FI962599L - Enantioselektiivinen menetelmä kiraalisten triaryylijohdannaisten ja niiden valmistuksessa käytettävien kiraalisten välituotteiden valmistamiseksi - Google Patents
Enantioselektiivinen menetelmä kiraalisten triaryylijohdannaisten ja niiden valmistuksessa käytettävien kiraalisten välituotteiden valmistamiseksi Download PDFInfo
- Publication number
- FI962599L FI962599L FI962599A FI962599A FI962599L FI 962599 L FI962599 L FI 962599L FI 962599 A FI962599 A FI 962599A FI 962599 A FI962599 A FI 962599A FI 962599 L FI962599 L FI 962599L
- Authority
- FI
- Finland
- Prior art keywords
- preparation
- chiral
- intermediates used
- enantioselective method
- triaryl derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939326173A GB9326173D0 (en) | 1993-12-22 | 1993-12-22 | Chemical compounds and process |
| PCT/GB1994/002799 WO1995017386A1 (en) | 1993-12-22 | 1994-12-22 | An enantioselective process for the preparation of chiral triaryl derivatives and chiral intermediates for use therein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI962599A0 FI962599A0 (fi) | 1996-06-20 |
| FI962599A7 FI962599A7 (fi) | 1996-06-20 |
| FI962599L true FI962599L (fi) | 1996-06-20 |
Family
ID=10747020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI962599A FI962599L (fi) | 1993-12-22 | 1994-12-22 | Enantioselektiivinen menetelmä kiraalisten triaryylijohdannaisten ja niiden valmistuksessa käytettävien kiraalisten välituotteiden valmistamiseksi |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5608070A (cs) |
| EP (1) | EP0736010A1 (cs) |
| JP (1) | JPH09510691A (cs) |
| KR (1) | KR100328191B1 (cs) |
| AU (1) | AU689837B2 (cs) |
| CA (1) | CA2177817A1 (cs) |
| CZ (1) | CZ294296B6 (cs) |
| FI (1) | FI962599L (cs) |
| GB (2) | GB9326173D0 (cs) |
| HU (1) | HUT76284A (cs) |
| NZ (1) | NZ277529A (cs) |
| WO (1) | WO1995017386A1 (cs) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9212673D0 (en) * | 1992-06-15 | 1992-07-29 | Celltech Ltd | Chemical compounds |
| GB9222253D0 (en) * | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds |
| GB9304920D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| GB9304919D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| GB9326699D0 (en) * | 1993-12-22 | 1994-03-02 | Celltech Ltd | Chemical compounds |
| WO1995017399A1 (en) * | 1993-12-22 | 1995-06-29 | Celltech Therapeutics Limited | Trisubstituted phenyl derivatives, processes for their preparation and their use as phosphodiesterase (type iv) inhibitors |
| US5786354A (en) * | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
| US6245774B1 (en) | 1994-06-21 | 2001-06-12 | Celltech Therapeutics Limited | Tri-substituted phenyl or pyridine derivatives |
| GB9412571D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9412573D0 (en) * | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9412672D0 (en) * | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9523675D0 (en) * | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| US5710170A (en) * | 1995-12-15 | 1998-01-20 | Merck Frosst Canada, Inc. | Tri-aryl ethane derivatives as PDE IV inhibitors |
| WO1997022586A1 (en) * | 1995-12-15 | 1997-06-26 | Merck Frosst Canada Inc. | Tri-aryl ethane derivatives as pde iv inhibitors |
| GB9603723D0 (en) * | 1996-02-22 | 1996-04-24 | Merck & Co Inc | Diphenyl pyridyl derivatives as pde iv inhibitors |
| GB9526246D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9526243D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9526245D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| AR006550A1 (es) * | 1996-04-17 | 1999-09-08 | Merck & Co Inc | Metodo de preparacion de inhibidores de fosfodiesterasa iv |
| GB9608435D0 (en) * | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
| ATE197148T1 (de) * | 1996-05-08 | 2000-11-15 | Merck & Co Inc | Verfahren zur herstellung von phosphodiesterase iv inhibitoren |
| US5808082A (en) * | 1996-05-08 | 1998-09-15 | Merck & Co., Inc. | Method of preparing phosphodiesterase IV inhibitors |
| GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
| DE69712631D1 (de) * | 1996-09-17 | 2002-06-20 | Merck & Co Inc | Verfahren zur herstellung von phosphodiesterase iv inhibitoren |
| AU4269597A (en) * | 1996-09-17 | 1998-04-14 | Merck & Co., Inc. | Process for bioreduction of bisaryl ketone to bisaryl alcohol |
| US5900368A (en) * | 1996-09-17 | 1999-05-04 | Merck & Co., Inc. | Process for bioreduction of bisaryl ketone to bisaryl alcohol |
| TW508353B (en) * | 1996-09-17 | 2002-11-01 | Merck & Co Inc | Method of preparing phosphodiesterase IV inhibitors |
| GB9622363D0 (en) | 1996-10-28 | 1997-01-08 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9625184D0 (en) * | 1996-12-04 | 1997-01-22 | Celltech Therapeutics Ltd | Chemical compounds |
| JP2001507349A (ja) * | 1996-12-23 | 2001-06-05 | セルテック セラピューティックス リミテッド | 縮合多環式２−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用 |
| GB9705361D0 (en) * | 1997-03-14 | 1997-04-30 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
| EP1367046A1 (en) | 1998-02-27 | 2003-12-03 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Disubstituted lavendustin A analogs and pharmaceutical compositions comprising the analogs |
| US6316434B1 (en) | 1999-03-03 | 2001-11-13 | Merck Frosst Canada & Co. | Assay for emetic activity |
| US6200993B1 (en) * | 1999-05-05 | 2001-03-13 | Merck Frosst Canada & Co. | Heterosubstituted pyridine derivatives as PDE4 inhibitors |
| US6316472B1 (en) * | 1999-05-13 | 2001-11-13 | Merck Frosst Canada & Co. | Heterosubstituted pyridine derivatives as PDE 4 inhibitors |
| GB9914258D0 (en) * | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
| EP2289549A3 (en) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunoconjugates for treating cancer |
| GB9924862D0 (en) * | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
| US6410563B1 (en) | 1999-12-22 | 2002-06-25 | Merck Frosst Canada & Co. | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors |
| US6639077B2 (en) | 2000-03-23 | 2003-10-28 | Merck Frosst Canada & Co. | Tri-aryl-substituted-ethane PDE4 inhibitors |
| MY123585A (en) | 2000-03-23 | 2006-05-31 | Merck Canada Inc | Tri-aryl-substituted-ethane pde4 inhibitors. |
| AU2001261962B2 (en) | 2000-05-25 | 2005-04-21 | Merck Frosst Canada Ltd | Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor |
| US6740666B2 (en) | 2000-12-20 | 2004-05-25 | Merck & Co., Inc. | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors |
| CA2447765C (en) | 2001-05-24 | 2011-01-25 | Merck Frosst Canada & Co./Merck Frosst Canada & Cie | 1-biaryl-1,8-napthyridin-4-one phosphodiesterase-4 inhibitors |
| RS94703A (en) * | 2001-05-29 | 2007-02-05 | Schering Aktiengesellschaft, | Cdk inhibiting pyrimidines, production thereof and their use as medicaments |
| JO2311B1 (en) | 2001-08-29 | 2005-09-12 | ميرك فروست كندا ليمتد | Alkyl inhibitors Ariel phosphodiesterase-4 |
| WO2004072066A1 (en) * | 2003-02-11 | 2004-08-26 | Prosidion Limited | Tri(cyclo) substituted amide glucokinase activator compounds |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
| CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| JP2009513672A (ja) | 2005-10-31 | 2009-04-02 | ブレインセルス，インコーポレイティド | 神経発生のｇａｂａ受容体媒介調節 |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | アンジオテンシン調節による神経新生 |
| JP2009536667A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | ５ｈｔ受容体介在性の神経新生 |
| AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2257272B1 (cs) * | 1974-01-15 | 1978-08-25 | Pharmascience Labo | |
| DE2413935A1 (de) * | 1974-03-20 | 1975-10-16 | Schering Ag | 4-(polyalkoxy-phenyl)-2-pyrrolidone |
| US4193926A (en) * | 1974-03-20 | 1980-03-18 | Schering Aktiengesellschaft | 4-(Polyalkoxy phenyl)-2-pyrrolidones |
| DE2541855A1 (de) * | 1975-09-18 | 1977-03-31 | Schering Ag | 4-(polyalkoxy-phenyl)-2-pyrrolidone ii |
| SU888821A3 (ru) * | 1976-12-03 | 1981-12-07 | Шеринг Аг (Инофирма) | Способ получени 5-(замещенный фенил)-оксазолидинонов или их серусодержащих аналогов |
| DE2962383D1 (en) * | 1978-06-15 | 1982-05-06 | Ici Plc | Anti-inflammatory 1-phenyl-2-aminoethanol derivatives, pharmaceutical compositions thereof for topical use, and processes for their manufacture |
| HU215433B (hu) * | 1986-04-29 | 2000-05-28 | Pfizer Inc. | Eljárás új 2-oxo-5-fenil-pirimidin-származékok előállítására |
| US5128358A (en) * | 1988-01-19 | 1992-07-07 | Pfizer Inc. | Aryl substituted nitrogen heterocyclic antidepressants |
| US4921862A (en) * | 1986-05-29 | 1990-05-01 | Syntex (U.S.A.) Inc. | Carbostyril derivatives as combined thromboxane synthetase and cyclic-amp phosphodiesterase inhibitors |
| US4792561A (en) * | 1986-05-29 | 1988-12-20 | Syntex (U.S.A.) Inc. | Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors |
| US4971959A (en) * | 1987-04-14 | 1990-11-20 | Warner-Lambert Company | Trisubstituted phenyl analogs having activity for congestive heart failure |
| US5274002A (en) * | 1987-04-14 | 1993-12-28 | Warner-Lambert Company | Trisubstituted phenyl analogs having activity for congestive heart failure |
| EP0469013B1 (de) * | 1989-04-17 | 1995-06-28 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue arylpyridazine, ihre herstellung, verwendung und sie enthaltende arzneimittel |
| DE4003919A1 (de) * | 1990-02-09 | 1991-08-14 | Basf Ag | Heteroarylalkene, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung |
| GB9007762D0 (en) * | 1990-04-05 | 1990-06-06 | Beecham Group Plc | Novel compounds |
| AU7854291A (en) * | 1990-04-27 | 1991-11-27 | Rorer International (Holdings), Inc. | Styryl compounds which inhibit egf receptor protein tyrosine kinase |
| MC2311A1 (fr) * | 1990-07-10 | 1993-09-27 | Smithkline Beecham Corp | Oxamides |
| US5124455A (en) * | 1990-08-08 | 1992-06-23 | American Home Products Corporation | Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents |
| JPH06501254A (ja) * | 1990-09-28 | 1994-02-10 | スミス・クライン・アンド・フレンチ・ラボラトリース・リミテッド | 医薬用フェニルピリジノール誘導体 |
| EP0553174B1 (de) * | 1990-10-16 | 1998-07-08 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Arylpyridazinone |
| AU9030691A (en) * | 1990-11-06 | 1992-05-26 | Smithkline Beecham Corporation | Imidazolidinone compounds |
| GB9027055D0 (en) * | 1990-12-13 | 1991-02-06 | Sandoz Ltd | Organic compounds |
| IE71647B1 (en) * | 1991-01-28 | 1997-02-26 | Rhone Poulenc Rorer Ltd | Benzamide derivatives |
| WO1992019602A1 (de) * | 1991-04-26 | 1992-11-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue pyridazine |
| US5191084A (en) * | 1991-05-01 | 1993-03-02 | American Home Products Corporation | Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents |
| PT100441A (pt) * | 1991-05-02 | 1993-09-30 | Smithkline Beecham Corp | Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso |
| EP0540165A1 (en) * | 1991-10-03 | 1993-05-05 | Zeneca Limited | Alkanoic acid derivatives |
| CA2080554A1 (en) * | 1991-10-15 | 1993-04-16 | Mitsubishi Chemical Corporation | Styrene derivatives |
| US5326898A (en) * | 1992-02-11 | 1994-07-05 | Allergan, Inc. | Substituted phenylethenyl compounds having retinoid-like biological activity |
| DE69328778T2 (de) * | 1992-04-02 | 2000-11-23 | Smithkline Beecham Corp., Philadelphia | Verbindungen für die behandlung von entzündlichen erkrankungen und zur hemmung der produktion von tumornekrosefaktor |
| AU4717693A (en) * | 1992-07-28 | 1994-02-14 | Rhone-Poulenc Rorer Limited | Inhibitors of c-amp phosphodiesterase and tnf |
| PT672031E (pt) * | 1992-12-02 | 2003-06-30 | Pfizer | Dieteres de catecol como inibidores selectivos de pde iv |
| TW263495B (cs) * | 1992-12-23 | 1995-11-21 | Celltech Ltd |
-
1993
- 1993-12-22 GB GB939326173A patent/GB9326173D0/en active Pending
-
1994
- 1994-12-21 US US08/361,439 patent/US5608070A/en not_active Expired - Lifetime
- 1994-12-22 NZ NZ277529A patent/NZ277529A/en not_active IP Right Cessation
- 1994-12-22 JP JP7517279A patent/JPH09510691A/ja active Pending
- 1994-12-22 WO PCT/GB1994/002799 patent/WO1995017386A1/en active IP Right Grant
- 1994-12-22 HU HU9601725A patent/HUT76284A/hu unknown
- 1994-12-22 CA CA002177817A patent/CA2177817A1/en not_active Abandoned
- 1994-12-22 AU AU12783/95A patent/AU689837B2/en not_active Ceased
- 1994-12-22 KR KR1019960703333A patent/KR100328191B1/ko not_active Expired - Fee Related
- 1994-12-22 CZ CZ19961819A patent/CZ294296B6/cs not_active IP Right Cessation
- 1994-12-22 EP EP95903885A patent/EP0736010A1/en not_active Withdrawn
- 1994-12-22 FI FI962599A patent/FI962599L/fi not_active IP Right Cessation
- 1994-12-22 GB GB9612213A patent/GB2299082B/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GB2299082A (en) | 1996-09-25 |
| GB9326173D0 (en) | 1994-02-23 |
| CZ294296B6 (cs) | 2004-11-10 |
| FI962599A0 (fi) | 1996-06-20 |
| EP0736010A1 (en) | 1996-10-09 |
| JPH09510691A (ja) | 1997-10-28 |
| HU9601725D0 (en) | 1996-08-28 |
| AU1278395A (en) | 1995-07-10 |
| KR100328191B1 (ko) | 2002-07-27 |
| GB2299082B (en) | 1998-06-17 |
| WO1995017386A1 (en) | 1995-06-29 |
| HUT76284A (en) | 1997-07-28 |
| FI962599A7 (fi) | 1996-06-20 |
| NZ277529A (en) | 1998-03-25 |
| CA2177817A1 (en) | 1995-06-29 |
| US5608070A (en) | 1997-03-04 |
| CZ181996A3 (en) | 1997-02-12 |
| AU689837B2 (en) | 1998-04-09 |
| GB9612213D0 (en) | 1996-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |