FR2189019A2 - Water-soluble immunological adjuvant - consisting of an oligomer of microbial cell wall components - Google Patents
Water-soluble immunological adjuvant - consisting of an oligomer of microbial cell wall componentsInfo
- Publication number
- FR2189019A2 FR2189019A2 FR7222120A FR7222120A FR2189019A2 FR 2189019 A2 FR2189019 A2 FR 2189019A2 FR 7222120 A FR7222120 A FR 7222120A FR 7222120 A FR7222120 A FR 7222120A FR 2189019 A2 FR2189019 A2 FR 2189019A2
- Authority
- FR
- France
- Prior art keywords
- cells
- immunological adjuvant
- esp
- water
- oligomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002421 cell wall Anatomy 0.000 title abstract 3
- 239000000568 immunological adjuvant Substances 0.000 title abstract 3
- 230000000813 microbial effect Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 4
- 241000187654 Nocardia Species 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 abstract 1
- 229930182847 D-glutamic acid Natural products 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- GMKMEZVLHJARHF-WHFBIAKZSA-N LL-2,6-diaminopimelic acid Chemical compound OC(=O)[C@@H](N)CCC[C@H](N)C(O)=O GMKMEZVLHJARHF-WHFBIAKZSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 abstract 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 abstract 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 abstract 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 abstract 1
- MSWZFWKMSRAUBD-QZABAPFNSA-N beta-D-glucosamine Chemical compound N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-QZABAPFNSA-N 0.000 abstract 1
- 229930182830 galactose Natural products 0.000 abstract 1
- 150000002337 glycosamines Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 230000000510 mucolytic effect Effects 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
- A61K2039/55594—Adjuvants of undefined constitution from bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE791472D BE791472A (fr) | 1971-11-19 | Adjuvants immunologiques solubles dans l'eau, notamment pour vaccins, obtenus a partir de mycobacteries et micro-organismes apparentes, et leur procede d'obtention | |
FR7222120A FR2189019A2 (en) | 1971-11-19 | 1972-06-19 | Water-soluble immunological adjuvant - consisting of an oligomer of microbial cell wall components |
LU66491A LU66491A1 (enrdf_load_stackoverflow) | 1971-11-19 | 1972-11-17 | |
NL7215627A NL7215627A (enrdf_load_stackoverflow) | 1971-11-19 | 1972-11-17 | |
OA54751A OA04926A (fr) | 1971-11-19 | 1972-11-18 | Procédé de fabrication d'adjuvants immunologiques solubles dans l'eau, notamment pour vaccins, à partir de mycobactéries et micro-organismes apparentés. |
DE2256838A DE2256838A1 (de) | 1971-11-19 | 1972-11-20 | Wasserloesliches immunologisches adjuvans |
ZA734076A ZA734076B (en) | 1972-06-19 | 1973-06-15 | Water-soluble immunological adjuvants,in particular for vaccines,obtained from mycobacteria and related microorganisms and process for their extraction |
GB2914973A GB1440842A (en) | 1971-11-19 | 1973-06-19 | Immunological adjuvants and process for their preparation |
CA174,362A CA1009972A (en) | 1971-11-19 | 1973-06-19 | Water-soluble immunological adjuvants in particular for vaccines, obtained from mycobacteria and related microorganisms and process for their extraction |
JP6913473A JPS4966817A (enrdf_load_stackoverflow) | 1972-06-19 | 1973-06-19 | |
AU57069/73A AU491315B2 (en) | 1973-06-19 | Water-soluble immunological adjuvants in particular for vaccines, obtained from mycobacteria and related microorganisms and process for their extraction | |
CH888573A CH587346A5 (enrdf_load_stackoverflow) | 1971-11-19 | 1973-06-19 | |
IE100873A IE38154B1 (en) | 1972-06-19 | 1973-06-19 | Immunological adjuvants and process fot their preparation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7141610A FR2160326B1 (enrdf_load_stackoverflow) | 1971-11-19 | 1971-11-19 | |
FR7222120A FR2189019A2 (en) | 1971-11-19 | 1972-06-19 | Water-soluble immunological adjuvant - consisting of an oligomer of microbial cell wall components |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2189019A2 true FR2189019A2 (en) | 1974-01-25 |
FR2189019B2 FR2189019B2 (enrdf_load_stackoverflow) | 1976-01-16 |
Family
ID=26216727
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7222120A Granted FR2189019A2 (en) | 1971-11-19 | 1972-06-19 | Water-soluble immunological adjuvant - consisting of an oligomer of microbial cell wall components |
Country Status (8)
Country | Link |
---|---|
BE (1) | BE791472A (enrdf_load_stackoverflow) |
CA (1) | CA1009972A (enrdf_load_stackoverflow) |
CH (1) | CH587346A5 (enrdf_load_stackoverflow) |
DE (1) | DE2256838A1 (enrdf_load_stackoverflow) |
FR (1) | FR2189019A2 (enrdf_load_stackoverflow) |
LU (1) | LU66491A1 (enrdf_load_stackoverflow) |
NL (1) | NL7215627A (enrdf_load_stackoverflow) |
OA (1) | OA04926A (enrdf_load_stackoverflow) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4186194A (en) * | 1973-10-23 | 1980-01-29 | Agence Nationale De Valorisation De La Recherche (Anvar) | Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents |
FR2682599A1 (fr) * | 1991-10-16 | 1993-04-23 | Debat Lab | Procede pour l'obtention d'extraits parietaux de nocardia, purifies et non pyrogenes, utiles notamment comme reactifs de diagnostic en imagerie medicale. |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3529057A (en) * | 1964-08-14 | 1970-09-15 | Takeda Chemical Industries Ltd | Purified periodic acid-oxidized mucopeptide of mycobacteria cell walls constituting a vaccine enhancing nonspecific host resistance against pathogenic bacterial infections |
-
0
- BE BE791472D patent/BE791472A/xx unknown
-
1972
- 1972-06-19 FR FR7222120A patent/FR2189019A2/fr active Granted
- 1972-11-17 LU LU66491A patent/LU66491A1/xx unknown
- 1972-11-17 NL NL7215627A patent/NL7215627A/xx not_active Application Discontinuation
- 1972-11-18 OA OA54751A patent/OA04926A/xx unknown
- 1972-11-20 DE DE2256838A patent/DE2256838A1/de not_active Withdrawn
-
1973
- 1973-06-19 CH CH888573A patent/CH587346A5/xx not_active IP Right Cessation
- 1973-06-19 CA CA174,362A patent/CA1009972A/en not_active Expired
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3529057A (en) * | 1964-08-14 | 1970-09-15 | Takeda Chemical Industries Ltd | Purified periodic acid-oxidized mucopeptide of mycobacteria cell walls constituting a vaccine enhancing nonspecific host resistance against pathogenic bacterial infections |
Non-Patent Citations (1)
Title |
---|
CHEMICAL ABSTRACTS, VOLUME 74, PAGE 138471P 1971 CITE: REV.ENR.ETUD.CHIM.BIOL. 16 1 , PAGES 55-8 1971 ) * |
Also Published As
Publication number | Publication date |
---|---|
NL7215627A (enrdf_load_stackoverflow) | 1973-05-22 |
FR2189019B2 (enrdf_load_stackoverflow) | 1976-01-16 |
CH587346A5 (enrdf_load_stackoverflow) | 1977-04-29 |
OA04926A (fr) | 1980-10-31 |
CA1009972A (en) | 1977-05-10 |
DE2256838A1 (de) | 1973-05-24 |
LU66491A1 (enrdf_load_stackoverflow) | 1973-06-08 |
BE791472A (fr) | 1973-05-16 |
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