FI961819A - Proteiini:farnesyylitransferaasin substituoidut di- ja tripeptidi-inhibiittorit - Google Patents

Proteiini:farnesyylitransferaasin substituoidut di- ja tripeptidi-inhibiittorit Download PDF

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Publication number
FI961819A
FI961819A FI961819A FI961819A FI961819A FI 961819 A FI961819 A FI 961819A FI 961819 A FI961819 A FI 961819A FI 961819 A FI961819 A FI 961819A FI 961819 A FI961819 A FI 961819A
Authority
FI
Finland
Prior art keywords
farnesyltransferase
protein
substituted
tripeptide inhibitors
tripeptide
Prior art date
Application number
FI961819A
Other languages
English (en)
Swedish (sv)
Other versions
FI961819A0 (fi
Inventor
Gary Louis Bolton
Mark Wallace Creswell
John Cooke Hodges
Michael William Wilson
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of FI961819A publication Critical patent/FI961819A/fi
Publication of FI961819A0 publication Critical patent/FI961819A0/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
FI961819A 1993-11-05 1996-04-29 Proteiini:farnesyylitransferaasin substituoidut di- ja tripeptidi-inhibiittorit FI961819A0 (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14873593A 1993-11-05 1993-11-05
US30330194A 1994-09-13 1994-09-13
PCT/US1994/011553 WO1995012612A1 (en) 1993-11-05 1994-10-12 Substituted di- and tripeptide inhibitors of protein:farnesyl transferase

Publications (2)

Publication Number Publication Date
FI961819A true FI961819A (fi) 1996-04-29
FI961819A0 FI961819A0 (fi) 1996-04-29

Family

ID=26846110

Family Applications (1)

Application Number Title Priority Date Filing Date
FI961819A FI961819A0 (fi) 1993-11-05 1996-04-29 Proteiini:farnesyylitransferaasin substituoidut di- ja tripeptidi-inhibiittorit

Country Status (10)

Country Link
EP (1) EP0730605A1 (fi)
JP (1) JP3597863B2 (fi)
KR (1) KR100362338B1 (fi)
AU (1) AU681454B2 (fi)
CA (1) CA2170766A1 (fi)
FI (1) FI961819A0 (fi)
HU (1) HUT75308A (fi)
NO (1) NO961814L (fi)
NZ (1) NZ275691A (fi)
WO (1) WO1995012612A1 (fi)

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US5968965A (en) * 1996-01-30 1999-10-19 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
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BR9709354A (pt) * 1996-05-22 1999-08-10 Warner Lambert Co Inibidores de proteína farnesil transferase
US6300501B1 (en) 1996-05-22 2001-10-09 Warner-Lambert Company Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase
PE46999A1 (es) * 1996-12-17 1999-05-20 Warner Lambert Co Inhibidores de cicloalquilo de la enzima farnesiltransferasa de las proteinas
FR2757855B1 (fr) * 1996-12-30 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
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US6124465A (en) * 1997-11-25 2000-09-26 Rhone-Poulenc S.A. Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments
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Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
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Also Published As

Publication number Publication date
CA2170766A1 (en) 1995-05-11
AU681454B2 (en) 1997-08-28
KR100362338B1 (ko) 2003-04-08
HUT75308A (en) 1997-05-28
NO961814D0 (no) 1996-05-03
NZ275691A (en) 1998-03-25
HU9601193D0 (en) 1996-07-29
AU7976094A (en) 1995-05-23
WO1995012612A1 (en) 1995-05-11
JP3597863B2 (ja) 2004-12-08
FI961819A0 (fi) 1996-04-29
EP0730605A1 (en) 1996-09-11
NO961814L (no) 1996-05-06
JPH09504547A (ja) 1997-05-06

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