FI970352A - MHC-luokan I -raskasketjuekspression vähenemiseen osaaottavan ihmisen sytomegaloviruksen geenin tunnistus - Google Patents

MHC-luokan I -raskasketjuekspression vähenemiseen osaaottavan ihmisen sytomegaloviruksen geenin tunnistus Download PDF

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Publication number
FI970352A
FI970352A FI970352A FI970352A FI970352A FI 970352 A FI970352 A FI 970352A FI 970352 A FI970352 A FI 970352A FI 970352 A FI970352 A FI 970352A FI 970352 A FI970352 A FI 970352A
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Finland
Prior art keywords
identification
reduction
heavy chain
mhc class
human cytomegalovirus
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FI970352A
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English (en)
Swedish (sv)
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FI970352A0 (fi
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Thomas R Jones
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American Cyanamid Co
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Publication of FI970352A publication Critical patent/FI970352A/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/03—Herpetoviridae, e.g. pseudorabies virus
    • C07K14/04—Varicella-zoster virus
    • C07K14/045—Cytomegalovirus
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
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    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16141—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
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    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16161—Methods of inactivation or attenuation
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    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16161—Methods of inactivation or attenuation
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FI970352A 1994-07-29 1997-01-28 MHC-luokan I -raskasketjuekspression vähenemiseen osaaottavan ihmisen sytomegaloviruksen geenin tunnistus FI970352A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/282,696 US5846806A (en) 1994-07-29 1994-07-29 Identification of a human cytomegalovirus gene region involved in down-regulation of MHC class I heavy chain expression
PCT/US1995/009799 WO1996004384A1 (en) 1994-07-29 1995-07-31 Identification of a human cytomegalovirus gene involved in down-regulation of mhc class i heavy chain expression

Publications (2)

Publication Number Publication Date
FI970352A0 FI970352A0 (fi) 1997-01-28
FI970352A true FI970352A (fi) 1997-01-28

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ID=23082718

Family Applications (2)

Application Number Title Priority Date Filing Date
FI970351A FI970351A0 (fi) 1994-07-29 1997-01-28 MHC luokan I-raskasketjuekspression vähenemiseen osaaottavan ihmisen sytomegaloviruksen geenialueen tunnistus
FI970352A FI970352A (fi) 1994-07-29 1997-01-28 MHC-luokan I -raskasketjuekspression vähenemiseen osaaottavan ihmisen sytomegaloviruksen geenin tunnistus

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI970351A FI970351A0 (fi) 1994-07-29 1997-01-28 MHC luokan I-raskasketjuekspression vähenemiseen osaaottavan ihmisen sytomegaloviruksen geenialueen tunnistus

Country Status (11)

Country Link
US (6) US5846806A (fi)
EP (2) EP0775209A1 (fi)
JP (2) JP4036469B2 (fi)
KR (2) KR970704884A (fi)
AU (2) AU709552B2 (fi)
CA (3) CA2195668C (fi)
FI (2) FI970351A0 (fi)
MX (1) MX9700676A (fi)
NO (2) NO970370L (fi)
NZ (2) NZ290718A (fi)
WO (2) WO1996004383A1 (fi)

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WO1997032605A1 (en) * 1996-03-08 1997-09-12 Massachusetts Institute Of Technology Cytomegalovirus nucleic acids encoding proteins having normal or altered class i mhc binding and treatment of diseases
DE69732498T2 (de) * 1996-07-31 2006-04-27 Ortho-Mcneil Pharmaceutical, Inc. Erkennung von menschlichen cytomegalovirus genes, welche die expression von mhc klasse i schweren ketten erniedrigen
WO1998031813A1 (de) * 1997-01-17 1998-07-23 Roche Diagnostics Gmbh Inhibitor für die präsentation von antigenen durch mhc-klasse i moleküle
WO1998047914A2 (de) * 1997-04-18 1998-10-29 Roche Diagnostics Gmbh Us6 gen aus dem humanen cytomegalovirus (hcmv)
EP1045920A1 (en) * 1998-01-14 2000-10-25 Human Gene Therapy Research Institute Nucleotide expression systems with reduced immunogenicity for use in gene therapy
US6100008A (en) * 1998-09-14 2000-08-08 Ppg Industries Ohio, Inc. Positive photoresist with improved contrast ratio and photospeed
AU2752900A (en) * 1999-02-02 2000-08-25 Oregon Health And Science University Inhibition of the mhc class ii antigen presentation pathway and presentation to cd4+ cells
EP1350113A2 (en) * 2000-08-30 2003-10-08 Chemocentryx, Inc. Inhibition of cmv infection and dissemination
AU2002242085A1 (en) * 2001-02-02 2002-08-19 Chemocentryx, Inc. Methods and compositions useful for stimulating an immune response
US20030118568A1 (en) * 2001-12-18 2003-06-26 Board Of Trustees Of The University Of Arkansas Viral stealth technology to prevent T cell-mediated rejection of xenografts
WO2004076645A2 (en) * 2003-02-27 2004-09-10 University Of Massachusetts Compositions and methods for cytomegalovirus treatment
KR20050093003A (ko) * 2004-03-17 2005-09-23 이재본 직류형 마이크로 터빈 발전기
CN101605808A (zh) 2007-02-07 2009-12-16 希格马托制药工业公司 人巨细胞病毒(hcmv)的重组抗原
MX2010005229A (es) 2007-11-12 2010-11-05 Univ Pennsylvania Vacunas novedosas contra sub-tipos multiples de virus de influenza.
CA2793959C (en) 2010-03-25 2019-06-04 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
HUE049725T2 (hu) 2010-05-14 2020-10-28 Univ Oregon Health & Science Hepatitisz B vírusból izolált heterológ antigént kódoló rekombináns HCMV és RhCMV vektorok és alkalmazásuk
PT2691530T (pt) 2011-06-10 2018-05-10 Univ Oregon Health & Science Glicoproteínas e vectores recombinantes cmv
LT2964769T (lt) 2013-03-05 2018-12-10 Oregon Health & Science University Citomegalo viruso vektoriai, leidžiantys kontroliuoti ląstelių nukreipimą į taikinį
MA39818A (fr) 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
EP3169787A1 (en) 2014-07-16 2017-05-24 Oregon Health & Science University Human cytomegalovirus comprising exogenous antigens
KR20170136512A (ko) * 2015-02-10 2017-12-11 오레곤 헬스 앤드 사이언스 유니버시티 넌-캐노니컬 cd8+ t 세포 반응 생성에 유용한 방법 및 조성물
US10688164B2 (en) 2015-11-20 2020-06-23 Oregon Health & Science University CMV vectors comprising microRNA recognition elements
US10611800B2 (en) 2016-03-11 2020-04-07 Pfizer Inc. Human cytomegalovirus gB polypeptide
CN109843321A (zh) 2016-06-22 2019-06-04 国际艾滋病疫苗行动组织公司 作为结核病疫苗的重组巨细胞病毒载体
EP3529363A4 (en) 2016-10-18 2020-05-06 Oregon Health & Science University CYTOMEGALOVIRUS VECTORS, CALLING OUT T-CELLS, RESTRICTED BY A LARGE HISTOCOMPATIBILITY COMPLEX E-MOLECULE
WO2019079155A1 (en) 2017-10-17 2019-04-25 International Aids Vaccine Initiative, Inc. CASSETTES OF ANTIGENS OF TUBERCULOSIS
US11629172B2 (en) 2018-12-21 2023-04-18 Pfizer Inc. Human cytomegalovirus gB polypeptide
US11857622B2 (en) 2020-06-21 2024-01-02 Pfizer Inc. Human cytomegalovirus GB polypeptide

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US4058598A (en) * 1974-10-18 1977-11-15 Harold Stern Cytomegalovirus attenuation method and vaccine
US4689225A (en) * 1984-11-02 1987-08-25 Institut Merieux Vaccine for cytomegalovirus
US4877612A (en) * 1985-05-20 1989-10-31 Frank M. Berger Immunological adjuvant and process for preparing the same, pharmaceutical compositions, and process
US4877737A (en) * 1985-09-06 1989-10-31 Prutech Research And Development Partnership Attenuated pseudorabies virus which has a deletion in at least a portion of a repeat sequence and vaccine containing same
US5273876A (en) * 1987-06-26 1993-12-28 Syntro Corporation Recombinant human cytomegalovirus containing foreign gene
ATE118822T1 (de) * 1987-06-26 1995-03-15 Syntro Corp Rekombinanter, fremde gene enthaltender menschlicher cytomegalovirus und seine verwendung.
WO1989010966A1 (en) * 1988-05-09 1989-11-16 The Children's Hospital, Incorporated Vectors encoding hcmv glycoprotein and expression products
EP0521427A1 (en) * 1991-07-05 1993-01-07 American Cyanamid Company Method for identifying non-essential genes of the human cytomegalovirus genome and for screening for inhibitors of human cytomegalovirus

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US5720957A (en) 1998-02-24
JP4036469B2 (ja) 2008-01-23
CA2196207A1 (en) 1996-02-15
AU3153595A (en) 1996-03-04
AU3274595A (en) 1996-03-04
US5846806A (en) 1998-12-08
NO970370L (no) 1997-03-24
US5753476A (en) 1998-05-19
EP0775209A1 (en) 1997-05-28
NZ290718A (en) 1999-03-29
MX9700710A (es) 1997-09-30
AU709552B2 (en) 1999-09-02
NO970369D0 (no) 1997-01-28
KR970704884A (ko) 1997-09-06
WO1996004384A1 (en) 1996-02-15
CA2195668A1 (en) 1996-02-15
JPH10503378A (ja) 1998-03-31
NO970369L (no) 1997-03-21
KR970704883A (ko) 1997-09-06
AU708983B2 (en) 1999-08-19
MX9700676A (es) 1997-04-30
EP0772681A1 (en) 1997-05-14
WO1996004383A1 (en) 1996-02-15
CA2195668C (en) 2004-09-21
FI970352A0 (fi) 1997-01-28
US5908780A (en) 1999-06-01
FI970351A (fi) 1997-01-28
CA2196207C (en) 2002-04-30
CA2328638A1 (en) 1996-02-15
US5906935A (en) 1999-05-25
JPH10506268A (ja) 1998-06-23
FI970351A0 (fi) 1997-01-28
NZ291571A (en) 1999-01-28
US5843458A (en) 1998-12-01
NO970370D0 (no) 1997-01-28

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