FI950908A0 - Antitussiv - Google Patents

Antitussiv

Info

Publication number
FI950908A0
FI950908A0 FI950908A FI950908A FI950908A0 FI 950908 A0 FI950908 A0 FI 950908A0 FI 950908 A FI950908 A FI 950908A FI 950908 A FI950908 A FI 950908A FI 950908 A0 FI950908 A0 FI 950908A0
Authority
FI
Finland
Prior art keywords
antitussive
Prior art date
Application number
FI950908A
Other languages
English (en)
Finnish (fi)
Other versions
FI950908A (sv
Inventor
Hiroshi Nagase
Koji Kawai
Takashi Endo
Shinaya Ueno
Yuji Negishi
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of FI950908A0 publication Critical patent/FI950908A0/sv
Publication of FI950908A publication Critical patent/FI950908A/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI950908A 1993-06-30 1995-02-28 Antitussiv FI950908A (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP16162693 1993-06-30
PCT/JP1994/001047 WO1995001178A1 (fr) 1993-06-30 1994-06-28 Antitussif

Publications (2)

Publication Number Publication Date
FI950908A0 true FI950908A0 (sv) 1995-02-28
FI950908A FI950908A (sv) 1995-04-28

Family

ID=15738765

Family Applications (1)

Application Number Title Priority Date Filing Date
FI950908A FI950908A (sv) 1993-06-30 1995-02-28 Antitussiv

Country Status (11)

Country Link
US (1) US5739145A (sv)
EP (1) EP0657163B1 (sv)
KR (1) KR950702833A (sv)
CN (1) CN1111900A (sv)
AU (1) AU683664B2 (sv)
CA (1) CA2143318A1 (sv)
DE (1) DE69413933T2 (sv)
FI (1) FI950908A (sv)
NO (1) NO950757L (sv)
TW (1) TW329386B (sv)
WO (1) WO1995001178A1 (sv)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE172201T1 (de) * 1992-01-23 1998-10-15 Toray Industries Morphinan-derivate und medizinische verwendung
CA2144770C (en) * 1993-07-19 2006-02-28 Hiroshi Nagase Brain cell protective agent
CA2143864C (en) 1993-07-23 2006-01-24 Hiroshi Nagase Morphinan derivatives and pharmaceutical use thereof
EP0829481A1 (en) * 1996-09-16 1998-03-18 Pfizer Inc. Morphinan hydroxamic acid compounds
CN1291717C (zh) * 1996-11-25 2006-12-27 东丽株式会社 止痒药物
US6440987B1 (en) 1996-11-25 2002-08-27 Toray Industries, Inc. Antipruritic
US6403602B1 (en) * 1997-02-20 2002-06-11 The University Of Kentucky Research Foundation Morphine-6-sulfate analogues and their use for the treatment of pain
CA2383146C (en) * 1999-08-24 2010-11-16 Hiroshi Nagase Therapeutic agent for neuropathic pain and neuropathic pain animal model
WO2002080918A1 (fr) * 2001-04-02 2002-10-17 Toray Industries, Inc. Agent therapeutique ou prophylactique en cas de miction frequente ou d'incontinence urinaire
KR101333620B1 (ko) 2005-04-06 2013-11-27 도레이 카부시키가이샤 모르피난 유도체의 결정 및 그 제조법
KR101477043B1 (ko) 2007-04-24 2014-12-29 도레이 카부시키가이샤 디스키네시아의 치료 또는 예방제
CA2691220C (en) * 2007-06-22 2015-05-05 Toray Industries, Inc. Remedy or preventive for integration dysfunction syndrome
WO2009103004A1 (en) * 2008-02-14 2009-08-20 Alkermes, Inc. Selective opioid compounds
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
JP2012518652A (ja) * 2009-02-23 2012-08-16 マリンクロッド インコーポレイテッド （＋）−６−ヒドロキシ−モルフィナンまたは（＋）−６−アミノ−モルフィナン誘導体
US8436174B2 (en) * 2009-02-23 2013-05-07 Mallinckrodt Llc (+)-morphinanium quaternary salts and processes for their production
CN102325777B (zh) * 2009-02-23 2015-08-12 马林克罗特公司 (+)-吗啡喃*n-氧化物及其制备方法
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CA2787323C (en) 2010-01-29 2017-08-29 Toray Industries, Inc. Therapeutic or prophylactic agent for biliary tract diseases
EP2630150B1 (en) 2010-10-19 2017-04-12 Memorial Sloan-Kettering Cancer Center 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain
EP2671585B1 (en) 2011-01-31 2016-07-13 Toray Industries, Inc. (-)-17-(cyclopropylmethyl)-3,14ß-dihydroxy-4,5a-epoxy-6ß-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan for use in treating or preventing cancer cachexia
ES2566620T3 (es) 2011-09-08 2016-04-14 Mallinckrodt Llc Procesamiento de alcaloides sin el aislamiento de intermedios
EP3291676B1 (en) 2015-04-30 2022-08-17 Memorial Sloan Kettering Cancer Center Mitragynine analogs and uses thereof
CN105461727A (zh) * 2015-12-01 2016-04-06 吕涛 一种纳呋拉啡的精制方法
CN106866688B (zh) * 2015-12-10 2019-05-03 山东诚创医药技术开发有限公司 一种纳呋拉啡的精制方法
CN115181109B (zh) * 2021-04-02 2024-06-04 南京正大天晴制药有限公司 吗啡喃衍生物的晶体及其制备方法
CN114736210A (zh) * 2022-03-29 2022-07-12 伊诺药物研究(南京)有限公司 吗啡喃衍生物的一种晶型的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB843908A (en) * 1957-12-20 1960-08-10 Hoffmann La Roche Novel morphinan derivatives and the manufacture thereof
FR1503524A (fr) * 1964-10-17 1967-12-01 Tanabe Seiyaku Co Morphine à noyaux b/c condensés en configuration trans, et son procédé de préparation
US3865943A (en) * 1971-02-19 1975-02-11 Boehringer Sohn Ingelheim Pharmaceutical compositions containing an n-(furyl-methyl)-3-oxy-morphinan and method of use
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
US3880863A (en) * 1973-08-31 1975-04-29 Warner Lambert Co 17-Aralkyl-6 beta-azido-4,5 alpha-epox-ymorphinan-3-01{hu s
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
US4613668A (en) * 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US4730048A (en) * 1985-12-12 1988-03-08 Regents Of The University Of Minnesota Gut-selective opiates
US4912114A (en) * 1988-03-18 1990-03-27 Sandoz Ltd. Morphinan derivatives
DE415693T1 (de) * 1989-08-28 1991-10-17 Arizona Technology Development Corp., Tucson, Ariz. Zusammensetzung und verfahren zur selektiven verstaerkung der opiat-wirkung und verminderung von opiat-toleranz und abhaengigkeit.
ATE172201T1 (de) * 1992-01-23 1998-10-15 Toray Industries Morphinan-derivate und medizinische verwendung

Also Published As

Publication number Publication date
EP0657163A1 (en) 1995-06-14
NO950757D0 (no) 1995-02-27
KR950702833A (ko) 1995-08-23
EP0657163B1 (en) 1998-10-14
WO1995001178A1 (fr) 1995-01-12
AU6984494A (en) 1995-01-24
AU683664B2 (en) 1997-11-20
TW329386B (en) 1998-04-11
DE69413933T2 (de) 1999-04-08
NO950757L (no) 1995-04-27
CN1111900A (zh) 1995-11-15
US5739145A (en) 1998-04-14
DE69413933D1 (de) 1998-11-19
FI950908A (sv) 1995-04-28
CA2143318A1 (en) 1995-01-12
EP0657163A4 (en) 1995-12-13

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