FI974001A - Uudet metyleenibisfosfonihappojohdannaiset - Google Patents

Uudet metyleenibisfosfonihappojohdannaiset Download PDF

Info

Publication number
FI974001A
FI974001A FI974001A FI974001A FI974001A FI 974001 A FI974001 A FI 974001A FI 974001 A FI974001 A FI 974001A FI 974001 A FI974001 A FI 974001A FI 974001 A FI974001 A FI 974001A
Authority
FI
Finland
Prior art keywords
acid derivatives
bisphosphonic acid
novel methylene
methylene bisphosphonic
novel
Prior art date
Application number
FI974001A
Other languages
English (en)
Swedish (sv)
Other versions
FI974001A0 (fi
FI104901B (fi
Inventor
Esko Kalervo Pohjala
Jouko Juhani Vepsaelaeinen
Heikki Nupponen
Jouni Pekka Kaehkoenen
Leena Lauren
Ritva Hannuniemi
Tomi Lauri Jaervinen
Marko Juhani Ahlmark
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of FI974001A0 publication Critical patent/FI974001A0/fi
Priority to FI974001A priority Critical patent/FI104901B/fi
Priority to JP2000516975A priority patent/JP2001520232A/ja
Priority to CNB988103710A priority patent/CN1147497C/zh
Priority to BR9813102-8A priority patent/BR9813102A/pt
Priority to KR1020007004256A priority patent/KR20010031269A/ko
Priority to CA002306080A priority patent/CA2306080A1/en
Priority to EEP200000239A priority patent/EE04061B1/xx
Priority to IL13563998A priority patent/IL135639A0/xx
Priority to EP98949022A priority patent/EP1032578A1/en
Priority to NZ504390A priority patent/NZ504390A/en
Priority to TR2000/01055T priority patent/TR200001055T2/xx
Priority to US09/529,826 priority patent/US6326363B1/en
Priority to RU2000112534/04A priority patent/RU2205833C2/ru
Priority to AU95437/98A priority patent/AU740355B2/en
Priority to PCT/FI1998/000814 priority patent/WO1999020634A1/en
Priority to HU0004386A priority patent/HUP0004386A3/hu
Priority to PL98340055A priority patent/PL340055A1/xx
Publication of FI974001A publication Critical patent/FI974001A/fi
Priority to NO20002006A priority patent/NO20002006L/no
Application granted granted Critical
Publication of FI104901B publication Critical patent/FI104901B/fi
Priority to BG104452A priority patent/BG104452A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
    • C07F9/4093—Compounds containing the structure P(=X)-X-C(=X)- (X = O, S, Se)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI974001A 1997-10-20 1997-10-20 Uudet metyleenibisfosfonihappojohdannaiset FI104901B (fi)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FI974001A FI104901B (fi) 1997-10-20 1997-10-20 Uudet metyleenibisfosfonihappojohdannaiset
TR2000/01055T TR200001055T2 (tr) 1997-10-20 1998-10-20 Yeni metilenbifosfonik asit türevleri
RU2000112534/04A RU2205833C2 (ru) 1997-10-20 1998-10-20 Производные ангидрида метиленбисфосфоновой кислоты, способы их получения, фармацевтическая композиция
BR9813102-8A BR9813102A (pt) 1997-10-20 1998-10-20 Derivados de ácido metilenobisfosfÈnico novos
KR1020007004256A KR20010031269A (ko) 1997-10-20 1998-10-20 신규한 메틸렌비스포스폰산 유도체
CA002306080A CA2306080A1 (en) 1997-10-20 1998-10-20 Novel methylenebisphosphonic acid derivatives
EEP200000239A EE04061B1 (et) 1997-10-20 1998-10-20 Metüleenbisfosfoonhappe derivaadid
IL13563998A IL135639A0 (en) 1997-10-20 1998-10-20 Novel methylenebisphosphonic acid derivatives
EP98949022A EP1032578A1 (en) 1997-10-20 1998-10-20 Novel methylenebisphosphonic acid derivatives
NZ504390A NZ504390A (en) 1997-10-20 1998-10-20 Methylenebisphosphonic acid anhydride derivatives and pharmaceuticals thereof
JP2000516975A JP2001520232A (ja) 1997-10-20 1998-10-20 新規なメチレンビスホスホン酸誘導体
US09/529,826 US6326363B1 (en) 1997-10-20 1998-10-20 Methylenebisphosphonic acid derivatives
CNB988103710A CN1147497C (zh) 1997-10-20 1998-10-20 亚甲基双膦酸类衍生物
AU95437/98A AU740355B2 (en) 1997-10-20 1998-10-20 Novel Methylenebisphosphonic Acid Derivatives
PCT/FI1998/000814 WO1999020634A1 (en) 1997-10-20 1998-10-20 Novel methylenebisphosphonic acid derivatives
HU0004386A HUP0004386A3 (en) 1997-10-20 1998-10-20 Methylenebisphosphonic acid derivatives, process for producing them and medicaments containing the same as active agent
PL98340055A PL340055A1 (en) 1997-10-20 1998-10-20 Novel derivatives of methylene biphosphonic acid
NO20002006A NO20002006L (no) 1997-10-20 2000-04-17 Nye metylenbisfosfonsyrederivater
BG104452A BG104452A (en) 1997-10-20 2000-05-17 New derivatives of the methylenebisphosphonic acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI974001 1997-10-20
FI974001A FI104901B (fi) 1997-10-20 1997-10-20 Uudet metyleenibisfosfonihappojohdannaiset

Publications (3)

Publication Number Publication Date
FI974001A0 FI974001A0 (fi) 1997-10-20
FI974001A true FI974001A (fi) 1999-04-21
FI104901B FI104901B (fi) 2000-04-28

Family

ID=8549759

Family Applications (1)

Application Number Title Priority Date Filing Date
FI974001A FI104901B (fi) 1997-10-20 1997-10-20 Uudet metyleenibisfosfonihappojohdannaiset

Country Status (19)

Country Link
US (1) US6326363B1 (fi)
EP (1) EP1032578A1 (fi)
JP (1) JP2001520232A (fi)
KR (1) KR20010031269A (fi)
CN (1) CN1147497C (fi)
AU (1) AU740355B2 (fi)
BG (1) BG104452A (fi)
BR (1) BR9813102A (fi)
CA (1) CA2306080A1 (fi)
EE (1) EE04061B1 (fi)
FI (1) FI104901B (fi)
HU (1) HUP0004386A3 (fi)
IL (1) IL135639A0 (fi)
NO (1) NO20002006L (fi)
NZ (1) NZ504390A (fi)
PL (1) PL340055A1 (fi)
RU (1) RU2205833C2 (fi)
TR (1) TR200001055T2 (fi)
WO (1) WO1999020634A1 (fi)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO313180B1 (no) * 2000-07-04 2002-08-26 Anticancer Therapeutic Inv Sa Bensökende alfapartikkel emitterende radiofarmasöytika
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
WO2008024169A1 (en) * 2006-07-21 2008-02-28 Glsynthesis, Inc. Reactive pyrophosphoric and bisphosphonic acid derivatives and methods of their use
WO2010059215A1 (en) 2008-11-20 2010-05-27 Glsynthesis Inc. Novel antithrombotic diadenosine tetraphosphates and related analogs
CN107011380A (zh) * 2016-01-28 2017-08-04 臧伟 一种二膦酸衍生物及含二膦酸衍生物的组合物治疗骨折的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447256A (en) 1977-07-20 1984-05-08 Nissan Chemical Industries, Ltd. N-(Unsubstituted or substituted pyridyl)aminomethylene-diphosphonic acids, herbicidal compositions containing same, their use for herbicides, and process for preparing same
DE2758580A1 (de) 1977-12-29 1979-07-05 Hoechst Ag Verfahren zur herstellung von phosphin- und phosphonsaeure-anhydriden
US4973576A (en) 1987-03-10 1990-11-27 Yamanouchi Pharmaceutical Co., Ltd. Bisphophonic acid derivatives and pharmaceutical compositions containing the same
US4933472A (en) 1988-04-08 1990-06-12 Yamanouchi Pharmaceutical Co., Ltd. Substituted aminomethylenebis(phosphonic acid) derivatives
EP0356866A3 (en) 1988-08-29 1991-03-27 E.R. SQUIBB & SONS, INC. Phosphorus-containing squalene synthetase inhibitors and method
FI83421C (fi) 1989-06-21 1991-07-10 Huhtamaeki Oy Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.
EP0416689B1 (en) 1989-09-06 1995-11-29 Merck & Co. Inc. Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
FI89366C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
FI89364C (fi) 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya, farmakologiskt anvaendbara metylenbisfosfonsyraderivat
FI89365C (fi) 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
PL297372A1 (en) 1991-04-06 1993-09-06 Fisons Plc Atp analogs
TW237386B (fi) 1992-04-15 1995-01-01 Ciba Geigy
SG47943A1 (en) * 1993-02-10 1998-04-17 Astra Pharma Prod N-alkyl-2-substituted atp analogues
US5462932A (en) 1994-05-17 1995-10-31 Merck & Co., Inc. Oral liquid alendronate formulations

Also Published As

Publication number Publication date
WO1999020634A1 (en) 1999-04-29
JP2001520232A (ja) 2001-10-30
EE04061B1 (et) 2003-06-16
EE200000239A (et) 2001-08-15
IL135639A0 (en) 2001-05-20
FI974001A0 (fi) 1997-10-20
EP1032578A1 (en) 2000-09-06
FI104901B (fi) 2000-04-28
HUP0004386A2 (hu) 2001-04-28
PL340055A1 (en) 2001-01-15
CA2306080A1 (en) 1999-04-29
KR20010031269A (ko) 2001-04-16
BR9813102A (pt) 2000-08-22
NO20002006L (no) 2000-06-15
RU2205833C2 (ru) 2003-06-10
CN1147497C (zh) 2004-04-28
NO20002006D0 (no) 2000-04-17
AU740355B2 (en) 2001-11-01
BG104452A (en) 2000-12-29
HUP0004386A3 (en) 2002-08-28
NZ504390A (en) 2001-10-26
TR200001055T2 (tr) 2000-09-21
CN1276793A (zh) 2000-12-13
AU9543798A (en) 1999-05-10
US6326363B1 (en) 2001-12-04

Similar Documents

Publication Publication Date Title
ATE248812T1 (de) Arylsulfonylhydroxamsäurederivate
DK1003720T3 (da) Aryloxyarylsulfonylaminohydroxamsyrederivater
DE69703385D1 (de) Alkoxyessigsäure-derivate
NO990821D0 (no) Arylsulfonylamino-hydroksaminsyre-derivater
ATE211131T1 (de) Arylsulfonylaminohydroxamsäurederivate
EE04772B1 (et) 3-arüül-2-hüdroksüpropaanhappe derivaat (I)
ATE269861T1 (de) Substituierte indolalkansäure
ATE239005T1 (de) (4-sulfonylamino)-tetrahydropyran-4-carbonsäure hydroxamiden
FI973754A0 (fi) Foerfarande foer saendning av ett kortmeddelande i et telekommunikationsnaet
ATE260243T1 (de) N-aroylphenylalaninderivate
ATE235220T1 (de) Resorcinderivate
PT1077957E (pt) Derivados do acido oxi-iminoalcanoico
ID20809A (id) Asam diaminokarboksilat tersubstitusi
DE69817186D1 (de) Diaminorhodamin-derivate
ID20807A (id) Asam sulfonilaminokarboksilat
NO20006114D0 (no) Nytt 3-aryl-2-hydroksypropionsyrederivat III
DK1100769T3 (da) Aminomethylcarboxylsyrederivater
ATE255098T1 (de) Substituierte chromanderivate
IS5562A (is) Nýjar díhýdroxýhexanósýru afleiður
ATE255099T1 (de) Substituierte chromanderivate
DE69841086D1 (de) 5-Deoxy-Cytidin-Derivate
FI972688A0 (fi) Foerfarande foer avkaenning av en signal i en mottagare i ett cellulaert radionaet
DE69718338D1 (de) 3-alkoxyisoxazol-4-yl-substituierte 2-aminocarbonsäurederivate
DE69829682D1 (de) Cis-disubstituierte aminocycloalkyl-pyrrolidin-derivate
DE69828780D1 (de) Amidinocamptpthecin-derivate

Legal Events

Date Code Title Description
MA Patent expired