ES433299A1 - Procedure for the preparation of new benzopiran derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new benzopiran derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES433299A1 ES433299A1 ES74433299A ES433299A ES433299A1 ES 433299 A1 ES433299 A1 ES 433299A1 ES 74433299 A ES74433299 A ES 74433299A ES 433299 A ES433299 A ES 433299A ES 433299 A1 ES433299 A1 ES 433299A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- see
- dibenzo
- pyran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
Abstract
Procedure for the preparation of new benzopyran derivatives, which have the general formula (I) **(See formula)** in which the symbol (see graphic) represents a double or single bond; one of the radicals R1 and R3 is an amine, unsubstituted or mono- or di-alkyl-substituted group or a heteromonocyclic radical containing, optionally, another heteroatom chosen from the group consisting of N, O, S and the other is hydrogen or a unsubstituted or mono-di-alkyl-substituted amine group or a heteromonocyclic radical as indicated above; each of the radicals R2 and R4, the same or different, can be hydrogen, halogen, hydroxyl, alkyl, alkoxy or trifluoromethyl; X can be (see formula), wherein R5 and R6 can be hydrogen or alkyl, and a respective pharmaceutically acceptable salt; with the exclusion of the following compounds: - 2-amino-6-oxo-6H-dibenzo [b, d] pyran, - 3-amino-6-oxo-6H-dibenzo [b, d] pyran, - 8-amino-6-oxo-6H-dibenzo [b, d] pyran, - 3-amino-8-methoxy-6-oxo-6H-dibenzo [b, d] pyran, - 3-amino-6-oxo-7,8,9,10-tetrahydro-6H-dibenzo [b, d] pyran, - 9-methyl-3-dimethylamino-6-oxo-7,8,9,10-tetrahydro-6H-dibenzo [b, d] pyran, - 3-dialkylamino-6-oxo-7,8,9,10-tetrahydro-6H-dibenzo- [b, d] pyran, characterized by reacting a compound of formula (II) **(See formula)** in which R3 and R4 have the meaning indicated above and R7 is an alkyl group, with a compound of the formula (III) **(See formula)** in which R1 and R2 have the meaning indicated above and R is hydrogen or alkyl, to obtain a compound of formula (I) where X is (see formula) and the symbol (see graph) represents a single bond and, if desired, dehydrogenating the compound of formula (I), thus obtained, to provide a compound of formula (I) where the symbol (see graph) represents a double bond and/or, if desired, reduce a compound of formula (I) where X is (see formula) to a compound of formula (I) where X is -CH2- and/or if desired, convert a compound of formula (I), where X is (see formula) in a compound of formula (I) where X is (see formula), where R5 and R6 are alkyl groups, by means of a Grignard reaction. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT3208873 | 1973-12-27 | ||
| IT2029474 | 1974-02-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES433299A1 true ES433299A1 (en) | 1976-12-01 |
Family
ID=26327481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES74433299A Expired ES433299A1 (en) | 1973-12-27 | 1974-12-24 | Procedure for the preparation of new benzopiran derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5096574A (en) |
| AU (1) | AU7612874A (en) |
| BE (1) | BE823873A (en) |
| DD (1) | DD115661A5 (en) |
| DE (1) | DE2459076A1 (en) |
| DK (1) | DK680174A (en) |
| ES (1) | ES433299A1 (en) |
| FI (1) | FI367874A (en) |
| FR (1) | FR2255895A1 (en) |
| IL (1) | IL46614A0 (en) |
| NL (1) | NL7416454A (en) |
| NO (1) | NO744713L (en) |
| SE (1) | SE7416126L (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4152450A (en) * | 1978-02-17 | 1979-05-01 | Eli Lilly And Company | 9-Amino-dibenzopyrans |
| ZA817002B (en) * | 1980-10-20 | 1982-09-29 | Erba Farmitalia | 6-substituted 6h-dibenzo(b,d)pyran derivatives and process for their preparation |
| CA2496097A1 (en) * | 2002-08-23 | 2004-03-04 | University Of Connecticut | Keto cannabinoids with therapeutic indications |
| AU2007219981B2 (en) * | 2006-02-28 | 2013-11-07 | Paloma Pharmaceuticals, Inc. | Compositions and methods to treat diseases characterized by cellular proliferation and angiogenesis |
| WO2012112791A1 (en) | 2011-02-16 | 2012-08-23 | Paloma Pharmaceuticals, Inc. | Radiation countermeasure agents |
-
1974
- 1974-12-05 AU AU76128/74A patent/AU7612874A/en not_active Expired
- 1974-12-13 DE DE19742459076 patent/DE2459076A1/en active Pending
- 1974-12-17 NL NL7416454A patent/NL7416454A/en unknown
- 1974-12-19 FI FI3678/74A patent/FI367874A/fi unknown
- 1974-12-20 SE SE7416126A patent/SE7416126L/xx unknown
- 1974-12-23 DK DK680174A patent/DK680174A/da unknown
- 1974-12-24 ES ES74433299A patent/ES433299A1/en not_active Expired
- 1974-12-24 DD DD183412A patent/DD115661A5/xx unknown
- 1974-12-27 NO NO744713A patent/NO744713L/no unknown
- 1974-12-27 BE BE151938A patent/BE823873A/en unknown
- 1974-12-27 JP JP50003007A patent/JPS5096574A/ja active Pending
- 1974-12-27 FR FR7443124A patent/FR2255895A1/en not_active Withdrawn
-
1975
- 1975-02-11 IL IL46614A patent/IL46614A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL46614A0 (en) | 1975-05-22 |
| BE823873A (en) | 1975-04-16 |
| DE2459076A1 (en) | 1975-07-10 |
| JPS5096574A (en) | 1975-07-31 |
| NL7416454A (en) | 1975-07-01 |
| AU7612874A (en) | 1976-06-10 |
| FI367874A (en) | 1975-06-28 |
| NO744713L (en) | 1975-07-21 |
| SE7416126L (en) | 1975-06-30 |
| DD115661A5 (en) | 1975-10-12 |
| DK680174A (en) | 1975-08-25 |
| FR2255895A1 (en) | 1975-07-25 |
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