FR16C0017I2 - Composes pour l'inhibition enzymatique du proteasome - Google Patents
Composes pour l'inhibition enzymatique du proteasomeInfo
- Publication number
- FR16C0017I2 FR16C0017I2 FR16C0017C FR16C0017C FR16C0017I2 FR 16C0017 I2 FR16C0017 I2 FR 16C0017I2 FR 16C0017 C FR16C0017 C FR 16C0017C FR 16C0017 C FR16C0017 C FR 16C0017C FR 16C0017 I2 FR16C0017 I2 FR 16C0017I2
- Authority
- FR
- France
- Prior art keywords
- compounds
- peptide
- proteasome
- based compounds
- activities
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- AIDS & HIV (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59940104P | 2004-08-06 | 2004-08-06 | |
US61000104P | 2004-09-14 | 2004-09-14 | |
US11/106,879 US7232818B2 (en) | 2004-04-15 | 2005-04-14 | Compounds for enzyme inhibition |
PCT/US2005/028246 WO2006017842A1 (fr) | 2004-08-06 | 2005-08-08 | Composes pour l'inhibition enzymatique du proteasome |
Publications (2)
Publication Number | Publication Date |
---|---|
FR16C0017I1 FR16C0017I1 (fr) | 2016-06-24 |
FR16C0017I2 true FR16C0017I2 (fr) | 2016-08-26 |
Family
ID=35502451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR16C0017C Active FR16C0017I2 (fr) | 2004-08-06 | 2016-05-12 | Composes pour l'inhibition enzymatique du proteasome |
Country Status (25)
Country | Link |
---|---|
US (12) | US7232818B2 (fr) |
EP (4) | EP1781688B1 (fr) |
JP (2) | JP4743720B2 (fr) |
KR (3) | KR101354280B1 (fr) |
CN (1) | CN102286070B (fr) |
AT (1) | ATE496062T1 (fr) |
AU (1) | AU2005271232B2 (fr) |
BR (2) | BRPI0514102B8 (fr) |
CA (1) | CA2589765C (fr) |
CY (3) | CY1116771T1 (fr) |
DE (1) | DE602005026019D1 (fr) |
DK (2) | DK3101026T3 (fr) |
ES (2) | ES2525248T3 (fr) |
FR (1) | FR16C0017I2 (fr) |
HK (4) | HK1103525A1 (fr) |
HU (2) | HUE038005T2 (fr) |
IL (3) | IL181127A (fr) |
LT (2) | LT3101026T (fr) |
LU (1) | LU93015I2 (fr) |
NO (2) | NO341015B1 (fr) |
PL (2) | PL3101026T3 (fr) |
PT (2) | PT3101026T (fr) |
SG (2) | SG155187A1 (fr) |
SI (2) | SI1781688T1 (fr) |
WO (1) | WO2006017842A1 (fr) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
US8198270B2 (en) * | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
US7232818B2 (en) * | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
EP1745064B1 (fr) | 2004-04-15 | 2011-01-05 | Proteolix, Inc. | Composés pour l'inhibition d'une enzyme de protéasome |
AU2005243140A1 (en) * | 2004-05-10 | 2005-11-24 | Proteolix, Inc. | Synthesis of amino acid keto-epoxides |
CA2565407A1 (fr) * | 2004-05-10 | 2005-11-24 | Proteolix, Inc. | Composes d'inhibition enzymatique |
DK1830838T3 (da) | 2004-12-03 | 2013-01-21 | Dana Farber Cancer Inst Inc | Sammensætninger og fremgangsmåder til behandling af neoplastiske sygdomme |
PL2261236T3 (pl) * | 2004-12-07 | 2015-12-31 | Onyx Therapeutics Inc | Kompozycja do hamowania proteasomu |
PT2623113T (pt) | 2005-11-09 | 2017-07-14 | Onyx Therapeutics Inc | Compostos para inibição de enzimas |
SI2041158T1 (sl) * | 2006-06-19 | 2013-09-30 | Onyx Therapeutics, Inc. | Peptidni epoksiketoni za inhibicijo proteasomov |
EP2040694A2 (fr) * | 2006-07-14 | 2009-04-01 | VIB vzw | Utilisation d'agonistes des ppar-alpha pour le traitement de troubles du dépérissement des muscles squelettiques |
US7642369B2 (en) * | 2006-09-12 | 2010-01-05 | University Of Kentucky Research Foundation | Epoxyketone-based immunoproteasome inhibitors |
AU2016231532B2 (en) * | 2007-10-04 | 2018-05-10 | Onyx Therapeutics, Inc. | Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides |
AU2013203566B2 (en) * | 2007-10-04 | 2016-10-13 | Onyx Therapeutics, Inc. | Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides |
TWI501773B (zh) | 2007-10-04 | 2015-10-01 | Onyx Therapeutics Inc | 結晶肽環氧酮蛋白酶抑制劑以及胺基酸酮環氧化物之合成 |
US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
EP2088205A1 (fr) | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10 : marqueur de diagnostic et cible thérapeutique de rejet chronique |
US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
JP2011519975A (ja) * | 2008-05-12 | 2011-07-14 | ネレアス ファーマシューティカルズ インコーポレイテッド | プロテアソーム阻害剤としてのサリノスポラミド誘導体 |
BRPI0919668A2 (pt) | 2008-10-21 | 2018-05-29 | Onyx Therapeutics, Inc. | terapia de combinação com epóxi-cetonas de peptídeo |
AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
US20110009332A1 (en) * | 2009-07-09 | 2011-01-13 | Southwest Research Institute | Therapeutic Treatment Of Wounds |
GB0914883D0 (en) | 2009-08-26 | 2009-09-30 | Univ Belfast | Compound |
US8853147B2 (en) | 2009-11-13 | 2014-10-07 | Onyx Therapeutics, Inc. | Use of peptide epoxyketones for metastasis suppression |
MX2012010017A (es) | 2010-03-01 | 2012-10-01 | Onyx Therapeutics Inc | Compuestos de para la inhibicion de inmunoproteasomas. |
MX2012011604A (es) | 2010-04-07 | 2013-02-27 | Onyx Therapeutics Inc | Inhibidor de inmunoproteasoma de péptido epoxicetona cristalino. |
US9126997B1 (en) | 2010-09-07 | 2015-09-08 | Northwestern University | Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma |
WO2012135528A2 (fr) | 2011-03-29 | 2012-10-04 | Texas Tech University System | Polythérapie par galectine-3c pour cancer humain |
WO2013009923A1 (fr) * | 2011-07-13 | 2013-01-17 | Creighton University | Procédés de favorisation de la croissance de neurones |
JP6286358B2 (ja) | 2011-11-11 | 2018-02-28 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | プロテアソーム阻害剤に応答するバイオマーカー |
CA2855356A1 (fr) | 2011-11-11 | 2013-05-16 | Millennium Pharmaceuticals, Inc. | Biomarqueurs de la sensibilite a des inhibiteurs du proteasome |
WO2013112601A1 (fr) | 2012-01-24 | 2013-08-01 | Millennium Pharmaceuticals, Inc. | Méthodes de traitement du cancer |
DK2814849T3 (da) | 2012-02-15 | 2020-03-09 | Cydex Pharmaceuticals Inc | Fremgangsmåde til fremstilling af cyclodextrin-derivater |
CA2873044C (fr) * | 2012-05-08 | 2021-01-26 | Onyx Therapeutics, Inc. | Methodes de complexation de cylodextrine servant a formuler des inhibiteurs de proteasome a peptide |
WO2014011695A2 (fr) | 2012-07-09 | 2014-01-16 | Onyx Therapeutics, Inc. | Promédicaments d'inhibiteurs d'époxy cétone protéase peptidique |
AU2013292647B2 (en) | 2012-07-18 | 2018-03-15 | Onyx Therapeutics, Inc. | Liposomal compositions of epoxyketone-based proteasome inhibitors |
WO2014029022A1 (fr) * | 2012-08-21 | 2014-02-27 | Abdelmalik Slassi | Composés tétrapeptidiques à base d'époxycétone fluorée et leurs utilisations en tant qu'inhibiteur du protéasome |
MX360192B (es) | 2012-10-22 | 2018-10-24 | Cydex Pharmaceuticals Inc | Composiciones de ciclodextrinas alquiladas y procesos para preparar y usar las mismas. |
SG10201707464SA (en) | 2013-03-13 | 2017-10-30 | Sanofi Sa | Compositions comprising anti-cd38 antibodies and carfilzomib |
AU2014240122B2 (en) | 2013-03-14 | 2019-02-14 | Onyx Therapeutics, Inc. | Dipeptide and tripeptide epoxy ketone protease inhibitors |
AR095426A1 (es) | 2013-03-14 | 2015-10-14 | Onyx Therapeutics Inc | Inhibidores tripeptídicos de la epoxicetona proteasa |
US20160166632A1 (en) | 2013-07-19 | 2016-06-16 | Onyx Therapeutics, Inc. | Peptide epoxyketone proteasome inhibitors in combination with pim kinase inhibitors for treatment of cancers |
CN103360348B (zh) * | 2013-07-25 | 2015-06-24 | 苏州鹏旭医药科技有限公司 | 一种Carfilzomib中间体及其制备方法和制备Carfilzomib的方法 |
CA2920220A1 (fr) * | 2013-09-06 | 2015-03-12 | Sandoz Ag | Synthese de cetones epoxy peptidiques |
EP3041832A1 (fr) * | 2013-09-06 | 2016-07-13 | Sandoz AG | Synthèse stéréosélective de diols et de triols par réaction de mannich et utilisation correspondante pour la synthèse de carfilzomib |
WO2015121769A1 (fr) | 2014-02-13 | 2015-08-20 | Ranbaxy Laboratories Limited | Procédé pour la préparation de méthyl n-[(benzyloxy)-carbonyl]-l-leucyl-l-phénylalaninate |
CN103864889B (zh) * | 2014-04-04 | 2017-01-11 | 重庆泰濠制药有限公司 | 环氧酮化合物、其制备方法及卡非佐米的制备方法 |
US10851184B2 (en) | 2014-08-22 | 2020-12-01 | Cydex Pharmaceuticals, Inc. | Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same |
US10329325B2 (en) | 2014-09-24 | 2019-06-25 | Biophore India Pharmaceuticals Pvt. Ltd | Process for the preparation of (S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxo-pentan-2-yl) amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido) pentanamide |
WO2016069479A1 (fr) | 2014-10-27 | 2016-05-06 | Apicore Us Llc | Procédés de préparation de carfilzomib et d'intermédiaires de celui-ci |
CN104402973A (zh) * | 2014-11-24 | 2015-03-11 | 重庆泰濠制药有限公司 | 一种卡非佐米无定型晶的制备方法 |
US10253066B2 (en) | 2014-12-02 | 2019-04-09 | Fresenius Kabi Oncology Limited | Process for purification of Carfilzomib |
WO2016108204A1 (fr) | 2014-12-31 | 2016-07-07 | Dr. Reddy's Laboratories Limited | Co-cristal de carfilzomib avec de l'acide maléique et procédé pour la préparation de carfilzomib pur |
WO2016170544A1 (fr) * | 2015-04-22 | 2016-10-27 | Msn Laboratories Private Limited | Procédé de préparation de (2s)-n-((s)-1-((s)-4-méthyl-1-((r)-2-méthyl oxiran-2-yl)-1-oxopentan-2-ylcarbamoyl)-2-phényléthyl)-2-((s)-2-(2-morpholino acétamido)-4-phénylbutanamido)-4-méthylpentanamide |
WO2016185450A1 (fr) | 2015-05-21 | 2016-11-24 | Laurus Labs Private Limited | Procédé perfectionné de préparation de carfilzomib ou de sels pharmaceutiquement acceptables de celui-ci |
CN106317188A (zh) * | 2015-06-18 | 2017-01-11 | 重庆医药工业研究院有限责任公司 | 一种制备卡非佐米无定型物的方法 |
WO2017032487A1 (fr) | 2015-08-27 | 2017-03-02 | Technische Universität München | Inhibiteur de protéasome comprenant une fraction d'émission de signal |
US20180362580A1 (en) | 2015-12-11 | 2018-12-20 | Mylan Laboratories Limited | Crystalline and amorphous forms of carfilzomib |
TWI636052B (zh) * | 2015-12-31 | 2018-09-21 | 中化合成生技股份有限公司 | 無定形卡非佐米(i)的製備方法 |
US11306107B2 (en) | 2016-02-25 | 2022-04-19 | Amgen Inc. | Compounds that inhibit MCL-1 protein |
TWI759301B (zh) | 2016-05-24 | 2022-04-01 | 美商安美基公司 | 聚乙二醇化卡非佐米化合物 |
EP3494126A1 (fr) | 2016-08-02 | 2019-06-12 | Synthon BV | Procédé de fabrication du carfilzomib |
ES2842575T3 (es) | 2016-08-05 | 2021-07-14 | Amgen Inc | Síntesis de (S)-2-amino-4-metil-1-((R)-2-metiloxiran-2-il)-pentan-1-ona y sales farmacéuticamente aceptables de la misma |
CN109689635A (zh) | 2016-09-14 | 2019-04-26 | 费森尤斯卡比肿瘤学有限公司 | 一种用于纯化卡非佐米中间体的方法 |
US11597708B2 (en) | 2016-09-16 | 2023-03-07 | Hsf Pharmaceuticals Sa | Inhibitors of heat shock factors and uses thereof |
EP3330260A1 (fr) | 2016-12-01 | 2018-06-06 | Enantia, S.L. | Procédé pour la préparation d'un intermédiaire pour la synthèse de i.a. carfilzomib |
WO2019053611A1 (fr) | 2017-09-14 | 2019-03-21 | Glaxosmithkline Intellectual Property Development Limited | Polythérapie pour le traitement du cancer |
WO2019099715A1 (fr) | 2017-11-16 | 2019-05-23 | Amgen Inc. | Compositions stables de composés carfilzomib pégylés |
CN117051096A (zh) * | 2017-12-08 | 2023-11-14 | 神经Gx有限责任公司 | 用于阿尔茨海默病的同步化细胞周期基因表达测试及相关治疗方法 |
US10537585B2 (en) | 2017-12-18 | 2020-01-21 | Dexcel Pharma Technologies Ltd. | Compositions comprising dexamethasone |
US10689416B2 (en) * | 2017-12-30 | 2020-06-23 | Unity Biotechnology, Inc. | Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer |
CA3043103C (fr) * | 2017-12-30 | 2021-02-09 | Unity Biotechnology | Inhibiteurs de proteasome fonde sur un peptide pour le traitement de troubles medies par des cellules senescentes et le traitement du cancer |
SG11202012765PA (en) * | 2018-06-22 | 2021-01-28 | Ucl Business Ltd | Novel compounds |
WO2021072212A1 (fr) * | 2019-10-11 | 2021-04-15 | Mayo Foundation For Medical Education And Research | Inhibiteurs de protéasome |
WO2023220641A2 (fr) | 2022-05-11 | 2023-11-16 | Juno Therapeutics, Inc. | Méthodes et utilisations associées à une thérapie par lymphocytes t et leur production |
WO2023220655A1 (fr) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Méthodes pour surmonter la résistance aux médicaments par ré-sensibilisation de cellules cancéreuses à un traitement avec une thérapie antérieure par l'intermédiaire d'un traitement avec une thérapie par lymphocytes t |
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