenation process
CH579531A5 (en) * 1972-02-24 1976-09-15 Ankerfarm Spa
AR208347A1 (en) * 1974-12-19 1976-12-20 Pfizer IMPROVEMENT IN THE PRODUCTION OF ALPHA-6-DEOXYTETRACYCLINES

Also Published As

Publication number Publication date
CH589605A5 (en) 1977-07-15
AR210453A1 (en) 1977-08-15
IN138662B (en) 1976-03-06
SE7400879L (en) 1974-09-12
FI58492C (en) 1986-09-05
NL166921B (en) 1981-05-15
IL44084A (en) 1977-10-31
LU69288A1 (en) 1974-09-25
YU39915B (en) 1985-06-30
NO153806C (en) 1986-05-28
NO153806B (en) 1986-02-17
JPS49102662A (en) 1974-09-27
NO740320L (en) 1974-08-02
NO151585C (en) 1985-05-08
NO151585B (en) 1985-01-21
FI58492B (en) 1980-10-31
DE2403714A1 (en) 1974-08-22
SE435619B (en) 1984-10-08
IL44084A0 (en) 1974-05-16
DE2403714C2 (en) 1987-04-09
FR2216268B1 (en) 1978-01-06
ES422758A1 (en) 1976-08-01
SE435619C (en) 1985-10-31
PH14446A (en) 1981-07-22
NO843825L (en) 1974-08-02
AU6490674A (en) 1975-07-31
JPS5912111B2 (en) 1984-03-21
FR2216268A1 (en) 1974-08-30
IE38797B1 (en) 1978-06-07
NL7401340A (en) 1974-08-05
DD110855A5 (en) 1975-01-12
CA1027117A (en) 1978-02-28
YU25374A (en) 1982-02-28

Similar Documents

Publication Publication Date Title
GB1472050A (en) Non-ionic x-ray contrast agents
IE38797L (en) 6 - deoxytetracyclines
ATE63913T1 (en) PYRAZOLO(3,4-B)PYRIDINE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION.
IE39482L (en) Propanolamines
ES423824A1 (en) Process for the preparation of cyanoazo compounds by reacting halogenoazo compounds with CuCN in an aqueous media in the presence of a nitrogen base
ES8105682A1 (en) A process of preparing platinum complexes.
GB1359542A (en) Diglycidyl derivatives of n-heterocyclic compounds processes for their production and the use thereof
ES431368A1 (en) Process for isolating easily soluble basic oxazine dyestuffs and phenazine dyestuffs
FR2379517A1 (en) METHOD FOR INTRODUCING A CARBONYL GROUP INTO A CYCLOHEXENE CORE
IE41509L (en) Process for di- and triamino naphthalene production
CS183634B2 (en) Method for producing novel derivatives of 2-aminomethyl-4,6-dihalogenephenol
BE810415A (en) Catalytic hydrogenation of 6-methylenetetracyclines - using rhodium-tert phosphine complex catalyst giving a stereospecific prod. in high yield
ES481264A1 (en) Arylacetic acid derivatives
CA1018918A (en) Process for producing cells of methanol-utilizing microorganisms
ATE30159T1 (en) ANTHRACYCLIN DERIVATIVES, PROCESS FOR THEIR PRODUCTION STARTING FROM A MICROORGANISM STRAIN, THE NEW STREPTOMYCES CYANEUS STRAIN AND THE USE OF ANTHRACYCLIN DERIVATIVES AS PHARMACEUTICAL PREPARATIONS.
ES452736A1 (en) Novel antifertility agents
IE39603B1 (en) Coloured fungicidal compositions, and processes for their preparation
CA1014879A (en) Process for culturing methanol-utilizing yeasts
PT65798A (en) IMIDAZOIDIDE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS PLANT GROWTH REGULATORS
ES371134A1 (en) Process for preparing 1,4-benzodiazepin-2-ones
KR830000210A (en) Hydrogenation method of 6-methylene tetracycline compound having an off-ring methylene group
GB1464432A (en) Indolobenzazepine derivatives
ES459821A1 (en) 1,3-Dihydrospiro{8 isobenzofuran-1,4{40 -piperidine{9 s
GB1290361A (en)
KR800001279B1 (en) Process preparing for pyrolidine derivatives