FR1485847A - Procédé de fabrication de nouvelles quinazolinediones - Google Patents

Procédé de fabrication de nouvelles quinazolinediones

Info

Publication number
FR1485847A
FR1485847A FR67057A FR67057A FR1485847A FR 1485847 A FR1485847 A FR 1485847A FR 67057 A FR67057 A FR 67057A FR 67057 A FR67057 A FR 67057A FR 1485847 A FR1485847 A FR 1485847A
Authority
FR
France
Prior art keywords
quinazolinediones
new
manufacturing process
manufacturing
new quinazolinediones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR67057A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US269168A priority Critical patent/US3274194A/en
Priority to GB11938/64A priority patent/GB1063894A/en
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Priority to FR67057A priority patent/FR1485847A/fr
Priority to BE683352D priority patent/BE683352A/xx
Application granted granted Critical
Publication of FR1485847A publication Critical patent/FR1485847A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR67057A 1963-03-29 1966-06-27 Procédé de fabrication de nouvelles quinazolinediones Expired FR1485847A (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US269168A US3274194A (en) 1963-03-29 1963-03-29 Quinazolinedione derivatives
GB11938/64A GB1063894A (en) 1963-03-29 1964-03-20 Quinazolinedione derivatives
FR67057A FR1485847A (fr) 1963-03-29 1966-06-27 Procédé de fabrication de nouvelles quinazolinediones
BE683352D BE683352A (fr) 1963-03-29 1966-06-29

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US269168A US3274194A (en) 1963-03-29 1963-03-29 Quinazolinedione derivatives
CA897976 1964-03-16
GB11938/64A GB1063894A (en) 1963-03-29 1964-03-20 Quinazolinedione derivatives
FR67057A FR1485847A (fr) 1963-03-29 1966-06-27 Procédé de fabrication de nouvelles quinazolinediones

Publications (1)

Publication Number Publication Date
FR1485847A true FR1485847A (fr) 1967-06-23

Family

ID=27426755

Family Applications (1)

Application Number Title Priority Date Filing Date
FR67057A Expired FR1485847A (fr) 1963-03-29 1966-06-27 Procédé de fabrication de nouvelles quinazolinediones

Country Status (4)

Country Link
US (1) US3274194A (fr)
BE (1) BE683352A (fr)
FR (1) FR1485847A (fr)
GB (1) GB1063894A (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2059481A1 (fr) * 1969-07-04 1971-06-04 Cassella Farbwerke Mainkur Ag
FR2059482A1 (fr) * 1969-07-04 1971-06-04 Cassella Farbwerke Mainkur Ag
FR2196803A1 (fr) * 1972-08-21 1974-03-22 Parke Davis & Co
FR2429216A1 (fr) * 1978-06-20 1980-01-18 Synthelabo Derives de phenylpiperazine, leur preparation et leur application en therapeutique
US4268511A (en) * 1980-03-11 1981-05-19 Berri-Balzac 3-Amino(1H,3H)quinazoline-2,4-dione derivatives and their therapeutic applications
EP0620210A1 (fr) * 1993-04-16 1994-10-19 ALFA WASSERMANN S.p.A. Dérivés de benzamide ayant une activité en pathologies gastrointestinales
EP0789020A1 (fr) * 1996-02-01 1997-08-13 Sumitomo Chemical Company, Limited Procédé de préparation de dioxoquinazolines

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1062357A (en) * 1965-03-23 1967-03-22 Pfizer & Co C Quinazolone derivatives
FR6720M (fr) * 1967-06-13 1969-02-17
US3846430A (en) * 1968-01-12 1974-11-05 Bruneau & Cie Lab 1-(2-methoxy-phenyl)-4-{8 2-(4-fluoro-benzamido)-ethyl{9 -piperazine
US3962244A (en) * 1971-01-23 1976-06-08 Hoechst Aktiengesellschaft Benzene sulfonyl ureas
US3919425A (en) * 1971-04-09 1975-11-11 Miles Lab Method of producing vasodilation using certain 3-substituted-quinazoline derivatives
SE368009B (fr) * 1971-09-16 1974-06-17 Kabi Ab
US3879393A (en) * 1973-06-18 1975-04-22 Miles Lab Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones
DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen
JPS58159480A (ja) * 1982-03-17 1983-09-21 Chugai Pharmaceut Co Ltd 新規なフエニルピペラジン誘導体
JPS608274A (ja) * 1983-06-27 1985-01-17 Fujisawa Pharmaceut Co Ltd 新規キナゾリノン誘導体およびその製造法・並びに抗アレルギ−剤
US4684654A (en) * 1985-08-14 1987-08-04 American Cyanamid Company 3-heteroalkyl-2,4-quinzaolinediones
EP0293500A1 (fr) * 1987-06-01 1988-12-07 American Cyanamid Company 3-Hétéroalkyl-2,4-quinazoline-diones, 3-hétéroaryl-1,2,3-benzotriazin-4(3H)-ones, 3-hétéroarylalkyl-4-quinazolinone
US4710502A (en) * 1985-11-04 1987-12-01 American Cyanamid Company 3-heteroarylalkyl-4-quinazolinones
US4753944A (en) * 1985-11-04 1988-06-28 American Cyanamid Company Pharmaceutical methods of using 3-heteroarylalkyl-4-quinazolinones
ATE126796T1 (de) * 1990-01-02 1995-09-15 Fujisawa Pharmaceutical Co Quinazolinderivate und ihre herstellung.
US5296487A (en) * 1990-01-02 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Quinazoline derivatives and their preparation
PL166839B1 (en) * 1990-04-24 1995-06-30 Dresden Arzneimittel Method of obtaining novel 3-(mercaptoalkyl)-quinazolino-(1h,3h)-diones-2,4
IE913473A1 (en) * 1990-10-15 1992-04-22 Fujisawa Pharmaceutical Co Quinazoline derivatives and their preparation
EP1026160A4 (fr) 1997-09-16 2003-01-22 Takeda Chemical Industries Ltd Composes azotes a cycles condenses, procede de preparation de ces composes et medicaments
US6458783B1 (en) * 1997-09-29 2002-10-01 Bristol-Myers Squibb Company Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase
US6521630B1 (en) 1999-08-31 2003-02-18 Pfizer Inc. Tetrahydroquinazoline-2,4-diones and therapeutic uses thereof
CA2546300C (fr) 2003-11-20 2012-10-02 Janssen Pharmaceutica N.V. 2-quinolinones et 2-quinoxalinones substituees par 6-alcenyle et 6-phenylalkyle utilisees comme inhibiteurs de la poly(adp-ribose) polymerase (parp)
CA2546002C (fr) * 2003-11-20 2012-09-18 Janssen Pharmaceutica N.V. 2-quinolinones et 2 quinoxalinones a substitution 7-phenylalkyl tenant lieu d'inhibiteurs de poly(adp-ribose) polymerase inhibitors
JP4806353B2 (ja) * 2003-12-05 2011-11-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ポリ（ａｄｐ−リボース）ポリメラーゼインヒビターとしての６−置換２−キノリノンおよび２−キノキサリノン
MXPA06014543A (es) 2004-06-30 2007-03-23 Janssen Pharmaceutica Nv Derivados de quinazolinona como inhibidores de la poli(adp-ribosa)polimerasa-i.
ES2563954T3 (es) * 2004-06-30 2016-03-16 Janssen Pharmaceutica Nv Derivados de ftalazina como inhibidores de PARP
CN1980913B (zh) * 2004-06-30 2011-12-14 詹森药业有限公司 作为parp抑制剂的喹唑啉二酮衍生物
WO2008107478A1 (fr) 2007-03-08 2008-09-12 Janssen Pharmaceutica Nv Dérivés de quinolinone comme inhibiteurs de parp et de tank
JP5525447B2 (ja) * 2007-10-26 2014-06-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐ阻害剤としてのキノリノン誘導体
WO2009118382A1 (fr) 2008-03-27 2009-10-01 Janssen Pharmaceutica Nv Tétrahydrophénanthridinones et tétrahydrocyclopentaquinolinones comme inhibiteurs de la polymérisation de la tubuline et de parp
JP5464609B2 (ja) * 2008-03-27 2014-04-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ チューブリン重合阻害剤としてのキナゾリノン誘導体
NZ595263A (en) 2009-02-26 2013-06-28 Compositions, synthesis, and methods of utilizing arylpiperazine derivatives
BRPI1003506B1 (pt) 2010-09-24 2019-12-03 Ache Int Bvi Ltd composto alquil-piperazino-fenil-4(3h)quinazolinonas e uso do composto alquil-piperazino-fenil-4(3h)quinazolinonas associado aos receptores serotoninérgicos 5-ht1a e 5-ht2a
US9546151B2 (en) * 2014-07-31 2017-01-17 Oregon Health & Science University VMAT inhibitory compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2688020A (en) * 1952-01-17 1954-08-31 American Cyanamid Co Preparation of dihydrouracils
US2680741A (en) * 1952-03-07 1954-06-08 Du Pont Process for preparing 3-aryl-2, 4-(1h, 3h)-quinazolinediones and their nitrogen heterocyclic analogs
US3096373A (en) * 1956-04-30 1963-07-02 Sterling Drug Inc N, n'-bis (di-lower-alkylamino-loweralkyl) dicarboxylic acid amides
US3161678A (en) * 1956-12-17 1964-12-15 Ile De France Process for making "ortho-chloroprocaine amide"
US3118930A (en) * 1959-08-25 1964-01-21 Chugai Pharmaceutical Co Ltd Process for the preparation of gamma-oxosenecioic acid esters
US3095443A (en) * 1960-05-03 1963-06-25 Vismara Francesco Spa Aryl derivatives

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2059481A1 (fr) * 1969-07-04 1971-06-04 Cassella Farbwerke Mainkur Ag
FR2059482A1 (fr) * 1969-07-04 1971-06-04 Cassella Farbwerke Mainkur Ag
FR2196803A1 (fr) * 1972-08-21 1974-03-22 Parke Davis & Co
FR2429216A1 (fr) * 1978-06-20 1980-01-18 Synthelabo Derives de phenylpiperazine, leur preparation et leur application en therapeutique
US4268511A (en) * 1980-03-11 1981-05-19 Berri-Balzac 3-Amino(1H,3H)quinazoline-2,4-dione derivatives and their therapeutic applications
EP0620210A1 (fr) * 1993-04-16 1994-10-19 ALFA WASSERMANN S.p.A. Dérivés de benzamide ayant une activité en pathologies gastrointestinales
EP0789020A1 (fr) * 1996-02-01 1997-08-13 Sumitomo Chemical Company, Limited Procédé de préparation de dioxoquinazolines
US5780628A (en) * 1996-02-01 1998-07-14 Sumitomo Chemical Company, Limited Process for producing dioxoquinazolines

Also Published As

Publication number Publication date
US3274194A (en) 1966-09-20
GB1063894A (en) 1967-04-05
BE683352A (fr) 1966-12-29

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