FI961819A - Protein: substituted farnesyltransferase di- and tripeptide inhibitors - Google Patents

Protein: substituted farnesyltransferase di- and tripeptide inhibitors Download PDF

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Publication number
FI961819A
FI961819A FI961819A FI961819A FI961819A FI 961819 A FI961819 A FI 961819A FI 961819 A FI961819 A FI 961819A FI 961819 A FI961819 A FI 961819A FI 961819 A FI961819 A FI 961819A
Authority
FI
Finland
Prior art keywords
farnesyltransferase
protein
substituted
tripeptide inhibitors
tripeptide
Prior art date
Application number
FI961819A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI961819A0 (en
Inventor
Gary Louis Bolton
Mark Wallace Creswell
John Cooke Hodges
Michael William Wilson
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of FI961819A0 publication Critical patent/FI961819A0/en
Publication of FI961819A publication Critical patent/FI961819A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FI961819A 1993-11-05 1996-04-29 Protein: substituted farnesyltransferase di- and tripeptide inhibitors FI961819A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14873593A 1993-11-05 1993-11-05
US30330194A 1994-09-13 1994-09-13
PCT/US1994/011553 WO1995012612A1 (en) 1993-11-05 1994-10-12 Substituted di- and tripeptide inhibitors of protein:farnesyl transferase

Publications (2)

Publication Number Publication Date
FI961819A0 FI961819A0 (en) 1996-04-29
FI961819A true FI961819A (en) 1996-04-29

Family

ID=26846110

Family Applications (1)

Application Number Title Priority Date Filing Date
FI961819A FI961819A (en) 1993-11-05 1996-04-29 Protein: substituted farnesyltransferase di- and tripeptide inhibitors

Country Status (10)

Country Link
EP (1) EP0730605A1 (en)
JP (1) JP3597863B2 (en)
KR (1) KR100362338B1 (en)
AU (1) AU681454B2 (en)
CA (1) CA2170766A1 (en)
FI (1) FI961819A (en)
HU (1) HUT75308A (en)
NO (1) NO961814L (en)
NZ (1) NZ275691A (en)
WO (1) WO1995012612A1 (en)

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US5981562A (en) * 1996-01-30 1999-11-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
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US6011029A (en) * 1996-02-26 2000-01-04 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase
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US6300501B1 (en) 1996-05-22 2001-10-09 Warner-Lambert Company Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase
DK0951471T3 (en) 1996-12-17 2004-07-19 Warner Lambert Co Cycloalkyl inhibitors of protein farnesyl transferase
FR2757855B1 (en) * 1996-12-30 1999-01-29 Rhone Poulenc Rorer Sa NOVEL FARNESYL TRANSFERASE INHIBITORS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US6013662A (en) * 1996-12-30 2000-01-11 Rhone-Poulenc Rorer S.A. Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments
US6124465A (en) * 1997-11-25 2000-09-26 Rhone-Poulenc S.A. Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments
US6423689B1 (en) 1997-12-22 2002-07-23 Warner-Lambert Company Peptidyl calcium channel blockers
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US20010031771A1 (en) 1999-05-24 2001-10-18 Gary Maurice Dull Pharmaceutical compositions and methods for use
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CA2770486C (en) 2006-09-22 2014-07-15 Merck Sharp & Dohme Corp. Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
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US8822497B2 (en) 2007-03-01 2014-09-02 Novartis Ag PIM kinase inhibitors and methods of their use
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JP5501227B2 (en) 2007-06-27 2014-05-21 メルク・シャープ・アンド・ドーム・コーポレーション 4-Carboxybenzylamino derivatives as histone deacetylase inhibitors
JP5452237B2 (en) 2008-02-07 2014-03-26 杏林製薬株式会社 Therapeutic or prophylactic agent for inflammatory bowel disease comprising an amino alcohol derivative as an active ingredient
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WO2010144909A1 (en) 2009-06-12 2010-12-16 Novartis Ag Fused heterocyclic compounds and their uses
US8859776B2 (en) 2009-10-14 2014-10-14 Merck Sharp & Dohme Corp. Substituted piperidines that increase p53 activity and the uses thereof
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US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
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US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
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EP3706742B1 (en) 2017-11-08 2023-03-15 Merck Sharp & Dohme LLC Prmt5 inhibitors
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Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2072033A1 (en) * 1991-06-28 1992-12-29 Jackson B. Gibbs Non-substrate inhibitors of farnesyl protein transferase

Also Published As

Publication number Publication date
KR100362338B1 (en) 2003-04-08
AU7976094A (en) 1995-05-23
EP0730605A1 (en) 1996-09-11
FI961819A0 (en) 1996-04-29
NZ275691A (en) 1998-03-25
HUT75308A (en) 1997-05-28
CA2170766A1 (en) 1995-05-11
AU681454B2 (en) 1997-08-28
NO961814D0 (en) 1996-05-03
WO1995012612A1 (en) 1995-05-11
NO961814L (en) 1996-05-06
JPH09504547A (en) 1997-05-06
JP3597863B2 (en) 2004-12-08
HU9601193D0 (en) 1996-07-29

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