FI972492L - Imidatsolijohdoksia proteiinikinaasien, erityisesti EGF-R-tyrosiinikinaasin, inhibiittoreina - Google Patents
Imidatsolijohdoksia proteiinikinaasien, erityisesti EGF-R-tyrosiinikinaasin, inhibiittoreina Download PDFInfo
- Publication number
- FI972492L FI972492L FI972492A FI972492A FI972492L FI 972492 L FI972492 L FI 972492L FI 972492 A FI972492 A FI 972492A FI 972492 A FI972492 A FI 972492A FI 972492 L FI972492 L FI 972492L
- Authority
- FI
- Finland
- Prior art keywords
- inhibitors
- tyrosine kinase
- protein kinases
- imidazole derivatives
- especially egf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH376894 | 1994-12-13 | ||
| PCT/EP1995/004741 WO1996018626A1 (en) | 1994-12-13 | 1995-12-01 | Imidazole derivatives as protein kinase inhibitors in particular egf-r tyrosine kinase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI972492A7 FI972492A7 (fi) | 1997-06-12 |
| FI972492A0 FI972492A0 (fi) | 1997-06-12 |
| FI972492L true FI972492L (fi) | 1997-06-12 |
Family
ID=4263074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI972492A FI972492L (fi) | 1994-12-13 | 1995-12-01 | Imidatsolijohdoksia proteiinikinaasien, erityisesti EGF-R-tyrosiinikinaasin, inhibiittoreina |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5959113A (de) |
| EP (1) | EP0797575B1 (de) |
| JP (1) | JPH10510281A (de) |
| CN (1) | CN1145623C (de) |
| AR (1) | AR003406A1 (de) |
| AT (1) | ATE252094T1 (de) |
| AU (1) | AU4301096A (de) |
| BR (1) | BR9509998A (de) |
| CA (1) | CA2207404C (de) |
| DE (1) | DE69531956T2 (de) |
| DK (1) | DK0797575T3 (de) |
| ES (1) | ES2208698T3 (de) |
| FI (1) | FI972492L (de) |
| PT (1) | PT797575E (de) |
| TR (1) | TR199501561A2 (de) |
| WO (1) | WO1996018626A1 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083949A (en) * | 1995-10-06 | 2000-07-04 | Merck & Co., Inc. | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
| JP2001504490A (ja) * | 1996-11-20 | 2001-04-03 | メルク エンド カンパニー インコーポレーテッド | トリアリール置換イミダゾール、そのような化合物を含む組成物及び使用方法 |
| US5880139A (en) * | 1996-11-20 | 1999-03-09 | Merck & Co., Inc. | Triaryl substituted imidazoles as glucagon antagonists |
| JP2000514088A (ja) * | 1996-11-20 | 2000-10-24 | メルク エンド カンパニー インコーポレーテッド | グルカゴンアンタゴニストとしてのトリアリール置換イミダゾール |
| US6022884A (en) | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
| AU4506399A (en) * | 1998-06-05 | 1999-12-30 | Novartis Ag | Aryl pyridinyl thiazoles |
| AU4395399A (en) * | 1998-07-02 | 2000-01-24 | Sankyo Company Limited | Five-membered heteroaryl compounds |
| JP3850596B2 (ja) | 1999-02-25 | 2006-11-29 | 本州化学工業株式会社 | 新規な部分保護トリスフェノール類とその製造方法 |
| WO2003024447A1 (en) * | 2001-09-20 | 2003-03-27 | Smithkline Beecham Corporation | Inhibitors of glycogen synthase kinase-3 |
| AR039241A1 (es) | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
| US6790852B2 (en) * | 2002-04-18 | 2004-09-14 | Hoffmann-La Roche Inc. | 2-(2,6-dichlorophenyl)-diarylimidazoles |
| ES2497116T3 (es) | 2002-08-19 | 2014-09-22 | Lorus Therapeutics Inc. | Imidazoles 2,4,5-trisustituidos y su uso como agentes antimicrobianos |
| US7144889B2 (en) * | 2003-10-16 | 2006-12-05 | Hoffman-La Roche Inc. | Triarylimidazoles |
| CN100436450C (zh) * | 2003-10-16 | 2008-11-26 | 霍夫曼-拉罗奇有限公司 | 三芳基咪唑 |
| US7169781B2 (en) | 2003-10-17 | 2007-01-30 | Hoffmann-La Roche Inc. | Imidazole derivatives and their use as pharmaceutical agents |
| CA2545942C (en) | 2003-11-14 | 2012-07-10 | Lorus Therapeutics Inc. | Aryl imidazoles and their use as anti-cancer agents |
| CN101080399B (zh) * | 2005-02-18 | 2012-12-12 | 独立行政法人科学技术振兴机构 | 光学活性环氧化合物的制造方法以及使用该方法的错合物及其制造方法 |
| CA2611032C (en) | 2005-05-25 | 2012-01-17 | Genesense Technologies Inc. | 2-indolyl imidazo[4,5-d]phenanthroline derivatives and their use in the treatment of cancer |
| JP5283872B2 (ja) | 2006-09-27 | 2013-09-04 | シスメックス株式会社 | 腫瘍細胞に対する阻害剤の増殖抑制効果を評価する方法、及び腫瘍細胞の増殖を阻害する化合物をスクリーニングする方法 |
| AU2007305423A1 (en) * | 2006-09-28 | 2008-04-10 | Follica, Inc. | Methods, kits, and compositions for generating new hair follicles and growing hair |
| WO2014153464A2 (en) | 2013-03-20 | 2014-09-25 | Lorus Therapeutics Inc. | 2-substituted imidazo[4,5-d]phenanthroline derivatives and their use in the treatment of cancer |
| CN105764511B (zh) | 2013-10-04 | 2019-01-11 | 艾普托斯生物科学公司 | 用于治疗癌症的组合物和方法 |
| CN106163509B (zh) | 2014-02-03 | 2019-05-03 | 夸德里加生物科学公司 | 作为化疗剂的β-取代的β-氨基酸及类似物 |
| US9394236B2 (en) | 2014-02-03 | 2016-07-19 | Quadriga Biosciences, Inc. | β-substituted γ-amino acids and analogs as chemotherapeutic agents |
| US10865384B2 (en) * | 2014-02-07 | 2020-12-15 | Agency For Science, Technology And Research | 2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis |
| JP6615983B2 (ja) | 2015-08-03 | 2019-12-04 | クワドリガ バイオサイエンシーズ， インコーポレイテッド | 化学療法剤としてのβ置換βアミノ酸および類似体ならびにそれらの使用 |
| CN109212045A (zh) * | 2017-07-04 | 2019-01-15 | 万全万特制药（厦门）有限公司 | 草酸艾司西酞普兰残留溶剂和杂质的分离测定方法 |
| KR20200096914A (ko) | 2017-10-30 | 2020-08-14 | 압토스 바이오사이언시스 인코포레이티드 | 암 치료용 아릴 이미다졸 |
| CN114262298B (zh) * | 2021-12-03 | 2023-09-26 | 郑州轻工业大学 | 2-溴-4-n,n-二甲氨基咪唑及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3707475A (en) * | 1970-11-16 | 1972-12-26 | Pfizer | Antiinflammatory imidazoles |
| US3940486A (en) * | 1971-05-10 | 1976-02-24 | Ciba-Geigy Corporation | Imidazole derivatives in the treatment of pain |
| CH561718A5 (de) * | 1971-05-10 | 1975-05-15 | Ciba Geigy Ag | |
| MC2096A1 (fr) * | 1989-02-23 | 1991-02-15 | Hoffmann La Roche | Pyrroles substitues |
| IL104369A0 (en) * | 1992-01-13 | 1993-05-13 | Smithkline Beecham Corp | Novel compounds and compositions |
| EP0624159B1 (de) * | 1992-01-13 | 1998-11-25 | Smithkline Beecham Corporation | Pyridyl-substituierte imidazole |
| WO1994003427A1 (en) * | 1992-08-06 | 1994-02-17 | Warner-Lambert Company | 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and which have antitumor properties |
| WO1995003297A1 (en) * | 1993-07-21 | 1995-02-02 | Smithkline Beecham Corporation | Imidazoles for treating cytokine mediated disease |
| DK0724588T3 (da) * | 1993-09-17 | 2000-05-15 | Smithkline Beecham Corp | Lægemiddelbindende protein |
-
1995
- 1995-12-01 CA CA002207404A patent/CA2207404C/en not_active Expired - Fee Related
- 1995-12-01 ES ES95941646T patent/ES2208698T3/es not_active Expired - Lifetime
- 1995-12-01 DK DK95941646T patent/DK0797575T3/da active
- 1995-12-01 CN CNB951976281A patent/CN1145623C/zh not_active Expired - Fee Related
- 1995-12-01 AU AU43010/96A patent/AU4301096A/en not_active Abandoned
- 1995-12-01 FI FI972492A patent/FI972492L/fi not_active IP Right Cessation
- 1995-12-01 DE DE69531956T patent/DE69531956T2/de not_active Expired - Fee Related
- 1995-12-01 AT AT95941646T patent/ATE252094T1/de not_active IP Right Cessation
- 1995-12-01 BR BR9509998A patent/BR9509998A/pt not_active IP Right Cessation
- 1995-12-01 WO PCT/EP1995/004741 patent/WO1996018626A1/en not_active Ceased
- 1995-12-01 EP EP95941646A patent/EP0797575B1/de not_active Expired - Lifetime
- 1995-12-01 PT PT95941646T patent/PT797575E/pt unknown
- 1995-12-01 JP JP8518206A patent/JPH10510281A/ja not_active Ceased
- 1995-12-01 US US08/860,750 patent/US5959113A/en not_active Expired - Fee Related
- 1995-12-11 AR ARP950100495A patent/AR003406A1/es unknown
- 1995-12-12 TR TR95/01561A patent/TR199501561A2/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10510281A (ja) | 1998-10-06 |
| AR003406A1 (es) | 1998-08-05 |
| DK0797575T3 (da) | 2004-02-16 |
| MX9704263A (es) | 1997-09-30 |
| EP0797575B1 (de) | 2003-10-15 |
| DE69531956D1 (de) | 2003-11-20 |
| US5959113A (en) | 1999-09-28 |
| ATE252094T1 (de) | 2003-11-15 |
| AU4301096A (en) | 1996-07-03 |
| ES2208698T3 (es) | 2004-06-16 |
| CN1145623C (zh) | 2004-04-14 |
| CA2207404C (en) | 2004-06-29 |
| DE69531956T2 (de) | 2004-07-29 |
| FI972492A7 (fi) | 1997-06-12 |
| CN1175252A (zh) | 1998-03-04 |
| FI972492A0 (fi) | 1997-06-12 |
| WO1996018626A1 (en) | 1996-06-20 |
| EP0797575A1 (de) | 1997-10-01 |
| PT797575E (pt) | 2004-02-27 |
| BR9509998A (pt) | 1997-12-30 |
| TR199501561A2 (tr) | 1996-07-21 |
| CA2207404A1 (en) | 1996-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |