FR2145424A1 - 2(3-trifluoromethyl thio-anilino)-nicotinic acid - and its alkyl esters - antiinflammatory analgesic,antipyretic - Google Patents

2(3-trifluoromethyl thio-anilino)-nicotinic acid - and its alkyl esters - antiinflammatory analgesic,antipyretic

Info

Publication number
FR2145424A1
FR2145424A1 FR7125859A FR7125859A FR2145424A1 FR 2145424 A1 FR2145424 A1 FR 2145424A1 FR 7125859 A FR7125859 A FR 7125859A FR 7125859 A FR7125859 A FR 7125859A FR 2145424 A1 FR2145424 A1 FR 2145424A1
Authority
FR
France
Prior art keywords
nicotinic acid
antipyretic
anilino
alkyl esters
trifluoromethyl thio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7125859A
Other languages
French (fr)
Other versions
FR2145424B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CRT Ste
Original Assignee
CRT Ste
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE789256D priority Critical patent/BE789256R/en
Application filed by CRT Ste filed Critical CRT Ste
Priority to FR7125859A priority patent/FR2145424A1/en
Priority to FR7135155A priority patent/FR2154329B2/fr
Priority to BE786262A priority patent/BE786262A/en
Priority to DK351672A priority patent/DK134988B/en
Priority to NO252072A priority patent/NO136642C/en
Priority to SE925072A priority patent/SE378104B/xx
Priority to CA147,134A priority patent/CA978966A/en
Priority to NL7209783A priority patent/NL146808B/en
Priority to GB3313372A priority patent/GB1380007A/en
Priority to ZA724877A priority patent/ZA724877B/en
Priority to NL7209781A priority patent/NL7209781A/xx
Priority to CH1060072A priority patent/CH550169A/en
Priority to DE19722234712 priority patent/DE2234712C3/en
Priority to ES404930A priority patent/ES404930A1/en
Priority to JP7121372A priority patent/JPS5224025B1/ja
Priority to AU44646/72A priority patent/AU477889B2/en
Priority to GB4487772A priority patent/GB1380179A/en
Priority to US00293547A priority patent/US3794657A/en
Publication of FR2145424A1 publication Critical patent/FR2145424A1/en
Application granted granted Critical
Publication of FR2145424B1 publication Critical patent/FR2145424B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel title cpds of formula: (where R=H or 1-6C alkyl) and their salts with acids and bases are prepd by reacting m-trifluoromethylthioaniline with a 2-substd nicotinic acid deriv. The 2-substituents is Cl, Br alkoxy, alkylthio, alkylsulphonyl or nitro.
FR7125859A 1971-07-15 1971-07-15 2(3-trifluoromethyl thio-anilino)-nicotinic acid - and its alkyl esters - antiinflammatory analgesic,antipyretic Granted FR2145424A1 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
BE789256D BE789256R (en) 1971-07-15 NEW DERIVATIVES OF
FR7125859A FR2145424A1 (en) 1971-07-15 1971-07-15 2(3-trifluoromethyl thio-anilino)-nicotinic acid - and its alkyl esters - antiinflammatory analgesic,antipyretic
FR7135155A FR2154329B2 (en) 1971-07-15 1971-09-30
DK351672A DK134988B (en) 1971-07-15 1972-07-13 Analogous process for the preparation of 2- (3'-trifluoromethylthio-anilino) -nicotinic acid and its esters or salts thereof with pharmaceutically acceptable acids or bases.
NO252072A NO136642C (en) 1971-07-15 1972-07-13 ANALOGICAL PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 2 (3`-TRIFLUOROMETHYLTIO-ANILINO) -NICOTIC ACID OR ESTER THEREOF
SE925072A SE378104B (en) 1971-07-15 1972-07-13
BE786262A BE786262A (en) 1971-07-15 1972-07-13 NEW DERIVATIVES OF PYRIDINE
ZA724877A ZA724877B (en) 1971-07-15 1972-07-14 Pyridine derivatives
NL7209783A NL146808B (en) 1971-07-15 1972-07-14 PROCESS FOR PREPARING MEDICINAL PRODUCTS BASED ON A 2-ANILINO-NICOTIC ACID COMPOUND WITH ANTI-INFLAMMATORY, PAIN-RELIEVING AND ANTI-POTENTIAL ACTION, PREPARATION OF PREPARATION OF MEDICINAL PRODUCTS OBTAINED AND PREPARATION OF PREPARATION.
GB3313372A GB1380007A (en) 1971-07-15 1972-07-14 Anilinonicotinic acid derivatives and pharmaceutical compositions containing them
CA147,134A CA978966A (en) 1971-07-15 1972-07-14 2-(3'-trifluoromethylthio-anilino)-nicotinic acid and its alkyl esters
NL7209781A NL7209781A (en) 1971-07-15 1972-07-14
CH1060072A CH550169A (en) 1971-07-15 1972-07-14 PROCESS FOR PREPARING NEW DERIVATIVES OF PYRIDINE.
DE19722234712 DE2234712C3 (en) 1971-07-15 1972-07-14 2- (3-Trifluoromethylthio-anilino) nicotinic acid derivatives, process for their preparation and pharmaceuticals
JP7121372A JPS5224025B1 (en) 1971-07-15 1972-07-15
ES404930A ES404930A1 (en) 1971-07-15 1972-07-15 Anilinonicotinic acid derivatives and pharmaceutical compositions containing them
AU44646/72A AU477889B2 (en) 1971-07-15 1972-07-17 Pyridine derivatives
GB4487772A GB1380179A (en) 1971-07-15 1972-09-28 2,-3,-trifluoromethylthioanilino nicotinate and pharmaceutical compositions containing it
US00293547A US3794657A (en) 1971-07-15 1972-09-29 2-(3'-trifluoromethylthio-anilino)-nicotinic acid,esters thereof and pharmaceutically acceptable inorganic or basic salts thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7125859A FR2145424A1 (en) 1971-07-15 1971-07-15 2(3-trifluoromethyl thio-anilino)-nicotinic acid - and its alkyl esters - antiinflammatory analgesic,antipyretic

Publications (2)

Publication Number Publication Date
FR2145424A1 true FR2145424A1 (en) 1973-02-23
FR2145424B1 FR2145424B1 (en) 1974-09-06

Family

ID=9080388

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7125859A Granted FR2145424A1 (en) 1971-07-15 1971-07-15 2(3-trifluoromethyl thio-anilino)-nicotinic acid - and its alkyl esters - antiinflammatory analgesic,antipyretic

Country Status (3)

Country Link
FR (1) FR2145424A1 (en)
NL (1) NL7209781A (en)
ZA (1) ZA724877B (en)

Also Published As

Publication number Publication date
ZA724877B (en) 1973-04-25
NL7209781A (en) 1973-01-17
FR2145424B1 (en) 1974-09-06

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