ES428063A1 - 2,3-methylene prostaglandins and their preparation - Google Patents

2,3-methylene prostaglandins and their preparation

Info

Publication number
ES428063A1
ES428063A1 ES74428063A ES428063A ES428063A1 ES 428063 A1 ES428063 A1 ES 428063A1 ES 74428063 A ES74428063 A ES 74428063A ES 428063 A ES428063 A ES 428063A ES 428063 A1 ES428063 A1 ES 428063A1
Authority
ES
Spain
Prior art keywords
formula
carbon atoms
see formula
iib
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES74428063A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH995973A external-priority patent/CH599147A5/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES428063A1 publication Critical patent/ES428063A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for the production of cyclopropane derivatives, of formula I: ** (See formula) ** where D is one of the four carbocycles of formulas IIa, IIb, IIc or IId, ** (See formula) ** R1 is hydrogen or alkyl of 1 to 8 carbon atoms, cycloalkyl of 3 to 10 carbon atoms or aralkyl of 7 to 12 carbon atoms, and R2 and R3 are, independently, hydrogen or alkyl of 1 to 4 carbon atoms; characterized in that any protecting group present in a compound of formula III is removed, ** (See formula) ** wherein R1, R2 and R3 have the meanings indicated above, R4 is trialkylsilyl or tetrahydropyranyl, and A is a carbocycle of formula IIa or IIb, defined above, or of formula IIe or IIf: ** (See formula) ** by hydrolysis in an acidic medium, preferably at a slightly elevated temperature. (Machine-translation by Google Translate, not legally binding)
ES74428063A 1973-07-09 1974-07-08 2,3-methylene prostaglandins and their preparation Expired ES428063A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH995973A CH599147A5 (en) 1973-07-09 1973-07-09 Long-acting synthetic prostaglandins
CH604974 1974-05-04

Publications (1)

Publication Number Publication Date
ES428063A1 true ES428063A1 (en) 1977-02-01

Family

ID=25698889

Family Applications (2)

Application Number Title Priority Date Filing Date
ES74428063A Expired ES428063A1 (en) 1973-07-09 1974-07-08 2,3-methylene prostaglandins and their preparation
ES448000A Expired ES448000A1 (en) 1973-07-09 1976-05-17 2,3-methylene prostaglandins and their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES448000A Expired ES448000A1 (en) 1973-07-09 1976-05-17 2,3-methylene prostaglandins and their preparation

Country Status (15)

Country Link
JP (1) JPS5040549A (en)
AT (1) AT355233B (en)
CA (1) CA1050976A (en)
DD (1) DD113348A5 (en)
DE (1) DE2431930A1 (en)
DK (1) DK142143B (en)
ES (2) ES428063A1 (en)
FI (1) FI58117C (en)
FR (2) FR2236490B1 (en)
GB (2) GB1479965A (en)
IE (1) IE41342B1 (en)
IL (1) IL45215A (en)
NL (1) NL7409119A (en)
NO (1) NO742378L (en)
SE (2) SE7408689L (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2638401A1 (en) * 1975-09-05 1977-03-17 Sandoz Ag NEW PROSTAGLANDIN, THEIR USE AND MANUFACTURING
JPS52116930U (en) * 1976-03-03 1977-09-05
JPS55147056U (en) * 1979-04-06 1980-10-22
US4431669A (en) * 1982-12-17 1984-02-14 Schering Corporation Cyclopropyl substituted polyenes
JPH04204679A (en) * 1990-11-30 1992-07-27 Fuji Photo Film Co Ltd Electrophotographic image recorder

Also Published As

Publication number Publication date
NL7409119A (en) 1975-01-13
IL45215A0 (en) 1975-02-10
AT355233B (en) 1980-02-25
ES448000A1 (en) 1977-11-01
DD113348A5 (en) 1975-06-05
IE41342B1 (en) 1979-12-05
FR2318169A1 (en) 1977-02-11
FI201174A (en) 1975-01-10
FR2236490B1 (en) 1978-07-21
JPS5040549A (en) 1975-04-14
GB1479965A (en) 1977-07-13
IL45215A (en) 1977-07-31
NO742378L (en) 1975-02-03
GB1479964A (en) 1977-07-13
FR2318169B1 (en) 1978-11-03
ATA559874A (en) 1979-07-15
CA1050976A (en) 1979-03-20
FI58117C (en) 1980-12-10
DK352974A (en) 1975-03-03
SE7512194L (en) 1975-10-30
IE41342L (en) 1975-01-09
FR2236490A1 (en) 1975-02-07
DE2431930A1 (en) 1975-01-30
DK142143B (en) 1980-09-08
FI58117B (en) 1980-08-29
SE7408689L (en) 1975-01-10
DK142143C (en) 1981-02-09

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