MX9704263A - Derivados de imidazol como inhibidores de la proteina cinasa, en particular la tirosina cinasa del egf-r. - Google Patents
Derivados de imidazol como inhibidores de la proteina cinasa, en particular la tirosina cinasa del egf-r.Info
- Publication number
- MX9704263A MX9704263A MX9704263A MX9704263A MX9704263A MX 9704263 A MX9704263 A MX 9704263A MX 9704263 A MX9704263 A MX 9704263A MX 9704263 A MX9704263 A MX 9704263A MX 9704263 A MX9704263 A MX 9704263A
- Authority
- MX
- Mexico
- Prior art keywords
- imidazole derivatives
- protein kinase
- alkyl
- kinase inhibitors
- tyrosine kinase
- Prior art date
Links
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title abstract 2
- 150000002460 imidazoles Chemical class 0.000 title abstract 2
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract 2
- 239000003909 protein kinase inhibitor Substances 0.000 title abstract 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 title 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 title 1
- 201000004384 Alopecia Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 231100000360 alopecia Toxicity 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- -1 hydroxy, amino Chemical group 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
Abstract
Derivados de imidazol de la formula general (I), en donde R1-R8 cada uno independientemente significan hidrogeno, alquilo inferior, alquilo inferior sustituido, alquenilo inferior, alcoxi inferior, alcoxi inferior sustituido, alcoxicarbonilo inferior, halogeno, hidroxi, amino, mono- o di(alquilo inferior) amino o nitro, y sales farmacéuticamente aceptables de los mismos son inhibidores de la proteína cinasa y se pueden usar como medicamentos, por ejemplo, para el control de desordenes hiperproliferativos tal como aterosclerosis, psoriasis y tumores así como de alopecía.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH3768/94-2 | 1994-12-13 | ||
| CH376894 | 1994-12-13 | ||
| PCT/EP1995/004741 WO1996018626A1 (en) | 1994-12-13 | 1995-12-01 | Imidazole derivatives as protein kinase inhibitors in particular egf-r tyrosine kinase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9704263A true MX9704263A (es) | 1997-09-30 |
| MXPA97004263A MXPA97004263A (es) | 1998-07-03 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10510281A (ja) | 1998-10-06 |
| EP0797575A1 (en) | 1997-10-01 |
| PT797575E (pt) | 2004-02-27 |
| ATE252094T1 (de) | 2003-11-15 |
| EP0797575B1 (en) | 2003-10-15 |
| WO1996018626A1 (en) | 1996-06-20 |
| DE69531956T2 (de) | 2004-07-29 |
| CA2207404C (en) | 2004-06-29 |
| ES2208698T3 (es) | 2004-06-16 |
| AU4301096A (en) | 1996-07-03 |
| TR199501561A2 (tr) | 1996-07-21 |
| DE69531956D1 (de) | 2003-11-20 |
| DK0797575T3 (da) | 2004-02-16 |
| CN1175252A (zh) | 1998-03-04 |
| US5959113A (en) | 1999-09-28 |
| CA2207404A1 (en) | 1996-06-20 |
| FI972492A0 (fi) | 1997-06-12 |
| AR003406A1 (es) | 1998-08-05 |
| BR9509998A (pt) | 1997-12-30 |
| CN1145623C (zh) | 2004-04-14 |
| FI972492A (fi) | 1997-06-12 |
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