ES424851A1 - A procedure for preparing piperazine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for preparing piperazine derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES424851A1
ES424851A1 ES424851A ES424851A ES424851A1 ES 424851 A1 ES424851 A1 ES 424851A1 ES 424851 A ES424851 A ES 424851A ES 424851 A ES424851 A ES 424851A ES 424851 A1 ES424851 A1 ES 424851A1
Authority
ES
Spain
Prior art keywords
formula
translation
procedure
machine
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES424851A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP3845373A external-priority patent/JPS5546400B2/ja
Priority claimed from JP5654473A external-priority patent/JPS565753B2/ja
Priority claimed from JP6446473A external-priority patent/JPS565755B2/ja
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Publication of ES424851A1 publication Critical patent/ES424851A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

A procedure for preparing piperazine derivatives of the formula **(See formula)** wherein R1 is a hydrogen atom or a lower alcohol group, and its pharmaceutically acceptable salt, comprising: subjecting a Dieckmann reaction to a compound of the formula **(See formula)** where R'1 is a hydrogen atom, a lower alcohol group or an acyl group and R2 is a cyano group, a lower alkoxycarbonyl group or a lower alkanoyl group, dehydrogenating the resulting compound of the formula **(See formula)** and then oxidize or hydrolyze the compound resulting from the formula **(See formula)** and if desired, converting the resulting compound to a pharmaceutically acceptable salt. (Machine-translation by Google Translate, not legally binding)
ES424851A 1973-04-03 1974-04-02 A procedure for preparing piperazine derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES424851A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3845373A JPS5546400B2 (en) 1973-04-03 1973-04-03
JP5654473A JPS565753B2 (en) 1973-05-21 1973-05-21
JP6446473A JPS565755B2 (en) 1973-06-07 1973-06-07

Publications (1)

Publication Number Publication Date
ES424851A1 true ES424851A1 (en) 1976-06-01

Family

ID=27289838

Family Applications (1)

Application Number Title Priority Date Filing Date
ES424851A Expired ES424851A1 (en) 1973-04-03 1974-04-02 A procedure for preparing piperazine derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (11)

Country Link
AR (2) AR204003A1 (en)
AT (1) AT340931B (en)
CA (1) CA1066701A (en)
CH (1) CH593281A5 (en)
ES (1) ES424851A1 (en)
FI (1) FI56011C (en)
IE (1) IE39102B1 (en)
NL (1) NL186087C (en)
NO (1) NO142221C (en)
PH (2) PH10529A (en)
SE (1) SE416051B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1209163B (en) * 1979-12-21 1989-07-10 Unibios S P A Trecate Novara PROCEDURE FOR THE MANUFACTURE OF: 6-ALCOSSICARBONIL-8-ETHYL-5-OXO-5,8 DIIDRO-APERTA PAR. SQUARE 2,3-DCHIUSA PAR. SQUARE-PRIMIDINE 2-REPLACED AND ACID CORRESPONDING BOOKS.
AR077280A1 (en) 2009-06-29 2011-08-17 Incyte Corp PYRIMIDINONES AS PI3K INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM
WO2011075630A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors
WO2011075643A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
TW201249844A (en) 2010-12-20 2012-12-16 Incyte Corp N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors
SI2751109T1 (en) 2011-09-02 2017-03-31 Incyte Holdings Corporation Heterocyclylamines as pi3k inhibitors
AR090548A1 (en) 2012-04-02 2014-11-19 Incyte Corp BICYCLIC AZAHETEROCICLOBENCILAMINS AS PI3K INHIBITORS
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
CN117800973A (en) 2015-02-27 2024-04-02 因赛特控股公司 Salts of PI3K inhibitors and methods of making the same
WO2016183060A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor

Also Published As

Publication number Publication date
NO740349L (en) 1974-10-04
CH593281A5 (en) 1977-11-30
PH10984A (en) 1977-10-18
NO142221B (en) 1980-04-08
PH10529A (en) 1977-05-30
NL186087C (en) 1990-09-17
AR204003A1 (en) 1975-11-12
NL7401509A (en) 1974-10-07
AT340931B (en) 1978-01-10
FI56011C (en) 1979-11-12
IE39102B1 (en) 1978-08-02
IE39102L (en) 1974-10-03
NL186087B (en) 1990-04-17
NO142221C (en) 1980-07-16
FI56011B (en) 1979-07-31
ATA277774A (en) 1977-05-15
AR204660A1 (en) 1976-02-20
SE416051B (en) 1980-11-24
CA1066701A (en) 1979-11-20

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