ES422758A1 - Procedure for catalytic reduction of 6-methylenetracyclines. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for catalytic reduction of 6-methylenetracyclines. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES422758A1
ES422758A1 ES422758A ES422758A ES422758A1 ES 422758 A1 ES422758 A1 ES 422758A1 ES 422758 A ES422758 A ES 422758A ES 422758 A ES422758 A ES 422758A ES 422758 A1 ES422758 A1 ES 422758A1
Authority
ES
Spain
Prior art keywords
translation
procedure
machine
legally binding
google translate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES422758A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27406609&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES422758(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES422758A1 publication Critical patent/ES422758A1/en
Expired legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/645—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/822—Rhodium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Procedure for the catalytic reduction of 6-methylenetetracyclines, characterized by treating a tetracycline compound, having an exocyclic methylene group, with hydrogen, in the presence of a catalyst that contains a rhodium complex with a tertiary phosphine of the formula: PR1R2R3 wherein: each of the symbols R1 and R2 is selected from the group consisting of phenyl and substituted phenyl, the substituent of which is selected from the group consisting of halogen, alkyl, alkoxy and dialkylamino and R3 is selected from the group consisting of R1, alkyl and benzyl, in a solvent medium in which the tetracycline compound and the catalyst are soluble. (Machine-translation by Google Translate, not legally binding)
ES422758A 1973-02-01 1974-01-30 Procedure for catalytic reduction of 6-methylenetracyclines. (Machine-translation by Google Translate, not legally binding) Expired ES422758A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32851473A 1973-02-01 1973-02-01
US36806073A 1973-06-08 1973-06-08
US42827873A 1973-12-26 1973-12-26

Publications (1)

Publication Number Publication Date
ES422758A1 true ES422758A1 (en) 1976-08-01

Family

ID=27406609

Family Applications (1)

Application Number Title Priority Date Filing Date
ES422758A Expired ES422758A1 (en) 1973-02-01 1974-01-30 Procedure for catalytic reduction of 6-methylenetracyclines. (Machine-translation by Google Translate, not legally binding)

Country Status (18)

Country Link
JP (1) JPS5912111B2 (en)
AR (1) AR210453A1 (en)
CA (1) CA1027117A (en)
CH (1) CH589605A5 (en)
DD (1) DD110855A5 (en)
DE (1) DE2403714A1 (en)
ES (1) ES422758A1 (en)
FI (1) FI58492C (en)
FR (1) FR2216268A1 (en)
IE (1) IE38797B1 (en)
IL (1) IL44084A (en)
IN (1) IN138662B (en)
LU (1) LU69288A1 (en)
NL (1) NL166921B (en)
NO (2) NO151585C (en)
PH (1) PH14446A (en)
SE (1) SE435619C (en)
YU (1) YU39915B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR208347A1 (en) * 1974-12-19 1976-12-20 Pfizer IMPROVEMENT IN THE PRODUCTION OF ALPHA-6-DEOXYTETRACYCLINES
YU41093B (en) * 1978-04-12 1986-12-31 Pliva Pharm & Chem Works Process for preparing 6-deoxy-5hydroxy-tetracycline
US4500458A (en) * 1982-01-19 1985-02-19 Plurichemie Anstalt Process for the preparation of α-6-deoxytetracyclines
USRE32535E (en) * 1982-01-19 1987-10-27 Plurichemie Anstalt Process for the preparation of α-6-deoxytetracyclines
PT76061A (en) * 1982-12-30 1983-01-01 Stable homogeneous hydrogenation rhodium catalyst - useful in high yield prodn. of doxycycline by stereospecific hydrogenation
DK386784A (en) * 1983-08-17 1985-02-18 Hovione Int Ltd PROCEDURE FOR PREPARING ALFA-6-DESOXY-TETRACYCLINES
US4987242A (en) * 1988-10-28 1991-01-22 Jagmohan Khanna Hydrogenation catalyst useful in the production of alpha-6-deoxytetracyclines
US4973719A (en) * 1988-10-28 1990-11-27 Ranbaxy Laboratories Limited Process for the production of alpha-6-deoxytetracyclines
US5049683A (en) * 1989-01-04 1991-09-17 Houba, Inc. Process for the production of alpha-6-deoxytetracyclines
DE68900339D1 (en) * 1989-04-03 1991-11-21 Ranbaxy Lab Ltd METHOD FOR PRODUCING ALPHA-6-DEOXYTETRACYCLINES.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639439A (en) * 1964-12-10 1972-02-01 Shell Oil Co Rhodium (i) halide complexes
US3489786A (en) * 1964-12-10 1970-01-13 Shell Oil Co Hydrogenation process
GB1121643A (en) * 1966-02-07 1968-07-31 Ici Ltd Hydrogenation process
CH579531A5 (en) * 1972-02-24 1976-09-15 Ankerfarm Spa
AR208347A1 (en) * 1974-12-19 1976-12-20 Pfizer IMPROVEMENT IN THE PRODUCTION OF ALPHA-6-DEOXYTETRACYCLINES

Also Published As

Publication number Publication date
NL166921B (en) 1981-05-15
NO740320L (en) 1974-08-02
NO151585B (en) 1985-01-21
DD110855A5 (en) 1975-01-12
YU25374A (en) 1982-02-28
CA1027117A (en) 1978-02-28
NO153806B (en) 1986-02-17
AU6490674A (en) 1975-07-31
YU39915B (en) 1985-06-30
JPS49102662A (en) 1974-09-27
JPS5912111B2 (en) 1984-03-21
NO153806C (en) 1986-05-28
DE2403714A1 (en) 1974-08-22
SE435619B (en) 1984-10-08
IL44084A (en) 1977-10-31
NL7401340A (en) 1974-08-05
FI58492B (en) 1980-10-31
DE2403714C2 (en) 1987-04-09
CH589605A5 (en) 1977-07-15
FI58492C (en) 1986-09-05
IE38797L (en) 1974-08-01
AR210453A1 (en) 1977-08-15
FR2216268B1 (en) 1978-01-06
SE435619C (en) 1985-11-18
SE7400879L (en) 1974-09-12
NO843825L (en) 1974-08-02
NO151585C (en) 1985-05-08
IL44084A0 (en) 1974-05-16
PH14446A (en) 1981-07-22
IN138662B (en) 1976-03-06
FR2216268A1 (en) 1974-08-30
IE38797B1 (en) 1978-06-07
LU69288A1 (en) 1974-09-25

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