FI99015B - Förfarande för framställning av ett biologiskt aktivt mutein av tumörnekrosisfaktor-proteinet - Google Patents

Förfarande för framställning av ett biologiskt aktivt mutein av tumörnekrosisfaktor-proteinet

Info

Publication number
FI99015B
FI99015B FI864036A FI864036A FI99015B FI 99015 B FI99015 B FI 99015B FI 864036 A FI864036 A FI 864036A FI 864036 A FI864036 A FI 864036A FI 99015 B FI99015 B FI 99015B
Authority
FI
Finland
Prior art keywords
mutein
producing
biologically active
necrosis factor
tumor necrosis
Prior art date
Application number
FI864036A
Other languages
English (en)
Finnish (fi)
Other versions
FI864036A (sv
FI864036A0 (sv
FI99015C (sv
Inventor
David F Mark
Leo S Lin
Shi-Da Yu Lu
Alice M Wang
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24807256&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI99015(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of FI864036A publication Critical patent/FI864036A/sv
Publication of FI864036A0 publication Critical patent/FI864036A0/sv
Publication of FI99015B publication Critical patent/FI99015B/sv
Application granted granted Critical
Publication of FI99015C publication Critical patent/FI99015C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
FI864036A 1985-02-07 1986-10-06 Förfarande för framställning av ett biologiskt aktivt mutein av tumörnekrosisfaktor-proteinet FI99015C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/698,939 US4959314A (en) 1984-11-09 1985-02-07 Cysteine-depleted muteins of biologically active proteins
US69893985 1985-02-07
US8600236 1986-02-03
PCT/US1986/000236 WO1986004606A1 (en) 1985-02-07 1986-02-03 Cysteine-depleted muteins of biologically active human tumor necrosis factor proteins

Publications (4)

Publication Number Publication Date
FI864036A FI864036A (sv) 1986-10-06
FI864036A0 FI864036A0 (sv) 1986-10-06
FI99015B true FI99015B (sv) 1997-06-13
FI99015C FI99015C (sv) 1997-09-25

Family

ID=24807256

Family Applications (1)

Application Number Title Priority Date Filing Date
FI864036A FI99015C (sv) 1985-02-07 1986-10-06 Förfarande för framställning av ett biologiskt aktivt mutein av tumörnekrosisfaktor-proteinet

Country Status (8)

Country Link
US (1) US4959314A (sv)
EP (1) EP0213175B1 (sv)
JP (1) JPS62501608A (sv)
AU (1) AU5518086A (sv)
DE (1) DE3672924D1 (sv)
DK (1) DK172276B1 (sv)
FI (1) FI99015C (sv)
WO (1) WO1986004606A1 (sv)

Families Citing this family (238)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI82266C (sv) * 1982-10-19 1991-02-11 Cetus Corp Förfarande för framställning av IL-2 -mutein
US5288852A (en) * 1984-03-06 1994-02-22 Dainippon Pharmaceutical Co., Ltd. Human tumor necrosis factor polypeptides
US5342614A (en) * 1984-12-21 1994-08-30 Otsuka Pharmaceutical Co., Ltd. Method of treating arthritus or inflammation with IL-1β or derivatives thereof
US6107465A (en) * 1984-12-21 2000-08-22 Otsuka Pharmaceutical Co., Ltd. IL-1β and derivatives thereof and drugs
US5516896A (en) * 1985-02-25 1996-05-14 Zymogenetics, Inc. Biologically active B-chain homodimers
US5244806A (en) * 1985-08-26 1993-09-14 Eli Lilly And Company DNA encoding novel tissue plasminogen activator derivatives having kringles 1 and 2 deleted, vectors and host cells
US5859208A (en) * 1988-07-06 1999-01-12 Fiddes; John C. Human basic fibroblast growth factor analog
EP0247906B1 (en) * 1986-02-04 1994-12-28 Mizuno, Den'Ichi DNA coding for anti-tumour polypeptides, the polypeptides and anti-tumour agents comprising said polypeptides
US5008374A (en) * 1986-03-14 1991-04-16 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and drugs
US5900476A (en) * 1986-05-30 1999-05-04 The Scripps Research Institute Therapeutic domains of van Willebrand factor
EP0257406B2 (en) * 1986-08-06 1998-08-12 Ajinomoto Co., Inc. Recombinant B-cell differentiation factor
US5681934A (en) * 1986-09-30 1997-10-28 Board Of Regents, The University Of Texas System 47-kilodalton antigen of Treponema pallidum
US6994988B1 (en) 1987-02-12 2006-02-07 Genetech, Inc. Methods and deoxyribonucleic acid for the preparation of tissue factor protein
US7049131B1 (en) * 1987-02-12 2006-05-23 Genentech, Inc. Methods and deoxyribonucleic acid for the preparation of tissue factor protein
US5852177A (en) * 1987-02-24 1998-12-22 Takeda Chemical Industries, Ltd. Basic fibroblast growth factor (bFGF) muteins
AU1346488A (en) * 1987-02-26 1988-09-26 Cetus Corporation Arginine-depleted human tumor necrosis factor
ZA884012B (en) * 1987-06-04 1989-02-22 Zymogenetics Inc Tissue plasminogen activator analogs having modified growth factor domains
DE68929273T2 (de) * 1988-08-24 2001-07-05 American Cyanamid Co., Wayne Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung
DE3907244A1 (de) * 1989-03-07 1990-09-13 Knoll Ag Erzeugnisse, enthaltend ein lithiumsalz und einen tumor-nekrose-faktor
US5621078A (en) * 1989-03-22 1997-04-15 Merck & Co., Inc. Modified pseudomonas exotoxin PE40
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US6207798B1 (en) * 1989-08-03 2001-03-27 Merck & Co., Inc. Modified PE40 toxin fusion proteins
FR2651130B1 (fr) * 1989-08-23 1991-12-13 Roussel Uclaf Sequence d'oligonucleotides anti-sens, anti-arn message du tnf alpha, procede de preparation, application a titre de medicaments et compositions pharmaceutiques.
AU641949B2 (en) * 1989-10-10 1993-10-07 Amgen, Inc. Compositions and methods for treating or preventing infections in canine and feline animals
AU6541090A (en) * 1989-10-16 1991-05-16 Amgen, Inc. Stem cell factor
US6852313B1 (en) 1989-10-16 2005-02-08 Amgen Inc. Method of stimulating growth of melanocyte cells by administering stem cell factor
US20040181044A1 (en) * 1989-10-16 2004-09-16 Zsebo Krisztina M. Method of stimulating growth of epithelial cells by administering stem cell factor
US7144731B2 (en) * 1989-10-16 2006-12-05 Amgen Inc. SCF antibody compositions and methods of using the same
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
US6566098B1 (en) * 1990-09-14 2003-05-20 The United States Of America As Represented By The Department Of Health And Human Services DNA encoding truncated hepatocyte growth factor variants
JPH05255393A (ja) * 1990-09-21 1993-10-05 Ishihara Sangyo Kaisha Ltd ポリペプチド
EP0477791B1 (en) * 1990-09-21 1996-08-07 Ishihara Sangyo Kaisha, Ltd. Polypeptide
ATE138687T1 (de) * 1990-11-23 1996-06-15 American Cyanamid Co Chimeres fibroblasten-wachstumsfaktor
US6833354B1 (en) * 1990-12-19 2004-12-21 Kaken Pharmaceutical Co., Ltd. Agent for the treatment of bone diseases
CA2107100A1 (en) * 1991-03-27 1992-09-28 Zaverio M. Ruggeri Therapeutic fragments of von willebrand factor
JP3303211B2 (ja) * 1991-04-26 2002-07-15 武田薬品工業株式会社 ｂＦＧＦムテインおよびその製造法
EP0590048B1 (en) * 1991-06-20 2004-12-01 Aventis Behring L.L.C. A process for preparing therapeutic fragments of von willebrand factor
US5847086A (en) * 1991-06-20 1998-12-08 Centeon L.L.C. Therapeutic fragments of von Willebrand factor
ZA924674B (en) * 1991-07-02 1993-04-28 Imclone Systems Inc Cysteine depleted il-6 mutein
US5248604A (en) * 1991-07-22 1993-09-28 Bio-Technology General Corp. Enzymatically active recombinant human acetylcholinesterase and hosts and vectors for expression thereof
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
GB9204439D0 (en) * 1992-02-27 1992-04-15 Fujisawa Pharmaceutical Co A new cephalosporin c acylase
US5444151A (en) * 1992-05-15 1995-08-22 Ludwig Institute For Cancer Research Platelet derived growth factor antagonists
US5326695A (en) * 1992-05-15 1994-07-05 Ludwig Institute For Cancer Research Platelet derived growth factor agonists
US5349056A (en) * 1992-10-09 1994-09-20 Regeneron Pharmaceuticals Modified ciliary neurotrophic factors
US5420019A (en) * 1993-02-02 1995-05-30 Xoma Corporation Stable bactericidal/permeability-increasing protein muteins
WO1995013385A2 (en) * 1993-11-12 1995-05-18 Gilead Sciences Thrombin mutants
US7060484B1 (en) 1993-11-12 2006-06-13 Gilead Sciences, Inc. Polypeptides and coagulation therapy
US5968477A (en) 1994-01-24 1999-10-19 Neorx Corporation Radiolabeled annexin conjugates with hexose and a chelator
US20030220233A1 (en) 1994-01-24 2003-11-27 Neorx Corporation Radiolabeled annexins
US5545723A (en) * 1994-03-15 1996-08-13 Biogen Inc. Muteins of IFN-β
JP4426646B2 (ja) * 1994-10-13 2010-03-03 アムジエン・インコーポレーテツド 表皮ケラチン細胞成長因子の類縁体
US6645933B1 (en) 1995-08-01 2003-11-11 Helsinki University Licensing Ltd. Oy Receptor ligand VEGF-C
US6130071A (en) * 1997-02-05 2000-10-10 Helsinki University Licensing, Ltd. Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof
US6818220B1 (en) 1994-11-14 2004-11-16 Licentia Ltd. Vascular endothelial growth factor C (VEGF-C) protein and gene mutants thereof, and uses thereof
IL114615A0 (en) 1995-07-16 1995-11-27 Yeda Res & Dev Modulators of the function of fas receptors and other proteins
IL117175A (en) * 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
US6361946B1 (en) 1997-02-05 2002-03-26 Licentia Ltd Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof
US7423125B2 (en) * 1995-08-01 2008-09-09 Vegenics Limited Antibodies to VEGF-C
US20030202980A1 (en) * 1995-12-29 2003-10-30 Caplan Michael J. Methods and reagents for decreasing clinical reaction to allergy
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
TW555765B (en) * 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
US20030144202A1 (en) * 1996-10-15 2003-07-31 Amgen Inc. Uses of keratinocyte growth factor-2
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
WO1998024463A2 (en) 1996-12-06 1998-06-11 Amgen Inc. Combination therapy using a tnf binding protein for treating tnf-mediated diseases
DK0951551T4 (da) * 1996-12-23 2012-09-10 Immunex Corp Ligand for NF-kappa B-receptoraktivator, ligand er medlem af TNF-superfamilien
WO1998033810A2 (en) 1997-01-30 1998-08-06 University Of Virginia Patent Foundation Cysteine-depleted peptides recognized by a3-restricted cytotoxic lymphocytes, and uses therefor
US7125714B2 (en) * 1997-02-05 2006-10-24 Licentia Ltd. Progenitor cell materials and methods
HU229476B1 (en) * 1997-04-15 2014-01-28 Daiichi Sankyo Company Antibodies against obm
RO128635A2 (ro) 1997-04-16 2013-07-30 Amgen Inc. Anticorp sau fragment al acestuia care se leagă la opgbp şi utilizarea acestuia, utilizarea unei forme solubile de odar, şi metodă de identificare a unui compus care descreşte activitatea opgbp
US6316408B1 (en) * 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
AU7383298A (en) * 1997-05-13 1998-12-08 Regents Of The University Of California, The Novel antiangiogenic peptide agents and their therapeutic and diagnostic use
US7723473B2 (en) * 1997-06-19 2010-05-25 St. Louis University Peptide antagonists of TGF-beta family members and therapeutic uses thereof
DE69831754T2 (de) * 1997-12-17 2006-06-29 Immunex Corp., Thousand Oaks Zelloberflächenglycoproteinen zusammenhang mit menschlicher b zell lymphomen - ulbp, dns und polypeptiden
US8101349B2 (en) 1997-12-23 2012-01-24 Novartis Vaccines And Diagnostics, Inc. Gene products differentially expressed in cancerous cells and their methods of use II
CA2319437C (en) 1998-01-31 2009-06-16 University Of Arkansas Methods and reagents for decreasing allergic reactions
US7879977B2 (en) 1998-01-31 2011-02-01 University Of Arkansas Methods and reagents for decreasing clinical reaction to allergy
US6955807B1 (en) * 1998-05-15 2005-10-18 Bayer Pharmaceuticals Corporation IL-2 selective agonists and antagonists
MXPA01000481A (es) * 1998-07-16 2002-11-29 Hyseq Inc Metodos y materiales relacionados con polipeptidos tipo cd39 novedosos.
US6447771B1 (en) * 1999-03-19 2002-09-10 Hyseq, Inc. Methods and materials relating to novel CD39-like polypeptides
US6387645B1 (en) 1998-07-16 2002-05-14 Hyseq, Inc. Methods and materials relating to novel CD39-like polypeptides
US6476211B1 (en) * 1998-07-16 2002-11-05 Hyseq, Inc. Methods and materials relating to CD39-like polypeptides
US6979442B1 (en) 1998-08-17 2005-12-27 Pfizer Inc. Stabilized protein compositions
EP2123292B1 (en) 1998-09-03 2016-05-04 Novartis Vaccines and Diagnostics, Inc. Angiogenically effective unit dose of FGF-2 and method of use
US6660843B1 (en) * 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US6696063B1 (en) * 1998-12-30 2004-02-24 Applied Research Systems Ars Holding N.V. Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
US7393823B1 (en) 1999-01-20 2008-07-01 Oregon Health And Science University HER-2 binding antagonists
US7625859B1 (en) * 2000-02-16 2009-12-01 Oregon Health & Science University HER-2 binding antagonists
US6899875B1 (en) 1999-01-29 2005-05-31 Nuvelo, Inc. Methods and compositions relating to CD39-like polypeptides and nucleic acids
US6780977B1 (en) 1999-01-29 2004-08-24 Nuvelo, Inc. Methods and compositions relating to CD39-like polypeptides and nucleic acids
US6350447B1 (en) 1999-01-29 2002-02-26 Hyseq, Inc. Methods and compositions relating to CD39-like polypeptides and nucleic acids
US6783959B1 (en) 1999-01-29 2004-08-31 Nuvelo, Inc. Methods and compositions relating to CD39-like polypeptides and nucleic acids
US6335013B1 (en) 1999-03-19 2002-01-01 Hyseq, Inc. Methods and materials relating to CD39-like polypeptides
WO2000061755A2 (en) * 1999-04-09 2000-10-19 Chiron Corporation Secreted human proteins
US6514729B1 (en) 1999-05-12 2003-02-04 Xencor, Inc. Recombinant interferon-beta muteins
US6703221B1 (en) 1999-08-19 2004-03-09 Chiron Corporation Notch receptor ligands and uses thereof
US6825333B1 (en) * 1999-08-20 2004-11-30 Chiron Corporation EGFH2 genes and gene products
DE60021760T2 (de) * 1999-12-09 2006-06-08 Chiron Corp., Emeryville Verfahren zur verabreichung von wirkstoffen in das zentrale nervensystem oder lymphsystem
US20030103978A1 (en) * 2000-02-23 2003-06-05 Amgen Inc. Selective binding agents of osteoprotegerin binding protein
EP1272213B1 (en) * 2000-04-06 2006-03-08 SEER Pharmaceuticals, LLC. Microbial delivery system
US20050063994A1 (en) * 2000-04-06 2005-03-24 Caplan Michael J. Methods and reagents for decreasing clinical reaction to allergy
US8246945B2 (en) * 2000-04-06 2012-08-21 University Of Arkansas Methods and reagents for decreasing clinical reaction to allergy
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
EP1803730A1 (en) * 2000-04-12 2007-07-04 Human Genome Sciences, Inc. Albumin fusion proteins
AU2001252458A1 (en) * 2000-05-05 2001-11-20 Martin Bachmann Molecular antigen arrays and vaccines
US7700359B2 (en) * 2000-06-02 2010-04-20 Novartis Vaccines And Diagnostics, Inc. Gene products differentially expressed in cancerous cells
ES2398391T3 (es) 2000-06-15 2013-03-15 Novartis Vaccines And Diagnostics, Inc. Polinucleótidos relacionados con cáncer de colon
FR2811323B1 (fr) * 2000-07-07 2006-10-06 Fuma Tech Gmbh Materiau hybride, utilisation dudit materiau hybride et procede de sa fabrication
WO2002006340A2 (en) * 2000-07-14 2002-01-24 Chiron Corporation Tetraspan protein and uses thereof
ES2397627T3 (es) 2000-12-07 2013-03-08 Novartis Vaccines And Diagnostics, Inc. Retrovirus endógenos regulados por aumento en el cáncer de próstata
US20020155473A1 (en) * 2000-12-22 2002-10-24 Zaoyuan Peng Methods for identifying G-protein coupled receptors associated with diseases
US7094409B2 (en) 2001-01-19 2006-08-22 Cytos Biotechnology Ag Antigen arrays for treatment of allergic eosinophilic diseases
WO2002059337A1 (en) * 2001-01-26 2002-08-01 Georgetown University School Of Medicine Anti-apoptopic gene scc-s2 and diagnostic and therapeutic uses thereof
AU2002258728A1 (en) 2001-04-06 2002-10-21 Georgetown University Gene brcc-3 and diagnostic and therapeutic uses thereof
WO2002081639A2 (en) * 2001-04-06 2002-10-17 Georgetown University Gene brcc2 and diagnostic and therapeutic uses thereof
WO2002081641A2 (en) * 2001-04-06 2002-10-17 Georgetown University Gene scc-112 and diagnostic and therapeutic uses thereof
AU2002303262A1 (en) * 2001-04-06 2002-10-21 Georgetown University Gene shinc-1 and diagnostic and therapeutic uses thereof
US6887462B2 (en) 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
US20050054051A1 (en) * 2001-04-12 2005-03-10 Human Genome Sciences, Inc. Albumin fusion proteins
US20050244931A1 (en) * 2001-04-12 2005-11-03 Human Genome Sciences, Inc. Albumin fusion proteins
US20060084794A1 (en) * 2001-04-12 2006-04-20 Human Genome Sciences, Inc. Albumin fusion proteins
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
ATE291925T1 (de) 2001-06-05 2005-04-15 Curevac Gmbh Stabilisierte mrna mit erhöhtem g/c-gehalt und optimierter codon usage für die gentherapie
CA2456470A1 (en) * 2001-08-13 2003-02-27 University Of Southern California Interleukin-2 mutants with reduced toxicity
US20070020622A1 (en) * 2001-09-14 2007-01-25 Invitrogen Corporation DNA Polymerases and mutants thereof
AU2002332041A1 (en) * 2001-10-05 2003-04-22 Human Genome Sciences, Inc. Albumin fusion proteins
US20040126762A1 (en) * 2002-12-17 2004-07-01 Morris David W. Novel compositions and methods in cancer
US20040166490A1 (en) * 2002-12-17 2004-08-26 Morris David W. Novel therapeutic targets in cancer
US20040197778A1 (en) * 2002-12-26 2004-10-07 Sagres Discovery, Inc. Novel compositions and methods in cancer
US20060040262A1 (en) * 2002-12-27 2006-02-23 Morris David W Novel compositions and methods in cancer
US20040180344A1 (en) * 2003-03-14 2004-09-16 Morris David W. Novel therapeutic targets in cancer
CA2469049A1 (en) * 2001-12-07 2003-06-19 Chiron Corporation Endogenous retrovirus polypeptides linked to oncogenic transformation
US20060275747A1 (en) * 2001-12-07 2006-12-07 Hardy Stephen F Endogenous retrovirus up-regulated in prostate cancer
DE10162480A1 (de) 2001-12-19 2003-08-07 Ingmar Hoerr Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen
EP2261250B1 (en) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin fusion proteins
IL147414A0 (en) 2001-12-31 2002-08-14 Yeda Res & Dev Ifnar2 mutants, their production and use
WO2003080808A2 (en) 2002-03-21 2003-10-02 Sagres Discovery, Inc. Novel compositions and methods in cancer
JP4761710B2 (ja) * 2002-04-05 2011-08-31 アムジェン インコーポレイテッド 選択的ｏｐｇｌ経路インヒビターとしてのヒト抗ｏｐｇｌ中和抗体
US7244565B2 (en) * 2002-04-10 2007-07-17 Georgetown University Gene shinc-3 and diagnostic and therapeutic uses thereof
RS89204A (en) * 2002-04-10 2006-12-15 Applied Research Systems Ars Holding N.V. Use of osteoprotegerin for the treatment and/or prevention of fibrotic disease
US7138512B2 (en) * 2002-04-10 2006-11-21 Georgetown University Gene SHINC-2 and diagnostic and therapeutic uses thereof
US7585840B2 (en) 2002-04-10 2009-09-08 Merck Serono S.A. Use of osteoprotegerin for the treatment and/or prevention of fibrotic disease
US20030228317A1 (en) * 2002-05-22 2003-12-11 Prafulla Gokhale Gene BRCC-1 and diagnostic and therapeutic uses thereof
TWI334785B (en) * 2002-06-03 2010-12-21 Serono Lab Use of recombinant ifn-β1a and pharmaceutical composition comprising recombinant ifn-β1a for the treatment of hcv infection in patients of asian race
EP2302039A1 (en) * 2002-06-13 2011-03-30 Novartis Vaccines and Diagnostics, Inc. Virus-like particles comprising HML-2 gag polypeptide
AU2003248845A1 (en) * 2002-07-12 2004-02-02 The Regents Of The University Of California Steroidogenic factor-1 protein variants and methods of making same
RU2450827C2 (ru) * 2002-07-19 2012-05-20 Цитос Биотехнологи Аг Композиции вакцин, содержащие наборы антигенов в виде амилоида бета 1-6
US20040175359A1 (en) * 2002-11-12 2004-09-09 Desjarlais John Rudolph Novel proteins with antiviral, antineoplastic, and/or immunomodulatory activity
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
US7767387B2 (en) * 2003-06-13 2010-08-03 Sagres Discovery, Inc. Therapeutic targets in cancer
US20070218071A1 (en) * 2003-09-15 2007-09-20 Morris David W Novel therapeutic targets in cancer
US20040170982A1 (en) * 2003-02-14 2004-09-02 Morris David W. Novel therapeutic targets in cancer
US20060210588A1 (en) * 2003-03-26 2006-09-21 Cytos Biotechnology Ag Hiv-peptide-carrier-conjugates
RU2351362C2 (ru) * 2003-03-26 2009-04-10 Цитос Байотекнолоджи Аг КОНЪЮГАТЫ ПЕПТИДА Melan-A, АНАЛОГА ВИРУСОПОДОБНОЙ ЧАСТИЦЫ
US7537767B2 (en) * 2003-03-26 2009-05-26 Cytis Biotechnology Ag Melan-A- carrier conjugates
CA2520023C (en) 2003-04-08 2013-02-05 Yeda Research And Development Co. Ltd Stem cells having increased sensitivity to sdf-1 and methods of generating and using same
FR2853551B1 (fr) 2003-04-09 2006-08-04 Lab Francais Du Fractionnement Formulation stabilisante pour compositions d'immunoglobulines g sous forme liquide et sous forme lyophilisee
TWI272948B (en) 2003-05-01 2007-02-11 Ares Trading Sa HSA-free stabilized interferon liquid formulations
US20070281896A1 (en) * 2003-09-30 2007-12-06 Morris David W Novel compositions and methods in cancer
IL158287A0 (en) 2003-10-07 2004-05-12 Yeda Res & Dev Antibodies to nik, their preparation and use
IL158868A0 (en) 2003-11-13 2004-05-12 Yeda Res & Dev Methods of generating and using stem cells enriched with immature primitive progenitor
DE102004008168B4 (de) * 2004-02-19 2015-12-10 Voxeljet Ag Verfahren und Vorrichtung zum Auftragen von Fluiden und Verwendung der Vorrichtung
CA2556339A1 (en) * 2004-03-01 2005-09-15 David Ray Filpula Interferon-beta polymer conjugates
IL161673A0 (en) 2004-04-29 2004-09-27 Applied Research Systems Compositions and methods for therapy of chemotherapy-induced neuropathy
CA2566364A1 (en) * 2004-05-17 2005-11-24 Ares Trading S.A. Hydrogel interferon formulations
ES2418833T3 (es) 2004-06-01 2013-08-16 Ares Trading S.A. Formulaciones líquidas de interferón estabilizadas
MXPA06014079A (es) 2004-06-01 2007-02-15 Ares Trading Sa Metodo para estabilizar proteinas.
US20060024677A1 (en) 2004-07-20 2006-02-02 Morris David W Novel therapeutic targets in cancer
DE102004042546A1 (de) 2004-09-02 2006-03-09 Curevac Gmbh Kombinationstherapie zur Immunstimulation
WO2006042002A2 (en) * 2004-10-05 2006-04-20 Oregon Health And Science University Compositions and methods for treating disease
GB0424563D0 (en) * 2004-11-05 2004-12-08 Novartis Ag Organic compounds
KR101330626B1 (ko) * 2004-11-10 2013-11-18 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 탈아미드화된 인터페론-베타
TW200633718A (en) * 2004-12-16 2006-10-01 Applied Research Systems Treatment of hepatitis c in the asian population
WO2006110585A2 (en) 2005-04-07 2006-10-19 Novartis Vaccines And Diagnostics Inc. Cancer-related genes (prlr)
CA2604885A1 (en) 2005-04-07 2006-10-19 Guoying Yu Cacna1e in cancer diagnosis, detection and treatment
US20060242012A1 (en) * 2005-04-22 2006-10-26 Sumit Agarwal Determining or scoring properties to solicit to join ad network using advertiser or aggregated advertiser interest
AU2006239405B2 (en) 2005-04-26 2011-12-08 Merck Serono Sa INSP163 polypeptides for the treatment or prevention of cancer and arthritis
SG195394A1 (en) 2005-05-18 2013-12-30 Biofactura Inc Compositions and methods for metabolic selection of transfected cells
DOP2006000116A (es) * 2005-05-19 2007-01-31 Schering Ag Sistema mejorado de expresión regulada y sus usos.
US20070179113A1 (en) * 2005-05-19 2007-08-02 Schering Aktiengesellachaft GM-CSF gene therapy for Crohn's disease using an improved regulated expression system
US20080076729A1 (en) * 2005-05-19 2008-03-27 Schering Aktiengesellachaft Interferon-beta gene therapy using an improved, regulated expression system
WO2006122972A1 (en) * 2005-05-19 2006-11-23 Bayer Schering Pharma Aktiengesellschaft Interferon-beta gene therapy using an improved, regulated expression system
AU2006254103B2 (en) 2005-06-03 2012-09-06 Ares Trading S.A. Production of recombinant IL-18 binding protein
RS52273B (en) * 2005-06-10 2012-10-31 Ares Trading S.A. PROCESS FOR PURIFICATION OF IL-18 BINDING PROTEIN
WO2007014156A2 (en) * 2005-07-21 2007-02-01 Buck Institute For Age Research Fibroblast growth factor-2 promotes neurogenesis and neuroprotection and prolongs survival in huntington's disease
WO2007014382A1 (en) * 2005-07-28 2007-02-01 Wyeth Compositions and methods of mutant nogo-66 domain proteins
US20070027305A1 (en) * 2005-07-29 2007-02-01 Novartis Ag Method and system for in vitro protein folding
LT1917276T (lt) 2005-08-26 2018-05-25 Ares Trading S.A. Glikozilinto interferono beta gavimo būdas
EP1760092A1 (en) 2005-08-26 2007-03-07 Applied Research Systems ARS Holding N.V. System for screening cells for high expression of a protein of interest
EA013816B1 (ru) * 2005-09-01 2010-08-30 Арес Трейдинг С.А. Лечение неврита зрительного нерва
SI1767545T1 (sl) 2005-09-22 2010-03-31 Biocompatibles Uk Ltd GLP Glukagonu podobni peptidi fuzijski polipeptidi s povečano rezistenco na peptidazo
PL2026832T3 (pl) 2006-05-24 2012-08-31 Merck Serono Sa Skojarzony reżim interferonu beta i kladrybiny do leczenia stwardnienia rozsianego
WO2008001370A2 (en) 2006-06-28 2008-01-03 Yeda Research And Development Co. Ltd Caspase-8 and inflammation, infection and wound healing
US9131648B2 (en) * 2006-07-07 2015-09-15 Washington State University Genes encoding chavicol/eugenol synthase from the creosote bush Larrea tridentata
EP2469283B1 (en) * 2006-09-08 2014-01-15 The Chancellor, Masters and Scholars of the University of Oxford Clinical diagnosis of hepatic fibrosis using human serum APOL1 as biomarker
WO2008079270A2 (en) * 2006-12-19 2008-07-03 Merrimack Pharmaceuticals, Inc. Coadministration of alpha-fetoprotein and an immunomodulatory agent to treat multiple sclerosis
WO2008125222A2 (en) * 2007-04-11 2008-10-23 Bayer Schering Pharma Aktiengesellschaft New modulation molecules for an improved regulated expression system
AU2008247815B2 (en) * 2007-05-02 2012-09-06 Ambrx, Inc. Modified interferon beta polypeptides and their uses
WO2009029656A1 (en) * 2007-08-27 2009-03-05 Auxagen, Inc. METHODS FOR INHIBITING TGF-β
WO2009045553A1 (en) * 2007-10-05 2009-04-09 Barofold, Inc. High pressure treatment of aggregated interferons
PL2234645T3 (pl) * 2007-12-20 2012-10-31 Merck Serono Sa Preparaty interferonu-beta modyfikowanego PEG
IL189408A0 (en) 2008-02-10 2009-02-11 Yeda Res & Dev Siva3, its preparation and pharmaceutical compositions containing it
EP2257628A4 (en) * 2008-03-04 2011-11-02 Univ Washington State COMPOSITIONS AND METHODS FOR THE DIFFERENTIAL REGULATION OF THE INSETICITY OF FATTY ACIDS IN MEMBRANLIPIDES AND SEED OIL
BRPI0911652A2 (pt) 2008-04-11 2015-08-04 Merrimack Pharmaceuticals Inc Ligantes de albumina sérica humana e seus conjugados
JP5773366B2 (ja) 2008-04-21 2015-09-02 ティシュー リジェネレイション セラピューティックス、インコーポレイテッド 生物学的又は化学的作用物質に対する予防又はそれらの治療のために遺伝子改変されたヒト臍帯血管周囲細胞
CN102159219B (zh) * 2008-09-16 2015-06-24 圣路易斯大学 提高转化生长因子-β信号发送的方法
CN102282168A (zh) 2008-11-18 2011-12-14 梅里麦克制药股份有限公司 人血清白蛋白接头以及其结合物
US9074005B2 (en) * 2009-01-02 2015-07-07 Washington State University Compositions and methods for modulating plant disease resistance and immunity
CN201397956Y (zh) * 2009-03-23 2010-02-03 富士康(昆山)电脑接插件有限公司 电连接器组件
KR20120041175A (ko) * 2009-05-14 2012-04-30 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 미량 존재하는 인간 혈장 단백질 바이오마커의 신규 패널을 이용한 간성 섬유증의 임상적 진단
EP2440251A4 (en) 2009-06-09 2013-01-16 Defyrus Inc INTERFERON ADMINISTRATION FOR PROPHYLAXIS AGAINST PATHOGEN INFECTION OR TREATMENT OF PATHOGEN INFECTION
US20110016548A1 (en) * 2009-07-16 2011-01-20 University Of Southern California Control of endogenous dnmt1 gene expression by exogenous binary regulatory systems
CU23734A1 (es) 2009-11-27 2011-11-15 Centro Inmunologia Molecular Polipéptidos inmunomoduladores derivados de la il-2 con actividad antagonista de esta citocina útiles en la terapia del cáncer y enfermedades infecciosas crónicas
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2622064B1 (en) 2010-10-01 2019-05-29 Modernatx, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
CU23923B1 (es) 2010-11-12 2013-07-31 Ct De Inmunología Molecular Polipéptidos derivados de la il-2 con actividad agonista
US8710200B2 (en) 2011-03-31 2014-04-29 Moderna Therapeutics, Inc. Engineered nucleic acids encoding a modified erythropoietin and their expression
EP3670536A3 (en) 2011-04-01 2020-10-07 Universität Stuttgart Recombinant tnf ligand family member polypeptides with antibody binding domain and uses thereof
WO2012159945A1 (en) 2011-05-20 2012-11-29 Ares Trading S.A. Ifn-beta compositions, preparation methods and uses thereof
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
HRP20220250T1 (hr) 2011-10-03 2022-04-29 Modernatx, Inc. Modificirani nukleozidi, nukleotidi i nukleinske kiseline, te njihove uporabe
EP2791160B1 (en) 2011-12-16 2022-03-02 ModernaTX, Inc. Modified mrna compositions
WO2013147153A1 (ja) 2012-03-29 2013-10-03 株式会社未来創薬研究所 抗ｌａｍｐ５抗体およびその利用
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
EP2834259A4 (en) 2012-04-02 2016-08-24 Moderna Therapeutics Inc MODIFIED POLYNUCLEOTIDES
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9345766B2 (en) 2012-08-30 2016-05-24 Merrimack Pharmaceuticals, Inc. Combination therapies comprising anti-ERBB3 agents
JP2016506373A (ja) * 2012-11-15 2016-03-03 エスペランス ファーマシューティカルズ， インコーポレイテッド 卵胞刺激ホルモン（ｆｓｈ）／溶解ドメイン融合コンストラクト及びその作製及び使用の方法
ES2921623T3 (es) 2012-11-26 2022-08-30 Modernatx Inc ARN modificado terminalmente
PT2953634T (pt) 2013-02-07 2021-09-02 Massachusetts Gen Hospital Métodos de expansão ou depleção das células t reguladoras
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2014152030A1 (en) 2013-03-15 2014-09-25 Moderna Therapeutics, Inc. Removal of dna fragments in mrna production process
EP3052521A1 (en) 2013-10-03 2016-08-10 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
CA2925021A1 (en) 2013-11-01 2015-05-07 Curevac Ag Modified rna with decreased immunostimulatory properties
AU2015328163B2 (en) 2014-10-09 2020-10-15 Dana-Farber Cancer Institute, Inc. Multiple-variable IL-2 dose regimen for treating immune disorders
CN108929383B (zh) * 2017-05-26 2021-10-15 阿思科力(苏州)生物科技有限公司 重组Slit2D2(C386S)-HSA融合蛋白及其在预防和/或治疗肺部炎症中的应用
WO2023122716A1 (en) 2021-12-22 2023-06-29 Vanderbilt University Next generation transpososomes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI82266C (sv) 1982-10-19 1991-02-11 Cetus Corp Förfarande för framställning av IL-2 -mutein
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
US4816566A (en) * 1983-06-01 1989-03-28 Hoffmann-La Roche, Inc. Polypeptides having interferon activity
IL71951A0 (en) * 1983-06-01 1984-09-30 Hoffmann La Roche Polypeptides having interferon activity,their preparation and pharmaceutical compositions containing them
CA1265444A (en) 1983-06-27 1990-02-06 Lloyd J. Old Effect of human tumor necrosis factor and human interferon on human cancer cells and methods
DE19975063I2 (de) 1984-03-06 2005-08-18 Dainippon Pharmaceutical Co DNS den menschlichen Tumornekrosisfaktor kodierendund das menschliche Tumornekronisfaktor-Polypepti d.
US4879226A (en) 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide
GR851626B (sv) 1984-07-05 1985-11-26 Genentech Inc

Also Published As

Publication number Publication date
FI864036A (sv) 1986-10-06
DE3672924D1 (de) 1990-08-30
AU5518086A (en) 1986-08-26
FI864036A0 (sv) 1986-10-06
EP0213175A1 (en) 1987-03-11
DK172276B1 (da) 1998-02-16
DK478786A (da) 1986-12-08
JPS62501608A (ja) 1987-07-02
US4959314A (en) 1990-09-25
WO1986004606A1 (en) 1986-08-14
FI99015C (sv) 1997-09-25
DK478786D0 (da) 1986-10-07
EP0213175B1 (en) 1990-07-25

Similar Documents

Publication Publication Date Title
FI99015B (sv) Förfarande för framställning av ett biologiskt aktivt mutein av tumörnekrosisfaktor-proteinet
FI94254B (sv) Förfarande för framställning av terapeutiskt aktiva peptidföreningar
IL83899A0 (en) Yeast production of human tumor necrosis factor
GB8508340D0 (en) Production of protein
ZA861323B (en) Biologically active proteins and a method for their production
FI864552A (fi) Human-lysozym.
IL75828A (en) Immobilization by biologically active proteins
NO169173C (no) Veksthormon-frigjoerende peptider
ZA867839B (en) Biologically active derivatives of human ypsilon-interferon
DK586586D0 (da) Biologisk aktive amidderivater
IT1186417B (it) Procedimento per il consolidamento di terreni
GR860360B (en) Gene for biologically active proteins
KR880005263A (ko) 단백질의 신규제법
KR870700632A (ko) 네틸마이신의 제조방법
IT1190249B (it) Metodo di produzione di ferroleghe
DE3678122D1 (de) Herstellungsverfahren von diisopropylcarbinol.
GB8600199D0 (en) Production of protein
GB8526951D0 (en) Production of protein
NO863976D0 (no) Cystein-beroevede muteiner av biologisk aktive human tumornekrosefaktorproteiner.
RO92640A2 (ro) Metoda pentru tratamentul keratitelor virotice
RO93784A2 (ro) Metoda de anestezie generala
ZA863081B (en) Production of protein
KR860008749A (ko) 장식용 반사구의 제조방법
ES551665A0 (es) Un metodo para preparar la proteina factor de estimulacion de colonias (csf-1)recombinante
ATE54941T1 (de) Cystein verminderte muteine von biologisch aktiven menschlichen tnf-proteinen.

Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: CHIRON CORPORATION

BB Publication of examined application
FG Patent granted

Owner name: CHIRON CORPORATION

MA Patent expired