FI952094A - Ihmisen serotoniinireseptoria (5-HT4B)koodaava DNA ja sen käyttö - Google Patents

Ihmisen serotoniinireseptoria (5-HT4B)koodaava DNA ja sen käyttö Download PDF

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Publication number
FI952094A
FI952094A FI952094A FI952094A FI952094A FI 952094 A FI952094 A FI 952094A FI 952094 A FI952094 A FI 952094A FI 952094 A FI952094 A FI 952094A FI 952094 A FI952094 A FI 952094A
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FI
Finland
Prior art keywords
ht4b
pct
dna encoding
serotonin receptor
human serotonin
Prior art date
Application number
FI952094A
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English (en)
Swedish (sv)
Other versions
FI952094A0 (fi
FI111337B (fi
Inventor
Jonathan A Bard
Theresa Branchek
Richard L Weinshank
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Synaptic Pharma Corp
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Application filed by Synaptic Pharma Corp filed Critical Synaptic Pharma Corp
Publication of FI952094A0 publication Critical patent/FI952094A0/fi
Publication of FI952094A publication Critical patent/FI952094A/fi
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0375—Animal model for cardiovascular diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
FI952094A 1992-11-03 1995-05-02 Ihmisen serotoniinireseptoria (5-HT4B) koodaava DNA ja sen käyttö FI111337B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US97169092A 1992-11-03 1992-11-03
US97169092 1992-11-03
PCT/US1993/010553 WO1994009828A1 (en) 1992-11-03 1993-10-29 Dna encoding a human serotonin receptor (5-ht4b) and uses thereof
US9310553 1993-10-29

Publications (3)

Publication Number Publication Date
FI952094A0 FI952094A0 (fi) 1995-05-02
FI952094A true FI952094A (fi) 1995-06-29
FI111337B FI111337B (fi) 2003-07-15

Family

ID=25518691

Family Applications (1)

Application Number Title Priority Date Filing Date
FI952094A FI111337B (fi) 1992-11-03 1995-05-02 Ihmisen serotoniinireseptoria (5-HT4B) koodaava DNA ja sen käyttö

Country Status (15)

Country Link
US (4) US5985585A (fi)
EP (1) EP0624100B1 (fi)
JP (1) JPH08506240A (fi)
KR (1) KR950704001A (fi)
AT (1) ATE192490T1 (fi)
AU (1) AU686580B2 (fi)
CA (1) CA2127117C (fi)
DE (2) DE624100T1 (fi)
ES (1) ES2070104T1 (fi)
FI (1) FI111337B (fi)
GR (1) GR950300029T1 (fi)
HU (1) HU221822B1 (fi)
NO (1) NO951689L (fi)
NZ (1) NZ258320A (fi)
WO (1) WO1994009828A1 (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6300087B1 (en) * 1992-11-03 2001-10-09 Synaptic Pharmaceutical Corporation DNA encoding a human serotonin receptor (5-HT4B) and uses thereof
DE624100T1 (de) 1992-11-03 1995-11-09 Synaptic Pharma Corp Für einen humanen serotoninrezeptor (5-ht4b) kodierende dns und ihre verwendung.
US6228864B1 (en) * 1997-10-28 2001-05-08 Vivus, Inc. Administration of 5-HT receptor agonists and antagonists, to treat premature ejaculation
FR2771741B1 (fr) * 1997-11-28 2001-07-13 Inst Nat Sante Rech Med Variants d'epissage du recepteur serotoninergique 5-ht4 humain et leurs applications, notamment pour le criblage
EP0998923A1 (en) * 1998-10-30 2000-05-10 Basf Aktiengesellschaft Use of 5-HT7 receptor agonists for the treatment or prophylaxis of ischemias
WO2000069437A1 (en) 1999-05-18 2000-11-23 Synaptic Pharmaceutical Corporation Use of agonists or antagonists of the 5-ht7 receptor to treat disorders of the bladder
ES2254382T3 (es) * 2000-02-17 2006-06-16 Glaxo Group Limited Polimorfismos del gen transportador de 5-hidroxitriptamina.
WO2002036629A2 (en) * 2000-10-31 2002-05-10 Bayer Aktiengesellschaft Regulation of human serotonin receptor precursor
US6989239B2 (en) * 2001-06-20 2006-01-24 R.E.D. Laboratories, N.V./S.A. Methods for diagnosis and treatment of chronic immune diseases
AU2003211501A1 (en) * 2002-02-08 2003-09-02 Nakoshi, Hideo Peptides
US7463934B2 (en) * 2002-04-12 2008-12-09 Medtronic, Inc. Implantable medical device with captivation fixation
FR2846559B1 (fr) 2002-10-31 2007-06-15 Centre Nat Rech Scient Composition pharmaceutique pour la preparation d'un medicament destine a traiter et/ou a prevenir une pathologie liee a une conduite obsessionnelle
US20070128603A1 (en) * 2003-05-28 2007-06-07 Bayer Healthcare Ag Diagnostic and therapeutics for diseases associated with 5-hydroxytryptamine (serotonin) receptor 7 (5-ht7)
US9395365B2 (en) * 2009-04-02 2016-07-19 Abbott Point Of Care, Inc. Detection of infectious disease in a human or animal by measuring specific phagocytosis in a thin film sample of their anticoagulated blood

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1208146A (en) * 1983-10-27 1986-07-22 Tai-Kin Wong Method of transferring genes into cells
US4985352A (en) * 1988-02-29 1991-01-15 The Trustees Of Columbia University In The City Of New York DNA encoding serotonin 1C (5HT1c) receptor, isolated 5HT1c receptor, mammalian cells expressing same and uses thereof
AU652349B2 (en) * 1989-10-27 1994-08-25 Salk Institute For Biological Studies, The Glutamate receptor compositions and methods
WO1991013979A1 (en) * 1990-03-05 1991-09-19 President And Fellows Of Harvard College Transgenic mouse overexpressing il-4 and method of use
US5155218A (en) * 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
US5225543A (en) * 1991-03-28 1993-07-06 American Cyanamid Company Receptors method for purification of g protein-linked
DE585415T1 (de) * 1991-12-02 1996-10-10 Synaptic Pharma Corp Dns-kodierend für den menschlichen 5-ht 1e rezeptor und seine verwendung.
US5360735A (en) * 1992-01-08 1994-11-01 Synaptic Pharmaceutical Corporation DNA encoding a human 5-HT1F receptor, vectors, and host cells
FR2693200B1 (fr) * 1992-07-01 1994-08-19 Inst Nat Sante Rech Med Nouveaux polypeptides ayant une activité de récepteur sérotoninergique, acides nucléiques codant pour ces polypeptides et utilisations.
FR2693201B1 (fr) * 1992-07-01 1994-08-19 Inst Nat Sante Rech Med Nouveaux polypeptides ayant une activité de récepteur sérotoninergique, acides nucléiques codant pour ces polyptides et utilisations.
DE69333660T2 (de) 1992-10-26 2006-02-23 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Pct-65 serotonin rezeptor
DE624100T1 (de) 1992-11-03 1995-11-09 Synaptic Pharma Corp Für einen humanen serotoninrezeptor (5-ht4b) kodierende dns und ihre verwendung.
FR2699922B1 (fr) * 1992-12-30 1995-02-10 Inst Nat Sante Rech Med Polypeptides à activité de récepteur sérotoninergique, médicaments les comprenant, séquences codant pour eux, sondes vecteurs et hôtes les exprimant, et application au criblage des médicaments.
US5968817A (en) * 1993-03-15 1999-10-19 The Scripps Research Institute DNA encoding serotonin receptors
US7980514B2 (en) * 2008-03-14 2011-07-19 Northrop Grumman Space & Mission Systems Corp. Solar array momentum control

Also Published As

Publication number Publication date
KR950704001A (ko) 1995-11-17
EP0624100B1 (en) 2000-05-03
AU686580B2 (en) 1998-02-12
ATE192490T1 (de) 2000-05-15
HU221822B1 (hu) 2003-01-28
AU5590994A (en) 1994-05-24
DE69328549T2 (de) 2000-08-24
FI952094A0 (fi) 1995-05-02
HUT72837A (en) 1996-05-28
NZ258320A (en) 1996-12-20
US6376243B1 (en) 2002-04-23
US6432655B1 (en) 2002-08-13
CA2127117A1 (en) 1994-05-11
NO951689D0 (no) 1995-05-02
US6083749A (en) 2000-07-04
JPH08506240A (ja) 1996-07-09
NO951689L (no) 1995-06-21
DE624100T1 (de) 1995-11-09
ES2070104T1 (es) 1995-06-01
WO1994009828A1 (en) 1994-05-11
FI111337B (fi) 2003-07-15
EP0624100A1 (en) 1994-11-17
US5985585A (en) 1999-11-16
GR950300029T1 (en) 1995-06-30
EP0624100A4 (en) 1995-11-29
CA2127117C (en) 2001-02-13
DE69328549D1 (de) 2000-06-08

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Owner name: LUNDBECK RESEARCH USA, INC.

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