FR2191889A1 - 4,4,5-Triphenyl-oxazolidin-2-one derivs - analgesics, antiinflammatories and sedatives from triphenyl-amino-ethanols with ethyl carbonate - Google Patents

4,4,5-Triphenyl-oxazolidin-2-one derivs - analgesics, antiinflammatories and sedatives from triphenyl-amino-ethanols with ethyl carbonate

Info

Publication number
FR2191889A1
FR2191889A1 FR7225427A FR7225427A FR2191889A1 FR 2191889 A1 FR2191889 A1 FR 2191889A1 FR 7225427 A FR7225427 A FR 7225427A FR 7225427 A FR7225427 A FR 7225427A FR 2191889 A1 FR2191889 A1 FR 2191889A1
Authority
FR
France
Prior art keywords
triphenyl
ethanols
derivs
amino
ethyl carbonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7225427A
Other languages
French (fr)
Other versions
FR2191889B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7225427A priority Critical patent/FR2191889A1/en
Publication of FR2191889A1 publication Critical patent/FR2191889A1/en
Application granted granted Critical
Publication of FR2191889B1 publication Critical patent/FR2191889B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel exazolidinone derivs of formula (I): (where Ar is a phenyl gp substd >=1 of 1-4C alkoxy, -OCH2O-, 1-4C alkoxy, -OCH2O-, 1-4C alkyl, or di-1-4C alkylamino gps), are prepd by reacting 1,1,2-triphenyl-1-amino-2-ethanols (II) with ethyl carbonate in the presence of NaOCH3. Cpds (I) are administered orally, in doses of 100-400 mg 1-5 times daily, or rectally, in doses of 100-300 mg 12-times daily.
FR7225427A 1972-07-13 1972-07-13 4,4,5-Triphenyl-oxazolidin-2-one derivs - analgesics, antiinflammatories and sedatives from triphenyl-amino-ethanols with ethyl carbonate Granted FR2191889A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7225427A FR2191889A1 (en) 1972-07-13 1972-07-13 4,4,5-Triphenyl-oxazolidin-2-one derivs - analgesics, antiinflammatories and sedatives from triphenyl-amino-ethanols with ethyl carbonate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7225427A FR2191889A1 (en) 1972-07-13 1972-07-13 4,4,5-Triphenyl-oxazolidin-2-one derivs - analgesics, antiinflammatories and sedatives from triphenyl-amino-ethanols with ethyl carbonate

Publications (2)

Publication Number Publication Date
FR2191889A1 true FR2191889A1 (en) 1974-02-08
FR2191889B1 FR2191889B1 (en) 1975-08-08

Family

ID=9101806

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7225427A Granted FR2191889A1 (en) 1972-07-13 1972-07-13 4,4,5-Triphenyl-oxazolidin-2-one derivs - analgesics, antiinflammatories and sedatives from triphenyl-amino-ethanols with ethyl carbonate

Country Status (1)

Country Link
FR (1) FR2191889A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3019231A (en) * 1959-05-11 1962-01-30 Jefferson Chem Co Inc Method of transvinylating
CH401059A (en) * 1961-04-04 1965-10-31 Science Union & Compagnie Soci Process for the preparation of new derivatives of Oxazolidone-2

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3019231A (en) * 1959-05-11 1962-01-30 Jefferson Chem Co Inc Method of transvinylating
CH401059A (en) * 1961-04-04 1965-10-31 Science Union & Compagnie Soci Process for the preparation of new derivatives of Oxazolidone-2

Also Published As

Publication number Publication date
FR2191889B1 (en) 1975-08-08

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Legal Events

Date Code Title Description
ST Notification of lapse